Chlorhexidine (diacetate)_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DTNA dystrobrevin, alpha 0.210148
RPS12 ribosomal protein S12 0.131593
RPL23 ribosomal protein L23 0.110215
MT2A metallothionein 2A 0.10813
EXT1 exostosin glycosyltransferase 1 0.104479
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0923551
RPS3 ribosomal protein S3 0.085734
NUP58 nucleoporin 58 0.083865
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.083122
RPL35A ribosomal protein L35a 0.0766969
MYH9 myosin, heavy chain 9, non-muscle 0.075571
TXNRD1 thioredoxin reductase 1 0.0747807
RUNX1 runt-related transcription factor 1 0.0738172
FTL ferritin, light polypeptide 0.0735783
DST dystonin 0.0698867
RPL37A ribosomal protein L37a 0.06874
NAP1L1 nucleosome assembly protein 1-like 1 0.0686653
KDM3A lysine (K)-specific demethylase 3A 0.0621469
EEF2 eukaryotic translation elongation factor 2 0.0612566
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0597117
SPAG9 sperm associated antigen 9 0.057112
YBX3 Y box binding protein 3 0.0571064
RPL12 ribosomal protein L12 0.0509278
RND3 Rho family GTPase 3 0.0508326
RPL26 ribosomal protein L26 0.050496
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0504856
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0500413
ENO1 enolase 1, (alpha) 0.0499964
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.049809
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0493652
RPS17 ribosomal protein S17 0.0487719
TPM3 tropomyosin 3 0.0485578
GOLGA4 golgin A4 0.0476626
RPS19 ribosomal protein S19 0.0475164
TMSB10 thymosin beta 10 0.0473689
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0464692
PGK1 phosphoglycerate kinase 1 0.0458253
MARCHF6 membrane associated ring-CH-type finger 6 0.0457739
RPL11 ribosomal protein L11 0.0456593
NAMPT nicotinamide phosphoribosyltransferase 0.04471
RPL36 ribosomal protein L36 0.0445395
RPS8 ribosomal protein S8 0.0436722
ADAM9 ADAM metallopeptidase domain 9 0.0435901
WSB1 WD repeat and SOCS box containing 1 0.0431307
APP amyloid beta (A4) precursor protein 0.0421098
ELL2 elongation factor, RNA polymerase II, 2 0.0420779
LIMA1 LIM domain and actin binding 1 0.0418431
HSPA8 heat shock 70kDa protein 8 0.0410589
WDR45B WD repeat domain 45B 0.0402446
ZNF292 zinc finger protein 292 0.0400938
LSAMP limbic system-associated membrane protein 0.0399914
RPL5 ribosomal protein L5 0.0399378
RPLP1 ribosomal protein, large, P1 0.039244
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0391108
UGCG UDP-glucose ceramide glucosyltransferase 0.0387621
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0387555
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0383856
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0373665
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.037156
RPS6 ribosomal protein S6 0.0369981
RPS13 ribosomal protein S13 0.0369273
CALD1 caldesmon 1 0.0368078
NCKAP1 NCK-associated protein 1 0.0364228
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0363754
KMT2C lysine (K)-specific methyltransferase 2C 0.0362861
ANKRD11 ankyrin repeat domain 11 0.0361375
RPL7 ribosomal protein L7 0.0358838
HOOK2 hook microtubule-tethering protein 2 0.0357404
CORO1C coronin, actin binding protein, 1C 0.0349808
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0349054
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0344191
SRRM2 serine/arginine repetitive matrix 2 0.0344025
RBM39 RNA binding motif protein 39 0.0343655
PRRC2C proline-rich coiled-coil 2C 0.0341524
FGFR1 fibroblast growth factor receptor 1 0.0338944
RAB6A RAB6A, member RAS oncogene family 0.033832
RPL13A ribosomal protein L13a 0.0338266
WDR43 WD repeat domain 43 0.0336323
MCTP1 multiple C2 domains, transmembrane 1 0.0330602
PICALM phosphatidylinositol binding clathrin assembly protein 0.0329102
KTN1 kinectin 1 (kinesin receptor) 0.0327806
RPL31 ribosomal protein L31 0.0327508
RPS2 ribosomal protein S2 0.032162
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0321451
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0316351
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0311604
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0307692
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0306083
KLC1 kinesin light chain 1 0.0305298
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0304381
RPL3 ribosomal protein L3 0.0299012
MARCHF4 membrane associated ring-CH-type finger 4 0.0297254
KIF5B kinesin family member 5B 0.029237
PLEC plectin 0.0291887
NAV3 neuron navigator 3 0.0290879
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0289833
EIF4B eukaryotic translation initiation factor 4B 0.0288959
YTHDC1 YTH domain containing 1 0.02886
UBE3A ubiquitin protein ligase E3A 0.0286051
RPL30 ribosomal protein L30 0.0285973

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.284376
AKAP12 A kinase (PRKA) anchor protein 12 -0.148239
VIM vimentin -0.146276
