Cepharanthine_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cepharanthine perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cepharanthine_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.356291
FTH1 ferritin, heavy polypeptide 1 0.229428
TGFBI transforming growth factor, beta-induced, 68kDa 0.102694
HOOK2 hook microtubule-tethering protein 2 0.0998762
SDC4 syndecan 4 0.0927476
VEGFA vascular endothelial growth factor A 0.0707943
TMSB4X thymosin beta 4, X-linked 0.0646024
EEF2 eukaryotic translation elongation factor 2 0.062711
ADM adrenomedullin 0.0575009
CALR calreticulin 0.0489148
MT2A metallothionein 2A 0.0477498
HLA-B major histocompatibility complex, class I, B 0.0471715
SHB Src homology 2 domain containing adaptor protein B 0.0466662
COL6A2 collagen, type VI, alpha 2 0.0460291
C1D C1D nuclear receptor corepressor 0.0419543
SRRM2 serine/arginine repetitive matrix 2 0.0417317
LOXL2 lysyl oxidase-like 2 0.0380096
FLNA filamin A, alpha 0.0376239
SMAD3 SMAD family member 3 0.0371096
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.034852
STC1 stanniocalcin 1 0.0347602
FLNB filamin B, beta 0.0340584
SF3A1 splicing factor 3a, subunit 1, 120kDa 0.0332698
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0331431
RND3 Rho family GTPase 3 0.0330852
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0330677
AKAP12 A kinase (PRKA) anchor protein 12 0.0328943
COPA coatomer protein complex, subunit alpha 0.0322963
DDIT4 DNA-damage-inducible transcript 4 0.0320335
CLTC clathrin, heavy chain (Hc) 0.0311027
AKAP9 A kinase (PRKA) anchor protein 9 0.0298119
ARHGAP32 Rho GTPase activating protein 32 0.0296266
FAM13A family with sequence similarity 13, member A 0.0292744
FAM219A family with sequence similarity 219, member A 0.0288602
ITCH itchy E3 ubiquitin protein ligase 0.028843
TPM3 tropomyosin 3 0.0284686
COL7A1 collagen, type VII, alpha 1 0.0283923
TRRAP transformation/transcription domain-associated protein 0.0278817
EIF4H eukaryotic translation initiation factor 4H 0.0278315
SREBF2 sterol regulatory element binding transcription factor 2 0.0278091
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.027212
FNIP1 folliculin interacting protein 1 0.027058
YEATS2 YEATS domain containing 2 0.0268132
PLEC plectin 0.0260592
RPN1 ribophorin I 0.0250859
ARRDC3 arrestin domain containing 3 0.0249765
UBA6 ubiquitin-like modifier activating enzyme 6 0.0245493
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0244315
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0243556
TNIP1 TNFAIP3 interacting protein 1 0.0242912
SMYD3 SET and MYND domain containing 3 0.0239596
HSPA8 heat shock 70kDa protein 8 0.0237297
UBR1 ubiquitin protein ligase E3 component n-recognin 1 0.023633
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0234776
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0234
NOTCH2 notch 2 0.023145
ANKRD11 ankyrin repeat domain 11 0.0226953
ELP2 elongator acetyltransferase complex subunit 2 0.0226626
COL6A1 collagen, type VI, alpha 1 0.0225622
STK10 serine/threonine kinase 10 0.0225446
PLD3 phospholipase D family, member 3 0.0220978
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0218486
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0216833
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0214413
TGFB1 transforming growth factor, beta 1 0.0214391
KYNU kynureninase 0.0213873
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0212881
APP amyloid beta (A4) precursor protein 0.0212828
CEMIP2 cell migration inducing hyaluronidase 2 0.0212197
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0211322
MYO9B myosin IXB 0.0210513
WWTR1 WW domain containing transcription regulator 1 0.0208898
KLF10 Kruppel-like factor 10 0.0207165
MMP2 matrix metallopeptidase 2 0.0206814
CHMP4B charged multivesicular body protein 4B 0.0206484
SKAP2 src kinase associated phosphoprotein 2 0.0203728
RPL23 ribosomal protein L23 0.0203201
PRRC2C proline-rich coiled-coil 2C 0.0201183
IGF2 insulin-like growth factor 2 0.0200447
PGM3 phosphoglucomutase 3 0.0199365
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0199252
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0199123
RPL8 ribosomal protein L8 0.0195729
IL6 interleukin 6 0.0195312
FMNL2 formin-like 2 0.0195051
APLP2 amyloid beta (A4) precursor-like protein 2 0.0194766
LDLR low density lipoprotein receptor 0.019409
NFE2L1 nuclear factor, erythroid 2-like 1 0.019196
SFTPA2 surfactant protein A2 0.0191919
PMM2 phosphomannomutase 2 0.0191601
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0191554
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0191069
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0190975
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0190269
SEPTIN9 septin 9 0.0188964
KDM5C lysine (K)-specific demethylase 5C 0.0187
TM4SF1 transmembrane 4 L six family member 1 0.0186952
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0186737
