Cepharanthine_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cepharanthine perturbation in NCI-H23 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Cepharanthine_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.245344
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.121509
EEF2 eukaryotic translation elongation factor 2 0.103932
YBX3 Y box binding protein 3 0.096319
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0861126
GRAMD1B GRAM domain containing 1B 0.0807603
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0780083
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.06336
TPM3 tropomyosin 3 0.0607761
MCL1 myeloid cell leukemia 1 0.0598958
ADIPOR2 adiponectin receptor 2 0.0582804
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0579588
CCNL1 cyclin L1 0.0562754
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0546292
FTH1 ferritin, heavy polypeptide 1 0.0480113
RAB7A RAB7A, member RAS oncogene family 0.0467425
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0464705
ACTN1 actinin, alpha 1 0.0460874
LPIN1 lipin 1 0.0447726
TMEM41B transmembrane protein 41B 0.042013
HOMER1 homer scaffolding protein 1 0.0410629
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0403839
COPA coatomer protein complex, subunit alpha 0.0403409
MYH9 myosin, heavy chain 9, non-muscle 0.0377411
BRD2 bromodomain containing 2 0.0375441
CSNK1A1 casein kinase 1, alpha 1 0.0366687
RTN4 reticulon 4 0.0366566
RPL3 ribosomal protein L3 0.0364797
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.036116
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0358276
FLNA filamin A, alpha 0.0356776
HOOK2 hook microtubule-tethering protein 2 0.034915
PRRC2A proline-rich coiled-coil 2A 0.0349095
FDPS farnesyl diphosphate synthase 0.0344007
RPL7A ribosomal protein L7a 0.0343993
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0337278
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0335416
SRRM2 serine/arginine repetitive matrix 2 0.033333
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0329651
SF3A1 splicing factor 3a, subunit 1, 120kDa 0.0328684
SFPQ splicing factor proline/glutamine-rich 0.0327241
JUN jun proto-oncogene 0.0323322
ACTG1 actin gamma 1 0.0318119
CAPRIN2 caprin family member 2 0.0310854
DOCK5 dedicator of cytokinesis 5 0.0310517
ELL2 elongation factor, RNA polymerase II, 2 0.0308672
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0307011
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0304948
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0303962
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0303145
HSPA8 heat shock 70kDa protein 8 0.0303055
SREBF2 sterol regulatory element binding transcription factor 2 0.0302208
KDM6B lysine (K)-specific demethylase 6B 0.0297081
MEF2D myocyte enhancer factor 2D 0.0289629
KRT18 keratin 18, type I 0.0288289
INTS1 integrator complex subunit 1 0.0283766
EIF4B eukaryotic translation initiation factor 4B 0.0278979
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0277101
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.0272805
MAGEA4 melanoma antigen family A4 0.0270584
APLP2 amyloid beta (A4) precursor-like protein 2 0.0267785
PLEC plectin 0.0267182
TPM2 tropomyosin 2 (beta) 0.0267048
HLA-B major histocompatibility complex, class I, B 0.0258269
ATP11A ATPase, class VI, type 11A 0.0255961
TXNRD1 thioredoxin reductase 1 0.0253209
IGF2 insulin-like growth factor 2 0.0252974
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0249557
SNX9 sorting nexin 9 0.0248381
INTS3 integrator complex subunit 3 0.0248341
CALR calreticulin 0.0245419
CTTN cortactin 0.0243978
MSN moesin 0.0242223
UBAP2L ubiquitin associated protein 2-like 0.0241571
RPN1 ribophorin I 0.0240291
GSK3B glycogen synthase kinase 3 beta 0.0239356
PER1 period circadian clock 1 0.0239298
SNAP25 synaptosomal-associated protein, 25kDa 0.0237931
ADAM17 ADAM metallopeptidase domain 17 0.0237172
KIF1A kinesin family member 1A 0.0237123
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0236463
OSMR oncostatin M receptor 0.0231733
NOTCH2 notch 2 0.022584
CCDC200 coiled-coil domain containing 200 0.0224921
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.022472
NFE2L1 nuclear factor, erythroid 2-like 1 0.0224222
NPC1 Niemann-Pick disease, type C1 0.022421
EGR1 early growth response 1 0.0223607
CSNK1D casein kinase 1, delta 0.0222868
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0219691
USP36 ubiquitin specific peptidase 36 0.0219198
KMT2D lysine (K)-specific methyltransferase 2D 0.0217025
PTPRF protein tyrosine phosphatase, receptor type, F 0.0214609
DCTN1 dynactin 1 0.0212867
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.020926
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0208553
SHB Src homology 2 domain containing adaptor protein B 0.0208481
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0207114
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.020612
MT2A metallothionein 2A 0.0205473

decreased expression

Symbol Name Standardized Value
