| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A member of the class of piperazines that is piperazine in which the hydrogens attached to nitrogen are replaced by a (4-chlorophenyl)(phenyl)methyl and a 2-(carboxymethoxy)ethyl group respectively. (Chemical Entities of Biological Interest Ontology, CHEBI_3561) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/2678 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Cetirizine relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYBPC2 | myosin binding protein C, fast type | 1.39 |
| KLHDC3 | kelch domain containing 3 | 1.38 |
| C12ORF60 | chromosome 12 open reading frame 60 | 1.22 |
| HTT | huntingtin | 0.93 |
| WWC3 | WWC family member 3 | 0.92 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 0.89 |
| FASTKD3 | FAST kinase domains 3 | 0.83 |
| DNAH6 | dynein, axonemal, heavy chain 6 | 0.76 |
| CCNYL1 | cyclin Y-like 1 | 0.74 |
| RPS21 | ribosomal protein S21 | 0.72 |
| SARDH | sarcosine dehydrogenase | 0.7 |
| RBP7 | retinol binding protein 7, cellular | 0.66 |
| CEP295 | centrosomal protein 295kDa | 0.64 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 0.62 |
| NPHP3 | nephronophthisis 3 (adolescent) | 0.6 |
| ZNF697 | zinc finger protein 697 | 0.59 |
| ZNF286B | zinc finger protein 286B | 0.57 |
| CD81 | CD81 molecule | 0.54 |
| BET1 | Bet1 golgi vesicular membrane trafficking protein | 0.5 |
| ARHGEF35 | Rho guanine nucleotide exchange factor (GEF) 35 | 0.49 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.48 |
| PCSK6 | proprotein convertase subtilisin/kexin type 6 | 0.48 |
| YBX3 | Y box binding protein 3 | 0.48 |
| DISP1 | dispatched homolog 1 (Drosophila) | 0.48 |
| BRCC3 | BRCA1/BRCA2-containing complex, subunit 3 | 0.47 |
| LPIN2 | lipin 2 | 0.46 |
| CLCN5 | chloride channel, voltage-sensitive 5 | 0.45 |
| OGG1 | 8-oxoguanine DNA glycosylase | 0.44 |
| METAP2 | methionyl aminopeptidase 2 | 0.43 |
| PLEKHM1 | pleckstrin homology domain containing, family M (with RUN domain) member 1 | 0.43 |
| DPH6 | diphthamine biosynthesis 6 | 0.42 |
| NFYA | nuclear transcription factor Y, alpha | 0.42 |
| CAV2 | caveolin 2 | 0.42 |
| SUMO1 | small ubiquitin-like modifier 1 | 0.42 |
| PIP | prolactin-induced protein | 0.41 |
| PSMG1 | proteasome (prosome, macropain) assembly chaperone 1 | 0.41 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | 0.4 |
| SH3YL1 | SH3 and SYLF domain containing 1 | 0.4 |
| HMGB2 | high mobility group box 2 | 0.39 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | 0.39 |
| ZBTB11 | zinc finger and BTB domain containing 11 | 0.38 |
| VWA5B2 | von Willebrand factor A domain containing 5B2 | 0.38 |
| SYTL2 | synaptotagmin-like 2 | 0.38 |
| MKRN1 | makorin ring finger protein 1 | 0.38 |
| BCORL1 | BCL6 corepressor-like 1 | 0.38 |
| TSN | translin | 0.38 |
| HIST3H2A | histone cluster 3, H2a | 0.38 |
| CRY2 | cryptochrome circadian clock 2 | 0.37 |
| UBE2A | ubiquitin-conjugating enzyme E2A | 0.37 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | 0.37 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.37 |
| RANBP17 | RAN binding protein 17 | 0.37 |
| TRABD | TraB domain containing | 0.37 |
| SETD9 | SET domain containing 9 | 0.37 |
| HAPLN3 | hyaluronan and proteoglycan link protein 3 | 0.36 |
| AGTRAP | angiotensin II receptor-associated protein | 0.35 |
| PIAS3 | protein inhibitor of activated STAT, 3 | 0.35 |
| VPS26A | vacuolar protein sorting 26 homolog A (S. pombe) | 0.35 |
| SET | SET nuclear proto-oncogene | 0.35 |
| AP1S2 | adaptor-related protein complex 1, sigma 2 subunit | 0.34 |
| TMEM173 | transmembrane protein 173 | 0.34 |
| SPEG | SPEG complex locus | 0.34 |
