Chlorhexidine (diacetate)_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.301312
FAM13A family with sequence similarity 13, member A 0.0824126
TRIO trio Rho guanine nucleotide exchange factor 0.081564
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0740011
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0715578
NALF1 NALCN channel auxiliary factor 1 0.0648867
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0623716
NDRG1 N-myc downstream regulated 1 0.0618135
MEIS2 Meis homeobox 2 0.061144
UBA6 ubiquitin-like modifier activating enzyme 6 0.0489191
HELZ helicase with zinc finger 0.0488687
RPL23 ribosomal protein L23 0.048584
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0480665
SEPTIN9 septin 9 0.0480542
ASPH aspartate beta-hydroxylase 0.0462729
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0456183
HSPA8 heat shock 70kDa protein 8 0.045549
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0434247
SOS1 son of sevenless homolog 1 (Drosophila) 0.0430594
MEF2A myocyte enhancer factor 2A 0.0430384
MACF1 microtubule-actin crosslinking factor 1 0.0426052
RPS12 ribosomal protein S12 0.0421987
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.040516
SET SET nuclear proto-oncogene 0.0404961
ANGPT1 angiopoietin 1 0.0399959
NCOR2 nuclear receptor corepressor 2 0.0398801
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.039863
LIMCH1 LIM and calponin homology domains 1 0.0394576
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0386748
SLITRK6 SLIT and NTRK-like family, member 6 0.0375238
RPL37A ribosomal protein L37a 0.0360952
RPL3 ribosomal protein L3 0.0358735
RUNX1 runt-related transcription factor 1 0.0351525
GSE1 Gse1 coiled-coil protein 0.0350508
AKAP13 A kinase (PRKA) anchor protein 13 0.0346048
UNC5C unc-5 homolog C (C. elegans) 0.033993
DST dystonin 0.0338127
COL18A1 collagen, type XVIII, alpha 1 0.0334217
SMYD3 SET and MYND domain containing 3 0.0331636
PEAK1 pseudopodium-enriched atypical kinase 1 0.0331034
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0330581
RPL35A ribosomal protein L35a 0.0322522
PCDH9 protocadherin 9 0.0303951
UNC5B unc-5 homolog B (C. elegans) 0.0301978
VEGFA vascular endothelial growth factor A 0.0300302
DPH6 diphthamine biosynthesis 6 0.029259
TPR translocated promoter region, nuclear basket protein 0.0285363
RPS3 ribosomal protein S3 0.0284644
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0283987
MYH9 myosin, heavy chain 9, non-muscle 0.0280819
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0280369
DNMBP dynamin binding protein 0.0277444
ZCCHC7 zinc finger, CCHC domain containing 7 0.0276973
SMAD3 SMAD family member 3 0.0274573
RBM20 RNA binding motif protein 20 0.02732
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0273028
ANKRD11 ankyrin repeat domain 11 0.0269507
ARRDC3 arrestin domain containing 3 0.0267668
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0263966
TNRC6A trinucleotide repeat containing 6A 0.0263563
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0261252
CADM1 cell adhesion molecule 1 0.0260793
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0260496
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0258659
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0258454
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.025814
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0256149
KCTD3 potassium channel tetramerization domain containing 3 0.0255746
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0250543
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.025015
ESYT2 extended synaptotagmin-like protein 2 0.0243834
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0240653
CTSB cathepsin B 0.023924
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0238331
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0237533
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.0237486
PTPRM protein tyrosine phosphatase, receptor type, M 0.0236599
TTC17 tetratricopeptide repeat domain 17 0.0236396
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.023474
ENO1 enolase 1, (alpha) 0.02343
FAM162A family with sequence similarity 162, member A 0.0230705
MARCHF6 membrane associated ring-CH-type finger 6 0.0230128
ZMIZ1 zinc finger, MIZ-type containing 1 0.0228832
TET2 tet methylcytosine dioxygenase 2 0.0228181
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0227751
SMAD6 SMAD family member 6 0.0226508
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0226047
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0225327
NUP58 nucleoporin 58 0.0224562
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0224233
PTEN phosphatase and tensin homolog 0.0223646
CTBP2 C-terminal binding protein 2 0.0223517
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0222372
NBAS neuroblastoma amplified sequence 0.022091
CSDE1 cold shock domain containing E1, RNA-binding 0.0219926
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.0217417
