Chlorhexidine (diacetate)_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.151126
FN1 fibronectin 1 0.133425
GPC6 glypican 6 0.131259
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.102331
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0758403
CD109 CD109 molecule 0.0741346
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0725256
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0710919
KMT2C lysine (K)-specific methyltransferase 2C 0.0694986
SETBP1 SET binding protein 1 0.0622235
NAV2 neuron navigator 2 0.0617782
ESYT2 extended synaptotagmin-like protein 2 0.0606778
AHR aryl hydrocarbon receptor 0.0588509
PRELID2 PRELI domain containing 2 0.0581777
ENO1 enolase 1, (alpha) 0.0581751
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0561997
SPRED1 sprouty-related, EVH1 domain containing 1 0.054651
NUP58 nucleoporin 58 0.0541857
FMNL2 formin-like 2 0.0537572
FNDC3B fibronectin type III domain containing 3B 0.0513992
DST dystonin 0.0504103
CHSY1 chondroitin sulfate synthase 1 0.0502566
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0496987
ASPH aspartate beta-hydroxylase 0.0496487
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0488934
LEF1 lymphoid enhancer-binding factor 1 0.0479122
NBAS neuroblastoma amplified sequence 0.0476837
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0471605
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0471012
PTK2 protein tyrosine kinase 2 0.0469798
FBXO7 F-box protein 7 0.0461122
NAMPT nicotinamide phosphoribosyltransferase 0.0449511
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0442196
STRIP2 striatin interacting protein 2 0.043988
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0437709
AFDN afadin, adherens junction formation factor 0.0434392
TMEM178B transmembrane protein 178B 0.043374
OXR1 oxidation resistance 1 0.0432419
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0429448
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.0425549
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0421744
ZNF292 zinc finger protein 292 0.0414027
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0407385
CUL3 cullin 3 0.0404254
RAD51B RAD51 paralog B 0.0401304
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.040082
TPR translocated promoter region, nuclear basket protein 0.0392351
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0383238
PI15 peptidase inhibitor 15 0.037997
CDK19 cyclin-dependent kinase 19 0.0379589
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0379303
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0377985
UBA6 ubiquitin-like modifier activating enzyme 6 0.0370969
IGFBP3 insulin-like growth factor binding protein 3 0.0368823
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0367808
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0364583
TMEM255B transmembrane protein 255B 0.0362785
KTN1 kinectin 1 (kinesin receptor) 0.0362086
KMT2E lysine (K)-specific methyltransferase 2E 0.0362068
PRRC2C proline-rich coiled-coil 2C 0.0357012
ZYX zyxin 0.0350239
MACF1 microtubule-actin crosslinking factor 1 0.0348461
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0346644
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0345744
TNIK TRAF2 and NCK interacting kinase 0.034178
BABAM2 BRISC and BRCA1 A complex member 2 0.0340869
SFPQ splicing factor proline/glutamine-rich 0.0340625
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0335687
APP amyloid beta (A4) precursor protein 0.0335647
SRPK2 SRSF protein kinase 2 0.0335114
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0333263
PPP1R12B protein phosphatase 1, regulatory subunit 12B 0.0328293
RNF145 ring finger protein 145 0.0324688
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.032362
MRTFA myocardin related transcription factor A 0.0323508
EXOC4 exocyst complex component 4 0.0321728
CABIN1 calcineurin binding protein 1 0.0308541
VMP1 vacuole membrane protein 1 0.0304013
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0302232
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0301169
FRMD6 FERM domain containing 6 0.0293427
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0292678
SRRM2 serine/arginine repetitive matrix 2 0.0291274
RPS12 ribosomal protein S12 0.0289022
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0286789
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0282911
FOXJ3 forkhead box J3 0.0282115
EXOC6B exocyst complex component 6B 0.0274018
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.0267172
RUNX1 runt-related transcription factor 1 0.0265221
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0264976
RBM33 RNA binding motif protein 33 0.0262279
PTPRF protein tyrosine phosphatase, receptor type, F 0.0258326
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0253642
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 0.0253431
RPL3 ribosomal protein L3 0.0250053
CDC73 cell division cycle 73 0.0249143
GANAB glucosidase, alpha; neutral AB 0.0248976
