Chlorhexidine (diacetate)_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.344266
NDRG1 N-myc downstream regulated 1 0.15687
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0771246
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0719295
DST dystonin 0.0689434
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0663105
ANKRD11 ankyrin repeat domain 11 0.0658655
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0656877
MYH9 myosin, heavy chain 9, non-muscle 0.0648134
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0641964
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0622303
MSN moesin 0.0620091
TGFBI transforming growth factor, beta-induced, 68kDa 0.0613361
FAM13A family with sequence similarity 13, member A 0.0549418
ANLN anillin, actin binding protein 0.0544625
ANTXR2 anthrax toxin receptor 2 0.0527567
ENO1 enolase 1, (alpha) 0.0523507
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0522551
TPM3 tropomyosin 3 0.0483199
MACF1 microtubule-actin crosslinking factor 1 0.0468012
NAV2 neuron navigator 2 0.046605
HELZ helicase with zinc finger 0.0438519
SMC4 structural maintenance of chromosomes 4 0.0426872
FAM219A family with sequence similarity 219, member A 0.0415602
ATP13A3 ATPase type 13A3 0.0413851
MKI67 marker of proliferation Ki-67 0.0409265
SFPQ splicing factor proline/glutamine-rich 0.0393536
FLNA filamin A, alpha 0.0391123
MAST4 microtubule associated serine/threonine kinase family member 4 0.0389617
EGFR epidermal growth factor receptor 0.0389563
SMAD3 SMAD family member 3 0.0389289
HSPA8 heat shock 70kDa protein 8 0.0387131
CENPF centromere protein F, 350/400kDa 0.0385917
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0376359
NFE2L1 nuclear factor, erythroid 2-like 1 0.0375682
RPS12 ribosomal protein S12 0.0365491
LPP LIM domain containing preferred translocation partner in lipoma 0.0363844
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0348046
KMT2E lysine (K)-specific methyltransferase 2E 0.0346353
FLNB filamin B, beta 0.0344591
RASA2 RAS p21 protein activator 2 0.0343333
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0339558
SDK1 sidekick cell adhesion molecule 1 0.0335707
STC1 stanniocalcin 1 0.0334115
ZNF148 zinc finger protein 148 0.0331189
RPL37A ribosomal protein L37a 0.0326514
RPS3 ribosomal protein S3 0.0324741
ZNF841 zinc finger protein 841 0.0320119
YEATS2 YEATS domain containing 2 0.0319874
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0319084
PLAUR plasminogen activator, urokinase receptor 0.0313855
VIM vimentin 0.0312238
IQGAP3 IQ motif containing GTPase activating protein 3 0.0310292
PCBP2 poly(rC) binding protein 2 0.0307378
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0307374
UBA6 ubiquitin-like modifier activating enzyme 6 0.0306121
CORO1C coronin, actin binding protein, 1C 0.0304704
SPRED1 sprouty-related, EVH1 domain containing 1 0.0304215
TOP2A topoisomerase (DNA) II alpha 170kDa 0.030114
CDK19 cyclin-dependent kinase 19 0.0300893
RPL3 ribosomal protein L3 0.0300608
CENPE centromere protein E, 312kDa 0.0299721
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0299559
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0298307
MCL1 myeloid cell leukemia 1 0.0297925
EEF2 eukaryotic translation elongation factor 2 0.0296119
TNIP1 TNFAIP3 interacting protein 1 0.0294888
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0294103
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0289529
YBX1 Y box binding protein 1 0.0287788
ASPH aspartate beta-hydroxylase 0.0286416
CALR calreticulin 0.0285722
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0284021
TRIP12 thyroid hormone receptor interactor 12 0.0282682
MT2A metallothionein 2A 0.0278929
RPL23 ribosomal protein L23 0.0278892
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0278098
ZNF292 zinc finger protein 292 0.0273607
GANAB glucosidase, alpha; neutral AB 0.027211
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.0271167
PLEC plectin 0.0268547
NUDCD3 NudC domain containing 3 0.0266372
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0266079
SHB Src homology 2 domain containing adaptor protein B 0.0265638
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0264826
PRRC2C proline-rich coiled-coil 2C 0.0263676
LDHA lactate dehydrogenase A 0.0263321
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0260212
HIPK2 homeodomain interacting protein kinase 2 0.0257814
USP9Y ubiquitin specific peptidase 9, Y-linked 0.0255901
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0255577
TNNC1 troponin C type 1 (slow) 0.0251966
FNIP1 folliculin interacting protein 1 0.0251151
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0248276
GIGYF2 GRB10 interacting GYF protein 2 0.0247458
NUP58 nucleoporin 58 0.0246263
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0245244
ADAM17 ADAM metallopeptidase domain 17 0.0244448
SNX13 sorting nexin 13 0.0244172
NSD2 nuclear receptor binding SET domain protein 2 0.0243645

