Chlorhexidine (diacetate)_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS12 ribosomal protein S12 0.16524
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.142051
PRELID2 PRELI domain containing 2 0.0826388
MUC13 mucin 13, cell surface associated 0.0758066
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0756072
RPL37A ribosomal protein L37a 0.0749235
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0722669
RPL23 ribosomal protein L23 0.0641211
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0624992
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0597657
AKAP13 A kinase (PRKA) anchor protein 13 0.0586082
RPL26 ribosomal protein L26 0.0569855
MYO5B myosin VB 0.0524081
PDE4D phosphodiesterase 4D, cAMP-specific 0.0521545
ITGB4 integrin, beta 4 0.0515623
ANXA11 annexin A11 0.050689
LAMB3 laminin, beta 3 0.0501885
EPHA2 EPH receptor A2 0.0489993
TPT1 tumor protein, translationally-controlled 1 0.0483279
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0471123
FRMD5 FERM domain containing 5 0.0460545
RPS17 ribosomal protein S17 0.0457422
MYH9 myosin, heavy chain 9, non-muscle 0.0446536
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0441174
ITPRID2 ITPR interacting domain containing 2 0.0437585
ZFAND3 zinc finger, AN1-type domain 3 0.0436015
NDRG1 N-myc downstream regulated 1 0.0432476
RPL35A ribosomal protein L35a 0.0419381
MPRIP myosin phosphatase Rho interacting protein 0.0419335
RPL3 ribosomal protein L3 0.0418158
LPP LIM domain containing preferred translocation partner in lipoma 0.0414095
FOXO1 forkhead box O1 0.0407389
ZNF292 zinc finger protein 292 0.0405179
AFDN afadin, adherens junction formation factor 0.0392191
KMT2C lysine (K)-specific methyltransferase 2C 0.0391597
RPL9 ribosomal protein L9 0.0391295
MED13L mediator complex subunit 13-like 0.0388609
FLNB filamin B, beta 0.0385231
CALB1 calbindin 1, 28kDa 0.0384419
CTNND1 catenin (cadherin-associated protein), delta 1 0.0380791
RPS3 ribosomal protein S3 0.037795
HLA-B major histocompatibility complex, class I, B 0.037748
ARHGAP26 Rho GTPase activating protein 26 0.037593
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0365515
PLAUR plasminogen activator, urokinase receptor 0.0365162
ESYT2 extended synaptotagmin-like protein 2 0.0362983
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0360157
NCKAP1 NCK-associated protein 1 0.0357268
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.034997
PCBP2 poly(rC) binding protein 2 0.0340917
SAMD5 sterile alpha motif domain containing 5 0.0338515
ABHD17C abhydrolase domain containing 17C 0.0336427
RPL11 ribosomal protein L11 0.0328938
DSG3 desmoglein 3 0.0328885
IFI6 interferon, alpha-inducible protein 6 0.0325537
KDM7A lysine (K)-specific demethylase 7A 0.0324292
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0322648
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0322523
RREB1 ras responsive element binding protein 1 0.0321302
TRAPPC9 trafficking protein particle complex 9 0.0320057
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0320046
ATXN1 ataxin 1 0.0316477
PARD3B par-3 family cell polarity regulator beta 0.0312614
PELI1 pellino E3 ubiquitin protein ligase 1 0.0307628
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0305886
SLTM SAFB-like, transcription modulator 0.030413
PDE8A phosphodiesterase 8A 0.0304014
CD9 CD9 molecule 0.0302552
MACF1 microtubule-actin crosslinking factor 1 0.0299426
AUTS2 autism susceptibility candidate 2 0.0298794
EIF4B eukaryotic translation initiation factor 4B 0.0297178
FHIT fragile histidine triad 0.0295524
CDK19 cyclin-dependent kinase 19 0.0295206
UBA6 ubiquitin-like modifier activating enzyme 6 0.0293607
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0293344
SPRED1 sprouty-related, EVH1 domain containing 1 0.0293332
TMEM45B transmembrane protein 45B 0.0293251
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0290946
DGLUCY D-glutamate cyclase 0.0290393
DSPP dentin sialophosphoprotein 0.0283153
TXNRD1 thioredoxin reductase 1 0.02814
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0279794
KDM2A lysine (K)-specific demethylase 2A 0.0279134
UBE3A ubiquitin protein ligase E3A 0.0278396
SH3RF1 SH3 domain containing ring finger 1 0.0278297
RPS19 ribosomal protein S19 0.0277311
RBM33 RNA binding motif protein 33 0.0274814
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0274449
SLK STE20-like kinase 0.0274247
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0272949
SVIL supervillin 0.0271807
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 0.0269447
SRSF5 serine/arginine-rich splicing factor 5 0.0267671
SFPQ splicing factor proline/glutamine-rich 0.0261177
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.0260557
RPS21 ribosomal protein S21 0.0259883
PARP12 poly (ADP-ribose) polymerase family, member 12 0.0259833
RNF145 ring finger protein 145 0.0256378
AFF1 AF4/FMR2 family, member 1 0.0255144
