Chlorhexidine (diacetate)_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL5A2 collagen, type V, alpha 2 0.114474
STAT1 signal transducer and activator of transcription 1, 91kDa 0.103268
JMJD1C jumonji domain containing 1C 0.0892991
DST dystonin 0.0871272
PDE4D phosphodiesterase 4D, cAMP-specific 0.0830797
RAD51B RAD51 paralog B 0.0818056
FMNL2 formin-like 2 0.077753
ZNF292 zinc finger protein 292 0.07294
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 0.0724696
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0716061
CELF2 CUGBP, Elav-like family member 2 0.0714396
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0690763
SOX5 SRY (sex determining region Y)-box 5 0.0680998
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0666129
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0656169
SFPQ splicing factor proline/glutamine-rich 0.0626631
PARD3 par-3 family cell polarity regulator 0.0613509
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0612119
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0589767
PUM2 pumilio RNA-binding family member 2 0.0580841
KMT2C lysine (K)-specific methyltransferase 2C 0.0572352
ZFAND3 zinc finger, AN1-type domain 3 0.056465
PTK2 protein tyrosine kinase 2 0.0564251
TOX thymocyte selection-associated high mobility group box 0.0556008
USP9X ubiquitin specific peptidase 9, X-linked 0.0555624
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0554032
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.0547595
CCNY cyclin Y 0.053125
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0520463
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0517637
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0498903
RAP1B RAP1B, member of RAS oncogene family 0.0494826
NUP58 nucleoporin 58 0.0491149
CHD7 chromodomain helicase DNA binding protein 7 0.0486452
MED13L mediator complex subunit 13-like 0.0484736
AUTS2 autism susceptibility candidate 2 0.048292
SETD5 SET domain containing 5 0.0480839
SRPK2 SRSF protein kinase 2 0.0471711
NFIA nuclear factor I/A 0.0469687
KDM6A lysine (K)-specific demethylase 6A 0.0458968
RFLNA refilin A 0.0449756
NEBL nebulette 0.0439504
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0434406
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0432212
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0431931
FUBP1 far upstream element (FUSE) binding protein 1 0.0427418
MIMS1 mitochondrial inner membrane scaffold 1 0.0422798
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0422401
KDM1A lysine (K)-specific demethylase 1A 0.0415566
WWC2 WW and C2 domain containing 2 0.0409942
YEATS2 YEATS domain containing 2 0.0405569
UBE3A ubiquitin protein ligase E3A 0.0398781
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0393885
BRD4 bromodomain containing 4 0.0384705
OSBPL10 oxysterol binding protein-like 10 0.0384202
WSB1 WD repeat and SOCS box containing 1 0.0383454
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0377721
PTPRG protein tyrosine phosphatase, receptor type, G 0.0373023
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0367207
ATP11A ATPase, class VI, type 11A 0.0366364
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0365134
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0364879
SMAP1 small ArfGAP 1 0.0363078
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0359453
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0357836
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0357717
MEMO1 mediator of cell motility 1 0.0353049
RBM33 RNA binding motif protein 33 0.035281
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0352763
ANKRD36 ankyrin repeat domain 36 0.0350749
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0350276
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0346798
NUP153 nucleoporin 153kDa 0.0345382
CDC73 cell division cycle 73 0.0345379
ADGRG6 adhesion G protein-coupled receptor G6 0.0344741
NCKAP1 NCK-associated protein 1 0.0341462
RPS3 ribosomal protein S3 0.0341341
DENND5A DENN/MADD domain containing 5A 0.0341271
BCAS3 breast carcinoma amplified sequence 3 0.0339595
QKI QKI, KH domain containing, RNA binding 0.0336728
MKI67 marker of proliferation Ki-67 0.0335895
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0335778
PCBP2 poly(rC) binding protein 2 0.0332073
TRIO trio Rho guanine nucleotide exchange factor 0.0331715
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0331548
EXT1 exostosin glycosyltransferase 1 0.0329562
RPL37A ribosomal protein L37a 0.0329199
NFIB nuclear factor I/B 0.0326461
ZEB1 zinc finger E-box binding homeobox 1 0.0325226
PHF21A PHD finger protein 21A 0.0321169
PIAS2 protein inhibitor of activated STAT, 2 0.0318208
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0316648
CTBP2 C-terminal binding protein 2 0.0313801
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0313356
FNBP1L formin binding protein 1-like 0.0312988
NALF1 NALCN channel auxiliary factor 1 0.0312682
GYS1 glycogen synthase 1 (muscle) 0.0312111
ABI2 abl-interactor 2 0.0311971
TNRC18 trinucleotide repeat containing 18 0.0311446
