Chlorhexidine (diacetate)_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.106295
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0996228
ENO1 enolase 1, (alpha) 0.0866954
MYH9 myosin, heavy chain 9, non-muscle 0.0670639
PRELID2 PRELI domain containing 2 0.0653993
TPM3 tropomyosin 3 0.0591295
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0583245
RAD51B RAD51 paralog B 0.0561291
TBC1D22A TBC1 domain family, member 22A 0.0550192
RPL23 ribosomal protein L23 0.0534318
NUP58 nucleoporin 58 0.0529554
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0529235
RPS12 ribosomal protein S12 0.0510804
LDHA lactate dehydrogenase A 0.0487489
RPS3 ribosomal protein S3 0.0486919
SET SET nuclear proto-oncogene 0.0481077
CTNND1 catenin (cadherin-associated protein), delta 1 0.0478292
YEATS2 YEATS domain containing 2 0.0463829
TMSB10 thymosin beta 10 0.0436234
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.042222
GANAB glucosidase, alpha; neutral AB 0.0418291
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0413659
ZNF292 zinc finger protein 292 0.0408342
N4BP2L2 NEDD4 binding protein 2-like 2 0.0404661
RPL37A ribosomal protein L37a 0.040452
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0403531
RPL3 ribosomal protein L3 0.0400348
TXNRD1 thioredoxin reductase 1 0.039767
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0391608
KDM4C lysine (K)-specific demethylase 4C 0.0378683
KTN1 kinectin 1 (kinesin receptor) 0.0372269
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0369586
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0365838
RPL9 ribosomal protein L9 0.0362348
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0360433
SLC35F5 solute carrier family 35, member F5 0.0357002
LPP LIM domain containing preferred translocation partner in lipoma 0.0352029
RAB6A RAB6A, member RAS oncogene family 0.0350676
NDRG1 N-myc downstream regulated 1 0.0350118
WSB1 WD repeat and SOCS box containing 1 0.0338382
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0336531
NCKAP1 NCK-associated protein 1 0.0333338
EEF2 eukaryotic translation elongation factor 2 0.0329343
WWC2 WW and C2 domain containing 2 0.0328796
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0328116
TNRC6A trinucleotide repeat containing 6A 0.0327304
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0324204
TMF1 TATA element modulatory factor 1 0.0318007
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0317649
DSPP dentin sialophosphoprotein 0.0317295
TRIO trio Rho guanine nucleotide exchange factor 0.0311834
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0311556
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0310599
KDM7A lysine (K)-specific demethylase 7A 0.0309381
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0307343
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0306898
NSRP1 nuclear speckle splicing regulatory protein 1 0.0304991
PCBP2 poly(rC) binding protein 2 0.0297767
CDK19 cyclin-dependent kinase 19 0.029744
UBE3A ubiquitin protein ligase E3A 0.0296997
AKAP12 A kinase (PRKA) anchor protein 12 0.029667
RBM26 RNA binding motif protein 26 0.0295462
SFPQ splicing factor proline/glutamine-rich 0.0295411
KRT18 keratin 18, type I 0.0293962
ZFAND3 zinc finger, AN1-type domain 3 0.0290942
TOR1AIP2 torsin A interacting protein 2 0.0290515
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0288471
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0287192
CCNC cyclin C 0.0286106
ATXN7 ataxin 7 0.0285106
BRD4 bromodomain containing 4 0.0281321
RFLNA refilin A 0.0280896
FLNB filamin B, beta 0.0280836
FUBP1 far upstream element (FUSE) binding protein 1 0.0275864
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0275203
CELF1 CUGBP, Elav-like family member 1 0.0273718
BBX bobby sox homolog (Drosophila) 0.0272513
SRSF5 serine/arginine-rich splicing factor 5 0.0271189
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0270931
ANKRD36 ankyrin repeat domain 36 0.0270617
BCLAF1 BCL2-associated transcription factor 1 0.0270401
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa 0.0269507
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0268931
RPL11 ribosomal protein L11 0.0265988
CORO1C coronin, actin binding protein, 1C 0.0264906
B2M beta-2-microglobulin 0.0263805
HMGA1 high mobility group AT-hook 1 0.0263476
FAM120A family with sequence similarity 120A 0.0259956
SPRED1 sprouty-related, EVH1 domain containing 1 0.0256568
ITCH itchy E3 ubiquitin protein ligase 0.0256531
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0255242
PNN pinin, desmosome associated protein 0.0253901
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0248668
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0248457
ANKRD11 ankyrin repeat domain 11 0.0246899
EP300 E1A binding protein p300 0.0245265
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0243488
TRA2B transformer 2 beta homolog (Drosophila) 0.0241786
NRDC nardilysin convertase 0.0241177
