Chlorhexidine (diacetate)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FRMD4A FERM domain containing 4A 0.15613
MYH9 myosin, heavy chain 9, non-muscle 0.142089
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.139521
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.102574
NDRG1 N-myc downstream regulated 1 0.0750369
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0744796
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0664183
TPM3 tropomyosin 3 0.06342
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0614879
ANKRD11 ankyrin repeat domain 11 0.0588625
CD44 CD44 molecule (Indian blood group) 0.0588556
B2M beta-2-microglobulin 0.0547898
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0517721
PAX8 paired box 8 0.0498941
CALR calreticulin 0.049768
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.049717
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0485253
MSN moesin 0.0464462
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0464136
FAT1 FAT atypical cadherin 1 0.0454147
NRIP1 nuclear receptor interacting protein 1 0.0452519
ATP13A3 ATPase type 13A3 0.0441957
PTK2 protein tyrosine kinase 2 0.0437753
ARRDC3 arrestin domain containing 3 0.0433425
CMIP c-Maf inducing protein 0.0432235
P3H2 prolyl 3-hydroxylase 2 0.042463
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0420778
UBA6 ubiquitin-like modifier activating enzyme 6 0.0418562
SMAD3 SMAD family member 3 0.0418102
GPC6 glypican 6 0.0417283
SET SET nuclear proto-oncogene 0.0416119
FNDC3B fibronectin type III domain containing 3B 0.0410766
RUNX1 runt-related transcription factor 1 0.0408643
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0394483
SEPTIN9 septin 9 0.039055
GLS2 glutaminase 2 (liver, mitochondrial) 0.0385688
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0371981
RND3 Rho family GTPase 3 0.036593
SP3 Sp3 transcription factor 0.0360522
ANKRD33B ankyrin repeat domain 33B 0.0357706
TRIO trio Rho guanine nucleotide exchange factor 0.0357371
PTPRJ protein tyrosine phosphatase, receptor type, J 0.034436
NAV2 neuron navigator 2 0.0342131
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0338139
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0329094
ADAM9 ADAM metallopeptidase domain 9 0.0328284
ETV6 ets variant 6 0.032443
TNRC6A trinucleotide repeat containing 6A 0.0321502
CADM1 cell adhesion molecule 1 0.0320507
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0320278
RPL3 ribosomal protein L3 0.0317268
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 0.0314153
BNC2 basonuclin 2 0.030954
WAC WW domain containing adaptor with coiled-coil 0.0305249
ADAM17 ADAM metallopeptidase domain 17 0.0302953
LOXL2 lysyl oxidase-like 2 0.0301608
NRP2 neuropilin 2 0.0301285
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0300445
RPS12 ribosomal protein S12 0.0297122
PFN1 profilin 1 0.0295993
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0292436
MBNL2 muscleblind-like splicing regulator 2 0.0288628
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0287273
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0286747
SLTM SAFB-like, transcription modulator 0.0285472
LDHA lactate dehydrogenase A 0.0284913
IRS2 insulin receptor substrate 2 0.02836
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.028271
SFPQ splicing factor proline/glutamine-rich 0.0282086
AKAP13 A kinase (PRKA) anchor protein 13 0.0278651
RIC1 RAB6A GEF complex partner 1 0.027805
RTN4 reticulon 4 0.0276724
TGFB2 transforming growth factor, beta 2 0.0276076
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0273562
ZFAND3 zinc finger, AN1-type domain 3 0.0272438
VEGFA vascular endothelial growth factor A 0.0268128
TGFBI transforming growth factor, beta-induced, 68kDa 0.0265952
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0265662
ABTB3 ankyrin repeat and BTB domain containing 3 0.0265374
FMNL2 formin-like 2 0.0263515
USP12 ubiquitin specific peptidase 12 0.0262342
MYO10 myosin X 0.0260487
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0259848
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0259084
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0257956
LPP LIM domain containing preferred translocation partner in lipoma 0.0257213
DENND2B DENN domain containing 2B 0.0256781
PDIA6 protein disulfide isomerase family A, member 6 0.0256187
KDM6A lysine (K)-specific demethylase 6A 0.025331
RPS7 ribosomal protein S7 0.0253157
ZFP36L1 ZFP36 ring finger protein-like 1 0.0251492
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0251412
RPL23 ribosomal protein L23 0.0248283
NCOR2 nuclear receptor corepressor 2 0.0248237
RASA2 RAS p21 protein activator 2 0.024727
SHB Src homology 2 domain containing adaptor protein B 0.0243553
TNS1 tensin 1 0.0240277
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0239294
EFHD2 EF-hand domain family, member D2 0.0235144
