Chlorhexidine (diacetate)_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EFNA5 ephrin-A5 0.0979786
NAMPT nicotinamide phosphoribosyltransferase 0.087701
DOCK5 dedicator of cytokinesis 5 0.0839378
PCBP2 poly(rC) binding protein 2 0.0686916
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0682385
KDM2A lysine (K)-specific demethylase 2A 0.0678045
FAM13A family with sequence similarity 13, member A 0.0616264
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0574095
NAV2 neuron navigator 2 0.0564229
SIK3 SIK family kinase 3 0.0556549
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0541765
USP34 ubiquitin specific peptidase 34 0.0511576
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0508525
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0473297
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0460915
ZEB2 zinc finger E-box binding homeobox 2 0.0445965
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.043539
ATF7 activating transcription factor 7 0.0432986
ETV6 ets variant 6 0.042742
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0426208
LRRC8C leucine rich repeat containing 8 family, member C 0.0419916
RUNX2 runt-related transcription factor 2 0.0419886
FLNB filamin B, beta 0.0414483
MEF2A myocyte enhancer factor 2A 0.0407048
RAB8B RAB8B, member RAS oncogene family 0.0404826
BACE2 beta-site APP-cleaving enzyme 2 0.0396563
ADD3 adducin 3 (gamma) 0.0390529
CEMIP cell migration inducing protein, hyaluronan binding 0.038837
BASP1 brain abundant, membrane attached signal protein 1 0.0387489
FNDC3B fibronectin type III domain containing 3B 0.0384392
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0384385
RAB27B RAB27B, member RAS oncogene family 0.0379728
DPYD dihydropyrimidine dehydrogenase 0.0377726
PIAS2 protein inhibitor of activated STAT, 2 0.037089
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0367998
EGFR epidermal growth factor receptor 0.0361488
MYO1B myosin IB 0.0359127
SMAD3 SMAD family member 3 0.0357092
TRIO trio Rho guanine nucleotide exchange factor 0.0354574
ZNF292 zinc finger protein 292 0.0352535
B2M beta-2-microglobulin 0.0352262
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0351523
RUNX1 runt-related transcription factor 1 0.0349217
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.033883
AKAP13 A kinase (PRKA) anchor protein 13 0.0338298
FANCL Fanconi anemia, complementation group L 0.0337683
YEATS2 YEATS domain containing 2 0.0337054
SDK1 sidekick cell adhesion molecule 1 0.0336817
UBA6 ubiquitin-like modifier activating enzyme 6 0.0333721
SOD2 superoxide dismutase 2, mitochondrial 0.0333067
P4HB prolyl 4-hydroxylase, beta polypeptide 0.032057
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0318568
NGLY1 N-glycanase 1 0.031418
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0312992
ANKRD36 ankyrin repeat domain 36 0.0312939
CCNY cyclin Y 0.0306343
RPS12 ribosomal protein S12 0.0304263
KDM6A lysine (K)-specific demethylase 6A 0.0299041
BMAL2 basic helix-loop-helix ARNT like 2 0.0293307
VEGFC vascular endothelial growth factor C 0.0292786
ATP13A3 ATPase type 13A3 0.0292058
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0288797
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0288073
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0281736
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0277488
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0272772
MCC mutated in colorectal cancers 0.027237
NBAS neuroblastoma amplified sequence 0.0270503
ZMYND8 zinc finger, MYND-type containing 8 0.0265255
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0265153
ARRDC3 arrestin domain containing 3 0.0264615
KYNU kynureninase 0.0262394
MAP2K1 mitogen-activated protein kinase kinase 1 0.0260323
PTBP2 polypyrimidine tract binding protein 2 0.0258785
ITCH itchy E3 ubiquitin protein ligase 0.025824
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.025644
PYGL phosphorylase, glycogen, liver 0.0255348
PID1 phosphotyrosine interaction domain containing 1 0.0253028
ENO2 enolase 2 (gamma, neuronal) 0.0250398
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0248943
PICALM phosphatidylinositol binding clathrin assembly protein 0.0247631
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0242869
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0241317
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0239496
FRMD4A FERM domain containing 4A 0.0239114
PTEN phosphatase and tensin homolog 0.0238125
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0236571
RPL37A ribosomal protein L37a 0.0236558
AOPEP aminopeptidase O (putative) 0.0235761
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0234961
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 0.023401
CTNNBL1 catenin, beta like 1 0.0232376
VEGFA vascular endothelial growth factor A 0.0231871
GRB10 growth factor receptor-bound protein 10 0.0231829
IGFBP3 insulin-like growth factor binding protein 3 0.0229958
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0228603
ARHGAP42 Rho GTPase activating protein 42 0.0228353
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0226346
