Chlorhexidine (diacetate)_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MEST mesoderm specific transcript 0.206827
GSE1 Gse1 coiled-coil protein 0.110642
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.102953
NFIB nuclear factor I/B 0.087318
TRIO trio Rho guanine nucleotide exchange factor 0.0767753
TSHZ2 teashirt zinc finger homeobox 2 0.0744771
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0728552
MED13L mediator complex subunit 13-like 0.0710171
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0655773
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.0607887
RPL3 ribosomal protein L3 0.0596247
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0582876
PRELID2 PRELI domain containing 2 0.0570068
SAMD4A sterile alpha motif domain containing 4A 0.0555743
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0547446
ZNF292 zinc finger protein 292 0.0531753
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0518601
YEATS2 YEATS domain containing 2 0.0506721
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0502681
HMGA1 high mobility group AT-hook 1 0.0499454
SFPQ splicing factor proline/glutamine-rich 0.0466815
THSD4 thrombospondin, type I, domain containing 4 0.0462399
COL5A2 collagen, type V, alpha 2 0.0457455
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0456899
NUP58 nucleoporin 58 0.0449924
RPL26 ribosomal protein L26 0.0445996
RPS12 ribosomal protein S12 0.0443556
PDE4B phosphodiesterase 4B, cAMP-specific 0.0436365
IGF2 insulin-like growth factor 2 0.0429797
RPS3 ribosomal protein S3 0.0404885
GTF2I general transcription factor IIi 0.0403223
FER fer (fps/fes related) tyrosine kinase 0.0397503
TNIP1 TNFAIP3 interacting protein 1 0.0397466
RPL35A ribosomal protein L35a 0.0396589
YME1L1 YME1-like 1 ATPase 0.0393572
CALR calreticulin 0.0386855
RPL23 ribosomal protein L23 0.0383737
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0375716
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0373244
PNISR PNN-interacting serine/arginine-rich protein 0.0367091
DENND5A DENN/MADD domain containing 5A 0.036584
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0364993
SET SET nuclear proto-oncogene 0.0361521
ENO1 enolase 1, (alpha) 0.0356821
BMPR1A bone morphogenetic protein receptor, type IA 0.0355583
SPIDR scaffolding protein involved in DNA repair 0.0355445
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.0353841
SMAP1 small ArfGAP 1 0.0349496
WDR43 WD repeat domain 43 0.0348129
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.034424
PTK2 protein tyrosine kinase 2 0.0341368
ITCH itchy E3 ubiquitin protein ligase 0.0340868
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0339522
DST dystonin 0.0339391
CNN3 calponin 3, acidic 0.0338202
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0331593
TMEM41B transmembrane protein 41B 0.0330689
SNX9 sorting nexin 9 0.0330661
PPP1R9A protein phosphatase 1, regulatory subunit 9A 0.0328217
EXT1 exostosin glycosyltransferase 1 0.0328144
RNF145 ring finger protein 145 0.0326453
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0325837
GANAB glucosidase, alpha; neutral AB 0.0324583
UBE3A ubiquitin protein ligase E3A 0.032141
MYH9 myosin, heavy chain 9, non-muscle 0.0320576
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0319727
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0315579
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0315301
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.031255
FUBP1 far upstream element (FUSE) binding protein 1 0.0311583
RPL7 ribosomal protein L7 0.0310613
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0308721
EXOC6B exocyst complex component 6B 0.0303919
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0302732
KDM7A lysine (K)-specific demethylase 7A 0.0302264
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0302147
BCLAF1 BCL2-associated transcription factor 1 0.0300534
AKAP12 A kinase (PRKA) anchor protein 12 0.0298577
PPME1 protein phosphatase methylesterase 1 0.0296956
FAM168A family with sequence similarity 168, member A 0.0296712
HIPK2 homeodomain interacting protein kinase 2 0.0295285
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0293346
LPP LIM domain containing preferred translocation partner in lipoma 0.0292284
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0291566
ZFAND6 zinc finger, AN1-type domain 6 0.0291553
TXNRD1 thioredoxin reductase 1 0.0291532
TMEM123 transmembrane protein 123 0.0291193
ZMIZ1 zinc finger, MIZ-type containing 1 0.0290946
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0289868
HOXA3 homeobox A3 0.0289683
SMAD3 SMAD family member 3 0.0289519
RPL5 ribosomal protein L5 0.0288925
ANKRD11 ankyrin repeat domain 11 0.0288138
YAP1 Yes-associated protein 1 0.0287063
ASPH aspartate beta-hydroxylase 0.028593
SMG6 SMG6 nonsense mediated mRNA decay factor 0.0285718
PDPK1 3-phosphoinositide dependent protein kinase 1 0.028386
SOX6 SRY (sex determining region Y)-box 6 0.0283169
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa 0.0278071
