Chlorhexidine (diacetate)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.138148
SMAD3 SMAD family member 3 0.107284
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0976083
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0846995
FLNA filamin A, alpha 0.0777895
LPP LIM domain containing preferred translocation partner in lipoma 0.0743789
APP amyloid beta (A4) precursor protein 0.0714499
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0694584
ANKRD10 ankyrin repeat domain 10 0.0661927
AFDN afadin, adherens junction formation factor 0.0659267
LAMB3 laminin, beta 3 0.0655583
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0625846
SVIL supervillin 0.0614208
PRELID2 PRELI domain containing 2 0.0598271
ANKRD36 ankyrin repeat domain 36 0.0596852
ZNF292 zinc finger protein 292 0.0587949
FNDC3B fibronectin type III domain containing 3B 0.056786
RPS12 ribosomal protein S12 0.0560179
RPL35A ribosomal protein L35a 0.0548857
RPL23 ribosomal protein L23 0.0545453
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0530721
SFPQ splicing factor proline/glutamine-rich 0.0525103
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0519241
KDM6A lysine (K)-specific demethylase 6A 0.051615
SET SET nuclear proto-oncogene 0.0515869
RPL37A ribosomal protein L37a 0.0515149
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0507947
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0487662
USP9X ubiquitin specific peptidase 9, X-linked 0.0485138
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0483887
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0467018
RPL5 ribosomal protein L5 0.0461536
RPL9 ribosomal protein L9 0.0454346
PLEC plectin 0.0454149
TRIO trio Rho guanine nucleotide exchange factor 0.0453154
RPL26 ribosomal protein L26 0.0444433
NCKAP1 NCK-associated protein 1 0.0424763
ANKRD11 ankyrin repeat domain 11 0.04191
PRRC2C proline-rich coiled-coil 2C 0.0415588
MACF1 microtubule-actin crosslinking factor 1 0.0411723
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0410509
RASA2 RAS p21 protein activator 2 0.0405435
YEATS2 YEATS domain containing 2 0.0401785
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0396851
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0393085
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0385312
EEF2 eukaryotic translation elongation factor 2 0.0383731
TPM3 tropomyosin 3 0.0379566
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0375591
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0375245
PUM1 pumilio RNA-binding family member 1 0.0374247
RPS8 ribosomal protein S8 0.0372888
FUBP1 far upstream element (FUSE) binding protein 1 0.0372451
CUL3 cullin 3 0.0371503
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0364641
RPL11 ribosomal protein L11 0.0363625
RPS2 ribosomal protein S2 0.0356483
ATXN7 ataxin 7 0.0353123
RPL3 ribosomal protein L3 0.0351462
WWC1 WW and C2 domain containing 1 0.0351005
TBC1D22A TBC1 domain family, member 22A 0.0344708
RPL13A ribosomal protein L13a 0.034468
CTBP2 C-terminal binding protein 2 0.034342
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.034085
NRIP1 nuclear receptor interacting protein 1 0.0339657
OSBPL10 oxysterol binding protein-like 10 0.033912
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.033847
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0338413
MPRIP myosin phosphatase Rho interacting protein 0.033767
RPS3 ribosomal protein S3 0.0336928
TNRC6A trinucleotide repeat containing 6A 0.0324269
TRIM2 tripartite motif containing 2 0.0324195
PTK2 protein tyrosine kinase 2 0.0322975
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0319834
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0319309
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0317487
KDM4B lysine (K)-specific demethylase 4B 0.0316627
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.030815
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.030511
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0304459
SEPTIN9 septin 9 0.0303285
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0301171
NAP1L1 nucleosome assembly protein 1-like 1 0.030108
CTNND1 catenin (cadherin-associated protein), delta 1 0.0300054
TMSB10 thymosin beta 10 0.0298812
SIK3 SIK family kinase 3 0.0298722
RTN4 reticulon 4 0.0296893
FNIP1 folliculin interacting protein 1 0.0296862
CAMTA1 calmodulin binding transcription activator 1 0.029529
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0292874
ACTN4 actinin, alpha 4 0.0292727
CELF1 CUGBP, Elav-like family member 1 0.0291908
ANXA11 annexin A11 0.029126
UBE3A ubiquitin protein ligase E3A 0.0288985
WAC WW domain containing adaptor with coiled-coil 0.0287849
TNIP1 TNFAIP3 interacting protein 1 0.0286273
ANKRD17 ankyrin repeat domain 17 0.0282821
HELZ helicase with zinc finger 0.0280473
BCAR3 breast cancer anti-estrogen resistance 3 0.027887
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.027761