| IDH3G | isocitrate dehydrogenase 3 (NAD+) gamma | 0.34 |
| PRAME | preferentially expressed antigen in melanoma | 0.33 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.33 |
| RPL37A | ribosomal protein L37a | 0.33 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | 0.32 |
| C1ORF109 | chromosome 1 open reading frame 109 | 0.32 |
| CHCHD6 | coiled-coil-helix-coiled-coil-helix domain containing 6 | 0.32 |
| WDFY3 | WD repeat and FYVE domain containing 3 | 0.32 |
| WDR90 | WD repeat domain 90 | 0.32 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.32 |
| TTN | titin | 0.31 |
| CHST3 | carbohydrate (chondroitin 6) sulfotransferase 3 | 0.31 |
| GCAT | glycine C-acetyltransferase | 0.31 |
| PRDM11 | PR domain containing 11 | 0.31 |
| PMFBP1 | polyamine modulated factor 1 binding protein 1 | 0.31 |
| SLC29A1 | solute carrier family 29 (equilibrative nucleoside transporter), member 1 | 0.31 |
| LRRC7 | leucine rich repeat containing 7 | 0.31 |
| NAF1 | nuclear assembly factor 1 ribonucleoprotein | 0.31 |
| REEP1 | receptor accessory protein 1 | 0.31 |
| RHBDD2 | rhomboid domain containing 2 | 0.3 |
| PGPEP1 | pyroglutamyl-peptidase I | 0.3 |
| POLR1D | polymerase (RNA) I polypeptide D, 16kDa | 0.3 |
| MTCH2 | mitochondrial carrier 2 | 0.3 |
| CARNMT1 | carnosine N-methyltransferase 1 | 0.3 |
| MAN2B2 | mannosidase, alpha, class 2B, member 2 | 0.3 |
| PRKAA2 | protein kinase, AMP-activated, alpha 2 catalytic subunit | 0.3 |
| EPC1 | enhancer of polycomb homolog 1 (Drosophila) | 0.3 |
| CKS2 | CDC28 protein kinase regulatory subunit 2 | 0.3 |
| DEPDC1B | DEP domain containing 1B | 0.3 |
| FOXD2 | forkhead box D2 | 0.3 |
| TIMM10B | translocase of inner mitochondrial membrane 10 homolog B (yeast) | 0.29 |
| PRKACB | protein kinase, cAMP-dependent, catalytic, beta | 0.29 |
| LBR | lamin B receptor | 0.29 |
| PTBP1 | polypyrimidine tract binding protein 1 | 0.29 |
| HYLS1 | hydrolethalus syndrome 1 | 0.29 |
| BSG | basigin (Ok blood group) | 0.28 |
| CCAR2 | cell cycle and apoptosis regulator 2 | 0.28 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 0.28 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH1 | myosin, heavy chain 1, skeletal muscle, adult | -1.93 |
| ZBTB4 | zinc finger and BTB domain containing 4 | -0.97 |
| CDK3 | cyclin-dependent kinase 3 | -0.81 |
| MTSS2 | MTSS I-BAR domain containing 2 | -0.78 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.76 |
| USP43 | ubiquitin specific peptidase 43 | -0.72 |
| ZNF483 | zinc finger protein 483 | -0.65 |
| PRDM16 | PR domain containing 16 | -0.62 |
| CRELD2 | cysteine-rich with EGF-like domains 2 | -0.62 |
| LYPD3 | LY6/PLAUR domain containing 3 | -0.56 |
| TTC9 | tetratricopeptide repeat domain 9 | -0.56 |
| PXMP4 | peroxisomal membrane protein 4, 24kDa | -0.55 |
| IFI30 | interferon, gamma-inducible protein 30 | -0.55 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.55 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | -0.54 |
| TMEM87B | transmembrane protein 87B | -0.54 |
| PEX2 | peroxisomal biogenesis factor 2 | -0.51 |
| SH3RF2 | SH3 domain containing ring finger 2 | -0.49 |
| DBNL | drebrin-like | -0.47 |
| ATXN1L | ataxin 1-like | -0.46 |
| ZKSCAN8 | zinc finger with KRAB and SCAN domains 8 | -0.46 |
| MCRS1 | microspherule protein 1 | -0.46 |
| TMOD1 | tropomodulin 1 | -0.46 |
| DNAL4 | dynein, axonemal, light chain 4 | -0.45 |
| NSUN4 | NOP2/Sun domain family, member 4 | -0.45 |
| NOTCH3 | notch 3 | -0.45 |
| ARL13B | ADP-ribosylation factor-like 13B | -0.45 |
| DOLPP1 | dolichyldiphosphatase 1 | -0.44 |
| KIAA1109 | KIAA1109 | -0.44 |
| ZDBF2 | zinc finger, DBF-type containing 2 | -0.44 |
| TMEM39A | transmembrane protein 39A | -0.43 |
