Chlorhexidine (diacetate)_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.128013
TNS4 tensin 4 0.109715
CEMIP cell migration inducing protein, hyaluronan binding 0.107568
RPL35A ribosomal protein L35a 0.107551
RPS12 ribosomal protein S12 0.101813
FAT1 FAT atypical cadherin 1 0.098609
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0854753
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0614845
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0581335
RPS19 ribosomal protein S19 0.0552848
RPL26 ribosomal protein L26 0.0538991
CADPS Ca++-dependent secretion activator 0.0517025
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0511579
ONECUT3 one cut homeobox 3 0.0505342
MYH9 myosin, heavy chain 9, non-muscle 0.0500941
RPS2 ribosomal protein S2 0.0492585
RPL37A ribosomal protein L37a 0.047194
LDHA lactate dehydrogenase A 0.0463837
MLEC malectin 0.0459233
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0458387
DSPP dentin sialophosphoprotein 0.0456605
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0449383
ABHD2 abhydrolase domain containing 2 0.0449262
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0430253
KDM7A lysine (K)-specific demethylase 7A 0.0423859
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0416022
RPS8 ribosomal protein S8 0.041562
PRSS3 protease, serine, 3 0.0415518
HSPA8 heat shock 70kDa protein 8 0.0406995
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0406312
TMEM45B transmembrane protein 45B 0.0401209
FAM13A family with sequence similarity 13, member A 0.0385057
ANXA11 annexin A11 0.038212
EREG epiregulin 0.0378039
RPL9 ribosomal protein L9 0.0375856
KLF6 Kruppel-like factor 6 0.0372877
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0369618
LAMB3 laminin, beta 3 0.0366809
PGK1 phosphoglycerate kinase 1 0.0358265
USP6NL USP6 N-terminal like 0.0355794
MT2A metallothionein 2A 0.0352621
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0350724
PLAUR plasminogen activator, urokinase receptor 0.0349653
RNF43 ring finger protein 43 0.0349041
RPL11 ribosomal protein L11 0.0346464
DERA deoxyribose-phosphate aldolase (putative) 0.0342505
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0341965
ZNF292 zinc finger protein 292 0.0339071
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0336195
RPL23 ribosomal protein L23 0.033574
PRELID2 PRELI domain containing 2 0.0335109
RPL3 ribosomal protein L3 0.0333374
AREG amphiregulin 0.0327244
PIGR polymeric immunoglobulin receptor 0.0324401
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.0321187
RPL7 ribosomal protein L7 0.0319805
SRRM2 serine/arginine repetitive matrix 2 0.031688
MINK1 misshapen-like kinase 1 0.0314649
MACF1 microtubule-actin crosslinking factor 1 0.0310403
ABHD17C abhydrolase domain containing 17C 0.0308271
RPS17 ribosomal protein S17 0.0306826
CD46 CD46 molecule, complement regulatory protein 0.0306607
AFDN afadin, adherens junction formation factor 0.0302818
NKD1 naked cuticle homolog 1 (Drosophila) 0.0299383
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0295314
VASP vasodilator-stimulated phosphoprotein 0.0294394
ITPRID2 ITPR interacting domain containing 2 0.028883
ITGB4 integrin, beta 4 0.0286609
SPRED1 sprouty-related, EVH1 domain containing 1 0.0286365
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0285033
MUC13 mucin 13, cell surface associated 0.0283996
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0281532
KLF3 Kruppel-like factor 3 (basic) 0.0281143
NEBL nebulette 0.0272769
TRIM2 tripartite motif containing 2 0.0269132
SLK STE20-like kinase 0.0268877
EPCAM epithelial cell adhesion molecule 0.0265005
KIF5B kinesin family member 5B 0.0263077
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0262683
RPS7 ribosomal protein S7 0.0259322
SRSF5 serine/arginine-rich splicing factor 5 0.0252434
ANKRD11 ankyrin repeat domain 11 0.0252377
TPM3 tropomyosin 3 0.0251383
HMGA1 high mobility group AT-hook 1 0.0248693
CAB39 calcium binding protein 39 0.0245868
ACTN4 actinin, alpha 4 0.0244499
PELI1 pellino E3 ubiquitin protein ligase 1 0.0244274
MPRIP myosin phosphatase Rho interacting protein 0.0242937
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.0242179
SET SET nuclear proto-oncogene 0.0238592
PTCH1 patched 1 0.0236958
GPA33 glycoprotein A33 (transmembrane) 0.0235863
SHROOM3 shroom family member 3 0.0235096
TBC1D5 TBC1 domain family, member 5 0.023323
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0232282
RPL36 ribosomal protein L36 0.0232263
EPHA2 EPH receptor A2 0.0231467
PFN1 profilin 1 0.0230108
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0229045
RPL12 ribosomal protein L12 0.0228668

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.311079
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.249392
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.19631
