Cepharanthine_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cepharanthine perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cepharanthine_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.131688
FMNL2 formin-like 2 0.111568
SMAD3 SMAD family member 3 0.102865
EEF2 eukaryotic translation elongation factor 2 0.0803762
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0651619
YBX3 Y box binding protein 3 0.0594795
MYH9 myosin, heavy chain 9, non-muscle 0.0578961
CD44 CD44 molecule (Indian blood group) 0.0530902
MSN moesin 0.0523386
FLNA filamin A, alpha 0.0497156
BHLHE40 basic helix-loop-helix family, member e40 0.0466829
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0464326
DSCAM Down syndrome cell adhesion molecule 0.0463661
SMYD3 SET and MYND domain containing 3 0.0446182
NAMPT nicotinamide phosphoribosyltransferase 0.0442803
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0439082
BIRC3 baculoviral IAP repeat containing 3 0.0436233
LDLR low density lipoprotein receptor 0.0435946
ENO2 enolase 2 (gamma, neuronal) 0.0434349
ANO6 anoctamin 6 0.0429942
CEP250 centrosomal protein 250kDa 0.0422232
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0415998
PKM pyruvate kinase, muscle 0.0409427
DGKD diacylglycerol kinase, delta 130kDa 0.0402393
CALR calreticulin 0.0391503
SDC4 syndecan 4 0.0388269
HOOK2 hook microtubule-tethering protein 2 0.0380941
STK24 serine/threonine kinase 24 0.0380007
FNDC3B fibronectin type III domain containing 3B 0.0366113
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0363362
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0354365
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.035361
OGA O-GlcNAcase 0.0339145
ADM adrenomedullin 0.0333942
RORA RAR-related orphan receptor A 0.0331935
YAP1 Yes-associated protein 1 0.0323805
TRIO trio Rho guanine nucleotide exchange factor 0.032262
TXNRD1 thioredoxin reductase 1 0.0318869
PBX3 pre-B-cell leukemia homeobox 3 0.0316939
AHNAK2 AHNAK nucleoprotein 2 0.0314
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0313569
RPL7A ribosomal protein L7a 0.0309423
APP amyloid beta (A4) precursor protein 0.0309124
PLEC plectin 0.0307086
SHB Src homology 2 domain containing adaptor protein B 0.0304424
IGF1R insulin-like growth factor 1 receptor 0.0302254
OXSR1 oxidative stress responsive 1 0.0302235
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0297107
MPRIP myosin phosphatase Rho interacting protein 0.0296955
HSPA8 heat shock 70kDa protein 8 0.0296498
AKAP12 A kinase (PRKA) anchor protein 12 0.0296301
MUSK muscle, skeletal, receptor tyrosine kinase 0.0294821
BASP1 brain abundant, membrane attached signal protein 1 0.0294579
SVIL supervillin 0.0294095
APLP2 amyloid beta (A4) precursor-like protein 2 0.0291366
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0287249
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0286766
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0286615
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0285341
FAM13A family with sequence similarity 13, member A 0.0276714
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 0.027636
SETD5 SET domain containing 5 0.0274072
NUMA1 nuclear mitotic apparatus protein 1 0.0273149
ANXA2 annexin A2 0.0271358
ACSS2 acyl-CoA synthetase short-chain family member 2 0.0270423
ARL15 ADP-ribosylation factor-like 15 0.0269756
CNOT12 CCR4-NOT transcription complex subunit 12 0.0269659
MBNL2 muscleblind-like splicing regulator 2 0.0269281
FLNB filamin B, beta 0.0267274
CSRNP1 cysteine-serine-rich nuclear protein 1 0.0267149
SLC38A2 solute carrier family 38, member 2 0.0266006
STEAP3 STEAP family member 3, metalloreductase 0.0257279
VEGFA vascular endothelial growth factor A 0.0256444
CPNE1 copine I 0.0251883
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0247346
SRRM2 serine/arginine repetitive matrix 2 0.0246497
SAMD4A sterile alpha motif domain containing 4A 0.0242584
ANKRD28 ankyrin repeat domain 28 0.0241185
NIBAN2 niban apoptosis regulator 2 0.0238631
WWTR1 WW domain containing transcription regulator 1 0.0237679
FNIP1 folliculin interacting protein 1 0.0231421
EHBP1L1 EH domain binding protein 1-like 1 0.0229657
DNMBP dynamin binding protein 0.0228755
PRELID2 PRELI domain containing 2 0.0228439
EIF4B eukaryotic translation initiation factor 4B 0.0228149
ITGB5 integrin, beta 5 0.0225514
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0224996
TXNIP thioredoxin interacting protein 0.0223432
NUP58 nucleoporin 58 0.0222906
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0218609
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0218568
MACF1 microtubule-actin crosslinking factor 1 0.0218422
RANBP2 RAN binding protein 2 0.0217539
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0215846
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0214924
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0214181
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0213434
CCNL1 cyclin L1 0.0213248
GIGYF2 GRB10 interacting GYF protein 2 0.0212977
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0209982