| MAPK8IP3 | mitogen-activated protein kinase 8 interacting protein 3 | -0.43 |
| PSEN2 | presenilin 2 | -0.42 |
| GPATCH3 | G patch domain containing 3 | -0.42 |
| MAP2 | microtubule-associated protein 2 | -0.41 |
| TIGD2 | tigger transposable element derived 2 | -0.41 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.41 |
| DST | dystonin | -0.41 |
| RNF126 | ring finger protein 126 | -0.4 |
| DPYD | dihydropyrimidine dehydrogenase | -0.4 |
| COMMD5 | COMM domain containing 5 | -0.4 |
| USP27X | ubiquitin specific peptidase 27, X-linked | -0.4 |
| TMEM102 | transmembrane protein 102 | -0.39 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.39 |
| STEAP2 | STEAP family member 2, metalloreductase | -0.38 |
| SYT7 | synaptotagmin VII | -0.38 |
| WDR54 | WD repeat domain 54 | -0.38 |
| ERCC6L2 | excision repair cross-complementation group 6-like 2 | -0.38 |
| LRRC58 | leucine rich repeat containing 58 | -0.37 |
| DUOX1 | dual oxidase 1 | -0.37 |
| BTG3 | BTG family, member 3 | -0.37 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.37 |
| NPM3 | nucleophosmin/nucleoplasmin 3 | -0.37 |
| BDH2 | 3-hydroxybutyrate dehydrogenase, type 2 | -0.37 |
| CEP112 | centrosomal protein 112kDa | -0.36 |
| UNKL | unkempt family zinc finger-like | -0.36 |
| TMCO4 | transmembrane and coiled-coil domains 4 | -0.36 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.36 |
| TNNC2 | troponin C type 2 (fast) | -0.36 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.35 |
| PRKCG | protein kinase C, gamma | -0.35 |
| CHST14 | carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 | -0.35 |
| APBB1 | amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) | -0.35 |
| P2RX4 | purinergic receptor P2X, ligand gated ion channel, 4 | -0.35 |
| ASB13 | ankyrin repeat and SOCS box containing 13 | -0.35 |
| CUX1 | cut-like homeobox 1 | -0.35 |
| GALNT6 | polypeptide N-acetylgalactosaminyltransferase 6 | -0.34 |
| TMEM263 | transmembrane protein 263 | -0.34 |
| CD82 | CD82 molecule | -0.34 |
| ZDHHC2 | zinc finger, DHHC-type containing 2 | -0.34 |
| C4ORF33 | chromosome 4 open reading frame 33 | -0.34 |
| HECW1 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 | -0.34 |
| PCYT1A | phosphate cytidylyltransferase 1, choline, alpha | -0.34 |
| PEF1 | penta-EF-hand domain containing 1 | -0.33 |
| RNF135 | ring finger protein 135 | -0.33 |
| AKNA | AT-hook transcription factor | -0.33 |
| FBXL15 | F-box and leucine-rich repeat protein 15 | -0.33 |
| SP140 | SP140 nuclear body protein | -0.33 |
| CHRD | chordin | -0.33 |
| CDIPT | CDP-diacylglycerol--inositol 3-phosphatidyltransferase | -0.33 |
| APBA3 | amyloid beta (A4) precursor protein-binding, family A, member 3 | -0.33 |
| KBTBD11 | kelch repeat and BTB (POZ) domain containing 11 | -0.33 |
| ZDHHC12 | zinc finger, DHHC-type containing 12 | -0.33 |
| DESI2 | desumoylating isopeptidase 2 | -0.33 |
| CRELD1 | cysteine-rich with EGF-like domains 1 | -0.32 |
| SYNGAP1 | synaptic Ras GTPase activating protein 1 | -0.32 |
| SLF2 | SMC5-SMC6 complex localization factor 2 | -0.32 |
| ARMC5 | armadillo repeat containing 5 | -0.32 |
| FANCC | Fanconi anemia, complementation group C | -0.32 |
| HOXA7 | homeobox A7 | -0.32 |
| DENND3 | DENN/MADD domain containing 3 | -0.32 |
| CLCN2 | chloride channel, voltage-sensitive 2 | -0.32 |
| ZNF691 | zinc finger protein 691 | -0.32 |
| RFX7 | regulatory factor X, 7 | -0.32 |
| MID2 | midline 2 | -0.31 |
| BORCS7 | BLOC-1 related complex subunit 7 | -0.31 |
| PLPP6 | phospholipid phosphatase 6 | -0.31 |
| JRKL | JRK-like | -0.31 |
| MRPL12 | mitochondrial ribosomal protein L12 | -0.31 |
| KLHL8 | kelch-like family member 8 | -0.31 |
