Chlorhexidine (diacetate)_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.138864
LAMB3 laminin, beta 3 0.106871
FAM13A family with sequence similarity 13, member A 0.105689
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.089491
TSC22D2 TSC22 domain family, member 2 0.0836745
HLA-B major histocompatibility complex, class I, B 0.0762427
APOL2 apolipoprotein L, 2 0.0756658
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0706985
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0670835
MUC4 mucin 4, cell surface associated 0.0665819
CCNY cyclin Y 0.0641233
NPEPPS aminopeptidase puromycin sensitive 0.0629014
NDRG1 N-myc downstream regulated 1 0.0627362
SPAG9 sperm associated antigen 9 0.0610182
SMAD3 SMAD family member 3 0.0608655
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0576831
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0572619
RPL35A ribosomal protein L35a 0.0571471
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0564475
NUP58 nucleoporin 58 0.0519166
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0517862
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0508092
ANKRD11 ankyrin repeat domain 11 0.0499927
HMGA1 high mobility group AT-hook 1 0.0489084
KMT2E lysine (K)-specific methyltransferase 2E 0.0482093
HLA-A major histocompatibility complex, class I, A 0.0436169
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0431088
ZNF292 zinc finger protein 292 0.0416946
WAC WW domain containing adaptor with coiled-coil 0.0416409
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.040838
TPT1 tumor protein, translationally-controlled 1 0.0403635
ANXA11 annexin A11 0.0396987
MXD1 MAX dimerization protein 1 0.0388086
ESYT2 extended synaptotagmin-like protein 2 0.0387388
FAM162A family with sequence similarity 162, member A 0.038738
PADI1 peptidyl arginine deiminase, type I 0.0372121
CIB1 calcium and integrin binding 1 (calmyrin) 0.0369071
MCL1 myeloid cell leukemia 1 0.035423
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0348598
OSBPL9 oxysterol binding protein-like 9 0.03442
TRIO trio Rho guanine nucleotide exchange factor 0.0341566
PDGFC platelet derived growth factor C 0.0341331
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0327902
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0326376
ITGB4 integrin, beta 4 0.0324072
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0322525
PABPC1 poly(A) binding protein, cytoplasmic 1 0.032076
GANAB glucosidase, alpha; neutral AB 0.0315444
RAB6A RAB6A, member RAS oncogene family 0.0314663
PGK1 phosphoglycerate kinase 1 0.0312883
PLAU plasminogen activator, urokinase 0.0312376
ANXA4 annexin A4 0.0310058
RAB8B RAB8B, member RAS oncogene family 0.0309734
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0305482
SFPQ splicing factor proline/glutamine-rich 0.0305342
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0303729
OGA O-GlcNAcase 0.0302852
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.03008
ADAM8 ADAM metallopeptidase domain 8 0.0300429
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0299373
CFB complement factor B 0.0295728
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0289847
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0287158
KLF6 Kruppel-like factor 6 0.0283019
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0282514
GPBP1L1 GC-rich promoter binding protein 1-like 1 0.0280798
PNPLA8 patatin-like phospholipase domain containing 8 0.0276608
CP ceruloplasmin (ferroxidase) 0.0275436
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0273378
ARRDC3 arrestin domain containing 3 0.0271585
TACSTD2 tumor-associated calcium signal transducer 2 0.0271157
CD47 CD47 molecule 0.0268165
STRN3 striatin, calmodulin binding protein 3 0.0267439
TNIP1 TNFAIP3 interacting protein 1 0.0266805
FLNB filamin B, beta 0.0266617
RBM39 RNA binding motif protein 39 0.0265573
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0265115
WDR45B WD repeat domain 45B 0.0262905
FRMD5 FERM domain containing 5 0.0262655
TRA2A transformer 2 alpha homolog (Drosophila) 0.0258506
WSB1 WD repeat and SOCS box containing 1 0.0258298
RPL23 ribosomal protein L23 0.0257502
UGCG UDP-glucose ceramide glucosyltransferase 0.0252402
ATP13A3 ATPase type 13A3 0.0252015
FNDC3B fibronectin type III domain containing 3B 0.0251616
TXNRD1 thioredoxin reductase 1 0.025104
FAT1 FAT atypical cadherin 1 0.025061
RNF213 ring finger protein 213 0.024968
USP3 ubiquitin specific peptidase 3 0.0246993
B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 0.0244573
CUL3 cullin 3 0.0244224
QKI QKI, KH domain containing, RNA binding 0.0243625
TGM2 transglutaminase 2 0.024362
CALR calreticulin 0.0242789
HELZ helicase with zinc finger 0.0242082
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0240845
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0240677
CEMIP cell migration inducing protein, hyaluronan binding 0.0240461