decreased expression

Symbol Name Standardized Value
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0957062
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.066368
LDHA lactate dehydrogenase A -0.0581232
HMGA2 high mobility group AT-hook 2 -0.0568159
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0474146
TAS2R14 taste receptor, type 2, member 14 -0.0466685
TMSB10 thymosin beta 10 -0.0434152
TPT1 tumor protein, translationally-controlled 1 -0.042701
FNDC3A fibronectin type III domain containing 3A -0.0412303
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0412248
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0410989
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0410019
PNRC1 proline-rich nuclear receptor coactivator 1 -0.037553
DST dystonin -0.0370314
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0367196
NF1 neurofibromin 1 -0.0359239
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0352909
GOLGA4 golgin A4 -0.0351991
RIGI RNA sensor RIG-I -0.0343902
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0338701
RPL26 ribosomal protein L26 -0.033142
ZBTB20 zinc finger and BTB domain containing 20 -0.0327145
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0326195
NKTR natural killer cell triggering receptor -0.0303387
EIF1 eukaryotic translation initiation factor 1 -0.0296407
VCL vinculin -0.0291204
FBXO11 F-box protein 11 -0.0283517
CLIP1 CAP-GLY domain containing linker protein 1 -0.0282259
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0281741
GPATCH2L G patch domain containing 2-like -0.0281667
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0281208
AEBP2 AE binding protein 2 -0.0279769
C6ORF62 chromosome 6 open reading frame 62 -0.0275209
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0272893
APOLD1 apolipoprotein L domain containing 1 -0.0271723
SETX senataxin -0.0270103
LOC112694756 uncharaterized LOC112694756 -0.0269298
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0266952
HM13 histocompatibility (minor) 13 -0.0265115
SLC35F3 solute carrier family 35, member F3 -0.0264241
FTL ferritin, light polypeptide -0.026397
AKAP10 A kinase (PRKA) anchor protein 10 -0.0259788
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0258353
SPAG9 sperm associated antigen 9 -0.0255801
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0255358
VIM vimentin -0.0254358
SBF2 SET binding factor 2 -0.0252619
RTN3 reticulon 3 -0.0252203
RPLP1 ribosomal protein, large, P1 -0.0252092
BTG1 B-cell translocation gene 1, anti-proliferative -0.0251815
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0248846
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0248249
MT2A metallothionein 2A -0.0244982
MYO9A myosin IXA -0.0244048
TMEM263 transmembrane protein 263 -0.0242257
PRSS23 protease, serine, 23 -0.0239949
ZNF609 zinc finger protein 609 -0.0237381
MBD5 methyl-CpG binding domain protein 5 -0.0235327
HILPDA hypoxia inducible lipid droplet-associated -0.0233799
GOSR1 golgi SNAP receptor complex member 1 -0.023208
TPM4 tropomyosin 4 -0.0232031
LCORL ligand dependent nuclear receptor corepressor-like -0.0229877
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.022979
TMEM123 transmembrane protein 123 -0.0229592
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -0.0229457
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0229034
ARMH4 armadillo like helical domain containing 4 -0.0226473
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0223834
CCND1 cyclin D1 -0.0217625
MAML2 mastermind-like 2 (Drosophila) -0.0217337
IARS1 isoleucyl-tRNA synthetase 1 -0.0215609
PYGL phosphorylase, glycogen, liver -0.0213194
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.021235
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0209582
DEK DEK proto-oncogene -0.0208939
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0208915
RPS25 ribosomal protein S25 -0.0206175
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0205436
IFIH1 interferon induced with helicase C domain 1 -0.0204465
CAVIN1 caveolae associated protein 1 -0.0203652
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 -0.0202834
SMC4 structural maintenance of chromosomes 4 -0.0202743
XRN1 5'-3' exoribonuclease 1 -0.0202242
ATG7 autophagy related 7 -0.0202108
GCC2 GRIP and coiled-coil domain containing 2 -0.0201775
RBM39 RNA binding motif protein 39 -0.0200899
TMEM14B transmembrane protein 14B -0.0197732
EPC1 enhancer of polycomb homolog 1 (Drosophila) -0.0197243
PCED1B PC-esterase domain containing 1B -0.0196172
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0195791
FAM114A1 family with sequence similarity 114, member A1 -0.0191449
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.019127
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0190387
COPB1 coatomer protein complex, subunit beta 1 -0.0188474
SEPTIN7 septin 7 -0.0187064
RPLP2 ribosomal protein, large, P2 -0.0186445
UBB ubiquitin B -0.0185689
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.018505
AK1 adenylate kinase 1 -0.0184869
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0184522