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.027359

decreased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0915005
PRKG1 protein kinase, cGMP-dependent, type I -0.0909613
SOX4 SRY (sex determining region Y)-box 4 -0.0848322
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0811791
VIM vimentin -0.0754372
BCOR BCL6 corepressor -0.0716582
TMSB4X thymosin beta 4, X-linked -0.065318
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.062591
CADM2 cell adhesion molecule 2 -0.0623175
CANX calnexin -0.061333
FNIP1 folliculin interacting protein 1 -0.0595892
PDE10A phosphodiesterase 10A -0.0593492
NFIA nuclear factor I/A -0.0586972
RPS24 ribosomal protein S24 -0.0549384
NIPBL Nipped-B homolog (Drosophila) -0.0542113
CENPF centromere protein F, 350/400kDa -0.0517079
TBCA tubulin folding cofactor A -0.0487526
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0483184
HMGA2 high mobility group AT-hook 2 -0.0478739
IER3 immediate early response 3 -0.0477516
SREBF2 sterol regulatory element binding transcription factor 2 -0.0475006
GOLGA4 golgin A4 -0.0463341
NSD3 nuclear receptor binding SET domain protein 3 -0.0462072
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0461079
TET1 tet methylcytosine dioxygenase 1 -0.0439767
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0430886
PHF3 PHD finger protein 3 -0.0429863
QKI QKI, KH domain containing, RNA binding -0.041954
IGF2R insulin-like growth factor 2 receptor -0.0406985
AFF4 AF4/FMR2 family, member 4 -0.0403731
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0391888
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0365407
PTMA prothymosin, alpha -0.0362675
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0362004
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0342862
DEK DEK proto-oncogene -0.0339328
ARID4B AT rich interactive domain 4B (RBP1-like) -0.033684
ARB2A ARB2 cotranscriptional regulator A -0.0334638
KLHDC10 kelch domain containing 10 -0.032942
SMC4 structural maintenance of chromosomes 4 -0.0324134
VDAC1 voltage-dependent anion channel 1 -0.0323214
RAB7A RAB7A, member RAS oncogene family -0.0322859
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0321558
TAOK1 TAO kinase 1 -0.0317612
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0314313
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0310922
KDM5B lysine (K)-specific demethylase 5B -0.0310052
MGP matrix Gla protein -0.0305538
NPR2 natriuretic peptide receptor 2 -0.0301512
PCM1 pericentriolar material 1 -0.0301084
TBC1D5 TBC1 domain family, member 5 -0.0299776
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.0298766
TUBB tubulin, beta class I -0.0294367
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0289449
SHISA3 shisa family member 3 -0.0279646
TASOR2 transcription activation suppressor family member 2 -0.0278562
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -0.027827
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0277508
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0277119
PRLR prolactin receptor -0.0274092
HIP1 huntingtin interacting protein 1 -0.0272848
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0272029
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 -0.027197
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0271951
FBXO11 F-box protein 11 -0.027019
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0269846
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0263896
TOP1 topoisomerase (DNA) I -0.0262627
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0259896
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.025728
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 -0.0256284
TAS2R14 taste receptor, type 2, member 14 -0.0255907
PLS3 plastin 3 -0.0255328
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0255103
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0254589
FRMD6 FERM domain containing 6 -0.0253553
UST uronyl-2-sulfotransferase -0.0252628
TULP4 tubby like protein 4 -0.0250775
RPLP1 ribosomal protein, large, P1 -0.0249847
PKM pyruvate kinase, muscle -0.0249524
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0246632
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0243802
ACACA acetyl-CoA carboxylase alpha -0.0242751
IARS1 isoleucyl-tRNA synthetase 1 -0.024242
FOXC1 forkhead box C1 -0.0240794
HOXC10 homeobox C10 -0.0240093
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0237979
TDRD3 tudor domain containing 3 -0.0236395
RPL14 ribosomal protein L14 -0.0235574
CLASP2 cytoplasmic linker associated protein 2 -0.0234678
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0233888
MYOF myoferlin -0.0233433
RPS6 ribosomal protein S6 -0.0233423
NAA60 N(alpha)-acetyltransferase 60, NatF catalytic subunit -0.0232041
HDAC8 histone deacetylase 8 -0.0231517
POM121C POM121 transmembrane nucleoporin C -0.0231321
GPHN gephyrin -0.0230512
ZFHX3 zinc finger homeobox 3 -0.0229827
NUSAP1 nucleolar and spindle associated protein 1 -0.0229772
RFX2 regulatory factor X, 2 (influences HLA class II expression) -0.022928