Chlorhexidine (diacetate)_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LAMB3 laminin, beta 3 0.191588
LMTK2 lemur tyrosine kinase 2 0.140881
TXNRD1 thioredoxin reductase 1 0.125368
AKAP12 A kinase (PRKA) anchor protein 12 0.124615
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.124351
SMAD3 SMAD family member 3 0.0927752
PSD3 pleckstrin and Sec7 domain containing 3 0.0873461
CAB39 calcium binding protein 39 0.085248
EFNA5 ephrin-A5 0.0772473
DOCK5 dedicator of cytokinesis 5 0.0757123
GLS2 glutaminase 2 (liver, mitochondrial) 0.0672307
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0646759
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0606277
CD59 CD59 molecule, complement regulatory protein 0.060435
EGFR epidermal growth factor receptor 0.0569465
TSC22D2 TSC22 domain family, member 2 0.0567102
PLEC plectin 0.0536845
AKAP13 A kinase (PRKA) anchor protein 13 0.0532611
DST dystonin 0.0525296
PTK2 protein tyrosine kinase 2 0.049487
RPS12 ribosomal protein S12 0.0482852
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0468031
PLAUR plasminogen activator, urokinase receptor 0.0458005
FGD4 FYVE, RhoGEF and PH domain containing 4 0.045578
EPS8 epidermal growth factor receptor pathway substrate 8 0.0432579
NEK7 NIMA-related kinase 7 0.0427955
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0415357
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0394076
SLTM SAFB-like, transcription modulator 0.0392372
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0389832
FOXO3 forkhead box O3 0.0389561
PTPRR protein tyrosine phosphatase, receptor type, R 0.0383158
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0382344
ANXA11 annexin A11 0.0382024
MYH9 myosin, heavy chain 9, non-muscle 0.0381231
RTN4 reticulon 4 0.0378959
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.037847
FLNB filamin B, beta 0.037307
TRRAP transformation/transcription domain-associated protein 0.0364947
MPRIP myosin phosphatase Rho interacting protein 0.0362934
PUM2 pumilio RNA-binding family member 2 0.0362595
CORO1C coronin, actin binding protein, 1C 0.0352961
HMGA1 high mobility group AT-hook 1 0.0349331
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0344153
RPL37A ribosomal protein L37a 0.0341474
BCAR3 breast cancer anti-estrogen resistance 3 0.0340813
WWC1 WW and C2 domain containing 1 0.0338318
B2M beta-2-microglobulin 0.0335894
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0334363
ANKRD10 ankyrin repeat domain 10 0.0333719
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.033037
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 0.0329868
ARHGAP42 Rho GTPase activating protein 42 0.0321607
NCOR2 nuclear receptor corepressor 2 0.032147
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0317427
LAMA4 laminin, alpha 4 0.0316183
PRSS3 protease, serine, 3 0.031482
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0309384
RPS2 ribosomal protein S2 0.0308491
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.030085
EPHA2 EPH receptor A2 0.0299569
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0298702
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0298135
ARHGAP26 Rho GTPase activating protein 26 0.0295287
USP12 ubiquitin specific peptidase 12 0.0294916
LPP LIM domain containing preferred translocation partner in lipoma 0.0289656
YTHDC1 YTH domain containing 1 0.0289321
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.02889
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0288193
ERBIN erbb2 interacting protein 0.0284717
FOXO1 forkhead box O1 0.0281524
CTNND1 catenin (cadherin-associated protein), delta 1 0.0280763
GREB1L growth regulation by estrogen in breast cancer-like 0.0277829
PROSER2 proline and serine rich 2 0.0271948
RPL23 ribosomal protein L23 0.0270319
ZEB1 zinc finger E-box binding homeobox 1 0.0269838
ITCH itchy E3 ubiquitin protein ligase 0.0269363
SEPTIN9 septin 9 0.0265257
LAMC2 laminin, gamma 2 0.0265205
HAPSTR1 HUWE1 associated protein modifying stress responses 0.0265093
OSBP2 oxysterol binding protein 2 0.0261078
HIBADH 3-hydroxyisobutyrate dehydrogenase 0.0259748
ZNF292 zinc finger protein 292 0.0257451
AFDN afadin, adherens junction formation factor 0.0256716
NCKAP1 NCK-associated protein 1 0.0256444
PCBP2 poly(rC) binding protein 2 0.0254042
PARD3 par-3 family cell polarity regulator 0.0252278
NPAS2 neuronal PAS domain protein 2 0.0250654
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0250524
SIK3 SIK family kinase 3 0.0248272
AHNAK2 AHNAK nucleoprotein 2 0.0247583
APOL2 apolipoprotein L, 2 0.0246776
RPL26 ribosomal protein L26 0.0246729
EEF2 eukaryotic translation elongation factor 2 0.024473
KMT2E lysine (K)-specific methyltransferase 2E 0.02446
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0244056
EXT1 exostosin glycosyltransferase 1 0.0241967
RPS8 ribosomal protein S8 0.0239719
AMBRA1 autophagy/beclin-1 regulator 1 0.0237834
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0235518

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.189192
PTMA prothymosin, alpha -0.153171
