Chlorhexidine (diacetate)_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.227661
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.18681
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.179169
AKAP12 A kinase (PRKA) anchor protein 12 0.151156
PODXL podocalyxin-like 0.122608
FLNB filamin B, beta 0.0938718
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0932865
PLAT plasminogen activator, tissue 0.0909017
CD44 CD44 molecule (Indian blood group) 0.0833169
DST dystonin 0.0830071
MYH9 myosin, heavy chain 9, non-muscle 0.0767923
FBN1 fibrillin 1 0.0759576
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0736968
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0729307
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0728591
NAV1 neuron navigator 1 0.0711949
SEPTIN9 septin 9 0.0711014
ATP13A3 ATPase type 13A3 0.0708844
COL5A2 collagen, type V, alpha 2 0.0694184
TRIO trio Rho guanine nucleotide exchange factor 0.0680282
LOXL2 lysyl oxidase-like 2 0.0657246
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0638288
TPM3 tropomyosin 3 0.0634304
GLIS3 GLIS family zinc finger 3 0.0573834
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0544911
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0535868
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0513103
COL3A1 collagen, type III, alpha 1 0.050777
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.048539
CALR calreticulin 0.0478215
PSD3 pleckstrin and Sec7 domain containing 3 0.0468698
SP3 Sp3 transcription factor 0.0439341
SOD2 superoxide dismutase 2, mitochondrial 0.0438121
NDRG1 N-myc downstream regulated 1 0.0434441
LOX lysyl oxidase 0.0417234
WWTR1 WW domain containing transcription regulator 1 0.0407194
VEGFC vascular endothelial growth factor C 0.0403157
AFDN afadin, adherens junction formation factor 0.0397593
NAV2 neuron navigator 2 0.0391738
AUTS2 autism susceptibility candidate 2 0.0387517
ANKRD36 ankyrin repeat domain 36 0.0385389
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.037767
SVIL supervillin 0.0375889
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0368935
ELL2 elongation factor, RNA polymerase II, 2 0.0368482
COL8A1 collagen, type VIII, alpha 1 0.0365065
ZNF148 zinc finger protein 148 0.0358518
YEATS2 YEATS domain containing 2 0.0353663
APP amyloid beta (A4) precursor protein 0.0347752
FNDC3B fibronectin type III domain containing 3B 0.0340304
SRRM2 serine/arginine repetitive matrix 2 0.0333536
RUNX1 runt-related transcription factor 1 0.0333436
NCOR2 nuclear receptor corepressor 2 0.0331999
TNIP1 TNFAIP3 interacting protein 1 0.0331836
PDIA6 protein disulfide isomerase family A, member 6 0.0327387
DPYSL3 dihydropyrimidinase-like 3 0.0325449
C1D C1D nuclear receptor corepressor 0.0323356
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.032301
NFE2L1 nuclear factor, erythroid 2-like 1 0.0320227
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0314407
CEP170 centrosomal protein 170kDa 0.0313886
MSN moesin 0.0308872
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0306055
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0303861
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0299187
BCL2L1 BCL2-like 1 0.0298889
PLEC plectin 0.0298158
ABTB3 ankyrin repeat and BTB domain containing 3 0.0296342
ERRFI1 ERBB receptor feedback inhibitor 1 0.0294445
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0292432
CD59 CD59 molecule, complement regulatory protein 0.0287769
EHBP1 EH domain binding protein 1 0.0287059
ARRDC3 arrestin domain containing 3 0.0285721
SLC22A23 solute carrier family 22, member 23 0.0282002
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.0279445
COL7A1 collagen, type VII, alpha 1 0.0279441
SET SET nuclear proto-oncogene 0.0275056
RAI14 retinoic acid induced 14 0.0272065
GLS2 glutaminase 2 (liver, mitochondrial) 0.0271298
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0265628
DOCK5 dedicator of cytokinesis 5 0.0263367
LPP LIM domain containing preferred translocation partner in lipoma 0.0257928
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0257608
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0256773
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0256351
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0253515
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0252439
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.025211
SBF2 SET binding factor 2 0.0252058
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0248767
FAM219A family with sequence similarity 219, member A 0.0248269
MKI67 marker of proliferation Ki-67 0.024665
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0243359
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0243166
DENND5A DENN/MADD domain containing 5A 0.0242791
ZEB1 zinc finger E-box binding homeobox 1 0.0241529
MTSS1 metastasis suppressor 1 0.0240702