MAML3 mastermind-like 3 (Drosophila) 0.0226141
TLR2 toll-like receptor 2 0.022313

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.169139
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.161738
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.157161
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.152551
CDH13 cadherin 13 -0.0909883
NCOA7 nuclear receptor coactivator 7 -0.0878058
CD44 CD44 molecule (Indian blood group) -0.0847279
IER3 immediate early response 3 -0.0766603
LMAN1 lectin, mannose-binding, 1 -0.0716127
DDIT3 DNA-damage-inducible transcript 3 -0.0679163
VCL vinculin -0.0591841
AHNAK AHNAK nucleoprotein -0.058262
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0580263
TMSB4X thymosin beta 4, X-linked -0.0570685
EGR1 early growth response 1 -0.05569
TNNC1 troponin C type 1 (slow) -0.0549274
MAP1B microtubule-associated protein 1B -0.0537993
AKAP12 A kinase (PRKA) anchor protein 12 -0.0525137
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0523251
CANX calnexin -0.0507684
FTL ferritin, light polypeptide -0.0493801
FTH1 ferritin, heavy polypeptide 1 -0.049258
SQSTM1 sequestosome 1 -0.0483072
RPLP1 ribosomal protein, large, P1 -0.047191
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0470828
PTMA prothymosin, alpha -0.0462487
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0449692
PSD3 pleckstrin and Sec7 domain containing 3 -0.0447196
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0446903
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.0443509
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0440604
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0427547
LRMDA leucine rich melanocyte differentiation associated -0.0421553
PKM pyruvate kinase, muscle -0.0417703
SLC38A1 solute carrier family 38, member 1 -0.0417586
RBM39 RNA binding motif protein 39 -0.0416973
TAS2R14 taste receptor, type 2, member 14 -0.0416938
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0415738
JUN jun proto-oncogene -0.0411003
PDIA3 protein disulfide isomerase family A, member 3 -0.0402916
SYT1 synaptotagmin I -0.040091
BZW1 basic leucine zipper and W2 domains 1 -0.039324
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0391203
GNAS GNAS complex locus -0.0387653
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0386476
GPC6 glypican 6 -0.0383276
TMEM263 transmembrane protein 263 -0.0382169
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0378021
SAMD9 sterile alpha motif domain containing 9 -0.0377331
H1-0 H1.0 linker histone -0.036586
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0365289
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0362742
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0353897
HDLBP high density lipoprotein binding protein -0.0350618
LTBP1 latent transforming growth factor beta binding protein 1 -0.0350454
RAB7A RAB7A, member RAS oncogene family -0.0350275
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0343979
SOS1 son of sevenless homolog 1 (Drosophila) -0.0339886
RAP1B RAP1B, member of RAS oncogene family -0.0335126
BTG1 B-cell translocation gene 1, anti-proliferative -0.03349
CREB5 cAMP responsive element binding protein 5 -0.0329848
RRBP1 ribosome binding protein 1 -0.0326783
BHLHE40 basic helix-loop-helix family, member e40 -0.0324973
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0324458
EZR ezrin -0.0319087
VIM vimentin -0.0315503
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.031253
EIF1 eukaryotic translation initiation factor 1 -0.0303225
MORF4L2 mortality factor 4 like 2 -0.0299943
ACBD3 acyl-CoA binding domain containing 3 -0.0297822
LOC102724023 ES1 protein homolog, mitochondrial -0.0289146
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0286299
NPC1 Niemann-Pick disease, type C1 -0.0285889
GLIPR1 GLI pathogenesis-related 1 -0.0284607
GLS2 glutaminase 2 (liver, mitochondrial) -0.0283833
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0282592
RPS24 ribosomal protein S24 -0.0280453
TPM4 tropomyosin 4 -0.0276794
AADAC arylacetamide deacetylase -0.0275877
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0270418
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0269023
ZNF804A zinc finger protein 804A -0.0267387
RPL4 ribosomal protein L4 -0.0267143
IFI16 interferon, gamma-inducible protein 16 -0.026552
LOC112694756 uncharaterized LOC112694756 -0.0264531
ELL2 elongation factor, RNA polymerase II, 2 -0.0264433
ACTG1 actin gamma 1 -0.0263372
TOP1 topoisomerase (DNA) I -0.0262697
COL12A1 collagen, type XII, alpha 1 -0.0262022
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0261669
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0259994
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0259482
LOXL2 lysyl oxidase-like 2 -0.0257172
GOLGB1 golgin B1 -0.0257032
SEC24D SEC24 family member D -0.0255446
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.025474
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0252004
HBP1 HMG-box transcription factor 1 -0.0248019
GRIK5 glutamate receptor, ionotropic, kainate 5 -0.0247892
CALU calumenin -0.0244798