Cepharanthine_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cepharanthine perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cepharanthine_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.180883
CEMIP cell migration inducing protein, hyaluronan binding 0.140671
ONECUT3 one cut homeobox 3 0.134972
SPTBN1 spectrin, beta, non-erythrocytic 1 0.132847
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.125928
FAT1 FAT atypical cadherin 1 0.123012
LMO7 LIM domain 7 0.108887
MUC13 mucin 13, cell surface associated 0.0790222
INSIG1 insulin induced gene 1 0.0760832
VEGFA vascular endothelial growth factor A 0.0737981
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.072435
KRT8 keratin 8, type II 0.0676106
FDPS farnesyl diphosphate synthase 0.0661035
TNS4 tensin 4 0.0643985
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0595736
KLF5 Kruppel-like factor 5 (intestinal) 0.0580666
ACTG1 actin gamma 1 0.0564358
ABHD2 abhydrolase domain containing 2 0.0540237
LPIN1 lipin 1 0.0524958
AHNAK AHNAK nucleoprotein 0.0516084
HSPA8 heat shock 70kDa protein 8 0.0514624
MYO1E myosin IE 0.0499652
CALR calreticulin 0.0486875
LDLR low density lipoprotein receptor 0.0481614
MYH9 myosin, heavy chain 9, non-muscle 0.0478518
ACSS2 acyl-CoA synthetase short-chain family member 2 0.0469458
FTH1 ferritin, heavy polypeptide 1 0.0457418
RPL7A ribosomal protein L7a 0.0445863
TPT1 tumor protein, translationally-controlled 1 0.043699
ADIPOR2 adiponectin receptor 2 0.0432578
EEF2 eukaryotic translation elongation factor 2 0.0430218
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.0420608
KRT18 keratin 18, type I 0.0416243
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.0415966
EPS8 epidermal growth factor receptor pathway substrate 8 0.0412049
ANXA2 annexin A2 0.0401708
H1-0 H1.0 linker histone 0.0399869
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0393691
MPRIP myosin phosphatase Rho interacting protein 0.0393329
SREBF2 sterol regulatory element binding transcription factor 2 0.0385658
TACC2 transforming, acidic coiled-coil containing protein 2 0.0383608
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.0383586
PCSK9 proprotein convertase subtilisin/kexin type 9 0.0382845
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0381761
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0380993
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0379175
AREG amphiregulin 0.0379149
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0374674
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0373007
TMSB4X thymosin beta 4, X-linked 0.03722
LIPG lipase, endothelial 0.0357917
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0352656
APP amyloid beta (A4) precursor protein 0.0352555
PDZD8 PDZ domain containing 8 0.0349694
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0349414
RNF43 ring finger protein 43 0.0348337
CEMIP2 cell migration inducing hyaluronidase 2 0.0340671
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0337606
MSMO1 methylsterol monooxygenase 1 0.0336399
SHB Src homology 2 domain containing adaptor protein B 0.0331432
SRRM2 serine/arginine repetitive matrix 2 0.0330546
DUSP4 dual specificity phosphatase 4 0.0322852
RIGI RNA sensor RIG-I 0.0320632
IDI1 isopentenyl-diphosphate delta isomerase 1 0.0315907
RNF213 ring finger protein 213 0.0314686
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0311353
BHLHE40 basic helix-loop-helix family, member e40 0.0309299
MED13 mediator complex subunit 13 0.0304557
PLEC plectin 0.0299497
MYO5B myosin VB 0.029658
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0295071
SDC4 syndecan 4 0.0288123
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0287881
TPM4 tropomyosin 4 0.0286996
MT2A metallothionein 2A 0.0286297
KLF3 Kruppel-like factor 3 (basic) 0.0283986
LOC102724023 ES1 protein homolog, mitochondrial 0.0283602
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0282898
B2M beta-2-microglobulin 0.0279752
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.026817
SOX9 SRY (sex determining region Y)-box 9 0.0266081
CTBP2 C-terminal binding protein 2 0.0264893
TJP2 tight junction protein 2 0.0263622
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0262349
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0260055
TNRC18 trinucleotide repeat containing 18 0.0259942
TGFBR3 transforming growth factor, beta receptor III 0.0259698
SQSTM1 sequestosome 1 0.0256253
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0255415
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0251578
TC2N tandem C2 domains, nuclear 0.0250582
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.0248618
PRSS3 protease, serine, 3 0.0248019
FLNA filamin A, alpha 0.0245136
TRIM2 tripartite motif containing 2 0.0244975
EXT1 exostosin glycosyltransferase 1 0.0241311
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0241239
ADGRV1 adhesion G protein-coupled receptor V1 0.024112
JUN jun proto-oncogene 0.0237846
CLCN3 chloride channel, voltage-sensitive 3 0.0236408

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.130026
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.101206
GOLGA4 golgin A4 -0.0841515
