Chlorhexidine (diacetate)_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EFNA5 ephrin-A5 0.175986
FN1 fibronectin 1 0.139717
NAMPT nicotinamide phosphoribosyltransferase 0.0907542
MCL1 myeloid cell leukemia 1 0.0864295
TRIO trio Rho guanine nucleotide exchange factor 0.079209
LIMCH1 LIM and calponin homology domains 1 0.0759714
ESYT2 extended synaptotagmin-like protein 2 0.0732039
DST dystonin 0.0728101
FNDC3B fibronectin type III domain containing 3B 0.0727904
PDE10A phosphodiesterase 10A 0.0712434
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0706368
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0682959
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0678891
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0674978
GRAMD1B GRAM domain containing 1B 0.0650412
COL5A2 collagen, type V, alpha 2 0.061318
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0603742
COL4A6 collagen, type IV, alpha 6 0.0588533
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0557986
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.054559
PCBP2 poly(rC) binding protein 2 0.0542834
FAM13A family with sequence similarity 13, member A 0.0527055
FLNB filamin B, beta 0.0518605
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.051405
RPS12 ribosomal protein S12 0.0513228
DNER delta/notch-like EGF repeat containing 0.0511557
KMT2C lysine (K)-specific methyltransferase 2C 0.0463526
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0459974
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0457372
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0447728
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0446763
PYGL phosphorylase, glycogen, liver 0.0427065
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0423983
CDH13 cadherin 13 0.0419184
NDRG1 N-myc downstream regulated 1 0.041733
IGFBP3 insulin-like growth factor binding protein 3 0.0416259
NBAS neuroblastoma amplified sequence 0.0410592
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0408839
PTPRM protein tyrosine phosphatase, receptor type, M 0.0406486
DOCK4 dedicator of cytokinesis 4 0.0405294
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0404243
PTK2 protein tyrosine kinase 2 0.039755
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0391509
TBXT T-box transcription factor T 0.0385618
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0381467
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0379455
PRELID2 PRELI domain containing 2 0.037944
KMT2E lysine (K)-specific methyltransferase 2E 0.0379127
KDM6A lysine (K)-specific demethylase 6A 0.0378322
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0377488
SFPQ splicing factor proline/glutamine-rich 0.0375158
TGFBI transforming growth factor, beta-induced, 68kDa 0.0375016
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0374698
ZNF292 zinc finger protein 292 0.0370346
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.036964
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0369174
B2M beta-2-microglobulin 0.0361747
STC2 stanniocalcin 2 0.035923
ARRDC3 arrestin domain containing 3 0.0357648
TPM3 tropomyosin 3 0.0350941
CTBP2 C-terminal binding protein 2 0.035011
UBA6 ubiquitin-like modifier activating enzyme 6 0.034662
AUTS2 autism susceptibility candidate 2 0.0345955
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0337294
SPAG9 sperm associated antigen 9 0.0336921
NUP58 nucleoporin 58 0.0336619
DGKD diacylglycerol kinase, delta 130kDa 0.0335811
SAMD4A sterile alpha motif domain containing 4A 0.0335427
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0333267
NALF1 NALCN channel auxiliary factor 1 0.0331146
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0329054
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0328644
FMNL2 formin-like 2 0.0326443
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0324312
DPY19L1 dpy-19-like 1 (C. elegans) 0.0319284
DOCK5 dedicator of cytokinesis 5 0.0316026
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0312341
RPS3 ribosomal protein S3 0.0309761
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0304911
RAB3B RAB3B, member RAS oncogene family 0.030182
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0300217
NCOR2 nuclear receptor corepressor 2 0.0298536
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0294975
ANKRD11 ankyrin repeat domain 11 0.0294093
TENT5A terminal nucleotidyltransferase 5A 0.0294051
CTSL cathepsin L 0.0293181
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.0292728
HLA-A major histocompatibility complex, class I, A 0.0288476
GPC6 glypican 6 0.0287609
HELZ helicase with zinc finger 0.0286148