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.196946
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.148603
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.124139
FTL ferritin, light polypeptide -0.108557
CCND1 cyclin D1 -0.0900878
ACTG1 actin gamma 1 -0.0793174
RHEX regulator of hemoglobinization and erythroid cell expansion -0.0745035
ALCAM activated leukocyte cell adhesion molecule -0.0616855
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0590486
GARS1 glycyl-tRNA synthetase 1 -0.0539288
AHNAK AHNAK nucleoprotein -0.0532373
TUBB tubulin, beta class I -0.0521112
CANX calnexin -0.0511878
HDLBP high density lipoprotein binding protein -0.0491602
IARS1 isoleucyl-tRNA synthetase 1 -0.0474274
TMSB4X thymosin beta 4, X-linked -0.0471012
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0469165
CREB5 cAMP responsive element binding protein 5 -0.0456641
PDIA3 protein disulfide isomerase family A, member 3 -0.0447617
TUBA1B tubulin, alpha 1b -0.044723
H1-0 H1.0 linker histone -0.0441486
FTH1 ferritin, heavy polypeptide 1 -0.041086
POTEF POTE ankyrin domain family, member F -0.0397291
RPLP0 ribosomal protein, large, P0 -0.0396851
RPS6 ribosomal protein S6 -0.0395078
MT2A metallothionein 2A -0.038379
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0377793
VDAC1 voltage-dependent anion channel 1 -0.0367097
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0366787
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0364407
MT1X metallothionein 1X -0.0357137
PKM pyruvate kinase, muscle -0.0354572
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0333106
RRBP1 ribosome binding protein 1 -0.0327813
WDR45B WD repeat domain 45B -0.0325319
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0322539
GNAS GNAS complex locus -0.0321709
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0313558
FHIT fragile histidine triad -0.0310409
LMAN1 lectin, mannose-binding, 1 -0.0306323
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0301081
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0298251
EREG epiregulin -0.0297735
F3 coagulation factor III (thromboplastin, tissue factor) -0.0292944
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0286072
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0286059
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0284794
RPL32 ribosomal protein L32 -0.0281001
WASF2 WAS protein family, member 2 -0.0280741
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0270661
S100A10 S100 calcium binding protein A10 -0.0266492
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0264953
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0262706
CDCP1 CUB domain containing protein 1 -0.0260564
DARS1 aspartyl-tRNA synthetase 1 -0.0251959
TKT transketolase -0.0249923
GAS2L3 growth arrest-specific 2 like 3 -0.0248573
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0246873
CBX3 chromobox homolog 3 -0.0246246
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0245927
S100A6 S100 calcium binding protein A6 -0.0245839
EGR1 early growth response 1 -0.0244317
VCAN versican -0.0242983
VCL vinculin -0.0242655
CCNI cyclin I -0.0242321
KRT19 keratin 19, type I -0.0239033
RSL1D1 ribosomal L1 domain containing 1 -0.0238411
LOC112694756 uncharaterized LOC112694756 -0.0237043
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 -0.0236177
WWOX WW domain containing oxidoreductase -0.0235054
RPS5 ribosomal protein S5 -0.0226851
EIF1 eukaryotic translation initiation factor 1 -0.0224376
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0222323
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0222136
PTMA prothymosin, alpha -0.0220928
BZW1 basic leucine zipper and W2 domains 1 -0.0220401
IER3 immediate early response 3 -0.0218871
DEK DEK proto-oncogene -0.0216882
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0215433
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0209338
RAP1B RAP1B, member of RAS oncogene family -0.0207838
PNRC1 proline-rich nuclear receptor coactivator 1 -0.020763
ABLIM1 actin binding LIM protein 1 -0.0206425
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0202094
BICD1 bicaudal D homolog 1 (Drosophila) -0.0198957
KMT2A lysine (K)-specific methyltransferase 2A -0.0198473
TPI1 triosephosphate isomerase 1 -0.019583
ZMYM4 zinc finger, MYM-type 4 -0.0194335
PERP PERP, TP53 apoptosis effector -0.0191923
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0191877
STAU1 staufen double-stranded RNA binding protein 1 -0.0190909
LITAF lipopolysaccharide-induced TNF factor -0.0190305
RPL14 ribosomal protein L14 -0.0187606
DLG1 discs, large homolog 1 (Drosophila) -0.0186992
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0186927
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0185415
SEPTIN2 septin 2 -0.0185001
NOLC1 nucleolar and coiled-body phosphoprotein 1 -0.0184014
RPL8 ribosomal protein L8 -0.0183802
LARS1 leucyl-tRNA synthetase 1 -0.0182032