Chlorhexidine (diacetate)_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERBB2 erb-b2 receptor tyrosine kinase 2 0.155304
ANKRD36C ankyrin repeat domain 36C 0.114178
TRPS1 trichorhinophalangeal syndrome I 0.101081
THSD4 thrombospondin, type I, domain containing 4 0.0932746
RPL23 ribosomal protein L23 0.0849439
SET SET nuclear proto-oncogene 0.0696781
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0665895
LPP LIM domain containing preferred translocation partner in lipoma 0.0611799
NTN4 netrin 4 0.0607693
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.05904
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0558676
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0552837
RIMS2 regulating synaptic membrane exocytosis 2 0.0522742
IFI6 interferon, alpha-inducible protein 6 0.0520943
TRAPPC9 trafficking protein particle complex 9 0.0519122
EXT1 exostosin glycosyltransferase 1 0.0517039
CTNND1 catenin (cadherin-associated protein), delta 1 0.0500002
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0487765
EFNA5 ephrin-A5 0.0483378
TRIO trio Rho guanine nucleotide exchange factor 0.0461143
ELOVL5 ELOVL fatty acid elongase 5 0.0455035
TC2N tandem C2 domains, nuclear 0.0454159
DTNA dystrobrevin, alpha 0.0442859
CATSPERB catsper channel auxiliary subunit beta 0.0440991
MYH9 myosin, heavy chain 9, non-muscle 0.0439689
CEP250 centrosomal protein 250kDa 0.0426377
PBX1 pre-B-cell leukemia homeobox 1 0.0420454
SRCIN1 SRC kinase signaling inhibitor 1 0.0410554
MLPH melanophilin 0.040973
MYO5B myosin VB 0.0404881
MSI2 musashi RNA-binding protein 2 0.0401366
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0400572
RPS12 ribosomal protein S12 0.0393572
KAZN kazrin, periplakin interacting protein 0.0392898
SAMD12 sterile alpha motif domain containing 12 0.0384322
CREB5 cAMP responsive element binding protein 5 0.0369522
GSE1 Gse1 coiled-coil protein 0.036554
TENM2 teneurin transmembrane protein 2 0.0360671
RPS3 ribosomal protein S3 0.0358299
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0354268
SMYD3 SET and MYND domain containing 3 0.0353567
MED13L mediator complex subunit 13-like 0.0352495
DOCK5 dedicator of cytokinesis 5 0.0352004
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0348022
IGFBP5 insulin-like growth factor binding protein 5 0.0346401
BCAS1 breast carcinoma amplified sequence 1 0.0344778
RPL37A ribosomal protein L37a 0.0344664
TPM3 tropomyosin 3 0.0340664
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0339017
OSMR oncostatin M receptor 0.0338353
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0337045
NRP1 neuropilin 1 0.0336724
SHROOM3 shroom family member 3 0.0333379
ZFAND3 zinc finger, AN1-type domain 3 0.0331807
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0327118
RPL26 ribosomal protein L26 0.0323395
MYO1B myosin IB 0.0322543
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.0319753
PATJ PATJ crumbs cell polarity complex component 0.0314771
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 0.0300663
IL1RAPL2 interleukin 1 receptor accessory protein-like 2 0.0300031
RPL30 ribosomal protein L30 0.0299696
LGALS12 lectin, galactoside-binding, soluble, 12 0.029492
KLF6 Kruppel-like factor 6 0.0292934
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.0286357
ALCAM activated leukocyte cell adhesion molecule 0.0280508
STS steroid sulfatase (microsomal), isozyme S 0.0279055
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0277747
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.0274748
SFPQ splicing factor proline/glutamine-rich 0.0274638
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0271863
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0269549
SAMD4A sterile alpha motif domain containing 4A 0.0264345
MACF1 microtubule-actin crosslinking factor 1 0.0262717
RPL12 ribosomal protein L12 0.0259669
TMEM45B transmembrane protein 45B 0.0259669
NRIP1 nuclear receptor interacting protein 1 0.0258012
SGMS1 sphingomyelin synthase 1 0.0255648
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0252583
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0252359
CEMIP cell migration inducing protein, hyaluronan binding 0.0245308
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0243071
RAI14 retinoic acid induced 14 0.0242882
LASP1 LIM and SH3 protein 1 0.0242292
AFF3 AF4/FMR2 family, member 3 0.0242113
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 0.0241086
TXNRD1 thioredoxin reductase 1 0.0238134
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.023534
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0233786
PTPRK protein tyrosine phosphatase, receptor type, K 0.0233572
ETV6 ets variant 6 0.0232223
RPL7 ribosomal protein L7 0.0232053
AHR aryl hydrocarbon receptor 0.0230128
KRT18 keratin 18, type I 0.0229754
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 0.0228139
TTC6 tetratricopeptide repeat domain 6 0.0227009
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0224622
PAWR PRKC, apoptosis, WT1, regulator 0.0220697