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.268112
IGFBP3 insulin-like growth factor binding protein 3 -0.219078
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.151017
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.10835
FTL ferritin, light polypeptide -0.100844
KYNU kynureninase -0.0909869
AHNAK AHNAK nucleoprotein -0.0900588
CANX calnexin -0.0850103
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0657867
IGFBP5 insulin-like growth factor binding protein 5 -0.0614931
LMAN1 lectin, mannose-binding, 1 -0.0596852
FN1 fibronectin 1 -0.0572036
TIMP3 TIMP metallopeptidase inhibitor 3 -0.05489
LOX lysyl oxidase -0.0521536
OSMR oncostatin M receptor -0.0513395
TNS3 tensin 3 -0.0508992
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0499863
VCL vinculin -0.0487474
TPM4 tropomyosin 4 -0.0429348
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0422597
RRBP1 ribosome binding protein 1 -0.0418835
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0411881
GARS1 glycyl-tRNA synthetase 1 -0.0382487
CAVIN1 caveolae associated protein 1 -0.0372818
NCOA7 nuclear receptor coactivator 7 -0.035373
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0351843
TPTE transmembrane phosphatase with tensin homology -0.0337595
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.033329
PALLD palladin, cytoskeletal associated protein -0.0316188
ANXA2 annexin A2 -0.0309784
TUBB tubulin, beta class I -0.0306042
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0302667
EMP1 epithelial membrane protein 1 -0.0298619
AHR aryl hydrocarbon receptor -0.0289394
MAP1B microtubule-associated protein 1B -0.0289295
IARS1 isoleucyl-tRNA synthetase 1 -0.0284433
RPLP1 ribosomal protein, large, P1 -0.0282764
INHBA inhibin, beta A -0.0281454
RHOBTB3 Rho-related BTB domain containing 3 -0.028138
HDLBP high density lipoprotein binding protein -0.0280704
S100A6 S100 calcium binding protein A6 -0.0280515
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0278367
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0276643
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.0274217
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0272944
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0270406
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0267636
CDK6 cyclin-dependent kinase 6 -0.0262501
TMSB4X thymosin beta 4, X-linked -0.0261165
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0260133
LYPD6B LY6/PLAUR domain containing 6B -0.0259973
FTH1 ferritin, heavy polypeptide 1 -0.0259968
EIF1 eukaryotic translation initiation factor 1 -0.0259772
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0252667
SQSTM1 sequestosome 1 -0.0250034
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.024825
MT1X metallothionein 1X -0.0247447
CCND1 cyclin D1 -0.0245428
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0240434
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0240282
RPLP0 ribosomal protein, large, P0 -0.0240259
IER3 immediate early response 3 -0.0237298
VDAC1 voltage-dependent anion channel 1 -0.0225787
FNDC3B fibronectin type III domain containing 3B -0.022556
PDLIM5 PDZ and LIM domain 5 -0.0225478
NALF1 NALCN channel auxiliary factor 1 -0.0223185
RPS24 ribosomal protein S24 -0.0223082
SLC38A1 solute carrier family 38, member 1 -0.0220875
IL6ST interleukin 6 signal transducer -0.0218962
MTDH metadherin -0.0218883
SH3KBP1 SH3-domain kinase binding protein 1 -0.0217386
SLC38A2 solute carrier family 38, member 2 -0.0214247
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0213646
PHF14 PHD finger protein 14 -0.0213641
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.021202
COPB1 coatomer protein complex, subunit beta 1 -0.0210032
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -0.0210012
PTCHD4 patched domain containing 4 -0.0209561
MAP4 microtubule-associated protein 4 -0.0206963
TRIM56 tripartite motif containing 56 -0.0202246
GNAS GNAS complex locus -0.0202131
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0201093
CCDC102B coiled-coil domain containing 102B -0.0200338
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0199388
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0198806
GDF15 growth differentiation factor 15 -0.0194843
NF1 neurofibromin 1 -0.0194824
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0194647
GPR173 G protein-coupled receptor 173 -0.0194292
ZC3H11A zinc finger CCCH-type containing 11A -0.0191883
FSTL1 follistatin-like 1 -0.0191658
BTG1 B-cell translocation gene 1, anti-proliferative -0.0189833
LRRC49 leucine rich repeat containing 49 -0.0189299
MORF4L2 mortality factor 4 like 2 -0.0189261
ZBTB20 zinc finger and BTB domain containing 20 -0.0188246
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.018735
PHF3 PHD finger protein 3 -0.0185969
HSPA13 heat shock protein 70kDa family, member 13 -0.0183673
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -0.018287
IFI16 interferon, gamma-inducible protein 16 -0.0182179