Chemical carcinogenesis - DNA adducts Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description It has been estimated that exposure to environmental chemical carcinogens may contribute significantly to the causation of a sizable fraction, perhaps a majority, of human cancers. Human carcinogens act through a variety of genotoxic and non-genotoxic mechanisms. Genotoxic carcinogens can attack biological macromolecules such as DNA and RNA either directly or indirectly through metabolism, resulting in the formation of adducts with these macromolecules. If DNA adducts escape cellular repair mechanisms and persist, they may lead to miscoding, resulting in permanent mutations. Mutations cause an undefined number of cell changes, translated into aberrant protein expression and in changes in cell cycle control. (Kyoto Encyclopedia of Genes and Genomes, hsa05204)
External Link https://www.kegg.jp/entry/hsa05204
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Genes

69 proteins participating in the Chemical carcinogenesis - DNA adducts pathway from the KEGG Pathways 2026 dataset.

Symbol Name
AKR1C2 aldo-keto reductase family 1, member C2
CBR1 carbonyl reductase 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2A7 cytochrome P450, family 2, subfamily A, polypeptide 7
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP3A7-CYP3A51P CYP3A7-CYP3A51P readthrough
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
GSTA1 glutathione S-transferase alpha 1
GSTA2 glutathione S-transferase alpha 2
GSTA3 glutathione S-transferase alpha 3
GSTA4 glutathione S-transferase alpha 4
GSTA5 glutathione S-transferase alpha 5
GSTK1 glutathione S-transferase kappa 1
GSTM1 glutathione S-transferase mu 1
GSTM2 glutathione S-transferase mu 2 (muscle)
GSTM3 glutathione S-transferase mu 3 (brain)
GSTM4 glutathione S-transferase mu 4
GSTM5 glutathione S-transferase mu 5
GSTO1 glutathione S-transferase omega 1
GSTO2 glutathione S-transferase omega 2
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene)
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene)
GSTT4 glutathione S-transferase theta 4
HPGDS hematopoietic prostaglandin D synthase
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSD11B1L hydroxysteroid (11-beta) dehydrogenase 1-like
MGST1 microsomal glutathione S-transferase 1
MGST2 microsomal glutathione S-transferase 2
MGST3 microsomal glutathione S-transferase 3
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
SLC38A1 solute carrier family 38, member 1
SLC38A3 solute carrier family 38, member 3
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SULT1A3 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
SULT1A4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4
UGT1A5 UDP glucuronosyltransferase 1 family, polypeptide A5
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9
UGT2A1 UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
UGT2A2 UDP glucuronosyltransferase 2 family, polypeptide A2
UGT2A3 UDP glucuronosyltransferase 2 family, polypeptide A3
UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10
UGT2B11 UDP glucuronosyltransferase 2 family, polypeptide B11
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7