MMP12 matrix metallopeptidase 12 -0.0888672
HMGA2 high mobility group AT-hook 2 -0.0713018
NAV1 neuron navigator 1 -0.0681125
ACTG1 actin gamma 1 -0.0661407
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.06526
INTS6 integrator complex subunit 6 -0.0632965
SAMD3 sterile alpha motif domain containing 3 -0.0552589
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0550925
VCL vinculin -0.0505043
EGR1 early growth response 1 -0.0500654
AHNAK AHNAK nucleoprotein -0.0480318
PTCHD4 patched domain containing 4 -0.0460593
NABP1 nucleic acid binding protein 1 -0.0388713
PDE4D phosphodiesterase 4D, cAMP-specific -0.0371811
POTEF POTE ankyrin domain family, member F -0.0368177
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0362635
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -0.0351581
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0344527
BTG1 B-cell translocation gene 1, anti-proliferative -0.0343453
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0332736
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.033006
FNDC3B fibronectin type III domain containing 3B -0.0329523
ZSWIM6 zinc finger, SWIM-type containing 6 -0.032382
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0310352
TPM4 tropomyosin 4 -0.0309548
MBD5 methyl-CpG binding domain protein 5 -0.0308067
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0304051
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0297103
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0294477
PTPRD protein tyrosine phosphatase, receptor type, D -0.0293541
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0286403
PTMA prothymosin, alpha -0.0271243
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0270762
NALF1 NALCN channel auxiliary factor 1 -0.0270695
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0263698
KIAA1549L KIAA1549-like -0.0257188
SDCCAG8 serologically defined colon cancer antigen 8 -0.0247669
CDH13 cadherin 13 -0.0246414
C2CD2 C2 calcium-dependent domain containing 2 -0.0242853
FOXP1 forkhead box P1 -0.0241279
KIAA1217 KIAA1217 -0.0239814
ALCAM activated leukocyte cell adhesion molecule -0.0236541
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0235521
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0231708
LRRC23 leucine rich repeat containing 23 -0.0228523
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0225802
CUX1 cut-like homeobox 1 -0.0224154
PCDH11X protocadherin 11 X-linked -0.0222713
RAD51B RAD51 paralog B -0.0222573
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0221779
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0217799
PTPRK protein tyrosine phosphatase, receptor type, K -0.021743
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0216078
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.02154
DPYD dihydropyrimidine dehydrogenase -0.0213644
NLGN1 neuroligin 1 -0.0212664
SASH1 SAM and SH3 domain containing 1 -0.0212193
EFNA5 ephrin-A5 -0.0210292
SP100 SP100 nuclear antigen -0.0203701
MYOF myoferlin -0.0202811
TUBB tubulin, beta class I -0.0198307
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0198283
VEPH1 ventricular zone expressed PH domain-containing 1 -0.0197751
NHSL1 NHS-like 1 -0.0196545
ZNF804A zinc finger protein 804A -0.0194073
IGFBP3 insulin-like growth factor binding protein 3 -0.0191152
FN1 fibronectin 1 -0.0190349
MARCKS myristoylated alanine-rich protein kinase C substrate -0.018594
CCDC80 coiled-coil domain containing 80 -0.018539
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 -0.018489
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0183942
ANO6 anoctamin 6 -0.0181816
MAML3 mastermind-like 3 (Drosophila) -0.0181356
ATXN1 ataxin 1 -0.0180376
BZW1 basic leucine zipper and W2 domains 1 -0.0179276
LOC102724023 ES1 protein homolog, mitochondrial -0.0179148
TAS2R14 taste receptor, type 2, member 14 -0.0179052
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0176209
GLIS3 GLIS family zinc finger 3 -0.0176046
TEX14 testis expressed 14 -0.0174844
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0173731
ZBTB20 zinc finger and BTB domain containing 20 -0.0173716
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0173148
WNT2B wingless-type MMTV integration site family, member 2B -0.0171106
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.0170793
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0170496
SLC38A2 solute carrier family 38, member 2 -0.016542
RAB7A RAB7A, member RAS oncogene family -0.0164692
RNF213 ring finger protein 213 -0.0163841
CEP112 centrosomal protein 112kDa -0.0163485
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -0.0162885
NETO1 neuropilin (NRP) and tolloid (TLL)-like 1 -0.0161767
MYADM myeloid-associated differentiation marker -0.0161623
ETV6 ets variant 6 -0.0160408
STAU2 staufen double-stranded RNA binding protein 2 -0.0160391
RSU1 Ras suppressor protein 1 -0.01582
PHF3 PHD finger protein 3 -0.0157612