Chlorhexidine (diacetate)_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.291469
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.150063
ERBIN erbb2 interacting protein 0.100781
ZNF841 zinc finger protein 841 0.0826284
EXT1 exostosin glycosyltransferase 1 0.0793576
MYH9 myosin, heavy chain 9, non-muscle 0.0759215
DST dystonin 0.074623
ATP13A3 ATPase type 13A3 0.0678509
SET SET nuclear proto-oncogene 0.0673715
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0657646
ELL2 elongation factor, RNA polymerase II, 2 0.0647733
TPM3 tropomyosin 3 0.0644392
CALR calreticulin 0.0635999
PALM2AKAP2 PALM2 and AKAP2 fusion 0.054152
CD59 CD59 molecule, complement regulatory protein 0.0540747
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0538766
PODXL podocalyxin-like 0.0496724
NAMPT nicotinamide phosphoribosyltransferase 0.0481252
RPL35A ribosomal protein L35a 0.0474574
FLNB filamin B, beta 0.0451092
CD44 CD44 molecule (Indian blood group) 0.0449711
HEG1 heart development protein with EGF-like domains 1 0.042477
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.041184
HLA-A major histocompatibility complex, class I, A 0.0408803
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0393664
RASA2 RAS p21 protein activator 2 0.0380068
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0358217
BCL2L1 BCL2-like 1 0.035782
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0355235
LDHA lactate dehydrogenase A 0.035073
NUP58 nucleoporin 58 0.0348767
RPS3 ribosomal protein S3 0.0331054
NEK7 NIMA-related kinase 7 0.032844
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0323189
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0321857
PTK2 protein tyrosine kinase 2 0.0320222
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0315586
SMAD3 SMAD family member 3 0.0313178
ENO1 enolase 1, (alpha) 0.0311587
UGCG UDP-glucose ceramide glucosyltransferase 0.0303983
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0300142
ARGLU1 arginine and glutamate rich 1 0.0297345
RPL26 ribosomal protein L26 0.0295244
PPME1 protein phosphatase methylesterase 1 0.0292899
BCAR3 breast cancer anti-estrogen resistance 3 0.0290667
RPL23 ribosomal protein L23 0.0288489
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0285794
ATAD2 ATPase family, AAA domain containing 2 0.028514
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0283295
RPS12 ribosomal protein S12 0.0283046
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0282924
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.028156
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0278836
TMSB10 thymosin beta 10 0.0277633
PDIA6 protein disulfide isomerase family A, member 6 0.026415
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0256755
COL7A1 collagen, type VII, alpha 1 0.0247038
MKI67 marker of proliferation Ki-67 0.024466
PTBP2 polypyrimidine tract binding protein 2 0.0242103
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0240817
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0238881
DENND5A DENN/MADD domain containing 5A 0.0237403
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0237266
ZNF148 zinc finger protein 148 0.0235215
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.02346
SMC4 structural maintenance of chromosomes 4 0.0231573
COL4A2 collagen, type IV, alpha 2 0.0230319
NCOR2 nuclear receptor corepressor 2 0.0229952
RPS2 ribosomal protein S2 0.0229696
OSMR oncostatin M receptor 0.0227334
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0224767
MATR3 matrin 3 0.02234
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0223311
UBA6 ubiquitin-like modifier activating enzyme 6 0.0223249
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.022088
AGFG1 ArfGAP with FG repeats 1 0.0215989
PUM1 pumilio RNA-binding family member 1 0.0215299
PICALM phosphatidylinositol binding clathrin assembly protein 0.0214543
ANGPTL4 angiopoietin-like 4 0.0214324
ANKRD36 ankyrin repeat domain 36 0.0212052
KLC1 kinesin light chain 1 0.0211385
CFB complement factor B 0.0210853
BASP1 brain abundant, membrane attached signal protein 1 0.0208698
TRA2B transformer 2 beta homolog (Drosophila) 0.0207457
NUP153 nucleoporin 153kDa 0.0205855
SFPQ splicing factor proline/glutamine-rich 0.0202551
ARRDC3 arrestin domain containing 3 0.0202283
CEP250 centrosomal protein 250kDa 0.020107
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0199813
B2M beta-2-microglobulin 0.0199786
GANAB glucosidase, alpha; neutral AB 0.0199759
SH3RF1 SH3 domain containing ring finger 1 0.0197495
SRSF5 serine/arginine-rich splicing factor 5 0.0196694
MSN moesin 0.0195731
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa 0.0195183
RPL37A ribosomal protein L37a 0.0194323
RPL30 ribosomal protein L30 0.0193701
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0193359
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0190413
