Cepharanthine_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cepharanthine perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cepharanthine_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.266549
FTH1 ferritin, heavy polypeptide 1 0.179755
NAMPT nicotinamide phosphoribosyltransferase 0.103461
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.080302
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.063549
ASPH aspartate beta-hydroxylase 0.0628129
SMAD3 SMAD family member 3 0.0602125
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0598829
OSMR oncostatin M receptor 0.053238
TMSB4X thymosin beta 4, X-linked 0.0501054
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0488448
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0474505
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.045516
FAM13A family with sequence similarity 13, member A 0.0431446
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0408127
APP amyloid beta (A4) precursor protein 0.0402577
AKAP12 A kinase (PRKA) anchor protein 12 0.0389403
GRB10 growth factor receptor-bound protein 10 0.0388248
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0377107
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0371074
ITGA1 integrin, alpha 1 0.0357741
MYH9 myosin, heavy chain 9, non-muscle 0.0355873
VEGFA vascular endothelial growth factor A 0.0346765
TRIO trio Rho guanine nucleotide exchange factor 0.0345692
LOXL2 lysyl oxidase-like 2 0.0345506
AHNAK AHNAK nucleoprotein 0.0339109
LIFR leukemia inhibitory factor receptor alpha 0.0334358
CALR calreticulin 0.0331811
ANKRD28 ankyrin repeat domain 28 0.0325555
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0323474
WWTR1 WW domain containing transcription regulator 1 0.0314997
TPR translocated promoter region, nuclear basket protein 0.0309289
MCTP2 multiple C2 domains, transmembrane 2 0.0305758
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0304827
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0300471
PLEC plectin 0.029894
ELL2 elongation factor, RNA polymerase II, 2 0.02944
BHLHE40 basic helix-loop-helix family, member e40 0.028761
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0287096
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0284157
FAT1 FAT atypical cadherin 1 0.0278056
LIMCH1 LIM and calponin homology domains 1 0.0276584
DENND5B DENN/MADD domain containing 5B 0.0271616
DOCK5 dedicator of cytokinesis 5 0.0270795
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0270614
HMGA2 high mobility group AT-hook 2 0.0264145
HSPA8 heat shock 70kDa protein 8 0.0262455
HIPK2 homeodomain interacting protein kinase 2 0.0261991
RPH3AL rabphilin 3A-like (without C2 domains) 0.025743
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0257197
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0252708
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0252148
AHNAK2 AHNAK nucleoprotein 2 0.0250443
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0248898
SEC23A Sec23 homolog A (S. cerevisiae) 0.0246017
SFTPA2 surfactant protein A2 0.0245927
TMEM156 transmembrane protein 156 0.024007
EZR ezrin 0.0237172
TPM3 tropomyosin 3 0.0236672
AFF1 AF4/FMR2 family, member 1 0.0236129
DDIT4 DNA-damage-inducible transcript 4 0.0236024
CAB39 calcium binding protein 39 0.0235402
MLPH melanophilin 0.0233585
EFNA5 ephrin-A5 0.0227021
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.0226333
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0223695
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0222144
RUNX2 runt-related transcription factor 2 0.0220142
AOPEP aminopeptidase O (putative) 0.0217232
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.021479
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0214425
FLNB filamin B, beta 0.0213595
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0208604
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0208418
PRPF8 pre-mRNA processing factor 8 0.0207631
CANX calnexin 0.0207507
STC2 stanniocalcin 2 0.020735
EMP1 epithelial membrane protein 1 0.0207291
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0206668
TGFA transforming growth factor, alpha 0.0204994
ZNF160 zinc finger protein 160 0.0204129
CNIH3 cornichon family AMPA receptor auxiliary protein 3 0.0201572
MUSK muscle, skeletal, receptor tyrosine kinase 0.0199735
PTK2 protein tyrosine kinase 2 0.0194691
NFE2L1 nuclear factor, erythroid 2-like 1 0.0192767
PARD3 par-3 family cell polarity regulator 0.0192351
NT5E 5'-nucleotidase, ecto (CD73) 0.0191371
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0189904
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0189013
ETV6 ets variant 6 0.0188963
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.018885
HLA-C major histocompatibility complex, class I, C 0.0188101
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0187852
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0187572
LTBP1 latent transforming growth factor beta binding protein 1 0.0185974
