| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A member of the class of aminopyrimidines that is 2,6-diamino-5-chloropyrimidine in which the amino groups at positions 2 and 6 are respectively carrying 2-methoxy-4-(piperidin-4-yl)-5-methylphenyl and 2-(isopropylsulfonylamino)phenyl substituents. Used for the treatment of ALK-positive metastatic non-small cell lung cancer. (Chemical Entities of Biological Interest Ontology, CHEBI_78432) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/57379345 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Ceritinib relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SRD5A3 | steroid 5 alpha-reductase 3 | 1.91 |
| SSPO | SCO-spondin | 1.9 |
| SUGCT | succinyl-CoA:glutarate-CoA transferase | 1.72 |
| TNKS2 | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 | 1.6 |
| FGB | fibrinogen beta chain | 1.38 |
| CAVIN2 | caveolae associated protein 2 | 1.32 |
| IFITM3 | interferon induced transmembrane protein 3 | 1.29 |
| FN1 | fibronectin 1 | 1.27 |
| DCHS1 | dachsous cadherin-related 1 | 1.23 |
| INPP5J | inositol polyphosphate-5-phosphatase J | 1.22 |
| KAT6B | K(lysine) acetyltransferase 6B | 1.12 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 1.11 |
| SRR | serine racemase | 1.09 |
| JUND | jun D proto-oncogene | 1.08 |
| CPEB3 | cytoplasmic polyadenylation element binding protein 3 | 1.03 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | 0.9 |
| GPR180 | G protein-coupled receptor 180 | 0.9 |
| SMAD5 | SMAD family member 5 | 0.89 |
| EEF2KMT | eukaryotic elongation factor 2 lysine methyltransferase | 0.89 |
| AADAT | aminoadipate aminotransferase | 0.85 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.84 |
| DUSP6 | dual specificity phosphatase 6 | 0.8 |
| STMN2 | stathmin 2 | 0.8 |
| SBNO2 | strawberry notch homolog 2 (Drosophila) | 0.79 |
| SOWAHC | sosondowah ankyrin repeat domain family member C | 0.77 |
| OPTN | optineurin | 0.75 |
| CDC42 | cell division cycle 42 | 0.75 |
| STMN1 | stathmin 1 | 0.74 |
| TRIM23 | tripartite motif containing 23 | 0.74 |
| SEZ6L2 | seizure related 6 homolog (mouse)-like 2 | 0.74 |
| RBL2 | retinoblastoma-like 2 | 0.73 |
| HECA | headcase homolog (Drosophila) | 0.72 |
| ELFN1 | extracellular leucine-rich repeat and fibronectin type III domain containing 1 | 0.71 |
| FGD1 | FYVE, RhoGEF and PH domain containing 1 | 0.71 |
| LYPLA1 | lysophospholipase I | 0.71 |
| RNF13 | ring finger protein 13 | 0.7 |
| GSTA1 | glutathione S-transferase alpha 1 | 0.7 |
| PPIC | peptidylprolyl isomerase C (cyclophilin C) | 0.69 |
| STAB1 | stabilin 1 | 0.69 |
| TMEM135 | transmembrane protein 135 | 0.69 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.68 |
| MSRB2 | methionine sulfoxide reductase B2 | 0.67 |
| TGFB1I1 | transforming growth factor beta 1 induced transcript 1 | 0.66 |
| FAM122B | family with sequence similarity 122B | 0.66 |
| PRAF2 | PRA1 domain family, member 2 | 0.66 |
| FGD4 | FYVE, RhoGEF and PH domain containing 4 | 0.65 |
| DUSP22 | dual specificity phosphatase 22 | 0.64 |
| TM7SF2 | transmembrane 7 superfamily member 2 | 0.64 |
| TTPA | tocopherol (alpha) transfer protein | 0.64 |
| COQ8A | coenzyme Q8A | 0.62 |
| H1FX | H1 histone family, member X | 0.62 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | 0.62 |
| ALDH6A1 | aldehyde dehydrogenase 6 family, member A1 | 0.62 |
| TTN | titin | 0.62 |
| PCMTD2 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 | 0.6 |
| PBXIP1 | pre-B-cell leukemia homeobox interacting protein 1 | 0.6 |
| SQLE | squalene epoxidase | 0.6 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 0.6 |
| DMGDH | dimethylglycine dehydrogenase | 0.59 |
