Chlorhexidine (diacetate)_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SMAD3 SMAD family member 3 0.174746
ARHGAP26 Rho GTPase activating protein 26 0.169074
SPTBN1 spectrin, beta, non-erythrocytic 1 0.106053
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0901736
PDE10A phosphodiesterase 10A 0.0790933
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0761787
DGKD diacylglycerol kinase, delta 130kDa 0.0720962
TRIO trio Rho guanine nucleotide exchange factor 0.0712649
FAM107B family with sequence similarity 107, member B 0.0710031
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0688738
RASA2 RAS p21 protein activator 2 0.0687614
NAMPT nicotinamide phosphoribosyltransferase 0.0623695
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0620442
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0609343
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0605582
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0589248
CMIP c-Maf inducing protein 0.0588179
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0556221
NAV2 neuron navigator 2 0.0553074
FNDC3B fibronectin type III domain containing 3B 0.0548164
RTN4 reticulon 4 0.0542131
NRIP1 nuclear receptor interacting protein 1 0.052309
TXNRD1 thioredoxin reductase 1 0.0515107
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0504549
ASPH aspartate beta-hydroxylase 0.0488965
MYH9 myosin, heavy chain 9, non-muscle 0.0481977
KIRREL3 kin of IRRE like 3 (Drosophila) 0.0473323
TM4SF1 transmembrane 4 L six family member 1 0.0442074
BCL2L1 BCL2-like 1 0.0436842
RPL23 ribosomal protein L23 0.0432648
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0429047
TNIP1 TNFAIP3 interacting protein 1 0.0422382
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0394931
AGFG1 ArfGAP with FG repeats 1 0.0391875
RPL37A ribosomal protein L37a 0.0357132
ITGB5 integrin, beta 5 0.0353919
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.03516
CEMIP cell migration inducing protein, hyaluronan binding 0.0338587
OSMR oncostatin M receptor 0.0332265
SAMD4A sterile alpha motif domain containing 4A 0.0332064
FLNB filamin B, beta 0.0326349
SMYD3 SET and MYND domain containing 3 0.0320021
ZFAND6 zinc finger, AN1-type domain 6 0.0318897
ANKRD28 ankyrin repeat domain 28 0.0318472
AOPEP aminopeptidase O (putative) 0.0315634
SHB Src homology 2 domain containing adaptor protein B 0.0311802
DSCAM Down syndrome cell adhesion molecule 0.0310846
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.031003
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0309296
RPS19 ribosomal protein S19 0.0307754
PDE8A phosphodiesterase 8A 0.0303787
RPL26 ribosomal protein L26 0.0303494
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0294821
TGM2 transglutaminase 2 0.0289707
RPL13A ribosomal protein L13a 0.0288979
APP amyloid beta (A4) precursor protein 0.0287983
ANKRD33B ankyrin repeat domain 33B 0.0287519
GPRIN3 GPRIN family member 3 0.0281748
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0281037
VEZT vezatin, adherens junctions transmembrane protein 0.0277667
RPS12 ribosomal protein S12 0.0277494
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0272148
CA8 carbonic anhydrase VIII 0.0270517
ANKRD11 ankyrin repeat domain 11 0.026821
SBF2 SET binding factor 2 0.0266494
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0265732
GRAMD1B GRAM domain containing 1B 0.0264267
WWC1 WW and C2 domain containing 1 0.0263492
MKI67 marker of proliferation Ki-67 0.0262644
NAP1L1 nucleosome assembly protein 1-like 1 0.0260497
THSD4 thrombospondin, type I, domain containing 4 0.0259028
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0258945
CD59 CD59 molecule, complement regulatory protein 0.0253999
MT2A metallothionein 2A 0.0252169
KDM7A lysine (K)-specific demethylase 7A 0.0250492
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0246231
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0244829
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.024277
BMAL2 basic helix-loop-helix ARNT like 2 0.024133
NUP58 nucleoporin 58 0.0239517
YEATS2 YEATS domain containing 2 0.023927
JAK1 Janus kinase 1 0.0237696
PRKCE protein kinase C, epsilon 0.0236291
ANGPTL4 angiopoietin-like 4 0.0236129
RPS3 ribosomal protein S3 0.0230838
NCKAP1 NCK-associated protein 1 0.0229416
PRELID2 PRELI domain containing 2 0.0228231
USP9X ubiquitin specific peptidase 9, X-linked 0.0227735
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0226423
FLNA filamin A, alpha 0.0222783
FMNL2 formin-like 2 0.0222305
DST dystonin 0.0222096
RPS7 ribosomal protein S7 0.0221518
KLF6 Kruppel-like factor 6 0.0219641
OGA O-GlcNAcase 0.0219154
TGFBI transforming growth factor, beta-induced, 68kDa 0.0218602
KIFC3 kinesin family member C3 0.0216836
WWOX WW domain containing oxidoreductase 0.0216699
FOXP1 forkhead box P1 0.0216316
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0215638

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.164332