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0254631

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.155946
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.138941
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.110427
LMO7 LIM domain 7 -0.102914
CANX calnexin -0.0854185
ACTG1 actin gamma 1 -0.0852641
RPS6 ribosomal protein S6 -0.0845584
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0798717
RPLP0 ribosomal protein, large, P0 -0.0797823
RPL4 ribosomal protein L4 -0.0796464
HDLBP high density lipoprotein binding protein -0.0789076
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0778802
EIF1 eukaryotic translation initiation factor 1 -0.0778152
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0728069
RPLP1 ribosomal protein, large, P1 -0.0707096
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0695498
MYOF myoferlin -0.0656626
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0650907
RRBP1 ribosome binding protein 1 -0.0639798
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0628929
VCL vinculin -0.0625161
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0620909
PTMA prothymosin, alpha -0.0615571
GDF15 growth differentiation factor 15 -0.0606898
IARS1 isoleucyl-tRNA synthetase 1 -0.0599559
PDIA3 protein disulfide isomerase family A, member 3 -0.058788
GARS1 glycyl-tRNA synthetase 1 -0.0577605
PKM pyruvate kinase, muscle -0.0543839
GOLGB1 golgin B1 -0.0534907
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0528712
MYO1E myosin IE -0.0528166
SP100 SP100 nuclear antigen -0.0525202
SLC38A2 solute carrier family 38, member 2 -0.0506281
TTC3 tetratricopeptide repeat domain 3 -0.0502081
PALLD palladin, cytoskeletal associated protein -0.0499277
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0487794
PTPRK protein tyrosine phosphatase, receptor type, K -0.0472666
THSD4 thrombospondin, type I, domain containing 4 -0.0446158
CATSPERB catsper channel auxiliary subunit beta -0.0425153
PTPRB protein tyrosine phosphatase, receptor type, B -0.0424858
AHNAK AHNAK nucleoprotein -0.0412989
LOC112694756 uncharaterized LOC112694756 -0.0408997
NRN1 neuritin 1 -0.0394666
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0388218
KLF5 Kruppel-like factor 5 (intestinal) -0.0380169
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0373498
PDLIM5 PDZ and LIM domain 5 -0.0372967
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0368611
KIF5B kinesin family member 5B -0.0368348
RPL14 ribosomal protein L14 -0.0355415
TMEM263 transmembrane protein 263 -0.034323
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 -0.0339952
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0338791
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0338047
RPS20 ribosomal protein S20 -0.0337061
VDAC1 voltage-dependent anion channel 1 -0.0332127
ATF4 activating transcription factor 4 -0.0324748
NT5C2 5'-nucleotidase, cytosolic II -0.0322511
GCC2 GRIP and coiled-coil domain containing 2 -0.0322286
COPB1 coatomer protein complex, subunit beta 1 -0.0322248
RPS5 ribosomal protein S5 -0.0313488
TJP1 tight junction protein 1 -0.0311554
PLSCR1 phospholipid scramblase 1 -0.0309315
NPR2 natriuretic peptide receptor 2 -0.0307306
MTDH metadherin -0.0304802
P3H2 prolyl 3-hydroxylase 2 -0.030423
ATP5F1B ATP synthase F1 subunit beta -0.0299464
RBM25 RNA binding motif protein 25 -0.0296234
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0295949
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0295418
IQGAP2 IQ motif containing GTPase activating protein 2 -0.0295285
RAP1B RAP1B, member of RAS oncogene family -0.0293859
AGR2 anterior gradient 2 -0.0292307
LARP1B La ribonucleoprotein domain family, member 1B -0.0284664
IFIH1 interferon induced with helicase C domain 1 -0.0283304
POF1B premature ovarian failure, 1B -0.0282603
CCNG1 cyclin G1 -0.0280568
TKT transketolase -0.0280558
NCOA7 nuclear receptor coactivator 7 -0.0278134
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0277549
ADIPOR2 adiponectin receptor 2 -0.0276949
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0275994
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0275202
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0274044
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0271611
RPS24 ribosomal protein S24 -0.0271047
RBBP6 retinoblastoma binding protein 6 -0.0270719
GOLGA4 golgin A4 -0.0270001
LARS1 leucyl-tRNA synthetase 1 -0.0268488
RPL19 ribosomal protein L19 -0.0267653
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0266942
RTN3 reticulon 3 -0.0266216
ARF1 ADP-ribosylation factor 1 -0.0261427
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0259715
LDHB lactate dehydrogenase B -0.0257665
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0257604
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0252782
RAD21 RAD21 homolog (S. pombe) -0.025197
HMGB1 high mobility group box 1 -0.0248271
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0247271