TRIP12 thyroid hormone receptor interactor 12 0.0185841
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0184836

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.23197
CALD1 caldesmon 1 -0.127847
F3 coagulation factor III (thromboplastin, tissue factor) -0.101561
LOX lysyl oxidase -0.0973171
COL1A2 collagen, type I, alpha 2 -0.0965786
COL1A1 collagen, type I, alpha 1 -0.0942724
PSD3 pleckstrin and Sec7 domain containing 3 -0.0909877
PRSS23 protease, serine, 23 -0.0832702
CAV1 caveolin 1, caveolae protein, 22kDa -0.080912
CDH13 cadherin 13 -0.0791832
VIM vimentin -0.0683806
VCL vinculin -0.0672195
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0602996
DST dystonin -0.0601876
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0598206
POTEF POTE ankyrin domain family, member F -0.0532796
PKM pyruvate kinase, muscle -0.0525302
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0518271
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0494494
FNDC3B fibronectin type III domain containing 3B -0.0483604
DPYD dihydropyrimidine dehydrogenase -0.0469741
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0465333
MEF2A myocyte enhancer factor 2A -0.0453883
TRIO trio Rho guanine nucleotide exchange factor -0.0450127
GLIS3 GLIS family zinc finger 3 -0.0449972
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0440069
CD44 CD44 molecule (Indian blood group) -0.0420531
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0419887
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0409193
LMAN1 lectin, mannose-binding, 1 -0.0408732
CALU calumenin -0.0404459
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0401331
PTMA prothymosin, alpha -0.0397566
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0395997
PDLIM5 PDZ and LIM domain 5 -0.0389281
PGK1 phosphoglycerate kinase 1 -0.0388276
TPM1 tropomyosin 1 (alpha) -0.0384064
DIAPH3 diaphanous-related formin 3 -0.0383429
SEPTIN7 septin 7 -0.0377304
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0374566
TPI1 triosephosphate isomerase 1 -0.0373794
DLG1 discs, large homolog 1 (Drosophila) -0.0371427
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0370396
TPST1 tyrosylprotein sulfotransferase 1 -0.0367714
TENT5A terminal nucleotidyltransferase 5A -0.0354425
VDAC1 voltage-dependent anion channel 1 -0.0353406
TAS2R14 taste receptor, type 2, member 14 -0.0346152
RRBP1 ribosome binding protein 1 -0.0343394
THBS1 thrombospondin 1 -0.0341965
NDRG1 N-myc downstream regulated 1 -0.034144
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0338961
TMSB10 thymosin beta 10 -0.0337049
MACF1 microtubule-actin crosslinking factor 1 -0.0328179
SSBP2 single-stranded DNA binding protein 2 -0.0315606
DNAH11 dynein, axonemal, heavy chain 11 -0.0314038
GLG1 golgi glycoprotein 1 -0.030412
SPDYA speedy/RINGO cell cycle regulator family member A -0.0303164
NBEAL1 neurobeachin-like 1 -0.030119
CADM1 cell adhesion molecule 1 -0.0300681
QKI QKI, KH domain containing, RNA binding -0.0300442
MAP4 microtubule-associated protein 4 -0.0297495
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0296417
FBN1 fibrillin 1 -0.0291574
PLCB4 phospholipase C, beta 4 -0.028224
TNPO1 transportin 1 -0.027994
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0279876
RAI14 retinoic acid induced 14 -0.0278692
TNS3 tensin 3 -0.027809
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.027684
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0276277
ENO1 enolase 1, (alpha) -0.0273887
PRKCA protein kinase C, alpha -0.0273785
MAP1B microtubule-associated protein 1B -0.0270046
FTL ferritin, light polypeptide -0.0265444
SEC31A SEC31 homolog A (S. cerevisiae) -0.0262409
COL5A2 collagen, type V, alpha 2 -0.0261064
MYLK myosin light chain kinase -0.0257386
WNT5A wingless-type MMTV integration site family, member 5A -0.0255192
TPT1 tumor protein, translationally-controlled 1 -0.0253477
RNF145 ring finger protein 145 -0.0253005
TENM3 teneurin transmembrane protein 3 -0.025121
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0250871
RAB7A RAB7A, member RAS oncogene family -0.0250785
SRPK2 SRSF protein kinase 2 -0.0249195
FRMD4A FERM domain containing 4A -0.0249007
ERRFI1 ERBB receptor feedback inhibitor 1 -0.024688
MBD5 methyl-CpG binding domain protein 5 -0.0246544
NCAPG2 non-SMC condensin II complex, subunit G2 -0.0243392
CHD9 chromodomain helicase DNA binding protein 9 -0.0242469
TNNC1 troponin C type 1 (slow) -0.0239273
CERT1 ceramide transporter 1 -0.0238049
HMGA2 high mobility group AT-hook 2 -0.023381
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0232534
PDIA3 protein disulfide isomerase family A, member 3 -0.0231373
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0231272
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0228744
ARF1 ADP-ribosylation factor 1 -0.0228346
RAB5A RAB5A, member RAS oncogene family -0.0226824
TAGLN2 transgelin 2 -0.0225121
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0224711