NCOR1 nuclear receptor corepressor 1 0.0309267

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.135864
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.124597
NPAS3 neuronal PAS domain protein 3 -0.0941459
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0822208
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.074968
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.071943
LOC112694756 uncharaterized LOC112694756 -0.0543099
SOX4 SRY (sex determining region Y)-box 4 -0.0517838
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0429746
CANX calnexin -0.0350795
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0326939
RPLP1 ribosomal protein, large, P1 -0.031628
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0313108
HMGB1 high mobility group box 1 -0.0290754
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0283003
RPS24 ribosomal protein S24 -0.0274341
HILPDA hypoxia inducible lipid droplet-associated -0.0264895
H1-0 H1.0 linker histone -0.0263182
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0255284
RPL32 ribosomal protein L32 -0.0244358
RPLP0 ribosomal protein, large, P0 -0.0233958
VDAC1 voltage-dependent anion channel 1 -0.0228987
SNX14 sorting nexin 14 -0.022816
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0225547
ACTG1 actin gamma 1 -0.0220112
TENM2 teneurin transmembrane protein 2 -0.0219267
RPL4 ribosomal protein L4 -0.0218206
GJA1 gap junction protein, alpha 1, 43kDa -0.0215649
RRBP1 ribosome binding protein 1 -0.0213935
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0207853
WASF2 WAS protein family, member 2 -0.0199844
MSH4 mutS homolog 4 -0.0199615
CCDC47 coiled-coil domain containing 47 -0.0195279
HDLBP high density lipoprotein binding protein -0.0194473
TUBB tubulin, beta class I -0.0192841
PBRM1 polybromo 1 -0.0192655
WDPCP WD repeat containing planar cell polarity effector -0.0192416
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0192362
EIF1 eukaryotic translation initiation factor 1 -0.0189427
DIAPH2 diaphanous-related formin 2 -0.0182911
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -0.0182578
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0181614
LDHA lactate dehydrogenase A -0.0179942
CCDC138 coiled-coil domain containing 138 -0.0177698
RPL28 ribosomal protein L28 -0.0176357
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0175548
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 -0.0174468
RPL14 ribosomal protein L14 -0.017444
RPS5 ribosomal protein S5 -0.017436
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0173723
RPS20 ribosomal protein S20 -0.0171232
UBAP2 ubiquitin associated protein 2 -0.0169588
NARS1 asparaginyl-tRNA synthetase 1 -0.0169259
S100A9 S100 calcium binding protein A9 -0.016854
PAIP2 poly(A) binding protein interacting protein 2 -0.0168131
NOLC1 nucleolar and coiled-body phosphoprotein 1 -0.0167511
TBCK TBC1 domain containing kinase -0.0167494
GOLM2 golgi membrane protein 2 -0.016553
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -0.0165385
NPR2 natriuretic peptide receptor 2 -0.016526
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0164609
HAUS6 HAUS augmin-like complex, subunit 6 -0.0164602
APAF1 apoptotic peptidase activating factor 1 -0.0164153
ATM ATM serine/threonine kinase -0.0163725
TAS2R14 taste receptor, type 2, member 14 -0.0162347
TUBA1B tubulin, alpha 1b -0.0161475
PNISR PNN-interacting serine/arginine-rich protein -0.0160976
GARS1 glycyl-tRNA synthetase 1 -0.0157656
NAP1L1 nucleosome assembly protein 1-like 1 -0.0157432
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0157212
THBS1 thrombospondin 1 -0.0157092
RPL12 ribosomal protein L12 -0.0156486
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0156304
SNX6 sorting nexin 6 -0.0155764
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.015481
GNAS GNAS complex locus -0.0154199
SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 -0.0154002
HELLS helicase, lymphoid-specific -0.015228
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0151501
ENOSF1 enolase superfamily member 1 -0.0150723
ACACA acetyl-CoA carboxylase alpha -0.0150687
LMAN1 lectin, mannose-binding, 1 -0.0149818
HM13 histocompatibility (minor) 13 -0.014812
RPS15 ribosomal protein S15 -0.0147112
RPL39 ribosomal protein L39 -0.0146951
NCBP3 nuclear cap binding subunit 3 -0.0146379
SRSF10 serine/arginine-rich splicing factor 10 -0.0144594
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like -0.0144155
ZNHIT6 zinc finger, HIT-type containing 6 -0.0143025
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0142267
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) -0.0142199
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0141178
ZBTB35 zinc finger and BTB domain containing 35 -0.0141013
CFAP97 cilia and flagella associated protein 97 -0.0140555
RPL7A ribosomal protein L7a -0.0140184
PCDH9 protocadherin 9 -0.0139157
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) -0.0139022
CASP8AP2 caspase 8 associated protein 2 -0.0138232
ZNF770 zinc finger protein 770 -0.0138189
CLIP1 CAP-GLY domain containing linker protein 1 -0.0137974