ARRDC3 arrestin domain containing 3 0.0241093

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.203246
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.176683
AHNAK AHNAK nucleoprotein -0.164441
PTMA prothymosin, alpha -0.126932
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.116594
INTS6 integrator complex subunit 6 -0.08549
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0803278
HDLBP high density lipoprotein binding protein -0.0792283
EGR1 early growth response 1 -0.0662229
EZR ezrin -0.0657691
UGDH UDP-glucose 6-dehydrogenase -0.058764
TPT1 tumor protein, translationally-controlled 1 -0.0575778
LOC102724023 ES1 protein homolog, mitochondrial -0.0564625
IARS1 isoleucyl-tRNA synthetase 1 -0.0556391
JUN jun proto-oncogene -0.054989
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.054772
SERINC5 serine incorporator 5 -0.0537606
LRRC23 leucine rich repeat containing 23 -0.0537322
VCL vinculin -0.0506263
FUS FUS RNA binding protein -0.0495385
RAB7A RAB7A, member RAS oncogene family -0.0489177
ACTG1 actin gamma 1 -0.0471429
RRBP1 ribosome binding protein 1 -0.0465891
RPLP0 ribosomal protein, large, P0 -0.0436808
SQSTM1 sequestosome 1 -0.0421569
FTL ferritin, light polypeptide -0.0416856
CADPS Ca++-dependent secretion activator -0.0414448
ZC3H11A zinc finger CCCH-type containing 11A -0.041102
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0400227
LMAN1 lectin, mannose-binding, 1 -0.0398351
CEMIP2 cell migration inducing hyaluronidase 2 -0.0398339
CANX calnexin -0.0394528
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0385056
CCND1 cyclin D1 -0.0366153
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0365933
NF1 neurofibromin 1 -0.0354537
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0352571
TPM4 tropomyosin 4 -0.0352428
ARF4 ADP-ribosylation factor 4 -0.0345124
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0341263
LOC112694756 uncharaterized LOC112694756 -0.0339964
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0335979
PKM pyruvate kinase, muscle -0.033506
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0334788
FOXO3 forkhead box O3 -0.0330147
NSD3 nuclear receptor binding SET domain protein 3 -0.0328439
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0328373
HBP1 HMG-box transcription factor 1 -0.031633
HMGB1 high mobility group box 1 -0.0315205
SNX14 sorting nexin 14 -0.0311968
TUBB tubulin, beta class I -0.0309737
MORF4L2 mortality factor 4 like 2 -0.0307696
COPB1 coatomer protein complex, subunit beta 1 -0.0304287
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0303896
RPS24 ribosomal protein S24 -0.0303474
SEC31A SEC31 homolog A (S. cerevisiae) -0.0303251
RPL4 ribosomal protein L4 -0.0303015
CLIC4 chloride intracellular channel 4 -0.0301662
DLG1 discs, large homolog 1 (Drosophila) -0.0301039
SPDYA speedy/RINGO cell cycle regulator family member A -0.029894
TKT transketolase -0.029209
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0291806
MCL1 myeloid cell leukemia 1 -0.0283423
TCF12 transcription factor 12 -0.0279606
P4HB prolyl 4-hydroxylase, beta polypeptide -0.027909
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0277615
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -0.0273077
RPL14 ribosomal protein L14 -0.0272359
WASF2 WAS protein family, member 2 -0.0271866
RBBP6 retinoblastoma binding protein 6 -0.0271828
RPS5 ribosomal protein S5 -0.0270504
GTF2B general transcription factor IIB -0.0270233
ARHGAP5 Rho GTPase activating protein 5 -0.0265629
LSR lipolysis stimulated lipoprotein receptor -0.026361
NASP nuclear autoantigenic sperm protein (histone-binding) -0.0263581
ARF1 ADP-ribosylation factor 1 -0.0261738
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0260773
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0259651
EPB41L5 erythrocyte membrane protein band 4.1 like 5 -0.0257072
RPS6 ribosomal protein S6 -0.0251814
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0251773
BZW2 basic leucine zipper and W2 domains 2 -0.0250329
RSL1D1 ribosomal L1 domain containing 1 -0.0248334
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0247645
UBC ubiquitin C -0.024722
BPTF bromodomain PHD finger transcription factor -0.0245498
RAD21 RAD21 homolog (S. pombe) -0.0245225
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -0.0240645
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0235521
RHOBTB3 Rho-related BTB domain containing 3 -0.0235064
SLC38A2 solute carrier family 38, member 2 -0.0234385
MT1E metallothionein 1E -0.0234274
MTAP methylthioadenosine phosphorylase -0.0232353
GNAS GNAS complex locus -0.0232243
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -0.0230564
MORC4 MORC family CW-type zinc finger 4 -0.0229932
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0228974
HOMER1 homer scaffolding protein 1 -0.0228593
SECISBP2 SECIS binding protein 2 -0.0228351
ERO1B endoplasmic reticulum oxidoreductase 1 beta -0.0228106