Chlorhexidine (diacetate)_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DST dystonin 0.145305
BIRC3 baculoviral IAP repeat containing 3 0.11733
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.111241
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.106278
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.103452
PDE4D phosphodiesterase 4D, cAMP-specific 0.103394
NAP1L1 nucleosome assembly protein 1-like 1 0.0960709
MKI67 marker of proliferation Ki-67 0.0834571
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.073484
RPS12 ribosomal protein S12 0.0734497
SMC4 structural maintenance of chromosomes 4 0.0733065
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0698411
PCDH7 protocadherin 7 0.0675441
YBX3 Y box binding protein 3 0.0620493
CALR calreticulin 0.0619065
ANXA1 annexin A1 0.0612262
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0577331
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0534478
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0523965
LDHA lactate dehydrogenase A 0.0505429
KIF5B kinesin family member 5B 0.0490339
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0485398
CELF2 CUGBP, Elav-like family member 2 0.0479338
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0423925
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0408017
SFPQ splicing factor proline/glutamine-rich 0.0402019
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0397417
ATP11A ATPase, class VI, type 11A 0.0391753
TPR translocated promoter region, nuclear basket protein 0.0390982
EEF2 eukaryotic translation elongation factor 2 0.0390268
TPM3 tropomyosin 3 0.0369327
ENO1 enolase 1, (alpha) 0.0367991
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0362781
XPO1 exportin 1 0.0360523
PDGFC platelet derived growth factor C 0.0350479
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.0348876
MATR3 matrin 3 0.0348027
PDIA6 protein disulfide isomerase family A, member 6 0.0345655
SET SET nuclear proto-oncogene 0.0344249
ECT2 epithelial cell transforming 2 0.0339488
AFDN afadin, adherens junction formation factor 0.0336033
ERBIN erbb2 interacting protein 0.0335443
NLGN1 neuroligin 1 0.0333832
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0318926
CENPF centromere protein F, 350/400kDa 0.031676
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0316055
HSPA8 heat shock 70kDa protein 8 0.0310878
TMEM41B transmembrane protein 41B 0.030945
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0308974
CMIP c-Maf inducing protein 0.0306736
NIPBL Nipped-B homolog (Drosophila) 0.0305779
LMO7 LIM domain 7 0.0299762
RPS3 ribosomal protein S3 0.0293158
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.0292601
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0290189
CEP192 centrosomal protein 192kDa 0.0287915
NCEH1 neutral cholesterol ester hydrolase 1 0.0284371
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0281561
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0279203
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0276281
MORF4L2 mortality factor 4 like 2 0.0275791
HMGB2 high mobility group box 2 0.0271065
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0268315
BIRC2 baculoviral IAP repeat containing 2 0.0267312
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 0.0264469
USP9X ubiquitin specific peptidase 9, X-linked 0.0263744
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0262273
CKAP5 cytoskeleton associated protein 5 0.0259691
TMSB10 thymosin beta 10 0.0258115
NEK7 NIMA-related kinase 7 0.0250092
MYL12B myosin, light chain 12B, regulatory 0.0249459
NDC80 NDC80 kinetochore complex component 0.0248047
RPL23 ribosomal protein L23 0.0246026
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.0244032
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.0242493
PEG10 paternally expressed 10 0.0239524
TMCC1 transmembrane and coiled-coil domain family 1 0.0238137
ANLN anillin, actin binding protein 0.0235104
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.0234178
KLF6 Kruppel-like factor 6 0.0231833
EFNA5 ephrin-A5 0.0230919
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0228118
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0227891
MARCHF6 membrane associated ring-CH-type finger 6 0.0226266
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0222755
KPNB1 karyopherin (importin) beta 1 0.0221793
CCDC47 coiled-coil domain containing 47 0.0221125
RRM2 ribonucleotide reductase M2 0.0220509
PDE4B phosphodiesterase 4B, cAMP-specific 0.0220451
PRRC2C proline-rich coiled-coil 2C 0.0220423
PGK1 phosphoglycerate kinase 1 0.0218902
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0218033
EZR ezrin 0.0217758
SRRM2 serine/arginine repetitive matrix 2 0.0217605
RAD21 RAD21 homolog (S. pombe) 0.0216803
MYH9 myosin, heavy chain 9, non-muscle 0.0216277