RPS2 ribosomal protein S2 0.023502

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.184133
CXCL8 chemokine (C-X-C motif) ligand 8 -0.11213
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0989155
VIM vimentin -0.0938846
RRBP1 ribosome binding protein 1 -0.0860694
FTL ferritin, light polypeptide -0.0771454
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0601547
HSPB1 heat shock 27kDa protein 1 -0.0586141
RPS24 ribosomal protein S24 -0.0558474
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.052525
CAVIN1 caveolae associated protein 1 -0.0508629
HDLBP high density lipoprotein binding protein -0.0501771
IGFBP3 insulin-like growth factor binding protein 3 -0.0497059
PTMA prothymosin, alpha -0.0489874
TPT1 tumor protein, translationally-controlled 1 -0.0479067
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0476645
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0452529
ARF1 ADP-ribosylation factor 1 -0.0442667
TKT transketolase -0.0432487
CP ceruloplasmin (ferroxidase) -0.0428178
SDCBP syndecan binding protein (syntenin) -0.0421294
RPS6 ribosomal protein S6 -0.0419429
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0417365
IARS1 isoleucyl-tRNA synthetase 1 -0.0401597
TMEM263 transmembrane protein 263 -0.039301
LMAN1 lectin, mannose-binding, 1 -0.0381739
VCL vinculin -0.0377626
GARS1 glycyl-tRNA synthetase 1 -0.0375078
CANX calnexin -0.0365946
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0363141
PKM pyruvate kinase, muscle -0.0358474
RIGI RNA sensor RIG-I -0.0358413
SP100 SP100 nuclear antigen -0.0357376
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0356611
UBC ubiquitin C -0.035515
AHNAK AHNAK nucleoprotein -0.0338765
MAP1B microtubule-associated protein 1B -0.0336575
ALCAM activated leukocyte cell adhesion molecule -0.0333446
MTDH metadherin -0.0329256
COPB1 coatomer protein complex, subunit beta 1 -0.0324175
ACTG1 actin gamma 1 -0.0321084
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0315913
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0312553
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.030959
NOLC1 nucleolar and coiled-body phosphoprotein 1 -0.0306176
SQSTM1 sequestosome 1 -0.0302681
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0301935
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0301305
TUBB tubulin, beta class I -0.0300443
RAD21 RAD21 homolog (S. pombe) -0.0298554
FUS FUS RNA binding protein -0.0297413
IFIH1 interferon induced with helicase C domain 1 -0.0297405
GCC2 GRIP and coiled-coil domain containing 2 -0.0296258
SRP72 signal recognition particle 72kDa -0.0295849
HMGB1 high mobility group box 1 -0.0295817
RPS5 ribosomal protein S5 -0.0289415
UGDH UDP-glucose 6-dehydrogenase -0.0283989
CA12 carbonic anhydrase XII -0.0283517
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0280269
EIF1 eukaryotic translation initiation factor 1 -0.02792
CALD1 caldesmon 1 -0.0275375
RPLP1 ribosomal protein, large, P1 -0.0274976
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0273463
VDAC1 voltage-dependent anion channel 1 -0.0273457
IFI16 interferon, gamma-inducible protein 16 -0.0272706
LOC112694756 uncharaterized LOC112694756 -0.0271615
ANXA2 annexin A2 -0.0269923
GNAS GNAS complex locus -0.0269813
GDF15 growth differentiation factor 15 -0.0267335
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0265062
PALLD palladin, cytoskeletal associated protein -0.0264415
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.026391
CEP350 centrosomal protein 350kDa -0.0262582
ZBTB20 zinc finger and BTB domain containing 20 -0.0258266
LTN1 listerin E3 ubiquitin protein ligase 1 -0.0257844
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0256556
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.025002
BZW1 basic leucine zipper and W2 domains 1 -0.0242765
ZC3H11A zinc finger CCCH-type containing 11A -0.0241538
CENPF centromere protein F, 350/400kDa -0.0241503
ZC3H15 zinc finger CCCH-type containing 15 -0.0241378
BTG1 B-cell translocation gene 1, anti-proliferative -0.0241334
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0240528
RPLP0 ribosomal protein, large, P0 -0.0237624
GOLGB1 golgin B1 -0.0234333
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0232167
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0227873
CCT8 chaperonin containing TCP1, subunit 8 (theta) -0.0227258
RAB1A RAB1A, member RAS oncogene family -0.0226398
RPS4X ribosomal protein S4, X-linked -0.022612
FTH1 ferritin, heavy polypeptide 1 -0.0225521
SEC24D SEC24 family member D -0.0224502
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0223663
RPL28 ribosomal protein L28 -0.0222439
XAF1 XIAP associated factor 1 -0.0220257
PDE4D phosphodiesterase 4D, cAMP-specific -0.0219414
GOLGA3 golgin A3 -0.0217976
THOC2 THO complex 2 -0.0217054
RSL1D1 ribosomal L1 domain containing 1 -0.0216329
H3-3B H3.3 histone B -0.0214013