Chikungunya Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A viral infectious disease that results_in infection located_in joint, has_material_basis_in Chikungunya virus, which is transmitted_by Aedes mosquito bite. The infection has_symptom fever, has_symptom arthralgia, and has_symptom maculopapular rash. (Human Disease Ontology, DOID_0050012)
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Genes

356 genes co-occuring with the disease Chikungunya in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
SH2D3A SH2 domain containing 3A 3.357
PRSS57 protease, serine, 57 3.219
SH2D3C SH2 domain containing 3C 3.207
MXRA8 matrix-remodelling associated 8 2.566
SENP8 SUMO/sentrin specific peptidase family member 8 2.475
ERVW-1 endogenous retrovirus group W, member 1 2.46
IFNA1 interferon, alpha 1 2.414
ACE2 angiotensin I converting enzyme 2 2.393
IFNAR1 interferon (alpha, beta and omega) receptor 1 2.304
KDR kinase insert domain receptor 2.288
IL6 interleukin 6 2.258
IFNG interferon, gamma 2.254
CD4 CD4 molecule 2.253
IFNB1 interferon, beta 1, fibroblast 2.247
FURIN furin (paired basic amino acid cleaving enzyme) 2.224
TLR3 toll-like receptor 3 2.202
RPS17 ribosomal protein S17 2.192
TNF tumor necrosis factor 2.171
CD8A CD8a molecule 2.167
IRF3 interferon regulatory factor 3 2.165
CD209 CD209 molecule 2.165
ERF Ets2 repressor factor 2.143
IFIH1 interferon induced with helicase C domain 1 2.133
IL1B interleukin 1, beta 2.115
CXCL10 chemokine (C-X-C motif) ligand 10 2.097
ERVFRD-1 endogenous retrovirus group FRD, member 1 2.06
ERV3-1 endogenous retrovirus group 3, member 1 2.06
MAVS mitochondrial antiviral signaling protein 2.057
IL10 interleukin 10 2.048
RPS7 ribosomal protein S7 2.037
KLRC2 killer cell lectin-like receptor subfamily C, member 2 2.029
CCL2 chemokine (C-C motif) ligand 2 2.013
ISG15 ISG15 ubiquitin-like modifier 2.009
IRF7 interferon regulatory factor 7 1.99
CRP C-reactive protein, pentraxin-related 1.975
ALB albumin 1.974
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 1.96
CCL5 chemokine (C-C motif) ligand 5 1.952
TLR7 toll-like receptor 7 1.942
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 1.932
HPGDS hematopoietic prostaglandin D synthase 1.918
ZNF883 zinc finger protein 883 1.91
CXCL8 chemokine (C-X-C motif) ligand 8 1.909
IL2 interleukin 2 1.905
STAT2 signal transducer and activator of transcription 2, 113kDa 1.894
NTPCR nucleoside-triphosphatase, cancer-related 1.876
RSAD2 radical S-adenosyl methionine domain containing 2 1.869
CCL3 chemokine (C-C motif) ligand 3 1.86
BST2 bone marrow stromal cell antigen 2 1.859
TMPRSS2 transmembrane protease, serine 2 1.852
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.837
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B 1.824
CCL4 chemokine (C-C motif) ligand 4 1.824
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.817
IL4 interleukin 4 1.814
IFNA2 interferon, alpha 2 1.785
IL17A interleukin 17A 1.772
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 1.768
STAT1 signal transducer and activator of transcription 1, 91kDa 1.766
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 1.76
GLIPR2 GLI pathogenesis-related 2 1.756
XRN1 5'-3' exoribonuclease 1 1.748
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 1.748
CTRL chymotrypsin-like 1.74
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 1.733
TLR8 toll-like receptor 8 1.733
IL1A interleukin 1, alpha 1.732
AXL AXL receptor tyrosine kinase 1.728
CXCL9 chemokine (C-X-C motif) ligand 9 1.727
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 1.706
MX1 MX dynamin-like GTPase 1 1.695
IFITM3 interferon induced transmembrane protein 3 1.678
IL18 interleukin 18 1.674
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 1.666
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 1.65
TBK1 TANK-binding kinase 1 1.645
IL15 interleukin 15 1.638
AGO2 argonaute RISC catalytic component 2 1.637
CGAS cyclic GMP-AMP synthase 1.626
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 1.623
IL7 interleukin 7 1.621
PIWIL4 piwi-like RNA-mediated gene silencing 4 1.616
NPC1 Niemann-Pick disease, type C1 1.61
CLEC4M C-type lectin domain family 4, member M 1.608
