Chlorhexidine (diacetate)_HT-29 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in HT-29 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.172583
ATXN1 ataxin 1 0.112873
GCLC glutamate-cysteine ligase, catalytic subunit 0.104255
LMO7 LIM domain 7 0.10017
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0916182
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0823723
PTK2 protein tyrosine kinase 2 0.0808261
NECTIN2 nectin cell adhesion molecule 2 0.071662
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0678224
CTNND1 catenin (cadherin-associated protein), delta 1 0.0657432
FOXO1 forkhead box O1 0.0626874
NF1 neurofibromin 1 0.0623996
AKAP13 A kinase (PRKA) anchor protein 13 0.0620195
TRAPPC9 trafficking protein particle complex 9 0.0559365
AFDN afadin, adherens junction formation factor 0.0550026
ACTN4 actinin, alpha 4 0.0544832
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0541993
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.054155
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0540479
EXT1 exostosin glycosyltransferase 1 0.0523935
STK24 serine/threonine kinase 24 0.0522029
BCL2L1 BCL2-like 1 0.0520964
KRT18 keratin 18, type I 0.0513689
PARP4 poly (ADP-ribose) polymerase family, member 4 0.050769
MBNL2 muscleblind-like splicing regulator 2 0.0482123
PKP4 plakophilin 4 0.0476486
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0469664
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0468304
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0463931
TRPS1 trichorhinophalangeal syndrome I 0.0462857
OGA O-GlcNAcase 0.0461603
PATJ PATJ crumbs cell polarity complex component 0.0459368
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0458371
DST dystonin 0.0457437
SFPQ splicing factor proline/glutamine-rich 0.0448934
EPS8 epidermal growth factor receptor pathway substrate 8 0.0446128
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0440974
NAMPT nicotinamide phosphoribosyltransferase 0.0439634
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0434476
RAD21 RAD21 homolog (S. pombe) 0.0431264
FAM91A1 family with sequence similarity 91, member A1 0.0429618
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0423346
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0410277
ZFAND3 zinc finger, AN1-type domain 3 0.0394379
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.038878
GPBP1L1 GC-rich promoter binding protein 1-like 1 0.0385791
TTC17 tetratricopeptide repeat domain 17 0.0384224
PLAUR plasminogen activator, urokinase receptor 0.038378
ETV6 ets variant 6 0.0383432
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0382757
LAMB3 laminin, beta 3 0.0382528
CHD7 chromodomain helicase DNA binding protein 7 0.0380948
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0378263
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0377362
ARHGAP29 Rho GTPase activating protein 29 0.037728
ANXA11 annexin A11 0.0376557
FAM135A family with sequence similarity 135, member A 0.0375103
TPM3 tropomyosin 3 0.0373108
MBNL1 muscleblind-like splicing regulator 1 0.0371103
CSNK1A1 casein kinase 1, alpha 1 0.0368115
PCCA propionyl CoA carboxylase, alpha polypeptide 0.03678
EXPH5 exophilin 5 0.0367759
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0367341
EXOC4 exocyst complex component 4 0.0359596
JMJD1C jumonji domain containing 1C 0.035941
VASP vasodilator-stimulated phosphoprotein 0.0359325
ANKRD10 ankyrin repeat domain 10 0.0359043
ITGB4 integrin, beta 4 0.0355764
GOLGB1 golgin B1 0.0352164
ARHGAP23 Rho GTPase activating protein 23 0.0350595
ESRP1 epithelial splicing regulatory protein 1 0.0349882
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0348719
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0348499
TJP2 tight junction protein 2 0.034789
EFR3A EFR3 homolog A (S. cerevisiae) 0.0347577
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0346027
PRKN parkin RBR E3 ubiquitin protein ligase 0.0344354
WWC1 WW and C2 domain containing 1 0.0343546
MKI67 marker of proliferation Ki-67 0.0342671
SMAD3 SMAD family member 3 0.0340146
MYH9 myosin, heavy chain 9, non-muscle 0.0330667
BTBD9 BTB (POZ) domain containing 9 0.0329081
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0328403
RPS12 ribosomal protein S12 0.032752
TAS2R14 taste receptor, type 2, member 14 0.0327215
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0320302
LPP LIM domain containing preferred translocation partner in lipoma 0.031872
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0314158
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.031375
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa 0.0313458
LMNA lamin A/C 0.0313003
ARHGAP32 Rho GTPase activating protein 32 0.0311756
PICALM phosphatidylinositol binding clathrin assembly protein 0.0310264
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0308741
SPATA13 spermatogenesis associated 13 0.0306679
CUL4A cullin 4A 0.0304484
SEPTIN9 septin 9 0.0304078