NALF1 NALCN channel auxiliary factor 1 -0.0726472
GREB1L growth regulation by estrogen in breast cancer-like -0.0723632
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0656037
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.063029
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0629548
TTC3 tetratricopeptide repeat domain 3 -0.0596593
SBF2 SET binding factor 2 -0.0588154
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0562244
ZCCHC7 zinc finger, CCHC domain containing 7 -0.055035
COG5 component of oligomeric golgi complex 5 -0.0543359
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.054257
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0539963
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0524464
ZNF292 zinc finger protein 292 -0.0494542
BIRC6 baculoviral IAP repeat containing 6 -0.0484455
ESYT2 extended synaptotagmin-like protein 2 -0.0480603
NDRG1 N-myc downstream regulated 1 -0.0479345
IARS1 isoleucyl-tRNA synthetase 1 -0.0476816
DLG1 discs, large homolog 1 (Drosophila) -0.0459348
BTBD9 BTB (POZ) domain containing 9 -0.0458858
SLC35F3 solute carrier family 35, member F3 -0.0458724
MON2 MON2 homolog (S. cerevisiae) -0.0456374
PTEN phosphatase and tensin homolog -0.0455265
MED13L mediator complex subunit 13-like -0.0454446
SEC31A SEC31 homolog A (S. cerevisiae) -0.0454026
ZFAND3 zinc finger, AN1-type domain 3 -0.0452897
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.045043
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0450343
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0445173
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0444934
PARD3 par-3 family cell polarity regulator -0.0441328
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0431233
EHBP1 EH domain binding protein 1 -0.0424022
PPARG peroxisome proliferator-activated receptor gamma -0.0420675
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0420523
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.0413996
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0407372
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0407096
CDK13 cyclin-dependent kinase 13 -0.0402421
RNF217 ring finger protein 217 -0.0399156
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0394679
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0392754
NFIA nuclear factor I/A -0.0362196
HMGA1 high mobility group AT-hook 1 -0.0359965
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0352047
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0345591
PUM2 pumilio RNA-binding family member 2 -0.0345556
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0345483
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0342286
MBNL2 muscleblind-like splicing regulator 2 -0.0335524
RAB1A RAB1A, member RAS oncogene family -0.033372
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0331568
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0326982
MBD5 methyl-CpG binding domain protein 5 -0.0326756
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0325133
NKTR natural killer cell triggering receptor -0.0319982
DIAPH2 diaphanous-related formin 2 -0.0319127
PDIA3 protein disulfide isomerase family A, member 3 -0.0317738
CALB1 calbindin 1, 28kDa -0.0314948
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0312161
SRP54 signal recognition particle 54kDa -0.0309164
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.030916
AKAP9 A kinase (PRKA) anchor protein 9 -0.0308701
RPS6 ribosomal protein S6 -0.03078
PTK2 protein tyrosine kinase 2 -0.0306529
FAM13A family with sequence similarity 13, member A -0.0305077
ALCAM activated leukocyte cell adhesion molecule -0.0305041
JMJD1C jumonji domain containing 1C -0.030088
USP34 ubiquitin specific peptidase 34 -0.0300747
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0297577
NBAS neuroblastoma amplified sequence -0.0295496
LCORL ligand dependent nuclear receptor corepressor-like -0.0295424
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 -0.0290843
FNDC3B fibronectin type III domain containing 3B -0.0290173
ZFC3H1 zinc finger, C3H1-type containing -0.0289198
MAML3 mastermind-like 3 (Drosophila) -0.0288159
TAS2R14 taste receptor, type 2, member 14 -0.0284763
TFG TRK-fused gene -0.028458
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0281928
EXOC1 exocyst complex component 1 -0.0277706
BRWD1 bromodomain and WD repeat domain containing 1 -0.0277007
PHKB phosphorylase kinase, beta -0.027696
ANTXR2 anthrax toxin receptor 2 -0.0275383
TMF1 TATA element modulatory factor 1 -0.027153
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0271034
SEC24D SEC24 family member D -0.0267087
ZNF644 zinc finger protein 644 -0.026676
FAF1 Fas (TNFRSF6) associated factor 1 -0.0259166
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0258657
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0257901
SETD5 SET domain containing 5 -0.0257226
RAB6A RAB6A, member RAS oncogene family -0.0255018
SENP6 SUMO1/sentrin specific peptidase 6 -0.0254878
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0251812
WDR43 WD repeat domain 43 -0.0251606
NCOR1 nuclear receptor corepressor 1 -0.0250977
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0250433