IFNA17 interferon, alpha 17 1.607
PIWIL1 piwi-like RNA-mediated gene silencing 1 1.606
ICAM3 intercellular adhesion molecule 3 1.605
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.602
TBL1X transducin (beta)-like 1X-linked 1.6
LAMP1 lysosomal-associated membrane protein 1 1.595
TLR9 toll-like receptor 9 1.593
TLR4 toll-like receptor 4 1.592
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 1.587
IFNA4 interferon, alpha 4 1.584
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 1.582
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 1.581
TYRO3 TYRO3 protein tyrosine kinase 1.579
MYD88 myeloid differentiation primary response 88 1.578
KLRD1 killer cell lectin-like receptor subfamily D, member 1 1.578
IL5 interleukin 5 1.564
CSF3 colony stimulating factor 3 (granulocyte) 1.562
AAK1 AP2 associated kinase 1 1.561
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.554
ZC3HAV1 zinc finger CCCH-type, antiviral 1 1.553
ACE angiotensin I converting enzyme 1.547
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 1.545
EIF4A2 eukaryotic translation initiation factor 4A2 1.543
GPR161 G protein-coupled receptor 161 1.541
IL13 interleukin 13 1.54
GTPBP1 GTP binding protein 1 1.538
ACHE acetylcholinesterase (Yt blood group) 1.537
EIF4A1 eukaryotic translation initiation factor 4A1 1.536
PGLYRP1 peptidoglycan recognition protein 1 1.535
GAK cyclin G associated kinase 1.533
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 1.532
IFNA14 interferon, alpha 14 1.519
IFNA6 interferon, alpha 6 1.518
TLR2 toll-like receptor 2 1.517
PRF1 perforin 1 (pore forming protein) 1.517
IFNA5 interferon, alpha 5 1.517
IFNA7 interferon, alpha 7 1.512
TRIM5 tripartite motif containing 5 1.511
CTSL cathepsin L 1.51
IFNA10 interferon, alpha 10 1.505
IFNA21 interferon, alpha 21 1.505
IFNA16 interferon, alpha 16 1.499
IFNA8 interferon, alpha 8 1.497
HLA-A major histocompatibility complex, class I, A 1.497
IFNA13 interferon, alpha 13 1.495
IFNL1 interferon, lambda 1 1.484
ACTB actin, beta 1.483
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 1.482
BECN1 beclin 1, autophagy related 1.478
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 1.472
RNGTT RNA guanylyltransferase and 5'-phosphatase 1.472
IRF1 interferon regulatory factor 1 1.466
F2 coagulation factor II (thrombin) 1.466
ISG20 interferon stimulated exonuclease gene 20kDa 1.465
ADCY4 adenylate cyclase 4 1.461
DBT dihydrolipoamide branched chain transacylase E2 1.457
JUN jun proto-oncogene 1.456
MX2 MX dynamin-like GTPase 2 1.455
ENPEP glutamyl aminopeptidase (aminopeptidase A) 1.455
KLRC1 killer cell lectin-like receptor subfamily C, member 1 1.453
CCL11 chemokine (C-C motif) ligand 11 1.453
PXDN peroxidasin 1.451
HLA-E major histocompatibility complex, class I, E 1.45
PXDNL peroxidasin-like 1.444
CTRB2 chymotrypsinogen B2 1.444
DICER1 dicer 1, ribonuclease type III 1.443
CALCOCO2 calcium binding and coiled-coil domain 2 1.443
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 1.44
CTRB1 chymotrypsinogen B1 1.438
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 1.436
HLA-B major histocompatibility complex, class I, B 1.433
GP2 glycoprotein 2 (zymogen granule membrane) 1.426
B3GAT1 beta-1,3-glucuronyltransferase 1 1.422
F3 coagulation factor III (thromboplastin, tissue factor) 1.419
PI4KB phosphatidylinositol 4-kinase, catalytic, beta 1.415
IFI16 interferon, gamma-inducible protein 16 1.414
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.409
OASL 2'-5'-oligoadenylate synthetase-like 1.408
RPL32 ribosomal protein L32 1.405
NLRP3 NLR family, pyrin domain containing 3 1.405
MYOM2 myomesin 2 1.4
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 1.392
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 1.39
RAB5A RAB5A, member RAS oncogene family 1.381
CXCL11 chemokine (C-X-C motif) ligand 11 1.365
CLEC5A C-type lectin domain family 5, member A 1.36
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.353
IRF9 interferon regulatory factor 9 1.351
ANKRD49 ankyrin repeat domain 49 1.351
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 1.35
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 1.35
AIM2 absent in melanoma 2 1.349