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.0239465
GRB10 growth factor receptor-bound protein 10 0.0237488

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.201543
MT2A metallothionein 2A -0.133474
TMSB4X thymosin beta 4, X-linked -0.116207
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.112195
APLP2 amyloid beta (A4) precursor-like protein 2 -0.102977
AHNAK AHNAK nucleoprotein -0.100261
ALCAM activated leukocyte cell adhesion molecule -0.0992168
ASPH aspartate beta-hydroxylase -0.0976272
ERRFI1 ERBB receptor feedback inhibitor 1 -0.096922
MMP7 matrix metallopeptidase 7 -0.0889875
EIF1 eukaryotic translation initiation factor 1 -0.0818018
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0810481
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.078616
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0771796
ARHGAP5 Rho GTPase activating protein 5 -0.0762822
PTMA prothymosin, alpha -0.0750501
ACTG1 actin gamma 1 -0.0747932
LAMC2 laminin, gamma 2 -0.0735664
IGFBP3 insulin-like growth factor binding protein 3 -0.0726518
AKAP12 A kinase (PRKA) anchor protein 12 -0.0683089
FTL ferritin, light polypeptide -0.0678724
PKM pyruvate kinase, muscle -0.0630223
KRT19 keratin 19, type I -0.0619304
MAP1B microtubule-associated protein 1B -0.0601796
CDCP1 CUB domain containing protein 1 -0.0597206
MYOF myoferlin -0.0557398
VCL vinculin -0.0546879
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0541366
BZW1 basic leucine zipper and W2 domains 1 -0.0540295
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0538749
SP100 SP100 nuclear antigen -0.0537315
POTEF POTE ankyrin domain family, member F -0.0530696
ZSWIM6 zinc finger, SWIM-type containing 6 -0.052938
NABP1 nucleic acid binding protein 1 -0.0525664
DSG2 desmoglein 2 -0.0513382
ITGA6 integrin, alpha 6 -0.0505006
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0495131
PHF3 PHD finger protein 3 -0.0494486
UBC ubiquitin C -0.0488615
MT1X metallothionein 1X -0.0457709
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0450811
RPS2 ribosomal protein S2 -0.0443169
LOC112694756 uncharaterized LOC112694756 -0.0418892
RRBP1 ribosome binding protein 1 -0.0397888
RPS6 ribosomal protein S6 -0.0395327
RAB7A RAB7A, member RAS oncogene family -0.0393973
TOP2A topoisomerase (DNA) II alpha 170kDa -0.039225
CANX calnexin -0.0390641
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0382228
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0378975
PDIA3 protein disulfide isomerase family A, member 3 -0.0377499
SAMD9 sterile alpha motif domain containing 9 -0.0376415
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.037416
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0370231
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0369567
APOL1 apolipoprotein L, 1 -0.0367867
GOLGB1 golgin B1 -0.0367276
BRD2 bromodomain containing 2 -0.0362977
OSMR oncostatin M receptor -0.0361199
TJP1 tight junction protein 1 -0.0355443
RPL19 ribosomal protein L19 -0.0347673
NUMB numb homolog (Drosophila) -0.0346884
MAML2 mastermind-like 2 (Drosophila) -0.0346392
NPC1 Niemann-Pick disease, type C1 -0.0343729
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0334376
RCOR1 REST corepressor 1 -0.0333846
NRG3 neuregulin 3 -0.0333129
GNAS GNAS complex locus -0.0331636
LAMA4 laminin, alpha 4 -0.0323767
TPM4 tropomyosin 4 -0.0317082
VEGFA vascular endothelial growth factor A -0.031622
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.030552
CAPN2 calpain 2, (m/II) large subunit -0.0303021
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0301972
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0301676
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0297062
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0296648
FTH1 ferritin, heavy polypeptide 1 -0.0289813
ERBIN erbb2 interacting protein -0.0287508
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0287004
NPAS2 neuronal PAS domain protein 2 -0.0286221
LY6E lymphocyte antigen 6 complex, locus E -0.0276776
AHR aryl hydrocarbon receptor -0.0275939
ACBD3 acyl-CoA binding domain containing 3 -0.0273165
MCU mitochondrial calcium uniporter -0.0268702
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0268115
ZC3H11A zinc finger CCCH-type containing 11A -0.0267692
STK17A serine/threonine kinase 17a -0.0266669
TAGLN2 transgelin 2 -0.0266179
SLC38A2 solute carrier family 38, member 2 -0.0265574
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0265016
JMJD1C jumonji domain containing 1C -0.0263756
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0262994
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0261477
LAMB1 laminin, beta 1 -0.0258205
HDLBP high density lipoprotein binding protein -0.025716
TXNIP thioredoxin interacting protein -0.0256075
CCNI cyclin I -0.0255251
CLIC4 chloride intracellular channel 4 -0.0254856
STC1 stanniocalcin 1 -0.0253553