Chlorhexidine (diacetate)_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.15906
NDRG1 N-myc downstream regulated 1 0.0914233
SLTM SAFB-like, transcription modulator 0.0841765
MCL1 myeloid cell leukemia 1 0.0817025
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0762387
FAM13A family with sequence similarity 13, member A 0.0747415
CEMIP cell migration inducing protein, hyaluronan binding 0.0589211
ARRDC3 arrestin domain containing 3 0.0557817
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0536532
SOD2 superoxide dismutase 2, mitochondrial 0.0507577
ELL2 elongation factor, RNA polymerase II, 2 0.0463367
TSC22D2 TSC22 domain family, member 2 0.0459417
LDHA lactate dehydrogenase A 0.0418806
CXCL8 chemokine (C-X-C motif) ligand 8 0.0405805
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0398228
TMEM45B transmembrane protein 45B 0.0358005
NGLY1 N-glycanase 1 0.035653
EGR1 early growth response 1 0.0353427
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0341754
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0337296
GRB10 growth factor receptor-bound protein 10 0.0333658
EPAS1 endothelial PAS domain protein 1 0.0307722
BCAR3 breast cancer anti-estrogen resistance 3 0.0304618
SRSF5 serine/arginine-rich splicing factor 5 0.029317
CES1 carboxylesterase 1 0.0284687
NAMPT nicotinamide phosphoribosyltransferase 0.0282802
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0272437
MYH9 myosin, heavy chain 9, non-muscle 0.0266502
PTPRJ protein tyrosine phosphatase, receptor type, J 0.026618
BLZF1 basic leucine zipper nuclear factor 1 0.0261887
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0260042
YTHDC1 YTH domain containing 1 0.0251333
ATP13A3 ATPase type 13A3 0.0250041
SMAD3 SMAD family member 3 0.0246457
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.0243304
LAMA4 laminin, alpha 4 0.0242683
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae) 0.0242484
STC1 stanniocalcin 1 0.0241527
SRRM2 serine/arginine repetitive matrix 2 0.0239331
USP9X ubiquitin specific peptidase 9, X-linked 0.0234614
ATP11A ATPase, class VI, type 11A 0.0234142
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0231032
ANKRD11 ankyrin repeat domain 11 0.0223552
SAMD4A sterile alpha motif domain containing 4A 0.0219476
ATXN1 ataxin 1 0.0217949
CCNL1 cyclin L1 0.0216451
MRPS6 mitochondrial ribosomal protein S6 0.0214196
UBA6 ubiquitin-like modifier activating enzyme 6 0.0206945
SPAG9 sperm associated antigen 9 0.0202554
LGALS12 lectin, galactoside-binding, soluble, 12 0.0200536
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0200493
RPS12 ribosomal protein S12 0.0200211
OGA O-GlcNAcase 0.0199117
SQOR sulfide quinone oxidoreductase 0.0197682
HELZ helicase with zinc finger 0.019602
CAMTA1 calmodulin binding transcription activator 1 0.0194434
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0184082
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0181081
RFLNA refilin A 0.0179579
SMTN smoothelin 0.0176856
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0173177
ERRFI1 ERBB receptor feedback inhibitor 1 0.0171595
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0171261
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.016738
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0165738
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0163762
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0162645
ITGB5 integrin, beta 5 0.0162581
SFPQ splicing factor proline/glutamine-rich 0.0162553
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 0.0161548
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0161175
FRY furry homolog (Drosophila) 0.0160835
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0160378
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0160054
C1D C1D nuclear receptor corepressor 0.0159811
IRS2 insulin receptor substrate 2 0.0156715
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0156704
ADAM17 ADAM metallopeptidase domain 17 0.0151462
VEGFC vascular endothelial growth factor C 0.0150381
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0149457
RAD51B RAD51 paralog B 0.0148124
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0146749
PM20D1 peptidase M20 domain containing 1 0.0146146
CUL3 cullin 3 0.014485
ESYT2 extended synaptotagmin-like protein 2 0.0142331
EXOC6B exocyst complex component 6B 0.0141556
PYGL phosphorylase, glycogen, liver 0.0137788
ARHGAP12 Rho GTPase activating protein 12 0.0137558
TRAPPC9 trafficking protein particle complex 9 0.0137388
EXT1 exostosin glycosyltransferase 1 0.0135992
KDM6A lysine (K)-specific demethylase 6A 0.0135282
SP3 Sp3 transcription factor 0.0135244
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.013415
LPCAT2 lysophosphatidylcholine acyltransferase 2 0.0133585
PHF21A PHD finger protein 21A 0.0133577
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0133013