RPS7 ribosomal protein S7 0.0216234
CAVIN1 caveolae associated protein 1 0.0215959
ABI2 abl-interactor 2 0.0212459
AXIN2 axin 2 0.0212403

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.486681
AREG amphiregulin -0.130491
ACTG1 actin gamma 1 -0.105367
VIM vimentin -0.0956747
MMP12 matrix metallopeptidase 12 -0.0870209
ATP5F1B ATP synthase F1 subunit beta -0.0862532
POTEF POTE ankyrin domain family, member F -0.0793812
TUBA1B tubulin, alpha 1b -0.0615597
RPS6 ribosomal protein S6 -0.0603218
RAB7A RAB7A, member RAS oncogene family -0.0567263
HMGA2 high mobility group AT-hook 2 -0.0532648
EGR1 early growth response 1 -0.0532212
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0521968
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0504012
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0501689
RPS23 ribosomal protein S23 -0.0489848
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0477372
BCHE butyrylcholinesterase -0.046885
HSPB1 heat shock 27kDa protein 1 -0.0445609
HMGA1 high mobility group AT-hook 1 -0.0436108
PTMA prothymosin, alpha -0.0416729
GARS1 glycyl-tRNA synthetase 1 -0.041368
RPLP2 ribosomal protein, large, P2 -0.039301
RPS15 ribosomal protein S15 -0.0380221
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0374958
UBC ubiquitin C -0.0368027
ANKRD12 ankyrin repeat domain 12 -0.0352654
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0337654
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0331256
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0326583
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.032176
JMJD1C jumonji domain containing 1C -0.0314537
VMP1 vacuole membrane protein 1 -0.0305166
SETD5 SET domain containing 5 -0.0303839
RPS29 ribosomal protein S29 -0.0303134
ZNF804A zinc finger protein 804A -0.0296502
VDAC1 voltage-dependent anion channel 1 -0.0293153
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0291901
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0287991
EHBP1 EH domain binding protein 1 -0.0286371
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0286304
SESN2 sestrin 2 -0.0285791
RPL19 ribosomal protein L19 -0.0281225
LDHB lactate dehydrogenase B -0.0275379
TAS2R14 taste receptor, type 2, member 14 -0.027409
RPS5 ribosomal protein S5 -0.0259872
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0256727
RPS16 ribosomal protein S16 -0.0253705
RPS21 ribosomal protein S21 -0.0249198
S100A10 S100 calcium binding protein A10 -0.0248884
RPS10 ribosomal protein S10 -0.0245057
RPS24 ribosomal protein S24 -0.0237827
MAP1B microtubule-associated protein 1B -0.0237192
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0236331
RAB10 RAB10, member RAS oncogene family -0.0233836
NABP1 nucleic acid binding protein 1 -0.0233419
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0229928
IARS1 isoleucyl-tRNA synthetase 1 -0.0225243
H3-3B H3.3 histone B -0.0224961
GCG glucagon -0.0224579
RPS13 ribosomal protein S13 -0.0220961
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0218943
RBM3 RNA binding motif (RNP1, RRM) protein 3 -0.0218554
BABAM2 BRISC and BRCA1 A complex member 2 -0.0217967
RPL8 ribosomal protein L8 -0.021784
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.0212341
ANKRD17 ankyrin repeat domain 17 -0.0211436
WASF2 WAS protein family, member 2 -0.0209743
AKAP12 A kinase (PRKA) anchor protein 12 -0.020599
RPLP0 ribosomal protein, large, P0 -0.0205496
TASOR2 transcription activation suppressor family member 2 -0.0202778
HLA-A major histocompatibility complex, class I, A -0.0199948
CBX3 chromobox homolog 3 -0.0197056
PFN1 profilin 1 -0.0193628
RPS11 ribosomal protein S11 -0.0193475
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0192998
RPL28 ribosomal protein L28 -0.0192563
TUBB tubulin, beta class I -0.0191008
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -0.0190189
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0189436
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0188206
HDGF hepatoma-derived growth factor -0.0186595
UHMK1 U2AF homology motif (UHM) kinase 1 -0.0186363
RSF1 remodeling and spacing factor 1 -0.0185034
ACLY ATP citrate lyase -0.0183114
CPOX coproporphyrinogen oxidase -0.0182879
RPL21 ribosomal protein L21 -0.0182105
CCND1 cyclin D1 -0.0181814
CUX1 cut-like homeobox 1 -0.0181552
SCFD1 sec1 family domain containing 1 -0.017814
BRD4 bromodomain containing 4 -0.0177301
DDIT3 DNA-damage-inducible transcript 3 -0.0177067
BRD2 bromodomain containing 2 -0.0175011
PRH1 proline-rich protein HaeIII subfamily 1 -0.0171145
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) -0.0171025
FNIP1 folliculin interacting protein 1 -0.0169037
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -0.0168109
RPS25 ribosomal protein S25 -0.0165739
KLHL24 kelch-like family member 24 -0.0165606
NAV3 neuron navigator 3 -0.0164503