S100A10 S100 calcium binding protein A10 -0.142029
POTEF POTE ankyrin domain family, member F -0.11097
VIM vimentin -0.110046
NDRG1 N-myc downstream regulated 1 -0.0940604
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0937602
IGFBP3 insulin-like growth factor binding protein 3 -0.0917129
TXNIP thioredoxin interacting protein -0.0698782
AHNAK AHNAK nucleoprotein -0.0695035
SLC38A2 solute carrier family 38, member 2 -0.0685453
DSG2 desmoglein 2 -0.0677127
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0662269
TMSB10 thymosin beta 10 -0.0640777
FTH1 ferritin, heavy polypeptide 1 -0.0632233
EGR1 early growth response 1 -0.0571607
BZW1 basic leucine zipper and W2 domains 1 -0.0541349
ANXA2 annexin A2 -0.0526317
S100A11 S100 calcium binding protein A11 -0.0521523
PERP PERP, TP53 apoptosis effector -0.0508671
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0504395
UBC ubiquitin C -0.0494144
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0493726
F3 coagulation factor III (thromboplastin, tissue factor) -0.048871
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0486394
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0483926
FAM107B family with sequence similarity 107, member B -0.0480046
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0469357
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.0461461
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0460965
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0441584
S100A6 S100 calcium binding protein A6 -0.0439221
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0433304
PKM pyruvate kinase, muscle -0.0432518
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0430775
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0428221
RIOK3 RIO kinase 3 -0.0426286
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0423679
LDHA lactate dehydrogenase A -0.0423601
SP100 SP100 nuclear antigen -0.0422965
SDC4 syndecan 4 -0.0417158
HMGA2 high mobility group AT-hook 2 -0.0411239
RRBP1 ribosome binding protein 1 -0.0409966
S100A4 S100 calcium binding protein A4 -0.0400618
HDLBP high density lipoprotein binding protein -0.0381523
COPB1 coatomer protein complex, subunit beta 1 -0.0376056
VDAC1 voltage-dependent anion channel 1 -0.0373894
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0372824
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0370917
ESYT2 extended synaptotagmin-like protein 2 -0.0365305
LY6E lymphocyte antigen 6 complex, locus E -0.0365148
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0360464
PGK1 phosphoglycerate kinase 1 -0.0353874
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.0350206
FAM3C family with sequence similarity 3, member C -0.0346556
SEC24A SEC24 family member A -0.0344581
LMO7 LIM domain 7 -0.0340502
FOS FBJ murine osteosarcoma viral oncogene homolog -0.033757
LOC112694756 uncharaterized LOC112694756 -0.0335014
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0333955
ACBD3 acyl-CoA binding domain containing 3 -0.0332822
GRB10 growth factor receptor-bound protein 10 -0.0332491
ENO1 enolase 1, (alpha) -0.0327457
SPDYA speedy/RINGO cell cycle regulator family member A -0.0326259
TMEM263 transmembrane protein 263 -0.0318881
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0314599
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0311835
ARF4 ADP-ribosylation factor 4 -0.0310025
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0305902
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0304075
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.0303436
RPS23 ribosomal protein S23 -0.0302464
CSTB cystatin B (stefin B) -0.0302272
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0300994
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0296955
BMP6 bone morphogenetic protein 6 -0.0296311
MMP1 matrix metallopeptidase 1 -0.0296205
IER3 immediate early response 3 -0.029519
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0287924
COPA coatomer protein complex, subunit alpha -0.0287842
MORF4L2 mortality factor 4 like 2 -0.0287269
DLG1 discs, large homolog 1 (Drosophila) -0.0278964
WASF2 WAS protein family, member 2 -0.0278497
SMNDC1 survival motor neuron domain containing 1 -0.0276958
PAIP2 poly(A) binding protein interacting protein 2 -0.0276906
TUBA1B tubulin, alpha 1b -0.0272997
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0269592
KRT19 keratin 19, type I -0.0266411
FOXN2 forkhead box N2 -0.0263445
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0263137
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0262374
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0260788
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -0.0259919
MT2A metallothionein 2A -0.0259449
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0256096
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0254286
SEC31A SEC31 homolog A (S. cerevisiae) -0.0254021
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0253629
GARS1 glycyl-tRNA synthetase 1 -0.0249652
HDAC9 histone deacetylase 9 -0.0248375