| AAMDC | adipogenesis associated, Mth938 domain containing | 0.58 |
| TRERF1 | transcriptional regulating factor 1 | 0.58 |
| GRB7 | growth factor receptor-bound protein 7 | 0.58 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.58 |
| CD109 | CD109 molecule | 0.58 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.57 |
| MSMO1 | methylsterol monooxygenase 1 | 0.57 |
| ABCA3 | ATP-binding cassette, sub-family A (ABC1), member 3 | 0.57 |
| ABTB1 | ankyrin repeat and BTB (POZ) domain containing 1 | 0.57 |
| TMEM128 | transmembrane protein 128 | 0.57 |
| MT2A | metallothionein 2A | 0.57 |
| LIFR | leukemia inhibitory factor receptor alpha | 0.56 |
| IFT140 | intraflagellar transport 140 | 0.56 |
| RHBDD1 | rhomboid domain containing 1 | 0.56 |
| CLDN3 | claudin 3 | 0.56 |
| NEBL | nebulette | 0.55 |
| LTBP4 | latent transforming growth factor beta binding protein 4 | 0.55 |
| PDP2 | pyruvate dehyrogenase phosphatase catalytic subunit 2 | 0.55 |
| NOVA2 | neuro-oncological ventral antigen 2 | 0.55 |
| E2F2 | E2F transcription factor 2 | 0.55 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.55 |
| PET100 | PET100 homolog (S. cerevisiae) | 0.54 |
| RTN2 | reticulon 2 | 0.54 |
| KITLG | KIT ligand | 0.54 |
| JRKL | JRK-like | 0.53 |
| IRS2 | insulin receptor substrate 2 | 0.53 |
| ELOVL6 | ELOVL fatty acid elongase 6 | 0.52 |
| HOMEZ | homeobox and leucine zipper encoding | 0.52 |
| APOBEC3F | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F | 0.52 |
| MAU2 | MAU2 sister chromatid cohesion factor | 0.52 |
| ZNF362 | zinc finger protein 362 | 0.52 |
| WNT16 | wingless-type MMTV integration site family, member 16 | 0.52 |
| TXNRD3 | thioredoxin reductase 3 | 0.52 |
| PPL | periplakin | 0.51 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.51 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | 0.51 |
| CBR3 | carbonyl reductase 3 | 0.51 |
| RTN4R | reticulon 4 receptor | 0.51 |
| PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 | 0.51 |
| CTHRC1 | collagen triple helix repeat containing 1 | 0.51 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PER2 | period circadian clock 2 | -1.83 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -1.67 |
| SPAG17 | sperm associated antigen 17 | -1.45 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -1.17 |
| CHST3 | carbohydrate (chondroitin 6) sulfotransferase 3 | -1.14 |
| MCOLN1 | mucolipin 1 | -1.11 |
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | -1.07 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | -1.05 |
| ABCA13 | ATP-binding cassette, sub-family A (ABC1), member 13 | -1.02 |
| ZNF483 | zinc finger protein 483 | -1.0 |
| ZNF175 | zinc finger protein 175 | -1.0 |
| SYN2 | synapsin II | -0.85 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | -0.85 |
| POF1B | premature ovarian failure, 1B | -0.83 |
| TRIM35 | tripartite motif containing 35 | -0.83 |
| CCNB1 | cyclin B1 | -0.81 |
| AKAP6 | A kinase (PRKA) anchor protein 6 | -0.8 |
| TNFSF9 | tumor necrosis factor (ligand) superfamily, member 9 | -0.8 |
| TOR1AIP2 | torsin A interacting protein 2 | -0.77 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.75 |
| PIP | prolactin-induced protein | -0.72 |
| ZC3H12C | zinc finger CCCH-type containing 12C | -0.72 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.71 |
| PLK1 | polo-like kinase 1 | -0.7 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.68 |
| SBSN | suprabasin | -0.68 |
| KIF2C | kinesin family member 2C | -0.68 |
| TP53 | tumor protein p53 | -0.67 |
| AURKA | aurora kinase A | -0.65 |
| UBE2S | ubiquitin-conjugating enzyme E2S | -0.63 |
| DNAH2 | dynein, axonemal, heavy chain 2 | -0.62 |