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 0.0219931
TCF12 transcription factor 12 0.0218563

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.215946
FTH1 ferritin, heavy polypeptide 1 -0.152641
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.107612
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0855502
ACTG1 actin gamma 1 -0.0800203
POTEF POTE ankyrin domain family, member F -0.0738174
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0726281
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0688269
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0685485
RPL19 ribosomal protein L19 -0.0674707
TMEM123 transmembrane protein 123 -0.0643752
CLTC clathrin, heavy chain (Hc) -0.0637425
RAB7A RAB7A, member RAS oncogene family -0.0584805
CCNI cyclin I -0.0576767
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0526671
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.052527
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0515758
PRR11 proline rich 11 -0.0501502
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0487622
PKM pyruvate kinase, muscle -0.0485144
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0479427
INTS6 integrator complex subunit 6 -0.0468413
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0467363
MT2A metallothionein 2A -0.0448298
WASF2 WAS protein family, member 2 -0.0446959
PCBP2 poly(rC) binding protein 2 -0.0444926
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0443217
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0442004
FBXL20 F-box and leucine-rich repeat protein 20 -0.043538
SMC4 structural maintenance of chromosomes 4 -0.04325
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0423418
ZC3H11A zinc finger CCCH-type containing 11A -0.040052
TUBA1B tubulin, alpha 1b -0.0394698
KDM2A lysine (K)-specific demethylase 2A -0.0393305
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0384996
UBC ubiquitin C -0.0384787
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0382679
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0378053
TMEM165 transmembrane protein 165 -0.0376197
LOC112694756 uncharaterized LOC112694756 -0.0376163
NCOA3 nuclear receptor coactivator 3 -0.0374522
SETD5 SET domain containing 5 -0.0357957
SETX senataxin -0.0354116
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 -0.0351792
RAB22A RAB22A, member RAS oncogene family -0.0351741
PDIA3 protein disulfide isomerase family A, member 3 -0.0345388
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0343699
KDM5B lysine (K)-specific demethylase 5B -0.0342274
ANKRD12 ankyrin repeat domain 12 -0.0340642
PERP PERP, TP53 apoptosis effector -0.0339514
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0338918
RPS6 ribosomal protein S6 -0.0337078
FADS2 fatty acid desaturase 2 -0.0331418
DYNLRB1 dynein, light chain, roadblock-type 1 -0.0326896
CBX3 chromobox homolog 3 -0.0322616
RTN3 reticulon 3 -0.032166
VEGFA vascular endothelial growth factor A -0.0318814
WDR45B WD repeat domain 45B -0.0318192
HILPDA hypoxia inducible lipid droplet-associated -0.030868
TOB1 transducer of ERBB2, 1 -0.030771
WSB1 WD repeat and SOCS box containing 1 -0.0307045
RPLP0 ribosomal protein, large, P0 -0.0304913
BBX bobby sox homolog (Drosophila) -0.0303096
GNAS GNAS complex locus -0.0302999
ATAD2 ATPase family, AAA domain containing 2 -0.0301999
VCL vinculin -0.0297667
LY6E lymphocyte antigen 6 complex, locus E -0.0297126
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0293795
LMAN1 lectin, mannose-binding, 1 -0.0290438
GRB10 growth factor receptor-bound protein 10 -0.0285978
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -0.0285043
GGNBP2 gametogenetin binding protein 2 -0.0281347
IPO7 importin 7 -0.027895
BIRC3 baculoviral IAP repeat containing 3 -0.0276943
LDHA lactate dehydrogenase A -0.0275701
MARK2 MAP/microtubule affinity-regulating kinase 2 -0.0273596
ECT2 epithelial cell transforming 2 -0.0273582
ATP5F1B ATP synthase F1 subunit beta -0.0271077
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.026833
ACBD3 acyl-CoA binding domain containing 3 -0.0268003
STAU1 staufen double-stranded RNA binding protein 1 -0.0265905
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0264129
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0263985
RPL8 ribosomal protein L8 -0.026185
SEC24A SEC24 family member A -0.0260915
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0260801
TAPBP TAP binding protein (tapasin) -0.025697
FOXO3 forkhead box O3 -0.0256173
KMT2E lysine (K)-specific methyltransferase 2E -0.0254026
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0253016
RPL28 ribosomal protein L28 -0.0251928
USP34 ubiquitin specific peptidase 34 -0.0251779
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0249417
VDAC1 voltage-dependent anion channel 1 -0.0248785
CLDN7 claudin 7 -0.0247469
EIF1 eukaryotic translation initiation factor 1 -0.0246863
TUBB tubulin, beta class I -0.0245335
RTN4 reticulon 4 -0.0244547
ZNF207 zinc finger protein 207 -0.0243443
DEK DEK proto-oncogene -0.0243203