Cepharanthine_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cepharanthine perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cepharanthine_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.196807
TMSB4X thymosin beta 4, X-linked 0.121369
LMO7 LIM domain 7 0.104328
PLEC plectin 0.097018
PODXL podocalyxin-like 0.0824572
TIMP3 TIMP metallopeptidase inhibitor 3 0.0800519
HLA-B major histocompatibility complex, class I, B 0.0794342
MEGF6 multiple EGF-like-domains 6 0.0683375
MT2A metallothionein 2A 0.0674081
B2M beta-2-microglobulin 0.0669901
EHBP1L1 EH domain binding protein 1-like 1 0.0603888
BHLHE40 basic helix-loop-helix family, member e40 0.0579192
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0555053
TMSB10 thymosin beta 10 0.0545395
HSPG2 heparan sulfate proteoglycan 2 0.0539935
LAMA5 laminin, alpha 5 0.0538074
EEF2 eukaryotic translation elongation factor 2 0.0537826
PALM2AKAP2 PALM2 and AKAP2 fusion 0.053053
NCOR2 nuclear receptor corepressor 2 0.051748
IGFBP6 insulin-like growth factor binding protein 6 0.0499045
MYH9 myosin, heavy chain 9, non-muscle 0.0495507
FLNA filamin A, alpha 0.0489752
AHNAK AHNAK nucleoprotein 0.0486734
PDE4D phosphodiesterase 4D, cAMP-specific 0.0478013
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0472325
RPL7A ribosomal protein L7a 0.0461656
SULF2 sulfatase 2 0.0459552
EZR ezrin 0.0457253
CALR calreticulin 0.0449176
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0439528
PCDH1 protocadherin 1 0.0438089
AHNAK2 AHNAK nucleoprotein 2 0.0433796
IFITM3 interferon induced transmembrane protein 3 0.041582
HLA-C major histocompatibility complex, class I, C 0.0395278
NAV2 neuron navigator 2 0.0394968
IFITM1 interferon induced transmembrane protein 1 0.0382047
C1D C1D nuclear receptor corepressor 0.0374252
FLNB filamin B, beta 0.0363037
FTL ferritin, light polypeptide 0.0360613
TGM2 transglutaminase 2 0.0360245
CEP250 centrosomal protein 250kDa 0.0357929
ITGB4 integrin, beta 4 0.0346512
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0341603
LAMC2 laminin, gamma 2 0.0338923
ACTN4 actinin, alpha 4 0.0335963
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0331945
HLA-A major histocompatibility complex, class I, A 0.0326331
SLC35F3 solute carrier family 35, member F3 0.0322761
CD44 CD44 molecule (Indian blood group) 0.0320624
ACSS2 acyl-CoA synthetase short-chain family member 2 0.0319973
SF3A1 splicing factor 3a, subunit 1, 120kDa 0.031652
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0316326
RNF213 ring finger protein 213 0.0315053
ZMYND8 zinc finger, MYND-type containing 8 0.0312426
SH3PXD2A SH3 and PX domains 2A 0.0305395
SRRM2 serine/arginine repetitive matrix 2 0.0304612
APP amyloid beta (A4) precursor protein 0.0292838
SFTPA2 surfactant protein A2 0.0292215
MPRIP myosin phosphatase Rho interacting protein 0.028219
TXNIP thioredoxin interacting protein 0.028163
TSPYL2 TSPY-like 2 0.0280889
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0276769
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 0.0275361
ADM adrenomedullin 0.027331
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.0267911
MKI67 marker of proliferation Ki-67 0.0266939
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0261894
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0258739
TSPAN3 tetraspanin 3 0.0255388
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0253738
RPS19 ribosomal protein S19 0.0252119
BACE2 beta-site APP-cleaving enzyme 2 0.0251739
JAG1 jagged 1 0.0248311
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0245529
H1-0 H1.0 linker histone 0.0243463
HSPA8 heat shock 70kDa protein 8 0.0242157
EXT1 exostosin glycosyltransferase 1 0.0240287
GRAMD1B GRAM domain containing 1B 0.0236098
YBX1 Y box binding protein 1 0.0233707
RASA3 RAS p21 protein activator 3 0.0233291
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0230203
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.02266
LOC112694756 uncharaterized LOC112694756 0.0225644
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.0223289
ANKRD11 ankyrin repeat domain 11 0.0222946
CSNK1E casein kinase 1, epsilon 0.021878
PLXNB2 plexin B2 0.0217214
TPT1 tumor protein, translationally-controlled 1 0.0213672
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.0212598
RYR2 ryanodine receptor 2 (cardiac) 0.0212275
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0211074
MT1X metallothionein 1X 0.0208474
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 0.020673
TPR translocated promoter region, nuclear basket protein 0.020479
ZMIZ1 zinc finger, MIZ-type containing 1 0.0204581
THRAP3 thyroid hormone receptor associated protein 3 0.0202966
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.020261
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0200761
PPP1R18 protein phosphatase 1, regulatory subunit 18 0.019759
VEGFA vascular endothelial growth factor A 0.0196654

decreased expression

Symbol Name Standardized Value
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.100852
