Chemical carcinogenesis - receptor activation Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description Carcinogenesis is a multistage process that consists of initiation, promotion, and progression stages. Chemicals or environmental factors may act at any of these stages to induce and/or enhance the carcinogenic process. Based on their mode-of-action, carcinogens can be classified as genotoxic or non-genotoxic. Genotoxic agent begins their action at the deoxyribonucleic acid (DNA) level, causing DNA damage through several mechanisms. Non-genotoxic carcinogens are chemicals that cause the development of tumors through multiple non-genotoxic events and epigenetic alterations without direct interaction with DNA. One non-genotoxic mechanism involves receptor activation. Biological mechanisms involving receptor activation fall into two broad categories: (i) those that involve cell surface receptors and some intracellular receptors that activate signal transduction pathways, resulting in biological responses, including gene transcription, and (ii) those that involve intracellular receptors that translocate into the nucleus and act as transcription factors regulating gene expression. Both classes of receptors can be involved in mechanisms of carcinogenesis. (Kyoto Encyclopedia of Genes and Genomes, hsa05207)
External Link https://www.kegg.jp/entry/hsa05207
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Genes

195 proteins participating in the Chemical carcinogenesis - receptor activation pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ADCY1 adenylate cyclase 1 (brain)
ADCY2 adenylate cyclase 2 (brain)
ADCY4 adenylate cyclase 4
ADCY5 adenylate cyclase 5
ADCY6 adenylate cyclase 6
ADCY7 adenylate cyclase 7
ADCY8 adenylate cyclase 8 (brain)
ADCY9 adenylate cyclase 9
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AHR aryl hydrocarbon receptor
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
AREG amphiregulin
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
ATF4 activating transcription factor 4
ATF6B activating transcription factor 6 beta
AURKAIP1 aurora kinase A interacting protein 1
BAD BCL2-associated agonist of cell death
BCL2 B-cell CLL/lymphoma 2
BCL6 B-cell CLL/lymphoma 6
BIRC5 baculoviral IAP repeat containing 5
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit
CCND1 cyclin D1
CCND3 cyclin D3
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal)
CLSTN1 calsyntenin 1
CREB1 cAMP responsive element binding protein 1
CREB3L1 cAMP responsive element binding protein 3-like 1
CREB3L2 cAMP responsive element binding protein 3-like 2
CREB3L3 cAMP responsive element binding protein 3-like 3
CREB3L4 cAMP responsive element binding protein 3-like 4
CREB5 cAMP responsive element binding protein 5
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DLL1 delta-like 1 (Drosophila)
DLL3 delta-like 3 (Drosophila)
DLL4 delta-like 4 (Drosophila)
E2F1 E2F transcription factor 1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPHX2 epoxide hydrolase 2, cytoplasmic
EPHX3 epoxide hydrolase 3
EPHX4 epoxide hydrolase 4
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
FGF10 fibroblast growth factor 10
FGF13 fibroblast growth factor 13
FGF16 fibroblast growth factor 16
FGF17 fibroblast growth factor 17
FGF18 fibroblast growth factor 18
FGF20 fibroblast growth factor 20
FGF22 fibroblast growth factor 22
FGF3 fibroblast growth factor 3
FGF4 fibroblast growth factor 4
FGF5 fibroblast growth factor 5
FGF6 fibroblast growth factor 6
FGF7 fibroblast growth factor 7
FGF8 fibroblast growth factor 8 (androgen-induced)
FGF9 fibroblast growth factor 9
FOS FBJ murine osteosarcoma viral oncogene homolog
GDNF glial cell derived neurotrophic factor
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
GNAS GNAS complex locus
GRB2 growth factor receptor-bound protein 2
GSTA1 glutathione S-transferase alpha 1
GSTA2 glutathione S-transferase alpha 2
GSTA3 glutathione S-transferase alpha 3
GSTA4 glutathione S-transferase alpha 4
GSTA5 glutathione S-transferase alpha 5
GSTM1 glutathione S-transferase mu 1
GSTM2 glutathione S-transferase mu 2 (muscle)
GSTM3 glutathione S-transferase mu 3 (brain)
GSTM4 glutathione S-transferase mu 4
GSTM5 glutathione S-transferase mu 5
GSTO1 glutathione S-transferase omega 1
GSTO2 glutathione S-transferase omega 2
GSTT1 glutathione S-transferase theta 1
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene)
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene)
GSTT4 glutathione S-transferase theta 4
HRAS Harvey rat sarcoma viral oncogene homolog
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
JAG1 jagged 1
JAK2 Janus kinase 2
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KPNA1 karyopherin alpha 1 (importin alpha 5)
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KPNA3 karyopherin alpha 3 (importin alpha 4)
KPNA4 karyopherin alpha 4 (importin alpha 3)
KPNA5 karyopherin alpha 5 (importin alpha 6)
KPNA6 karyopherin alpha 6 (importin alpha 7)
KPNA7 karyopherin alpha 7 (importin alpha 8)
KPNB1 karyopherin (importin) beta 1
LNCEGFL7OS lncRNA EGFL7 opposite strand
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MGST1 microsomal glutathione S-transferase 1
MGST2 microsomal glutathione S-transferase 2
MGST3 microsomal glutathione S-transferase 3
MIA3 melanoma inhibitory activity family, member 3
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOTCH2 notch 2
NR1I3 nuclear receptor subfamily 1, group I, member 3
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PAQR5 progestin and adipoQ receptor family member V
PAQR7 progestin and adipoQ receptor family member VII
PAQR8 progestin and adipoQ receptor family member VIII
PGR progesterone receptor
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PPARA peroxisome proliferator-activated receptor alpha
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCG protein kinase C, gamma
PTGES3 prostaglandin E synthase 3 (cytosolic)
RB1 retinoblastoma 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RNASE3 ribonuclease, RNase A family, 3
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
RXRA retinoid X receptor, alpha
RXRB retinoid X receptor, beta
RXRG retinoid X receptor, gamma
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4
UGT1A5 UDP glucuronosyltransferase 1 family, polypeptide A5
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9
UGT2A1 UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
UGT2A2 UDP glucuronosyltransferase 2 family, polypeptide A2
UGT2A3 UDP glucuronosyltransferase 2 family, polypeptide A3
UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10
UGT2B11 UDP glucuronosyltransferase 2 family, polypeptide B11
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
WNT1 wingless-type MMTV integration site family, member 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase