Chlorhexidine (diacetate)_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.166021
GRAMD1B GRAM domain containing 1B 0.104634
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0991858
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0862341
TPM3 tropomyosin 3 0.0816701
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0738922
CALR calreticulin 0.0713671
RPL23 ribosomal protein L23 0.0712034
SAMD4A sterile alpha motif domain containing 4A 0.0689695
APP amyloid beta (A4) precursor protein 0.0663889
BASP1 brain abundant, membrane attached signal protein 1 0.0656495
IGF2 insulin-like growth factor 2 0.0634354
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0631515
RPS12 ribosomal protein S12 0.0608744
MYH9 myosin, heavy chain 9, non-muscle 0.0591998
FNDC3B fibronectin type III domain containing 3B 0.0586478
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0580474
CFLAR CASP8 and FADD-like apoptosis regulator 0.0572243
FMNL2 formin-like 2 0.0558868
NAMPT nicotinamide phosphoribosyltransferase 0.0547337
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0544386
MACF1 microtubule-actin crosslinking factor 1 0.0534776
ZNF292 zinc finger protein 292 0.0520924
ANGPTL4 angiopoietin-like 4 0.0497754
FAM168A family with sequence similarity 168, member A 0.049268
RPS3 ribosomal protein S3 0.0475807
LPP LIM domain containing preferred translocation partner in lipoma 0.0472891
TPD52 tumor protein D52 0.0457633
NDRG1 N-myc downstream regulated 1 0.0452588
HLA-B major histocompatibility complex, class I, B 0.0450305
RPL37A ribosomal protein L37a 0.0447852
LDHA lactate dehydrogenase A 0.0441605
SOD2 superoxide dismutase 2, mitochondrial 0.0428779
B2M beta-2-microglobulin 0.042852
DOCK5 dedicator of cytokinesis 5 0.0427382
CCL5 chemokine (C-C motif) ligand 5 0.042534
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0417339
SMAD3 SMAD family member 3 0.0415729
CYTH1 cytohesin 1 0.0414137
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0411065
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0400763
SFTPA2 surfactant protein A2 0.0387752
JAK1 Janus kinase 1 0.0381739
KMT2E lysine (K)-specific methyltransferase 2E 0.0368616
PYGL phosphorylase, glycogen, liver 0.0367136
ASPH aspartate beta-hydroxylase 0.0361253
NAP1L1 nucleosome assembly protein 1-like 1 0.0360433
AKAP13 A kinase (PRKA) anchor protein 13 0.0358156
RPL3 ribosomal protein L3 0.0357643
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.034561
ANKRD11 ankyrin repeat domain 11 0.034348
RPS7 ribosomal protein S7 0.0341197
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0338419
HSPA8 heat shock 70kDa protein 8 0.0338215
RPL26 ribosomal protein L26 0.032966
FLNB filamin B, beta 0.0326639
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0326588
PDIA6 protein disulfide isomerase family A, member 6 0.03256
ARHGAP26 Rho GTPase activating protein 26 0.0318759
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0316752
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0316388
EGFR epidermal growth factor receptor 0.0314935
SFPQ splicing factor proline/glutamine-rich 0.0314911
PTK2 protein tyrosine kinase 2 0.0313328
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0313053
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 0.0310627
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0304697
USP3 ubiquitin specific peptidase 3 0.0304382
EEF2 eukaryotic translation elongation factor 2 0.0303134
RPL35A ribosomal protein L35a 0.0302627
ENO1 enolase 1, (alpha) 0.0302168
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0300943
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0300771
TNIP1 TNFAIP3 interacting protein 1 0.0291013
RPS8 ribosomal protein S8 0.0289253
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0288949
PARD3 par-3 family cell polarity regulator 0.0287187
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0284756
IGFBP3 insulin-like growth factor binding protein 3 0.0283611
RPS17 ribosomal protein S17 0.0283012
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0279788
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0276993
WAC WW domain containing adaptor with coiled-coil 0.027691
SET SET nuclear proto-oncogene 0.0274274
NCKAP1 NCK-associated protein 1 0.0271416
ANXA1 annexin A1 0.027076
KTN1 kinectin 1 (kinesin receptor) 0.0269157
SIK3 SIK family kinase 3 0.026434
MRTFA myocardin related transcription factor A 0.0262245
FGA fibrinogen alpha chain 0.0262197
RAB6A RAB6A, member RAS oncogene family 0.0260235
BCAR3 breast cancer anti-estrogen resistance 3 0.0259556
ZFAND3 zinc finger, AN1-type domain 3 0.0259249
YME1L1 YME1-like 1 ATPase 0.0258663
FNBP1L formin binding protein 1-like 0.0258555
EEF1G eukaryotic translation elongation factor 1 gamma 0.0258019
TFG TRK-fused gene 0.0256984
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0256268
CASC3 cancer susceptibility candidate 3 0.0255114
TNRC6A trinucleotide repeat containing 6A 0.025401