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0132348
TMED2 transmembrane emp24 domain trafficking protein 2 0.0132121
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0131915
NPTN neuroplastin 0.0130327

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.275479
TMSB10 thymosin beta 10 -0.171704
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.171241
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.118594
ACTG1 actin gamma 1 -0.115441
PKM pyruvate kinase, muscle -0.11384
CAV1 caveolin 1, caveolae protein, 22kDa -0.109424
AKR1C1 aldo-keto reductase family 1, member C1 -0.105347
TXNRD1 thioredoxin reductase 1 -0.101117
CST3 cystatin C -0.0819608
KRT7 keratin 7, type II -0.0794126
PTMA prothymosin, alpha -0.0761672
CCND1 cyclin D1 -0.0754561
TPT1 tumor protein, translationally-controlled 1 -0.0716356
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0680113
PDLIM5 PDZ and LIM domain 5 -0.066854
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0626308
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0625457
S100A10 S100 calcium binding protein A10 -0.0614198
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0594607
AHNAK AHNAK nucleoprotein -0.0585259
SLC38A1 solute carrier family 38, member 1 -0.057812
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0567786
LRP1B low density lipoprotein receptor-related protein 1B -0.0554853
RPS6 ribosomal protein S6 -0.0548562
MYOF myoferlin -0.05471
B2M beta-2-microglobulin -0.0545995
PTPRM protein tyrosine phosphatase, receptor type, M -0.0541876
LAMC2 laminin, gamma 2 -0.0521714
IGFBP3 insulin-like growth factor binding protein 3 -0.0500719
RPS25 ribosomal protein S25 -0.0500217
RPS24 ribosomal protein S24 -0.0495778
FTL ferritin, light polypeptide -0.0493503
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0487624
ANXA2 annexin A2 -0.0471066
HDLBP high density lipoprotein binding protein -0.0470224
PATJ PATJ crumbs cell polarity complex component -0.0456159
KRT8 keratin 8, type II -0.0451921
RPS23 ribosomal protein S23 -0.0431329
RAB10 RAB10, member RAS oncogene family -0.0406654
RPLP1 ribosomal protein, large, P1 -0.0401317
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0397041
EFNA5 ephrin-A5 -0.0384068
MYO1E myosin IE -0.0376996
CUX1 cut-like homeobox 1 -0.0373412
EIF1 eukaryotic translation initiation factor 1 -0.0371271
RPL34 ribosomal protein L34 -0.0369627
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0349099
CANX calnexin -0.0347879
PRKCA protein kinase C, alpha -0.034404
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0341244
DSCAM Down syndrome cell adhesion molecule -0.0340712
RPS29 ribosomal protein S29 -0.0338867
S100A9 S100 calcium binding protein A9 -0.0335453
OSMR oncostatin M receptor -0.033519
LOC112694756 uncharaterized LOC112694756 -0.0334219
TNS3 tensin 3 -0.0330921
MYO1D myosin ID -0.0328662
HLA-B major histocompatibility complex, class I, B -0.0325318
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0315617
RNF213 ring finger protein 213 -0.0314666
RPL19 ribosomal protein L19 -0.0308902
VCL vinculin -0.0307076
PRRC2C proline-rich coiled-coil 2C -0.0300212
THSD4 thrombospondin, type I, domain containing 4 -0.0298378
GCLM glutamate-cysteine ligase, modifier subunit -0.0297379
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0296611
S100A11 S100 calcium binding protein A11 -0.0293933
LPP LIM domain containing preferred translocation partner in lipoma -0.0292983
GPHN gephyrin -0.0284915
USP34 ubiquitin specific peptidase 34 -0.0283343
KRT18 keratin 18, type I -0.0281578
CHML choroideremia-like (Rab escort protein 2) -0.0280676
POTEF POTE ankyrin domain family, member F -0.028016
RPL8 ribosomal protein L8 -0.0277935
JMJD1C jumonji domain containing 1C -0.027605
UBC ubiquitin C -0.0274334
KDM2A lysine (K)-specific demethylase 2A -0.0269646
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0269166
RBM39 RNA binding motif protein 39 -0.0267942
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0264375
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0262713
GNAS GNAS complex locus -0.0260778
BZW1 basic leucine zipper and W2 domains 1 -0.0255451
SDC4 syndecan 4 -0.0255033
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0254727
ASPH aspartate beta-hydroxylase -0.0253687
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0252195
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0249151
WSB1 WD repeat and SOCS box containing 1 -0.0248914
RPS8 ribosomal protein S8 -0.0248184
NT5C2 5'-nucleotidase, cytosolic II -0.0247324
RAB1A RAB1A, member RAS oncogene family -0.0246743
ANKRD17 ankyrin repeat domain 17 -0.0246489
TMOD3 tropomodulin 3 (ubiquitous) -0.0244562
NRIP1 nuclear receptor interacting protein 1 -0.0244208
DSG2 desmoglein 2 -0.0243951
PLS3 plastin 3 -0.0243568
UGDH UDP-glucose 6-dehydrogenase -0.024277
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0242066