NDRG1 N-myc downstream regulated 1 -0.134182
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0922088
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0901867
PDE4D phosphodiesterase 4D, cAMP-specific -0.0842321
AKAP12 A kinase (PRKA) anchor protein 12 -0.0749953
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0736135
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0649777
FTH1 ferritin, heavy polypeptide 1 -0.0638814
VCL vinculin -0.0611488
ALCAM activated leukocyte cell adhesion molecule -0.0596703
EFNA5 ephrin-A5 -0.058074
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0563598
FTL ferritin, light polypeptide -0.0549599
PKM pyruvate kinase, muscle -0.0532842
INTS6 integrator complex subunit 6 -0.0470407
PRKCA protein kinase C, alpha -0.0457616
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0456485
VIM vimentin -0.0447316
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0445437
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0443687
EGFR epidermal growth factor receptor -0.0431461
ACTG1 actin gamma 1 -0.0426827
STC1 stanniocalcin 1 -0.0426145
BTG1 B-cell translocation gene 1, anti-proliferative -0.0425192
HMGA2 high mobility group AT-hook 2 -0.0419202
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.041678
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0405359
EGR1 early growth response 1 -0.0401307
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0399059
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0398717
FBXO11 F-box protein 11 -0.0398172
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0393361
CANX calnexin -0.0390668
GOLGB1 golgin B1 -0.0387909
AUTS2 autism susceptibility candidate 2 -0.0382868
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0380006
HDLBP high density lipoprotein binding protein -0.0359592
AADAC arylacetamide deacetylase -0.0356151
SP100 SP100 nuclear antigen -0.0352732
WASF2 WAS protein family, member 2 -0.0348748
PDLIM5 PDZ and LIM domain 5 -0.0347946
CA12 carbonic anhydrase XII -0.0339656
EIF1 eukaryotic translation initiation factor 1 -0.0338103
SQSTM1 sequestosome 1 -0.0333018
MORF4L2 mortality factor 4 like 2 -0.0331586
SEC31A SEC31 homolog A (S. cerevisiae) -0.0314991
COPA coatomer protein complex, subunit alpha -0.0311487
DUSP16 dual specificity phosphatase 16 -0.0308362
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0300512
IARS1 isoleucyl-tRNA synthetase 1 -0.0300449
RRBP1 ribosome binding protein 1 -0.0300126
PALLD palladin, cytoskeletal associated protein -0.0299667
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0298164
ACBD3 acyl-CoA binding domain containing 3 -0.0297943
GOLGA4 golgin A4 -0.029274
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 -0.0287722
DOCK5 dedicator of cytokinesis 5 -0.028716
MYADM myeloid-associated differentiation marker -0.0281483
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0276198
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.026991
BZW1 basic leucine zipper and W2 domains 1 -0.0267203
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0265446
IGFBP4 insulin-like growth factor binding protein 4 -0.0265164
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0261821
RHCG Rh family, C glycoprotein -0.0252404
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0251414
TCIM transcriptional and immune response regulator -0.0251392
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0249979
COPB1 coatomer protein complex, subunit beta 1 -0.0249052
RAB1A RAB1A, member RAS oncogene family -0.024368
EHBP1 EH domain binding protein 1 -0.0241557
TMEM263 transmembrane protein 263 -0.023755
SRP54 signal recognition particle 54kDa -0.0236003
ZBTB20 zinc finger and BTB domain containing 20 -0.0235503
FNIP1 folliculin interacting protein 1 -0.0235368
CUX1 cut-like homeobox 1 -0.0235156
LMAN1 lectin, mannose-binding, 1 -0.0230273
RPS6 ribosomal protein S6 -0.0227714
H1-0 H1.0 linker histone -0.0223102
PTMA prothymosin, alpha -0.0222945
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0221846
USP34 ubiquitin specific peptidase 34 -0.022139
KRT81 keratin 81, type II -0.0218199
RND3 Rho family GTPase 3 -0.0215112
PNRC1 proline-rich nuclear receptor coactivator 1 -0.021285
RPS24 ribosomal protein S24 -0.0210574
KDM3A lysine (K)-specific demethylase 3A -0.0207322
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0206347
FRMD6 FERM domain containing 6 -0.0206342
RAB7A RAB7A, member RAS oncogene family -0.0206332
SPDYA speedy/RINGO cell cycle regulator family member A -0.0205951
S100A10 S100 calcium binding protein A10 -0.0204457
FAM13A family with sequence similarity 13, member A -0.0204083
TKT transketolase -0.0203595
SOD2 superoxide dismutase 2, mitochondrial -0.0202214
ARF4 ADP-ribosylation factor 4 -0.0202037
HILPDA hypoxia inducible lipid droplet-associated -0.0199586
JUN jun proto-oncogene -0.0198521
VDAC1 voltage-dependent anion channel 1 -0.0198199