SLCO6A1 solute carrier organic anion transporter family, member 6A1 1.349
MPG N-methylpurine-DNA glycosylase 1.347
RAG1 recombination activating gene 1 1.346
DNAH8 dynein, axonemal, heavy chain 8 1.345
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 1.344
AGO1 argonaute RISC catalytic component 1 1.338
HLA-C major histocompatibility complex, class I, C 1.337
IL9 interleukin 9 1.334
TGFB1 transforming growth factor, beta 1 1.331
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.328
HSPA4 heat shock 70kDa protein 4 1.322
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 1.32
IFT81 intraflagellar transport 81 1.316
CD69 CD69 molecule 1.314
PYDC1 PYD (pyrin domain) containing 1 1.313
ADAR adenosine deaminase, RNA-specific 1.308
CD300A CD300a molecule 1.307
SAMHD1 SAM domain and HD domain 1 1.3
C6ORF15 chromosome 6 open reading frame 15 1.298
KRT76 keratin 76, type II 1.298
CCL7 chemokine (C-C motif) ligand 7 1.297
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.294
ASZ1 ankyrin repeat, SAM and basic leucine zipper domain containing 1 1.293
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 1.286
KIF22 kinesin family member 22 1.285
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 1.281
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.276
LDLRAD3 low density lipoprotein receptor class A domain containing 3 1.276
MAPRE3 microtubule-associated protein, RP/EB family, member 3 1.272
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 1.27
LGALS4 lectin, galactoside-binding, soluble, 4 1.269
HCFC2 host cell factor C2 1.264
AGO3 argonaute RISC catalytic component 3 1.259
NUTF2 nuclear transport factor 2 1.25
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 1.248
GOLPH3 golgi phosphoprotein 3 (coat-protein) 1.242
LTF lactotransferrin 1.241
CTSB cathepsin B 1.241
IFITM1 interferon induced transmembrane protein 1 1.241
ZBTB22 zinc finger and BTB domain containing 22 1.241
CTSS cathepsin S 1.236
DPP4 dipeptidyl-peptidase 4 1.235
PTPRC protein tyrosine phosphatase, receptor type, C 1.231
TRIM25 tripartite motif containing 25 1.229
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3 1.228
JAK1 Janus kinase 1 1.226
ATG5 autophagy related 5 1.224
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.224
CD86 CD86 molecule 1.222
RTP4 receptor (chemosensory) transporter protein 4 1.221
DNAAF2 dynein, axonemal, assembly factor 2 1.22
NCR1 natural cytotoxicity triggering receptor 1 1.218
GABARAPL2 GABA(A) receptor-associated protein-like 2 1.216
ADCY10 adenylate cyclase 10 (soluble) 1.216
ICAM1 intercellular adhesion molecule 1 1.211
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.21
CCL8 chemokine (C-C motif) ligand 8 1.21
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 1.205
C3 complement component 3 1.204
PARP10 poly (ADP-ribose) polymerase family, member 10 1.204
NCAM1 neural cell adhesion molecule 1 1.203
PARP12 poly (ADP-ribose) polymerase family, member 12 1.2
NCR3 natural cytotoxicity triggering receptor 3 1.2
CD46 CD46 molecule, complement regulatory protein 1.198
INS insulin 1.198
NCR2 natural cytotoxicity triggering receptor 2 1.197
IFI6 interferon, alpha-inducible protein 6 1.193
HSPA8 heat shock 70kDa protein 8 1.189
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 1.189
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3 1.185
SENP7 SUMO1/sentrin specific peptidase 7 1.182
MTX3 metaxin 3 1.18
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.179
UBA7 ubiquitin-like modifier activating enzyme 7 1.178
CD19 CD19 molecule 1.177
ATG12 autophagy related 12 1.175
IL2RA interleukin 2 receptor, alpha 1.163
BSG basigin (Ok blood group) 1.162
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) 1.162
LINS1 lines homolog 1 1.161
TLR1 toll-like receptor 1 1.161
PDXP pyridoxal (pyridoxine, vitamin B6) phosphatase 1.16
CD80 CD80 molecule 1.159
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.158
EIF4E eukaryotic translation initiation factor 4E 1.157
PPIG peptidylprolyl isomerase G (cyclophilin G) 1.156
IL3 interleukin 3 1.148
GYPC glycophorin C (Gerbich blood group) 1.148
PARP14 poly (ADP-ribose) polymerase family, member 14 1.146
