Chlorhexidine (diacetate)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FLNB filamin B, beta 0.231653
NDRG1 N-myc downstream regulated 1 0.149339
TRIO trio Rho guanine nucleotide exchange factor 0.116647
CEMIP cell migration inducing protein, hyaluronan binding 0.116181
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.107976
MYH9 myosin, heavy chain 9, non-muscle 0.0996195
MYOF myoferlin 0.0845116
FOXO1 forkhead box O1 0.0801222
MEF2A myocyte enhancer factor 2A 0.077138
DOCK5 dedicator of cytokinesis 5 0.07233
BCL2L1 BCL2-like 1 0.0696061
SMAD3 SMAD family member 3 0.0614428
EFHD2 EF-hand domain family, member D2 0.0610036
RIN2 Ras and Rab interactor 2 0.0583163
ESYT2 extended synaptotagmin-like protein 2 0.0572908
BLCAP bladder cancer associated protein 0.0562447
MSN moesin 0.0554297
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0548645
TGM2 transglutaminase 2 0.0543201
CLU clusterin 0.0537795
PRELID2 PRELI domain containing 2 0.0531159
TPM3 tropomyosin 3 0.052432
SLK STE20-like kinase 0.0511003
NRG1 neuregulin 1 0.0487962
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0479851
PLEC plectin 0.0475181
CD44 CD44 molecule (Indian blood group) 0.047264
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0471387
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0462787
NCOR2 nuclear receptor corepressor 2 0.0458317
ENO1 enolase 1, (alpha) 0.0453061
SULF1 sulfatase 1 0.0443947
MCL1 myeloid cell leukemia 1 0.0443324
CAPRIN2 caprin family member 2 0.0428673
FNDC3B fibronectin type III domain containing 3B 0.042805
CTNND1 catenin (cadherin-associated protein), delta 1 0.0423569
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0418733
ANKRD33B ankyrin repeat domain 33B 0.0416182
MBNL2 muscleblind-like splicing regulator 2 0.0412712
NRIP1 nuclear receptor interacting protein 1 0.0411073
LAMA5 laminin, alpha 5 0.0410607
PDLIM1 PDZ and LIM domain 1 0.0409418
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0407335
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0398308
CMIP c-Maf inducing protein 0.0397929
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0396096
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0389495
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0389136
PLAT plasminogen activator, tissue 0.0388715
KIAA1217 KIAA1217 0.0385671
SEPTIN9 septin 9 0.0385401
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.037876
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0378218
NAMPT nicotinamide phosphoribosyltransferase 0.0371256
NEK7 NIMA-related kinase 7 0.0365788
AKAP9 A kinase (PRKA) anchor protein 9 0.0361106
EFNA5 ephrin-A5 0.0360269
LOXL2 lysyl oxidase-like 2 0.0353663
ITCH itchy E3 ubiquitin protein ligase 0.0344797
DOK5 docking protein 5 0.0344336
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0342334
AOPEP aminopeptidase O (putative) 0.0338324
ARHGAP21 Rho GTPase activating protein 21 0.0332669
KTN1 kinectin 1 (kinesin receptor) 0.0331229
IFITM1 interferon induced transmembrane protein 1 0.0329577
ANXA11 annexin A11 0.0326481
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0326146
METTL15 methyltransferase like 15 0.0321587
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0320493
DST dystonin 0.0318509
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0316115
EPHA2 EPH receptor A2 0.0314906
LNPEP leucyl/cystinyl aminopeptidase 0.0311852
PODXL podocalyxin-like 0.0307238
KIF16B kinesin family member 16B 0.0305029
SLTM SAFB-like, transcription modulator 0.0303804
APLP2 amyloid beta (A4) precursor-like protein 2 0.0301996
TSC22D1 TSC22 domain family, member 1 0.0299667
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0298425
EZR ezrin 0.029592
ITGB4 integrin, beta 4 0.0295693
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0293912
EHBP1L1 EH domain binding protein 1-like 1 0.0292168
ARHGAP23 Rho GTPase activating protein 23 0.0291211
DGKD diacylglycerol kinase, delta 130kDa 0.0286299
CD59 CD59 molecule, complement regulatory protein 0.0286205
KDM7A lysine (K)-specific demethylase 7A 0.0282666
ANXA1 annexin A1 0.0282632
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0280026
FOXP1 forkhead box P1 0.0279538
KMT2E lysine (K)-specific methyltransferase 2E 0.0277544
ARRDC3 arrestin domain containing 3 0.0275927
SOX13 SRY (sex determining region Y)-box 13 0.0275749
RPL3 ribosomal protein L3 0.027175
SLC45A4 solute carrier family 45, member 4 0.0265868
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0265104
SYNJ2 synaptojanin 2 0.026475
CD47 CD47 molecule 0.0263781
FLNA filamin A, alpha 0.0261734
YBX3 Y box binding protein 3 0.0260719

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.227234
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.170002