PELO pelota homolog (Drosophila) 0.0185163
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0183353
EHBP1L1 EH domain binding protein 1-like 1 0.0181662
SHB Src homology 2 domain containing adaptor protein B 0.0178784
MAP3K9 mitogen-activated protein kinase kinase kinase 9 0.0175525

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0990633
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.090978
NRG1 neuregulin 1 -0.0874868
VCL vinculin -0.0854394
IFI27 interferon, alpha-inducible protein 27 -0.0827816
TMSB10 thymosin beta 10 -0.0747085
S100A6 S100 calcium binding protein A6 -0.0743264
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0648392
SQSTM1 sequestosome 1 -0.0540943
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0532814
LOC102724023 ES1 protein homolog, mitochondrial -0.0475967
FTL ferritin, light polypeptide -0.046988
POTEF POTE ankyrin domain family, member F -0.0464829
EGR1 early growth response 1 -0.0446852
HMGA1 high mobility group AT-hook 1 -0.0439035
VIM vimentin -0.0417251
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0409516
PTMA prothymosin, alpha -0.0401263
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0351506
MT2A metallothionein 2A -0.0347553
INTS6 integrator complex subunit 6 -0.0334926
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0319287
CENPF centromere protein F, 350/400kDa -0.0319058
EXT1 exostosin glycosyltransferase 1 -0.0316445
AEBP2 AE binding protein 2 -0.0308119
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0303317
GPATCH2L G patch domain containing 2-like -0.0296705
RPS6 ribosomal protein S6 -0.0295535
RPL9 ribosomal protein L9 -0.0291647
TPT1 tumor protein, translationally-controlled 1 -0.0288761
ADIPOR2 adiponectin receptor 2 -0.0273572
RPS24 ribosomal protein S24 -0.0270669
PFN1 profilin 1 -0.0267919
SPDYA speedy/RINGO cell cycle regulator family member A -0.0266163
NTN4 netrin 4 -0.026291
S100A9 S100 calcium binding protein A9 -0.0257499
RPS21 ribosomal protein S21 -0.0252735
IFI6 interferon, alpha-inducible protein 6 -0.0249868
PLIN2 perilipin 2 -0.0238346
RPL35A ribosomal protein L35a -0.0233931
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0232049
MAP1B microtubule-associated protein 1B -0.0228312
RPL34 ribosomal protein L34 -0.0227022
BLZF1 basic leucine zipper nuclear factor 1 -0.0213074
VMP1 vacuole membrane protein 1 -0.0212504
RPS23 ribosomal protein S23 -0.0208711
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0208002
LY6E lymphocyte antigen 6 complex, locus E -0.020729
KRT81 keratin 81, type II -0.020638
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0204861
RPL31 ribosomal protein L31 -0.020465
CTSD cathepsin D -0.0202162
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0195556
SYT1 synaptotagmin I -0.0195238
RPS29 ribosomal protein S29 -0.0193975
RAB7A RAB7A, member RAS oncogene family -0.0192976
RPLP2 ribosomal protein, large, P2 -0.0192406
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0192236
RPL37 ribosomal protein L37 -0.0190686
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0189743
RPS5 ribosomal protein S5 -0.018736
BIRC6 baculoviral IAP repeat containing 6 -0.0183375
IER3 immediate early response 3 -0.0180566
ARF4 ADP-ribosylation factor 4 -0.0179545
PDLIM5 PDZ and LIM domain 5 -0.0178521
RPS12 ribosomal protein S12 -0.0177669
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0177257
RPL11 ribosomal protein L11 -0.0176616
EIF5B eukaryotic translation initiation factor 5B -0.0176438
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0176343
RPLP0 ribosomal protein, large, P0 -0.0174949
UBAP2 ubiquitin associated protein 2 -0.017433
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0173365
DSTN destrin (actin depolymerizing factor) -0.0169826
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0168463
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.01669
SEC31A SEC31 homolog A (S. cerevisiae) -0.0166254
TPM4 tropomyosin 4 -0.0165759
ERLEC1 endoplasmic reticulum lectin 1 -0.0164941
KLHL5 kelch-like family member 5 -0.0164648
TUBA1B tubulin, alpha 1b -0.0163733
RPL30 ribosomal protein L30 -0.0162992
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0160674
RPLP1 ribosomal protein, large, P1 -0.0160591
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.016034
PRH1 proline-rich protein HaeIII subfamily 1 -0.0159946
TAGLN2 transgelin 2 -0.0158998
TBCA tubulin folding cofactor A -0.0158764
RPS27A ribosomal protein S27a -0.0156324
RPL26 ribosomal protein L26 -0.0156223
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0155942
CCDC138 coiled-coil domain containing 138 -0.0152832
TPI1 triosephosphate isomerase 1 -0.0152502
BICD1 bicaudal D homolog 1 (Drosophila) -0.0151622
RPS19 ribosomal protein S19 -0.0151524
RPS25 ribosomal protein S25 -0.015103
DIAPH3 diaphanous-related formin 3 -0.0150802
RPS28 ribosomal protein S28 -0.0150547
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0149761
KPNB1 karyopherin (importin) beta 1 -0.0149301