BACE2 beta-site APP-cleaving enzyme 2 0.024685
XPO6 exportin 6 0.0246443

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.267656
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.19651
VGF VGF nerve growth factor inducible -0.190202
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.147649
MT2A metallothionein 2A -0.0878592
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0851988
VIM vimentin -0.0787211
INSIG1 insulin induced gene 1 -0.0717042
IGFBP5 insulin-like growth factor binding protein 5 -0.0656421
IFI16 interferon, gamma-inducible protein 16 -0.0569793
PDIA4 protein disulfide isomerase family A, member 4 -0.0562712
AHNAK AHNAK nucleoprotein -0.0545086
NPR2 natriuretic peptide receptor 2 -0.0472975
ACTG1 actin gamma 1 -0.0467807
TRIM2 tripartite motif containing 2 -0.0464551
CANX calnexin -0.0446455
IER3 immediate early response 3 -0.0424745
RRBP1 ribosome binding protein 1 -0.0412093
A2M alpha-2-macroglobulin -0.0393928
IFRD1 interferon-related developmental regulator 1 -0.0390662
GNAS GNAS complex locus -0.0389201
ZC3H11A zinc finger CCCH-type containing 11A -0.0383903
MACROD2 MACRO domain containing 2 -0.0374916
FUS FUS RNA binding protein -0.0371229
NAV3 neuron navigator 3 -0.0359002
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0317462
ZNF704 zinc finger protein 704 -0.0308062
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0298412
SDCBP syndecan binding protein (syntenin) -0.028196
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0281196
NCOA7 nuclear receptor coactivator 7 -0.027794
LOC112694756 uncharaterized LOC112694756 -0.0275218
PCDH7 protocadherin 7 -0.0274407
FRMD4A FERM domain containing 4A -0.0268475
CALU calumenin -0.0268016
TMEM263 transmembrane protein 263 -0.0262111
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0261798
VCL vinculin -0.0255418
ATF6 activating transcription factor 6 -0.0254407
SFTPA2 surfactant protein A2 -0.0251511
CUX1 cut-like homeobox 1 -0.0248727
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.024591
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.024588
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0239489
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.023181
IGF1R insulin-like growth factor 1 receptor -0.0227596
RPS24 ribosomal protein S24 -0.0224224
CTTNBP2 cortactin binding protein 2 -0.0223768
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0222199
ZBTB20 zinc finger and BTB domain containing 20 -0.0215704
TAGLN2 transgelin 2 -0.0214181
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0211629
NPC1 Niemann-Pick disease, type C1 -0.0210204
RPLP1 ribosomal protein, large, P1 -0.0209632
GTF2B general transcription factor IIB -0.0209263
AKAP12 A kinase (PRKA) anchor protein 12 -0.0208982
UHMK1 U2AF homology motif (UHM) kinase 1 -0.0207538
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 -0.0205142
FBXO32 F-box protein 32 -0.0205067
BTG1 B-cell translocation gene 1, anti-proliferative -0.0204841
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0201
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0200256
NPAS2 neuronal PAS domain protein 2 -0.0200118
PDLIM5 PDZ and LIM domain 5 -0.0194138
LRRC23 leucine rich repeat containing 23 -0.0193755
HBP1 HMG-box transcription factor 1 -0.0193133
NASP nuclear autoantigenic sperm protein (histone-binding) -0.0191354
EGR1 early growth response 1 -0.0188416
COTL1 coactosin-like F-actin binding protein 1 -0.0187196
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -0.0186397
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0183798
FHIT fragile histidine triad -0.0183201
VDAC1 voltage-dependent anion channel 1 -0.0182901
HMCN1 hemicentin 1 -0.0182689
BZW1 basic leucine zipper and W2 domains 1 -0.0182628
MTDH metadherin -0.0179705
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0179338
HSPB1 heat shock 27kDa protein 1 -0.0178608
ZEB2 zinc finger E-box binding homeobox 2 -0.0173045
TSPAN14 tetraspanin 14 -0.0171452
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0170579
TLE4 transducin-like enhancer of split 4 -0.0170573
GARS1 glycyl-tRNA synthetase 1 -0.0169562
CAVIN1 caveolae associated protein 1 -0.0168859
SLC38A1 solute carrier family 38, member 1 -0.0168758
INPP5F inositol polyphosphate-5-phosphatase F -0.0166582
TKT transketolase -0.0165783
ADNP activity-dependent neuroprotector homeobox -0.0164729
ZFYVE28 zinc finger, FYVE domain containing 28 -0.0163553
PDE10A phosphodiesterase 10A -0.0162636
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0160914
FCRLA Fc receptor-like A -0.0160309
RNF130 ring finger protein 130 -0.0159915
IARS1 isoleucyl-tRNA synthetase 1 -0.0159304
BZW2 basic leucine zipper and W2 domains 2 -0.0158469
LIMA1 LIM domain and actin binding 1 -0.0157239
MITF microphthalmia-associated transcription factor -0.0156776
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0155886
SREBF2 sterol regulatory element binding transcription factor 2 -0.0155807
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0154048