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.163556
TPT1 tumor protein, translationally-controlled 1 -0.115936
PTMA prothymosin, alpha -0.0987845
INTS6 integrator complex subunit 6 -0.0897683
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0884764
RPS24 ribosomal protein S24 -0.0678006
AHNAK AHNAK nucleoprotein -0.066115
SLC35F3 solute carrier family 35, member F3 -0.0633381
S100A10 S100 calcium binding protein A10 -0.0596679
RPS6 ribosomal protein S6 -0.056987
RPS21 ribosomal protein S21 -0.0563756
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0562097
STC1 stanniocalcin 1 -0.0541832
ALCAM activated leukocyte cell adhesion molecule -0.054174
POTEF POTE ankyrin domain family, member F -0.0531151
GNAS GNAS complex locus -0.0524351
RIGI RNA sensor RIG-I -0.0513196
ABI3BP ABI family, member 3 (NESH) binding protein -0.0492621
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0477381
PLS3 plastin 3 -0.047425
TMSB4X thymosin beta 4, X-linked -0.0456357
LMO7 LIM domain 7 -0.0427346
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0424395
IARS1 isoleucyl-tRNA synthetase 1 -0.0423241
RPS25 ribosomal protein S25 -0.0416481
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0395476
GRB10 growth factor receptor-bound protein 10 -0.0390557
SOD2 superoxide dismutase 2, mitochondrial -0.0387639
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0378918
RPL34 ribosomal protein L34 -0.0373126
HMGA2 high mobility group AT-hook 2 -0.0370586
PRSS23 protease, serine, 23 -0.0362006
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0361778
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0360302
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0355001
H1-0 H1.0 linker histone -0.034977
VDAC1 voltage-dependent anion channel 1 -0.0349548
STAU1 staufen double-stranded RNA binding protein 1 -0.0347364
TMSB10 thymosin beta 10 -0.0347136
ACTG1 actin gamma 1 -0.0341013
RPS8 ribosomal protein S8 -0.0337053
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.0336574
FNDC3A fibronectin type III domain containing 3A -0.0335025
RPLP0 ribosomal protein, large, P0 -0.0334425
PALLD palladin, cytoskeletal associated protein -0.033285
LAMC2 laminin, gamma 2 -0.0327872
PSD3 pleckstrin and Sec7 domain containing 3 -0.0327846
SQSTM1 sequestosome 1 -0.032641
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.032576
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0321943
RPLP2 ribosomal protein, large, P2 -0.0317242
CAV1 caveolin 1, caveolae protein, 22kDa -0.0313081
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 -0.0307364
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0304347
RPLP1 ribosomal protein, large, P1 -0.0301842
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0301286
PDE4D phosphodiesterase 4D, cAMP-specific -0.0295511
BZW1 basic leucine zipper and W2 domains 1 -0.029477
TOP1 topoisomerase (DNA) I -0.0291152
LRP1B low density lipoprotein receptor-related protein 1B -0.0289582
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0284699
WARS1 tryptophanyl-tRNA synthetase 1 -0.0281359
RPS23 ribosomal protein S23 -0.0264948
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.0264612
WASF2 WAS protein family, member 2 -0.0260784
GARS1 glycyl-tRNA synthetase 1 -0.0260495
RPL7A ribosomal protein L7a -0.0258319
RPL12 ribosomal protein L12 -0.0255403
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0253045
CCND1 cyclin D1 -0.0252825
HMGB1 high mobility group box 1 -0.0251392
RPL19 ribosomal protein L19 -0.0250541
RTN3 reticulon 3 -0.024739
ZMYND8 zinc finger, MYND-type containing 8 -0.0243244
FTH1 ferritin, heavy polypeptide 1 -0.0238189
RPL27A ribosomal protein L27a -0.0237712
CAVIN1 caveolae associated protein 1 -0.0236367
ARF1 ADP-ribosylation factor 1 -0.0236266
THBD thrombomodulin -0.0234696
RPL8 ribosomal protein L8 -0.0232638
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0230996
UBC ubiquitin C -0.023067
SULF2 sulfatase 2 -0.0229616
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0224309
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0223872
ANO1 anoctamin 1, calcium activated chloride channel -0.0223525
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0222784
CAPN2 calpain 2, (m/II) large subunit -0.0219194
RCOR1 REST corepressor 1 -0.0218983
MT1E metallothionein 1E -0.0218791
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0218365
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0217987
ZNFX1 zinc finger, NFX1-type containing 1 -0.0217676
ABLIM1 actin binding LIM protein 1 -0.0215545
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0214915
RPS16 ribosomal protein S16 -0.0214366
SAMD9 sterile alpha motif domain containing 9 -0.0214113
IER3 immediate early response 3 -0.021395