FAT1 FAT atypical cadherin 1 0.0188591

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.250481
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.222776
ABI3BP ABI family, member 3 (NESH) binding protein -0.154046
NALF1 NALCN channel auxiliary factor 1 -0.118578
FN1 fibronectin 1 -0.100256
INTS6 integrator complex subunit 6 -0.0900184
MAP1B microtubule-associated protein 1B -0.0894876
DEK DEK proto-oncogene -0.0825273
FTH1 ferritin, heavy polypeptide 1 -0.0790765
HLA-B major histocompatibility complex, class I, B -0.0679328
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0602707
AHNAK AHNAK nucleoprotein -0.0579031
IARS1 isoleucyl-tRNA synthetase 1 -0.0576823
SQSTM1 sequestosome 1 -0.0558892
SLIT2 slit homolog 2 (Drosophila) -0.0514292
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0511073
IGFBP3 insulin-like growth factor binding protein 3 -0.0498451
POTEF POTE ankyrin domain family, member F -0.044659
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0444659
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0417329
PLIN2 perilipin 2 -0.0408054
CCND1 cyclin D1 -0.0405401
COPB1 coatomer protein complex, subunit beta 1 -0.0400378
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0395283
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0387659
F3 coagulation factor III (thromboplastin, tissue factor) -0.0387487
STAU1 staufen double-stranded RNA binding protein 1 -0.0367547
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.035607
MTDH metadherin -0.035576
CTSD cathepsin D -0.0355609
CANX calnexin -0.0349361
ACTG1 actin gamma 1 -0.0346049
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0341898
GOLGB1 golgin B1 -0.0339541
ZBTB20 zinc finger and BTB domain containing 20 -0.0332328
RAB7A RAB7A, member RAS oncogene family -0.0331426
WASF2 WAS protein family, member 2 -0.0322688
PKM pyruvate kinase, muscle -0.0320011
RTN3 reticulon 3 -0.0312723
TMSB4X thymosin beta 4, X-linked -0.0310002
MT1X metallothionein 1X -0.0306525
NABP1 nucleic acid binding protein 1 -0.030144
LMAN1 lectin, mannose-binding, 1 -0.0299812
HDLBP high density lipoprotein binding protein -0.0293092
MAP4 microtubule-associated protein 4 -0.029007
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0289736
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0285698
BZW1 basic leucine zipper and W2 domains 1 -0.0282744
ATXN1 ataxin 1 -0.0280413
CDK6 cyclin-dependent kinase 6 -0.0279545
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.027918
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0279137
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.027867
COPA coatomer protein complex, subunit alpha -0.0277679
VDAC1 voltage-dependent anion channel 1 -0.0277574
MMP12 matrix metallopeptidase 12 -0.0276687
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0275369
SETX senataxin -0.0274101
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0270838
DLG1 discs, large homolog 1 (Drosophila) -0.0265554
TKT transketolase -0.0263053
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0259784
MYOF myoferlin -0.0259568
LARS1 leucyl-tRNA synthetase 1 -0.0259295
RPS6 ribosomal protein S6 -0.025921
ARF4 ADP-ribosylation factor 4 -0.0256906
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0256327
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0255551
LOC112694756 uncharaterized LOC112694756 -0.0254174
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0253492
FNIP1 folliculin interacting protein 1 -0.025174
GOLGA4 golgin A4 -0.0250563
CCDC80 coiled-coil domain containing 80 -0.0249386
PHACTR1 phosphatase and actin regulator 1 -0.0247554
BTG1 B-cell translocation gene 1, anti-proliferative -0.0246104
SLC38A2 solute carrier family 38, member 2 -0.0245602
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0240944
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0240723
NIBAN1 niban apoptosis regulator 1 -0.0240574
CAVIN1 caveolae associated protein 1 -0.0239462
ZXDC ZXD family zinc finger C -0.0237907
AFF4 AF4/FMR2 family, member 4 -0.023461
CLIC4 chloride intracellular channel 4 -0.0233531
S100A10 S100 calcium binding protein A10 -0.023255
CUX1 cut-like homeobox 1 -0.0229966
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.022959
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0228582
TPM4 tropomyosin 4 -0.0228546
PLCB4 phospholipase C, beta 4 -0.0228334
RPL28 ribosomal protein L28 -0.0223476
POSTN periostin, osteoblast specific factor -0.0222241
BBX bobby sox homolog (Drosophila) -0.0220241
SEC31A SEC31 homolog A (S. cerevisiae) -0.021948
EGR1 early growth response 1 -0.0217497
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0213858
UBC ubiquitin C -0.0213179
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0212995
TMEM263 transmembrane protein 263 -0.0211796
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0211442
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0210108