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.436705
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.118547
VIM vimentin -0.0935941
ACTG1 actin gamma 1 -0.092174
EGR1 early growth response 1 -0.0877912
FTL ferritin, light polypeptide -0.0876111
TFPI2 tissue factor pathway inhibitor 2 -0.0799205
POTEF POTE ankyrin domain family, member F -0.0798028
SLC38A2 solute carrier family 38, member 2 -0.0648916
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0591418
TMSB10 thymosin beta 10 -0.0564459
FTH1 ferritin, heavy polypeptide 1 -0.0516805
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0508871
LOC102724023 ES1 protein homolog, mitochondrial -0.0504202
MT1F metallothionein 1F -0.0493165
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0479712
THSD4 thrombospondin, type I, domain containing 4 -0.0466244
OSMR oncostatin M receptor -0.0444423
NABP1 nucleic acid binding protein 1 -0.0441448
PM20D1 peptidase M20 domain containing 1 -0.0426966
MT1X metallothionein 1X -0.0410381
TM4SF1 transmembrane 4 L six family member 1 -0.040119
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0399324
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0397833
ATP5F1B ATP synthase F1 subunit beta -0.0395428
COPA coatomer protein complex, subunit alpha -0.0386025
HDAC9 histone deacetylase 9 -0.038478
AK1 adenylate kinase 1 -0.0369492
PKM pyruvate kinase, muscle -0.0367566
PDLIM5 PDZ and LIM domain 5 -0.0365036
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0364944
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0362307
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0359715
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0347149
VMP1 vacuole membrane protein 1 -0.0345703
USP34 ubiquitin specific peptidase 34 -0.0341398
KYNU kynureninase -0.0325632
RPL19 ribosomal protein L19 -0.03226
RPLP0 ribosomal protein, large, P0 -0.0314335
TUBB tubulin, beta class I -0.0305436
AGO2 argonaute RISC catalytic component 2 -0.0300437
ZNF804A zinc finger protein 804A -0.029665
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0289924
TASOR2 transcription activation suppressor family member 2 -0.0288207
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0286563
NCOA7 nuclear receptor coactivator 7 -0.0279218
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0276607
RAB10 RAB10, member RAS oncogene family -0.0272329
RPS5 ribosomal protein S5 -0.027073
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0270102
ZNF644 zinc finger protein 644 -0.0270073
FBXO11 F-box protein 11 -0.0268564
GNAS GNAS complex locus -0.0267149
VDAC1 voltage-dependent anion channel 1 -0.0264954
PTMA prothymosin, alpha -0.0261163
TPM4 tropomyosin 4 -0.0260778
TUBA1B tubulin, alpha 1b -0.024914
RAB7A RAB7A, member RAS oncogene family -0.0248749
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0248185
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0248052
RPS23 ribosomal protein S23 -0.0246989
RPL8 ribosomal protein L8 -0.0242954
JMJD1C jumonji domain containing 1C -0.0241175
NUP98 nucleoporin 98kDa -0.0241129
BICC1 BicC family RNA binding protein 1 -0.0237463
ATF4 activating transcription factor 4 -0.0234532
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0226105
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0224451
CDK12 cyclin-dependent kinase 12 -0.0220917
UBC ubiquitin C -0.0219625
HDLBP high density lipoprotein binding protein -0.021943
RPS24 ribosomal protein S24 -0.0219146
RASAL2 RAS protein activator like 2 -0.0215272
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0215131
TMEM87A transmembrane protein 87A -0.0214704
RHOA ras homolog family member A -0.0212624
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0210319
SPIDR scaffolding protein involved in DNA repair -0.0208572
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0208411
STAU1 staufen double-stranded RNA binding protein 1 -0.0206878
IER2 immediate early response 2 -0.0205405
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0204785
GOSR1 golgi SNAP receptor complex member 1 -0.0204094
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0203739
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0203738
ARF4 ADP-ribosylation factor 4 -0.0199152
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0199061
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -0.0198374
INTS6 integrator complex subunit 6 -0.0198203
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0192512
RPS25 ribosomal protein S25 -0.0191548
IARS1 isoleucyl-tRNA synthetase 1 -0.018729
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.018713
PHF3 PHD finger protein 3 -0.0183017
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0182978
MAP1B microtubule-associated protein 1B -0.0182228
HMGB1 high mobility group box 1 -0.0180586
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0180423
SEC31A SEC31 homolog A (S. cerevisiae) -0.0180192
LARP4B La ribonucleoprotein domain family, member 4B -0.0178434