Chlorhexidine (diacetate)_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RUNX1 runt-related transcription factor 1 0.12101
MBNL2 muscleblind-like splicing regulator 2 0.102206
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0999587
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0938989
ZMYND8 zinc finger, MYND-type containing 8 0.0745143
EPHB2 EPH receptor B2 0.0713387
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0633163
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0606175
NDRG1 N-myc downstream regulated 1 0.0568953
ZNRF3 zinc and ring finger 3 0.0555077
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0554804
ATP11A ATPase, class VI, type 11A 0.0553671
TRIM2 tripartite motif containing 2 0.0539589
AOPEP aminopeptidase O (putative) 0.0536197
SREBF2 sterol regulatory element binding transcription factor 2 0.0535432
RNF43 ring finger protein 43 0.0533266
MACC1 metastasis associated in colon cancer 1 0.0532311
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0532172
SPATA13 spermatogenesis associated 13 0.0514987
NKD1 naked cuticle homolog 1 (Drosophila) 0.0510655
RHOBTB3 Rho-related BTB domain containing 3 0.0508275
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0508042
BCLAF1 BCL2-associated transcription factor 1 0.0507149
RNF149 ring finger protein 149 0.0493576
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0492501
BTBD9 BTB (POZ) domain containing 9 0.0481193
MEIS2 Meis homeobox 2 0.0480662
MSI2 musashi RNA-binding protein 2 0.0459415
PRELID2 PRELI domain containing 2 0.0447261
PTEN phosphatase and tensin homolog 0.0446735
ATP10B ATPase, class V, type 10B 0.0445249
UBAC2 UBA domain containing 2 0.044341
HDAC4 histone deacetylase 4 0.0440564
GRK3 G protein-coupled receptor kinase 3 0.0437255
IL20RA interleukin 20 receptor, alpha 0.0431827
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0427404
SORBS1 sorbin and SH3 domain containing 1 0.0406826
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0406427
ATXN1 ataxin 1 0.040041
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0396728
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.039117
PTPRJ protein tyrosine phosphatase, receptor type, J 0.038611
SBF2 SET binding factor 2 0.0378894
MECOM MDS1 and EVI1 complex locus 0.0374789
YEATS2 YEATS domain containing 2 0.0374394
SAMD4A sterile alpha motif domain containing 4A 0.037302
ABHD2 abhydrolase domain containing 2 0.036996
ESYT2 extended synaptotagmin-like protein 2 0.0366471
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0366302
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.036574
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0364438
TRIO trio Rho guanine nucleotide exchange factor 0.0360926
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0353181
DIAPH3 diaphanous-related formin 3 0.035069
CD46 CD46 molecule, complement regulatory protein 0.0347511
FNIP1 folliculin interacting protein 1 0.034588
SRRM2 serine/arginine repetitive matrix 2 0.0344926
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0344537
DSCAM Down syndrome cell adhesion molecule 0.0343567
ARGLU1 arginine and glutamate rich 1 0.033993
AFF1 AF4/FMR2 family, member 1 0.0339636
OGA O-GlcNAcase 0.0338772
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.033603
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0331931
MACF1 microtubule-actin crosslinking factor 1 0.0329204
PRKCA protein kinase C, alpha 0.0328702
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0325308
CALR calreticulin 0.0322278
MYH9 myosin, heavy chain 9, non-muscle 0.0320798
PTK2 protein tyrosine kinase 2 0.0320088
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 0.0319407
ETV6 ets variant 6 0.0317855
GRAMD2B GRAM domain containing 2B 0.0315124
SCARB1 scavenger receptor class B, member 1 0.0311324
FNDC3B fibronectin type III domain containing 3B 0.031026
DENND4C DENN/MADD domain containing 4C 0.0306692
NRIP1 nuclear receptor interacting protein 1 0.0304235
TJP2 tight junction protein 2 0.0299795
TMEM62 transmembrane protein 62 0.0295197
METTL15 methyltransferase like 15 0.0294032
MCTP2 multiple C2 domains, transmembrane 2 0.0293432
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0292784
DNM2 dynamin 2 0.029122
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0289854
YAP1 Yes-associated protein 1 0.0289777
XRN1 5'-3' exoribonuclease 1 0.0288477
CEMIP2 cell migration inducing hyaluronidase 2 0.0288152
IFNGR1 interferon gamma receptor 1 0.028633
PHC3 polyhomeotic homolog 3 (Drosophila) 0.028549
ARHGAP32 Rho GTPase activating protein 32 0.028436
BICRAL BICRA like chromatin remodeling complex associated protein 0.0282641
ETNK1 ethanolamine kinase 1 0.0282562
MLPH melanophilin 0.0279634
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0279105
RBM26 RNA binding motif protein 26 0.0276197
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0275931
EHF ets homologous factor 0.027568
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0274358