| HSBP1 | heat shock factor binding protein 1 | -0.62 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.61 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | -0.61 |
| SHCBP1 | SHC SH2-domain binding protein 1 | -0.61 |
| RPL26 | ribosomal protein L26 | -0.61 |
| STC2 | stanniocalcin 2 | -0.59 |
| CCNB2 | cyclin B2 | -0.59 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.59 |
| KPNA2 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | -0.59 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | -0.59 |
| CETN1 | centrin, EF-hand protein, 1 | -0.57 |
| GTSE1 | G-2 and S-phase expressed 1 | -0.57 |
| SMTN | smoothelin | -0.57 |
| CENPE | centromere protein E, 312kDa | -0.57 |
| BIRC5 | baculoviral IAP repeat containing 5 | -0.56 |
| SNAI1 | snail family zinc finger 1 | -0.55 |
| MED22 | mediator complex subunit 22 | -0.55 |
| CDC20 | cell division cycle 20 | -0.55 |
| DUS4L | dihydrouridine synthase 4-like (S. cerevisiae) | -0.55 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.55 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.54 |
| SESN2 | sestrin 2 | -0.54 |
| SMOX | spermine oxidase | -0.54 |
| TESC | tescalcin | -0.53 |
| LTN1 | listerin E3 ubiquitin protein ligase 1 | -0.53 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.53 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.53 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | -0.53 |
| TGOLN2 | trans-golgi network protein 2 | -0.53 |
| DIXDC1 | DIX domain containing 1 | -0.52 |
| SASS6 | spindle assembly 6 homolog (C. elegans) | -0.52 |
| HAUS7 | HAUS augmin-like complex, subunit 7 | -0.52 |
| OSGIN1 | oxidative stress induced growth inhibitor 1 | -0.52 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.51 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | -0.49 |
| SMPD1 | sphingomyelin phosphodiesterase 1, acid lysosomal | -0.49 |
| SPDL1 | spindle apparatus coiled-coil protein 1 | -0.48 |
| KIF20A | kinesin family member 20A | -0.48 |
| ANLN | anillin, actin binding protein | -0.48 |
| RGN | regucalcin | -0.48 |
| CLN3 | ceroid-lipofuscinosis, neuronal 3 | -0.48 |
| THAP3 | THAP domain containing, apoptosis associated protein 3 | -0.47 |
| RNF181 | ring finger protein 181 | -0.47 |
| SGO2 | shugoshin 2 | -0.46 |
| NECTIN3 | nectin cell adhesion molecule 3 | -0.46 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.45 |
| BCL2L12 | BCL2-like 12 (proline rich) | -0.45 |
| YRDC | yrdC N(6)-threonylcarbamoyltransferase domain containing | -0.45 |
| HTD2 | hydroxyacyl-thioester dehydratase type 2 | -0.45 |
| IPPK | inositol 1,3,4,5,6-pentakisphosphate 2-kinase | -0.45 |
| LYSMD3 | LysM, putative peptidoglycan-binding, domain containing 3 | -0.45 |
| CDCA2 | cell division cycle associated 2 | -0.45 |
| GID8 | GID complex subunit 8 | -0.45 |
| ZNHIT3 | zinc finger, HIT-type containing 3 | -0.44 |
| CKAP2 | cytoskeleton associated protein 2 | -0.44 |
| TIGAR | TP53 induced glycolysis regulatory phosphatase | -0.44 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -0.44 |
| SLC7A6 | solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 | -0.44 |
| FTL | ferritin, light polypeptide | -0.44 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | -0.44 |
| CLN5 | ceroid-lipofuscinosis, neuronal 5 | -0.43 |
| KIF23 | kinesin family member 23 | -0.43 |
| PRC1 | protein regulator of cytokinesis 1 | -0.43 |
| AREG | amphiregulin | -0.43 |
| UROC1 | urocanate hydratase 1 | -0.43 |
| ARHGEF19 | Rho guanine nucleotide exchange factor (GEF) 19 | -0.43 |
| SIAH1 | siah E3 ubiquitin protein ligase 1 | -0.43 |
| AURKB | aurora kinase B | -0.42 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.42 |