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0239665
ARL15 ADP-ribosylation factor-like 15 0.023822
SFTPA2 surfactant protein A2 0.0237926

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.307416
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.174573
VIM vimentin -0.111347
AHNAK AHNAK nucleoprotein -0.105227
ABI3BP ABI family, member 3 (NESH) binding protein -0.100289
CDH13 cadherin 13 -0.0868305
FN1 fibronectin 1 -0.0822994
S100A10 S100 calcium binding protein A10 -0.0814241
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0666422
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0607469
IGFBP3 insulin-like growth factor binding protein 3 -0.0603352
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0584523
PTMA prothymosin, alpha -0.0580821
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0568751
TPT1 tumor protein, translationally-controlled 1 -0.0560861
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0555081
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0552094
TMSB10 thymosin beta 10 -0.0551159
SQSTM1 sequestosome 1 -0.0526933
SLC39A11 solute carrier family 39, member 11 -0.0486671
CAVIN1 caveolae associated protein 1 -0.0457009
SAMD9 sterile alpha motif domain containing 9 -0.0451808
CANX calnexin -0.0444449
HSPB1 heat shock 27kDa protein 1 -0.040833
IFIH1 interferon induced with helicase C domain 1 -0.0394353
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0383246
FTL ferritin, light polypeptide -0.0382916
CCND1 cyclin D1 -0.0381091
SLC38A1 solute carrier family 38, member 1 -0.0378559
ACTG1 actin gamma 1 -0.0376794
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0372377
RPS24 ribosomal protein S24 -0.0370979
IFITM3 interferon induced transmembrane protein 3 -0.0368573
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0361667
S100A6 S100 calcium binding protein A6 -0.0359283
SP100 SP100 nuclear antigen -0.0353494
RHOBTB3 Rho-related BTB domain containing 3 -0.0343381
RIGI RNA sensor RIG-I -0.0336912
SORBS2 sorbin and SH3 domain containing 2 -0.0333611
PKM pyruvate kinase, muscle -0.0324982
VDAC1 voltage-dependent anion channel 1 -0.0323176
TUBB tubulin, beta class I -0.0310397
LMNA lamin A/C -0.0302764
RRBP1 ribosome binding protein 1 -0.0299756
IARS1 isoleucyl-tRNA synthetase 1 -0.0296669
GNAS GNAS complex locus -0.0292107
INTS6 integrator complex subunit 6 -0.0287548
FNDC3A fibronectin type III domain containing 3A -0.0282897
FSTL1 follistatin-like 1 -0.028252
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.028032
LOC112694756 uncharaterized LOC112694756 -0.0278136
IL7R interleukin 7 receptor -0.0277899
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0276711
RPL28 ribosomal protein L28 -0.0274757
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0265743
UBC ubiquitin C -0.0265414
HDLBP high density lipoprotein binding protein -0.0262201
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0262172
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0258185
CD99 CD99 molecule -0.0257555
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0253799
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0252628
MAP1B microtubule-associated protein 1B -0.0251143
RPS15 ribosomal protein S15 -0.0249832
ARF1 ADP-ribosylation factor 1 -0.0243993
CSTB cystatin B (stefin B) -0.0242082
LRRC17 leucine rich repeat containing 17 -0.0241535
COPB1 coatomer protein complex, subunit beta 1 -0.0240069
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0238855
ANXA2 annexin A2 -0.0233487
RPLP1 ribosomal protein, large, P1 -0.0230872
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.02306
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 -0.0228153
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0227961
STAU1 staufen double-stranded RNA binding protein 1 -0.0227174
WARS1 tryptophanyl-tRNA synthetase 1 -0.0226648
FBXO11 F-box protein 11 -0.0225436
FLT1 fms-related tyrosine kinase 1 -0.0223662
LY6E lymphocyte antigen 6 complex, locus E -0.0222157
RPS5 ribosomal protein S5 -0.0221535
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0219878
HLA-B major histocompatibility complex, class I, B -0.0219179
RPL32 ribosomal protein L32 -0.0217709
SEPTIN2 septin 2 -0.0216092
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0214856
TMEM263 transmembrane protein 263 -0.0212496
MYOF myoferlin -0.0212069
COL1A1 collagen, type I, alpha 1 -0.0209703
RND3 Rho family GTPase 3 -0.0209313
RPS6 ribosomal protein S6 -0.0208398
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0206296
TAGLN2 transgelin 2 -0.0204816
IER3 immediate early response 3 -0.0203835
TPM4 tropomyosin 4 -0.020171
GLG1 golgi glycoprotein 1 -0.0200882
TMSB4X thymosin beta 4, X-linked -0.0200869
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -0.0200671
H3-3B H3.3 histone B -0.0200603
EIF1 eukaryotic translation initiation factor 1 -0.0200264
BTG1 B-cell translocation gene 1, anti-proliferative -0.0200133