Cepharanthine_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cepharanthine perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cepharanthine_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TMSB4X thymosin beta 4, X-linked 0.161102
PDE4D phosphodiesterase 4D, cAMP-specific 0.154421
EEF2 eukaryotic translation elongation factor 2 0.106477
PDGFC platelet derived growth factor C 0.0932569
EZR ezrin 0.0708779
GSE1 Gse1 coiled-coil protein 0.0703019
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0685908
SRRM2 serine/arginine repetitive matrix 2 0.0644654
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0636044
SOX6 SRY (sex determining region Y)-box 6 0.0591273
TMEM65 transmembrane protein 65 0.0566475
ENO2 enolase 2 (gamma, neuronal) 0.0528883
PTMA prothymosin, alpha 0.0520367
ZNF608 zinc finger protein 608 0.0515668
PRELID2 PRELI domain containing 2 0.0511223
CAMTA1 calmodulin binding transcription activator 1 0.0481842
EIF4B eukaryotic translation initiation factor 4B 0.0441828
NCEH1 neutral cholesterol ester hydrolase 1 0.0417451
HSPA8 heat shock 70kDa protein 8 0.041227
AMOTL2 angiomotin like 2 0.0408783
LOXL3 lysyl oxidase-like 3 0.0396554
PDE4B phosphodiesterase 4B, cAMP-specific 0.0391465
VCL vinculin 0.0390427
RPL3 ribosomal protein L3 0.0379835
NFE2L1 nuclear factor, erythroid 2-like 1 0.0374114
MACROD2 MACRO domain containing 2 0.0373306
APLP2 amyloid beta (A4) precursor-like protein 2 0.0366468
EGFR epidermal growth factor receptor 0.0357715
PRPF38B pre-mRNA processing factor 38B 0.0338862
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0320145
RPL7A ribosomal protein L7a 0.0318772
LPP LIM domain containing preferred translocation partner in lipoma 0.0318418
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0307669
FLNB filamin B, beta 0.030323
BRD2 bromodomain containing 2 0.0296463
FLNA filamin A, alpha 0.0294627
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0291758
CEP250 centrosomal protein 250kDa 0.0291163
SMC4 structural maintenance of chromosomes 4 0.0283363
MYH9 myosin, heavy chain 9, non-muscle 0.0279921
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0275361
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0273051
FAM168A family with sequence similarity 168, member A 0.0271974
EIF4A2 eukaryotic translation initiation factor 4A2 0.0271712
CSF1 colony stimulating factor 1 (macrophage) 0.0270901
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0268704
SPRY2 sprouty homolog 2 (Drosophila) 0.0267499
EEF1G eukaryotic translation elongation factor 1 gamma 0.0264969
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0263117
PLXNA1 plexin A1 0.0261362
ATP9B ATPase, class II, type 9B 0.0260391
AHCYL2 adenosylhomocysteinase-like 2 0.0259908
RCOR1 REST corepressor 1 0.0258198
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0257239
SLC38A2 solute carrier family 38, member 2 0.0254098
ZEB1 zinc finger E-box binding homeobox 1 0.0253765
ANXA1 annexin A1 0.0252775
EHBP1L1 EH domain binding protein 1-like 1 0.0251892
SMAD6 SMAD family member 6 0.0246667
ZMIZ1 zinc finger, MIZ-type containing 1 0.0246559
FTH1 ferritin, heavy polypeptide 1 0.0245478
CALR calreticulin 0.0241584
NPAS2 neuronal PAS domain protein 2 0.0239021
IGF1R insulin-like growth factor 1 receptor 0.023849
SF3A1 splicing factor 3a, subunit 1, 120kDa 0.0237542
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.0236793
TNRC18 trinucleotide repeat containing 18 0.023545
CTNND1 catenin (cadherin-associated protein), delta 1 0.0233451
FNIP1 folliculin interacting protein 1 0.0233435
ASPHD1 aspartate beta-hydroxylase domain containing 1 0.0230227
ANKRD12 ankyrin repeat domain 12 0.0223585
RRM2 ribonucleotide reductase M2 0.0223324
NCKIPSD NCK interacting protein with SH3 domain 0.02233
CKAP5 cytoskeleton associated protein 5 0.022057
SLCO5A1 solute carrier organic anion transporter family, member 5A1 0.0220437
CAPZB capping protein (actin filament) muscle Z-line, beta 0.0218385
RAB27B RAB27B, member RAS oncogene family 0.0218199
ACTG1 actin gamma 1 0.0218168
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B 0.0213817
CTBP2 C-terminal binding protein 2 0.0212008
ANXA3 annexin A3 0.0211471
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0207933
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 0.0207675
SFPQ splicing factor proline/glutamine-rich 0.0206834
KMT2D lysine (K)-specific methyltransferase 2D 0.0206525
UNC13A unc-13 homolog A (C. elegans) 0.0204972
LMCD1 LIM and cysteine-rich domains 1 0.0204374
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0202726
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0202702
RBM5 RNA binding motif protein 5 0.0201239
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0197927
CCNY cyclin Y 0.0196678
CENPF centromere protein F, 350/400kDa 0.0195539
TPR translocated promoter region, nuclear basket protein 0.0195073
ZNF26 zinc finger protein 26 0.0194528
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0194299
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0194171
HOOK2 hook microtubule-tethering protein 2 0.0194067
VEGFA vascular endothelial growth factor A 0.019344