NPSR1 neuropeptide S receptor 1 -0.188418
PTMA prothymosin, alpha -0.160441
AHNAK AHNAK nucleoprotein -0.146342
UBC ubiquitin C -0.105993
ACTG1 actin gamma 1 -0.0748396
RPS27A ribosomal protein S27a -0.0621926
PDIA4 protein disulfide isomerase family A, member 4 -0.0616968
PKM pyruvate kinase, muscle -0.059366
ANTXR2 anthrax toxin receptor 2 -0.0576554
CANX calnexin -0.0567968
POTEF POTE ankyrin domain family, member F -0.054096
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0493605
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0430687
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0407446
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0393573
PDIA3 protein disulfide isomerase family A, member 3 -0.037835
TPT1 tumor protein, translationally-controlled 1 -0.0368339
CCND1 cyclin D1 -0.0363755
FHIT fragile histidine triad -0.0361533
SLC35F3 solute carrier family 35, member F3 -0.0350931
GREB1L growth regulation by estrogen in breast cancer-like -0.033843
AGR2 anterior gradient 2 -0.0337556
BTG1 B-cell translocation gene 1, anti-proliferative -0.0333744
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0333297
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0321253
RPS24 ribosomal protein S24 -0.0319752
PTPRK protein tyrosine phosphatase, receptor type, K -0.0315086
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.031341
LOC112694756 uncharaterized LOC112694756 -0.0311955
IARS1 isoleucyl-tRNA synthetase 1 -0.0309183
PSD3 pleckstrin and Sec7 domain containing 3 -0.0307011
S100A6 S100 calcium binding protein A6 -0.0305878
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0301949
VCL vinculin -0.0300978
HDLBP high density lipoprotein binding protein -0.0300918
ATP5F1B ATP synthase F1 subunit beta -0.0298293
RPL14 ribosomal protein L14 -0.0295636
TUBB tubulin, beta class I -0.0284388
RNF217 ring finger protein 217 -0.0282837
ECT2 epithelial cell transforming 2 -0.0281954
DLG1 discs, large homolog 1 (Drosophila) -0.0281729
CCNI cyclin I -0.0273045
NRN1 neuritin 1 -0.0271829
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0270066
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0269793
GLG1 golgi glycoprotein 1 -0.0268053
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0263053
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0262881
RRBP1 ribosome binding protein 1 -0.0252155
ZBTB20 zinc finger and BTB domain containing 20 -0.0250643
CLOCK clock circadian regulator -0.0249757
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.024975
RBM25 RNA binding motif protein 25 -0.0246925
RTN3 reticulon 3 -0.0245994
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0245679
TUBA1B tubulin, alpha 1b -0.0245357
PCBP2 poly(rC) binding protein 2 -0.024374
RHOA ras homolog family member A -0.0242874
ALCAM activated leukocyte cell adhesion molecule -0.0242576
NPR2 natriuretic peptide receptor 2 -0.0241144
EXT1 exostosin glycosyltransferase 1 -0.024061
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0238931
FBXO11 F-box protein 11 -0.0237881
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0237764
MAML2 mastermind-like 2 (Drosophila) -0.0237386
SLC38A2 solute carrier family 38, member 2 -0.0236093
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0235918
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0235213
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.023503
COPB1 coatomer protein complex, subunit beta 1 -0.0232938
DIAPH2 diaphanous-related formin 2 -0.0230886
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0230001
ABLIM1 actin binding LIM protein 1 -0.0228851
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0227262
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.022686
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0226152
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0223376
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0223155
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0222167
DENND1A DENN/MADD domain containing 1A -0.022173
TOP1 topoisomerase (DNA) I -0.0220239
ZFC3H1 zinc finger, C3H1-type containing -0.0219911
BZW1 basic leucine zipper and W2 domains 1 -0.0219284
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0219125
DEK DEK proto-oncogene -0.0218372
GCC2 GRIP and coiled-coil domain containing 2 -0.0217997
STAU1 staufen double-stranded RNA binding protein 1 -0.0216918
SPDYA speedy/RINGO cell cycle regulator family member A -0.021689
ZNF638 zinc finger protein 638 -0.0216766
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 -0.0212336
RPL28 ribosomal protein L28 -0.0212007
JUN jun proto-oncogene -0.0210568
RAB10 RAB10, member RAS oncogene family -0.0210168
BRD2 bromodomain containing 2 -0.0209566
LSAMP limbic system-associated membrane protein -0.0209528
FUS FUS RNA binding protein -0.0206573
TPM4 tropomyosin 4 -0.0206004