FAT1 FAT atypical cadherin 1 0.0270366
CMIP c-Maf inducing protein 0.0269613

decreased expression

Symbol Name Standardized Value
INTS6 integrator complex subunit 6 -0.188069
TPT1 tumor protein, translationally-controlled 1 -0.143318
EGR1 early growth response 1 -0.119336
ANXA2 annexin A2 -0.116798
VCL vinculin -0.113608
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.104925
PLSCR2 phospholipid scramblase 2 -0.102452
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0859697
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0816851
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0801973
SP100 SP100 nuclear antigen -0.0735965
TM4SF19 transmembrane 4 L six family member 19 -0.0693156
B2M beta-2-microglobulin -0.0674356
AREG amphiregulin -0.0667511
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0656464
PERP PERP, TP53 apoptosis effector -0.0637211
RAB7A RAB7A, member RAS oncogene family -0.0624369
ACTG1 actin gamma 1 -0.0614587
PKM pyruvate kinase, muscle -0.0611337
C6ORF132 chromosome 6 open reading frame 132 -0.0602587
XAF1 XIAP associated factor 1 -0.0601785
FTL ferritin, light polypeptide -0.0581873
GCLC glutamate-cysteine ligase, catalytic subunit -0.0564222
TJP1 tight junction protein 1 -0.0536839
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0511357
RNF213 ring finger protein 213 -0.0511324
POU2F2 POU class 2 homeobox 2 -0.0511222
MAP7 microtubule-associated protein 7 -0.050903
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0503941
MCTP1 multiple C2 domains, transmembrane 1 -0.0480135
MUC20 mucin 20, cell surface associated -0.0462477
POF1B premature ovarian failure, 1B -0.0456357
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0449837
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0446208
NPSR1 neuropeptide S receptor 1 -0.0440872
SDC4 syndecan 4 -0.0437028
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0435674
GOLGB1 golgin B1 -0.042817
TM4SF1 transmembrane 4 L six family member 1 -0.042422
RPLP1 ribosomal protein, large, P1 -0.0421561
EIF1 eukaryotic translation initiation factor 1 -0.0420861
RIGI RNA sensor RIG-I -0.0415208
NABP1 nucleic acid binding protein 1 -0.0406071
UBAP2 ubiquitin associated protein 2 -0.0405388
PTMA prothymosin, alpha -0.0385325
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0382366
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.038034
ANKRD10 ankyrin repeat domain 10 -0.0375165
SLC38A1 solute carrier family 38, member 1 -0.0375144
RPS6 ribosomal protein S6 -0.0372447
MX2 MX dynamin-like GTPase 2 -0.0370323
EZR ezrin -0.0367891
SETX senataxin -0.0364844
LYZ lysozyme -0.0359105
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0341135
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0337936
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0336044
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0333828
PLSCR1 phospholipid scramblase 1 -0.032669
RPS24 ribosomal protein S24 -0.0326277
IFI6 interferon, alpha-inducible protein 6 -0.0320155
LCN2 lipocalin 2 -0.0317498
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.0313415
PMP22 peripheral myelin protein 22 -0.0311385
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0311197
NCOA7 nuclear receptor coactivator 7 -0.0298755
EFNB2 ephrin-B2 -0.029779
HM13 histocompatibility (minor) 13 -0.0294144
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0292594
RPL34 ribosomal protein L34 -0.0290533
DIAPH1 diaphanous-related formin 1 -0.0289739
HKDC1 hexokinase domain containing 1 -0.0284199
FBXO39 F-box protein 39 -0.0283451
TNS4 tensin 4 -0.0281841
IGFBP3 insulin-like growth factor binding protein 3 -0.028152
MCL1 myeloid cell leukemia 1 -0.0280195
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -0.0279066
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0279043
IFIH1 interferon induced with helicase C domain 1 -0.0278424
STS steroid sulfatase (microsomal), isozyme S -0.0276952
LOC112694756 uncharaterized LOC112694756 -0.027546
MX1 MX dynamin-like GTPase 1 -0.0274156
STAU1 staufen double-stranded RNA binding protein 1 -0.0271903
FOSL1 FOS-like antigen 1 -0.0265448
HOMER1 homer scaffolding protein 1 -0.0265029
ARF1 ADP-ribosylation factor 1 -0.02644
POTEF POTE ankyrin domain family, member F -0.0264171
RPL31 ribosomal protein L31 -0.0262686
SLC38A2 solute carrier family 38, member 2 -0.0260245
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0258064
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.025593
PLAUR plasminogen activator, urokinase receptor -0.0255118
HLA-B major histocompatibility complex, class I, B -0.0253617
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0249227
GMDS GDP-mannose 4,6-dehydratase -0.0248274
ATF4 activating transcription factor 4 -0.0247322
RPL35A ribosomal protein L35a -0.024729
LAMA4 laminin, alpha 4 -0.0246528
LRRC8A leucine rich repeat containing 8 family, member A -0.0246215
RPLP0 ribosomal protein, large, P0 -0.0244524