SKIL SKI-like proto-oncogene 0.0216384
PICALM phosphatidylinositol binding clathrin assembly protein 0.0215485
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0215377
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0213666

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.222206
VCL vinculin -0.16529
PTMA prothymosin, alpha -0.132064
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.100239
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0976188
VIM vimentin -0.0864205
COL1A1 collagen, type I, alpha 1 -0.0765404
ACTG1 actin gamma 1 -0.0677655
PTPRD protein tyrosine phosphatase, receptor type, D -0.0643913
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0617333
UBC ubiquitin C -0.0600866
AHNAK AHNAK nucleoprotein -0.059958
LSAMP limbic system-associated membrane protein -0.0572355
RPS24 ribosomal protein S24 -0.0556299
TLE4 transducin-like enhancer of split 4 -0.0534323
EXT1 exostosin glycosyltransferase 1 -0.0533698
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0524385
SIK2 salt-inducible kinase 2 -0.0493496
GLCCI1 glucocorticoid induced 1 -0.0487542
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.045026
H3-3B H3.3 histone B -0.0445792
TPM1 tropomyosin 1 (alpha) -0.0433852
FNDC3A fibronectin type III domain containing 3A -0.0430766
RPLP1 ribosomal protein, large, P1 -0.0423074
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0421146
BCAS3 breast carcinoma amplified sequence 3 -0.0406904
FMN1 formin 1 -0.0399869
NPAS2 neuronal PAS domain protein 2 -0.0396612
RPL38 ribosomal protein L38 -0.0382344
HMGB2 high mobility group box 2 -0.0379487
SYT1 synaptotagmin I -0.0368566
ARID5B AT rich interactive domain 5B (MRF1-like) -0.0368163
RPS27A ribosomal protein S27a -0.0362625
PDLIM5 PDZ and LIM domain 5 -0.0361292
NCOA7 nuclear receptor coactivator 7 -0.0360147
POTEF POTE ankyrin domain family, member F -0.0357861
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0357244
IER3 immediate early response 3 -0.0352041
HAND2 heart and neural crest derivatives expressed 2 -0.0349165
TPST1 tyrosylprotein sulfotransferase 1 -0.0338024
STK38L serine/threonine kinase 38 like -0.0336167
COL3A1 collagen, type III, alpha 1 -0.0334134
VMP1 vacuole membrane protein 1 -0.0332746
ZNF804A zinc finger protein 804A -0.0328434
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0321462
RPL19 ribosomal protein L19 -0.0319136
SOD2 superoxide dismutase 2, mitochondrial -0.0311607
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.031141
IRS1 insulin receptor substrate 1 -0.030056
HDLBP high density lipoprotein binding protein -0.0299886
FRMD4A FERM domain containing 4A -0.0297758
SYNPO2 synaptopodin 2 -0.0295761
NRP1 neuropilin 1 -0.0294811
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0293937
RBM25 RNA binding motif protein 25 -0.0286492
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0286329
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0285568
CDK12 cyclin-dependent kinase 12 -0.0284414
TUBB tubulin, beta class I -0.0284097
SP100 SP100 nuclear antigen -0.0280373
CANX calnexin -0.0277742
LMNA lamin A/C -0.0272012
CCNI cyclin I -0.0271004
MYO1E myosin IE -0.0269626
RC3H1 ring finger and CCCH-type domains 1 -0.0268089
AHR aryl hydrocarbon receptor -0.0267368
LPIN1 lipin 1 -0.0266683
KLHL13 kelch-like family member 13 -0.0264583
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 -0.0262364
RTN3 reticulon 3 -0.0261812
TRIP12 thyroid hormone receptor interactor 12 -0.0260169
GREM2 gremlin 2, DAN family BMP antagonist -0.0258825
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0256258
GPATCH8 G patch domain containing 8 -0.0255253
DNAH14 dynein, axonemal, heavy chain 14 -0.0253388
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0249985
COL4A5 collagen, type IV, alpha 5 -0.0248439
ACBD3 acyl-CoA binding domain containing 3 -0.024783
TMSB10 thymosin beta 10 -0.0246517
LOC112694756 uncharaterized LOC112694756 -0.0245896
ZFC3H1 zinc finger, C3H1-type containing -0.0244455
ZFR zinc finger RNA binding protein -0.0243639
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0243577
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0243221
NCAM2 neural cell adhesion molecule 2 -0.0242609
RPS5 ribosomal protein S5 -0.023984
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0239002
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0238795
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 -0.0236802
GNAS GNAS complex locus -0.0234854
ZC3H13 zinc finger CCCH-type containing 13 -0.0233687
GOSR2 golgi SNAP receptor complex member 2 -0.0232431
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0232378
NPEPPS aminopeptidase puromycin sensitive -0.0231784
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0231556
RIGI RNA sensor RIG-I -0.0227442
ITGA1 integrin, alpha 1 -0.0225812
RPL14 ribosomal protein L14 -0.0224187
NREP neuronal regeneration related protein -0.0223392
ZC3H15 zinc finger CCCH-type containing 15 -0.0223089