RSF1 remodeling and spacing factor 1 0.0192042

decreased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.159267
CPED1 cadherin-like and PC-esterase domain containing 1 -0.125652
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.107555
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.102924
RPS6 ribosomal protein S6 -0.094654
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0900432
RPLP0 ribosomal protein, large, P0 -0.0884436
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0878171
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0837612
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0815693
NAP1L1 nucleosome assembly protein 1-like 1 -0.0770539
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0723271
S100A6 S100 calcium binding protein A6 -0.071405
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0701664
TPT1 tumor protein, translationally-controlled 1 -0.069375
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0663863
RPLP1 ribosomal protein, large, P1 -0.0586849
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0581064
BMP10 bone morphogenetic protein 10 -0.0573366
RPL34 ribosomal protein L34 -0.0565266
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0556075
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0544382
S100A4 S100 calcium binding protein A4 -0.0517139
RPL5 ribosomal protein L5 -0.0499387
RPL31 ribosomal protein L31 -0.0485828
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.048271
NFIA nuclear factor I/A -0.0478912
RPL11 ribosomal protein L11 -0.0466291
GOLGA4 golgin A4 -0.046469
RPL35A ribosomal protein L35a -0.0461649
RPS27A ribosomal protein S27a -0.0440233
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0439429
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0436231
RPL27A ribosomal protein L27a -0.0430535
RPL19 ribosomal protein L19 -0.0420538
CCND1 cyclin D1 -0.0420524
PFN1 profilin 1 -0.0418973
RPLP2 ribosomal protein, large, P2 -0.0417716
RPS23 ribosomal protein S23 -0.0416117
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0415381
RPS8 ribosomal protein S8 -0.0414033
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0413522
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0413469
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0409494
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0396049
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0383659
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0381801
NEBL nebulette -0.0378039
RPL13A ribosomal protein L13a -0.0377711
XPO1 exportin 1 -0.0374748
TTC3 tetratricopeptide repeat domain 3 -0.0372982
RPS24 ribosomal protein S24 -0.0369378
EML4 echinoderm microtubule associated protein like 4 -0.0364926
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0364779
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0362365
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0359254
RACK1 receptor for activated C kinase 1 -0.0354537
ZNF438 zinc finger protein 438 -0.0353202
RPS13 ribosomal protein S13 -0.0352526
RPS12 ribosomal protein S12 -0.0349824
KPNB1 karyopherin (importin) beta 1 -0.0349257
MON2 MON2 homolog (S. cerevisiae) -0.0339915
LOC112694756 uncharaterized LOC112694756 -0.0337089
CAMKMT calmodulin-lysine N-methyltransferase -0.0331805
GPHN gephyrin -0.0328561
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0326126
VDAC1 voltage-dependent anion channel 1 -0.0323717
RPS19 ribosomal protein S19 -0.0320204
SMC3 structural maintenance of chromosomes 3 -0.0319794
LMAN1 lectin, mannose-binding, 1 -0.0318679
RPL30 ribosomal protein L30 -0.0318173
PNISR PNN-interacting serine/arginine-rich protein -0.0312224
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0312127
DLG1 discs, large homolog 1 (Drosophila) -0.0311101
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0311041
TASOR2 transcription activation suppressor family member 2 -0.0305547
IARS1 isoleucyl-tRNA synthetase 1 -0.0302769
RPL26 ribosomal protein L26 -0.0301476
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0300846
PHF14 PHD finger protein 14 -0.0296026
HMGB1 high mobility group box 1 -0.0295685
DSTN destrin (actin depolymerizing factor) -0.0295283
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0294382
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0282211
FNDC3B fibronectin type III domain containing 3B -0.0282102
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0279804
RPS21 ribosomal protein S21 -0.0277188
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0276898
S100A10 S100 calcium binding protein A10 -0.0276748
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 -0.0274011
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) -0.0270866
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0267523
USP3 ubiquitin specific peptidase 3 -0.0267375
AHI1 Abelson helper integration site 1 -0.0263549
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) -0.0258864
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0258116
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0257264
RTN4 reticulon 4 -0.0256384
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0254852
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.025349