TMPRSS11D transmembrane protease, serine 11D 1.145
ADCY5 adenylate cyclase 5 1.144
GAS6 growth arrest-specific 6 1.144
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 1.143
GABARAPL1 GABA(A) receptor-associated protein like 1 1.14
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 1.139
CD40LG CD40 ligand 1.138
KLRK1 killer cell lectin-like receptor subfamily K, member 1 1.132
FHL1 four and a half LIM domains 1 1.13
IFNAR2 interferon (alpha, beta and omega) receptor 2 1.128
PPIA peptidylprolyl isomerase A (cyclophilin A) 1.127
MBL2 mannose-binding lectin (protein C) 2, soluble 1.127
DROSHA drosha, ribonuclease type III 1.124
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 1.122
SNX5 sorting nexin 5 1.122
NUP50 nucleoporin 50kDa 1.12
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.118
USP18 ubiquitin specific peptidase 18 1.117
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 1.116
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.114
FUZ fuzzy planar cell polarity protein 1.113
SENP6 SUMO1/sentrin specific peptidase 6 1.108
ANPEP alanyl (membrane) aminopeptidase 1.107
TPCN2 two pore segment channel 2 1.105
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.101
CCR2 chemokine (C-C motif) receptor 2 1.1
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 1.1
IRAK1 interleukin-1 receptor-associated kinase 1 1.1
CRY1 cryptochrome circadian clock 1 1.098
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G 1.098
IL22 interleukin 22 1.095
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.094
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 1.094
CXCR3 chemokine (C-X-C motif) receptor 3 1.093
CKM creatine kinase, muscle 1.092
JMJD6 jumonji domain containing 6 1.092
ADA adenosine deaminase 1.091
CBS cystathionine-beta-synthase 1.09
SQSTM1 sequestosome 1 1.086
CD40 CD40 molecule, TNF receptor superfamily member 5 1.086
IRF5 interferon regulatory factor 5 1.083
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 1.082
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.077
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.076
CKMT1B creatine kinase, mitochondrial 1B 1.075
TICAM1 toll-like receptor adaptor molecule 1 1.073
CKB creatine kinase, brain 1.072
CNIH1 cornichon family AMPA receptor auxiliary protein 1 1.072
IFNE interferon, epsilon 1.071
IL16 interleukin 16 1.07
COL20A1 collagen, type XX, alpha 1 1.07
PARS2 prolyl-tRNA synthetase 2, mitochondrial (putative) 1.069
AFF2 AF4/FMR2 family, member 2 1.068
RIOK3 RIO kinase 3 1.065
STING1 stimulator of interferon response cGAMP interactor 1 1.063
MARCO macrophage receptor with collagenous structure 1.062
PHB2 prohibitin 2 1.062
CD200 CD200 molecule 1.061
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 1.059
TP53 tumor protein p53 1.059
MACROD2 MACRO domain containing 2 1.058
CXCR4 chemokine (C-X-C motif) receptor 4 1.058
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 1.05
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.049
PHGDH phosphoglycerate dehydrogenase 1.049
EPS15 epidermal growth factor receptor pathway substrate 15 1.048
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 1.047
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3 1.047
TIMD4 T-cell immunoglobulin and mucin domain containing 4 1.046
NPC2 Niemann-Pick disease, type C2 1.045
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 1.045
PABPC1 poly(A) binding protein, cytoplasmic 1 1.043
VWF von Willebrand factor 1.042
MPO myeloperoxidase 1.04
RPL8 ribosomal protein L8 1.035
PEX19 peroxisomal biogenesis factor 19 1.034
HP haptoglobin 1.034
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 1.034
SCP2 sterol carrier protein 2 1.032
PRTN3 proteinase 3 1.026
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.026
BCL2 B-cell CLL/lymphoma 2 1.023
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 1.023
LVRN laeverin 1.02
RPS6 ribosomal protein S6 1.02
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 1.015
CCR7 chemokine (C-C motif) receptor 7 1.012
ATF6 activating transcription factor 6 1.01
CRY2 cryptochrome circadian clock 2 1.009
ULK1 unc-51 like autophagy activating kinase 1 1.008
MACROD1 MACRO domain containing 1 1.008