RAD51B RAD51 paralog B -0.119235
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.117829
TAS2R14 taste receptor, type 2, member 14 -0.101804
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0981887
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0933681
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0887677
EXOC4 exocyst complex component 4 -0.080009
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0742906
PDE4D phosphodiesterase 4D, cAMP-specific -0.0652204
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0598691
RIMS2 regulating synaptic membrane exocytosis 2 -0.0584679
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0578524
TFPI2 tissue factor pathway inhibitor 2 -0.055664
USP34 ubiquitin specific peptidase 34 -0.0527052
RYR3 ryanodine receptor 3 -0.050265
PDE10A phosphodiesterase 10A -0.0500912
NCOA7 nuclear receptor coactivator 7 -0.0483555
EHBP1 EH domain binding protein 1 -0.0468655
EML4 echinoderm microtubule associated protein like 4 -0.0468625
THSD4 thrombospondin, type I, domain containing 4 -0.0463437
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0461974
HMGA2 high mobility group AT-hook 2 -0.0451892
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0442005
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0440504
PRH1 proline-rich protein HaeIII subfamily 1 -0.0432257
BBX bobby sox homolog (Drosophila) -0.0431676
FAF1 Fas (TNFRSF6) associated factor 1 -0.0430687
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0427827
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0422499
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.041776
SBF2 SET binding factor 2 -0.0408149
FNDC3B fibronectin type III domain containing 3B -0.0403574
PHIP pleckstrin homology domain interacting protein -0.0400664
NAP1L1 nucleosome assembly protein 1-like 1 -0.0397141
EFNA5 ephrin-A5 -0.0393942
PTMA prothymosin, alpha -0.0388584
NF1 neurofibromin 1 -0.0380919
ZBTB20 zinc finger and BTB domain containing 20 -0.0379634
ADGRG6 adhesion G protein-coupled receptor G6 -0.036816
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0366952
CCND2 cyclin D2 -0.0355915
VIM vimentin -0.0348146
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0347553
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0334276
VCL vinculin -0.033243
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0322942
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0320243
SMYD3 SET and MYND domain containing 3 -0.0316717
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0316114
DENND5B DENN/MADD domain containing 5B -0.0312702
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0303954
TBC1D5 TBC1 domain family, member 5 -0.0302585
CCDC91 coiled-coil domain containing 91 -0.0298306
DIAPH3 diaphanous-related formin 3 -0.0298013
MBD5 methyl-CpG binding domain protein 5 -0.029681
ZNF638 zinc finger protein 638 -0.029369
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0288631
STYK1 serine/threonine/tyrosine kinase 1 -0.0288584
TRIO trio Rho guanine nucleotide exchange factor -0.0286038
AEBP2 AE binding protein 2 -0.0283466
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0283407
KMT2A lysine (K)-specific methyltransferase 2A -0.0279277
ATXN1 ataxin 1 -0.027203
KIAA1328 KIAA1328 -0.0271308
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0269763
E2F3 E2F transcription factor 3 -0.0269687
CUX1 cut-like homeobox 1 -0.0268254
RPS21 ribosomal protein S21 -0.0266645
BABAM2 BRISC and BRCA1 A complex member 2 -0.0265863
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.026297
ZNF292 zinc finger protein 292 -0.026134
WWOX WW domain containing oxidoreductase -0.0261291
RPLP0 ribosomal protein, large, P0 -0.0261075
NUP155 nucleoporin 155kDa -0.026046
SPIDR scaffolding protein involved in DNA repair -0.0257788
TMSB10 thymosin beta 10 -0.0257677
DIAPH2 diaphanous-related formin 2 -0.0257128
SSH2 slingshot protein phosphatase 2 -0.0254551
TLK1 tousled-like kinase 1 -0.0253609
RFC3 replication factor C (activator 1) 3, 38kDa -0.025293
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0252921
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0252887
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.025276
BCAS3 breast carcinoma amplified sequence 3 -0.0252198
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0251985
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0250719
ZNF207 zinc finger protein 207 -0.0250129
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0249615
BIRC6 baculoviral IAP repeat containing 6 -0.0249496
FMN1 formin 1 -0.0247311
WDR70 WD repeat domain 70 -0.0246913
CENPF centromere protein F, 350/400kDa -0.0245637
PHF20 PHD finger protein 20 -0.0245602
HDAC8 histone deacetylase 8 -0.0244962
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.024496
BICD1 bicaudal D homolog 1 (Drosophila) -0.0244736
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0244431
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0241769
RPL12 ribosomal protein L12 -0.024169
PRRC2C proline-rich coiled-coil 2C -0.0241602