ERBIN erbb2 interacting protein 0.0303868
AGO2 argonaute RISC catalytic component 2 0.0302413
FAT1 FAT atypical cadherin 1 0.0302108

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.206179
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.16047
INTS6 integrator complex subunit 6 -0.10319
RPS6 ribosomal protein S6 -0.0918446
KRT20 keratin 20, type I -0.085855
MYH14 myosin, heavy chain 14, non-muscle -0.0843856
PKM pyruvate kinase, muscle -0.0831216
LYZ lysozyme -0.0786522
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.075985
FTH1 ferritin, heavy polypeptide 1 -0.0745855
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.074414
NDRG1 N-myc downstream regulated 1 -0.0659602
PDIA3 protein disulfide isomerase family A, member 3 -0.0637167
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0600814
FRY furry homolog (Drosophila) -0.0557082
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0549794
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0516645
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0506065
EGR1 early growth response 1 -0.0503551
RPLP0 ribosomal protein, large, P0 -0.0497777
FOS FBJ murine osteosarcoma viral oncogene homolog -0.049349
LOC112694756 uncharaterized LOC112694756 -0.0475534
FOXO3 forkhead box O3 -0.0457388
DDIT3 DNA-damage-inducible transcript 3 -0.0452855
POF1B premature ovarian failure, 1B -0.0450544
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0443983
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0443566
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0430061
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0417579
GNAS GNAS complex locus -0.0417071
GARS1 glycyl-tRNA synthetase 1 -0.0410833
RPLP1 ribosomal protein, large, P1 -0.0403156
EIF1 eukaryotic translation initiation factor 1 -0.0395451
VCL vinculin -0.0392348
INSIG1 insulin induced gene 1 -0.0391767
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0374602
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0356755
RPL28 ribosomal protein L28 -0.0355477
KRT19 keratin 19, type I -0.0353597
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.035109
JUN jun proto-oncogene -0.033365
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0333168
PGK1 phosphoglycerate kinase 1 -0.0331484
ACTG1 actin gamma 1 -0.0327877
RPL12 ribosomal protein L12 -0.0322855
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0322676
AHNAK AHNAK nucleoprotein -0.032143
MT2A metallothionein 2A -0.0320064
FBXO32 F-box protein 32 -0.0318555
BTG1 B-cell translocation gene 1, anti-proliferative -0.0308231
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0304824
FAM13A family with sequence similarity 13, member A -0.0303408
SERTAD2 SERTA domain containing 2 -0.0300555
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.029524
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0283877
LDHA lactate dehydrogenase A -0.0279879
S100A10 S100 calcium binding protein A10 -0.0278524
TPI1 triosephosphate isomerase 1 -0.0277573
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0273578
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0273436
VIM vimentin -0.0269049
PERP PERP, TP53 apoptosis effector -0.026823
RPS23 ribosomal protein S23 -0.0267866
ACACA acetyl-CoA carboxylase alpha -0.0267708
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0261895
SQSTM1 sequestosome 1 -0.0257207
SNX14 sorting nexin 14 -0.0256363
RPLP2 ribosomal protein, large, P2 -0.0254417
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0253465
TPT1 tumor protein, translationally-controlled 1 -0.0250316
TLE4 transducin-like enhancer of split 4 -0.0242281
ARF4 ADP-ribosylation factor 4 -0.024087
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.023886
RPL21 ribosomal protein L21 -0.0238482
PTMA prothymosin, alpha -0.0236474
POTEF POTE ankyrin domain family, member F -0.0236469
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 -0.0234928
PRR5L proline rich 5 like -0.0233836
RPL27A ribosomal protein L27a -0.0233647
IFRD1 interferon-related developmental regulator 1 -0.0232822
PHF3 PHD finger protein 3 -0.0231818
RPL19 ribosomal protein L19 -0.0226176
RPS16 ribosomal protein S16 -0.022583
RPS20 ribosomal protein S20 -0.0223871
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.0223704
ADM adrenomedullin -0.0222246
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.02217
WDR45B WD repeat domain 45B -0.0221498
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0216703
IARS1 isoleucyl-tRNA synthetase 1 -0.0211819
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0210442
LAMA4 laminin, alpha 4 -0.0208038
HILPDA hypoxia inducible lipid droplet-associated -0.0207673
KDM5B lysine (K)-specific demethylase 5B -0.0206144
SESN2 sestrin 2 -0.0201993
RPS24 ribosomal protein S24 -0.0201458
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -0.0200085
RPS5 ribosomal protein S5 -0.0199797
GSTP1 glutathione S-transferase pi 1 -0.0199556
LGALS4 lectin, galactoside-binding, soluble, 4 -0.0198384