DPYD dihydropyrimidine dehydrogenase -0.0929912
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.080392
RBM39 RNA binding motif protein 39 -0.0703789
NAMPT nicotinamide phosphoribosyltransferase -0.0678169
CLU clusterin -0.0624017
MEF2A myocyte enhancer factor 2A -0.0602221
CUL4B cullin 4B -0.0598234
ITCH itchy E3 ubiquitin protein ligase -0.0576982
MTSS1 metastasis suppressor 1 -0.0566889
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0562304
RPS2 ribosomal protein S2 -0.0533067
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0531798
NRIP1 nuclear receptor interacting protein 1 -0.051314
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0505159
ANKRD33B ankyrin repeat domain 33B -0.049946
PDLIM5 PDZ and LIM domain 5 -0.0496378
CANX calnexin -0.0490188
CDK6 cyclin-dependent kinase 6 -0.047947
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0477699
POTEF POTE ankyrin domain family, member F -0.0472867
FOXO1 forkhead box O1 -0.046586
VCL vinculin -0.0458214
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0451743
RAI14 retinoic acid induced 14 -0.0450483
GOLGA4 golgin A4 -0.0449076
KMT2E lysine (K)-specific methyltransferase 2E -0.0439442
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0418954
RIN2 Ras and Rab interactor 2 -0.0417948
MBNL1 muscleblind-like splicing regulator 1 -0.0415556
DSTN destrin (actin depolymerizing factor) -0.0413949
SEC31A SEC31 homolog A (S. cerevisiae) -0.0412302
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0402528
CLIC4 chloride intracellular channel 4 -0.0397257
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0388896
SULF1 sulfatase 1 -0.0388422
PLS3 plastin 3 -0.0379706
ANLN anillin, actin binding protein -0.0378796
KRT6A keratin 6A, type II -0.0373398
NEK7 NIMA-related kinase 7 -0.0372949
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0363234
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0349355
VMP1 vacuole membrane protein 1 -0.0344607
STC1 stanniocalcin 1 -0.0340821
CAV1 caveolin 1, caveolae protein, 22kDa -0.0340466
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0339736
KDM6A lysine (K)-specific demethylase 6A -0.0337643
PRELID2 PRELI domain containing 2 -0.0331515
RAB10 RAB10, member RAS oncogene family -0.0328014
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0310513
KTN1 kinectin 1 (kinesin receptor) -0.0309411
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0308217
PTK2 protein tyrosine kinase 2 -0.0302786
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0301937
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0301287
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0297597
SPAG9 sperm associated antigen 9 -0.0297174
COG6 component of oligomeric golgi complex 6 -0.0291247
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0290858
COG5 component of oligomeric golgi complex 5 -0.029035
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.028847
KIAA1217 KIAA1217 -0.0288224
PIBF1 progesterone immunomodulatory binding factor 1 -0.0286518
PICALM phosphatidylinositol binding clathrin assembly protein -0.0284704
ZNF292 zinc finger protein 292 -0.0283055
COPB1 coatomer protein complex, subunit beta 1 -0.0281941
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0279219
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0278906
SRP54 signal recognition particle 54kDa -0.0278294
NCOA3 nuclear receptor coactivator 3 -0.0272865
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0272716
IL6ST interleukin 6 signal transducer -0.0272506
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0272022
TPX2 TPX2, microtubule-associated -0.0271897
ZFC3H1 zinc finger, C3H1-type containing -0.0268964
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.026507
SUCO SUN domain containing ossification factor -0.026214
NAP1L1 nucleosome assembly protein 1-like 1 -0.026186
TRIO trio Rho guanine nucleotide exchange factor -0.0261615
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0261306
FNDC3B fibronectin type III domain containing 3B -0.0261034
SDCBP syndecan binding protein (syntenin) -0.0260613
SAMD9 sterile alpha motif domain containing 9 -0.0258811
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0255404
KDM7A lysine (K)-specific demethylase 7A -0.0253826
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0253802
MYO10 myosin X -0.0253782
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.025302
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0252803
YAP1 Yes-associated protein 1 -0.0252153
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0252089
ITGA6 integrin, alpha 6 -0.0250497
FNDC3A fibronectin type III domain containing 3A -0.0250367
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0250152
IARS1 isoleucyl-tRNA synthetase 1 -0.024998
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0249479
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0248827
LNPEP leucyl/cystinyl aminopeptidase -0.0248031
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.0246528
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0245516