CEP170 centrosomal protein 170kDa 0.0279206
RPL3 ribosomal protein L3 0.0278366
MSN moesin 0.0276112
GLIS3 GLIS family zinc finger 3 0.0275893
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0274037
DENND1A DENN/MADD domain containing 1A 0.0273714
PTEN phosphatase and tensin homolog 0.0271479
USP34 ubiquitin specific peptidase 34 0.0270163
OGA O-GlcNAcase 0.0270132
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 0.0268075

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.32484
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.108347
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.10129
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.101149
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0921819
TFPI2 tissue factor pathway inhibitor 2 -0.0831033
VCL vinculin -0.0826923
BZW1 basic leucine zipper and W2 domains 1 -0.0688791
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0664737
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0626894
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0588296
NCOA7 nuclear receptor coactivator 7 -0.0566645
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0556558
EIF1 eukaryotic translation initiation factor 1 -0.054161
PDLIM5 PDZ and LIM domain 5 -0.0527651
RPS24 ribosomal protein S24 -0.0512586
FTL ferritin, light polypeptide -0.0491321
KYNU kynureninase -0.0482662
PSD3 pleckstrin and Sec7 domain containing 3 -0.0437228
SMYD3 SET and MYND domain containing 3 -0.0420149
SH3KBP1 SH3-domain kinase binding protein 1 -0.0419747
ACTG1 actin gamma 1 -0.0414182
VIM vimentin -0.0405001
RGS2 regulator of G-protein signaling 2 -0.0400462
PDE4D phosphodiesterase 4D, cAMP-specific -0.0391338
RPLP1 ribosomal protein, large, P1 -0.0383352
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0358209
FTH1 ferritin, heavy polypeptide 1 -0.0357092
GNAS GNAS complex locus -0.0354521
MAP1B microtubule-associated protein 1B -0.0349609
RPS6 ribosomal protein S6 -0.0345852
CANX calnexin -0.0342097
HDLBP high density lipoprotein binding protein -0.0328997
IARS1 isoleucyl-tRNA synthetase 1 -0.0328033
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0315199
MT2A metallothionein 2A -0.0312024
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0307621
TM4SF1 transmembrane 4 L six family member 1 -0.0289436
AKR1C1 aldo-keto reductase family 1, member C1 -0.0288276
RRBP1 ribosome binding protein 1 -0.0284492
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0279897
NIBAN1 niban apoptosis regulator 1 -0.0273603
TXNRD1 thioredoxin reductase 1 -0.0273436
LMAN1 lectin, mannose-binding, 1 -0.0269578
AHNAK AHNAK nucleoprotein -0.0258042
EPHA4 EPH receptor A4 -0.0251719
ARF1 ADP-ribosylation factor 1 -0.0250213
RPLP0 ribosomal protein, large, P0 -0.0248176
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0247899
LSAMP limbic system-associated membrane protein -0.0245323
PM20D1 peptidase M20 domain containing 1 -0.0243028
IER3 immediate early response 3 -0.0239211
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0236741
PRKN parkin RBR E3 ubiquitin protein ligase -0.0234877
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0230799
TKT transketolase -0.0227067
ATAD1 ATPase family, AAA domain containing 1 -0.0226489
LOC112694756 uncharaterized LOC112694756 -0.0225997
VDAC1 voltage-dependent anion channel 1 -0.0222981
AGTPBP1 ATP/GTP binding protein 1 -0.0220314
SLC38A2 solute carrier family 38, member 2 -0.0218592
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0218308
S100A6 S100 calcium binding protein A6 -0.0211593
RPL4 ribosomal protein L4 -0.0211536
CHML choroideremia-like (Rab escort protein 2) -0.0206182
GARS1 glycyl-tRNA synthetase 1 -0.0204248
OSMR oncostatin M receptor -0.0199856
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0198959
BTG1 B-cell translocation gene 1, anti-proliferative -0.0198811
SOX4 SRY (sex determining region Y)-box 4 -0.0198355
INHBA inhibin, beta A -0.0196895
ZNF804A zinc finger protein 804A -0.0194702
NFX1 nuclear transcription factor, X-box binding 1 -0.0194371
TMSB4X thymosin beta 4, X-linked -0.0192261
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0190113
UGDH UDP-glucose 6-dehydrogenase -0.0188122
MAP7 microtubule-associated protein 7 -0.0187616
RPL14 ribosomal protein L14 -0.0186471
LARS1 leucyl-tRNA synthetase 1 -0.0184638
RHOB ras homolog family member B -0.0182307
NTN4 netrin 4 -0.0175245
DNAH14 dynein, axonemal, heavy chain 14 -0.0175133
TPT1 tumor protein, translationally-controlled 1 -0.0174076
RAB31 RAB31, member RAS oncogene family -0.0172893
GLCCI1 glucocorticoid induced 1 -0.0172179
RPL34 ribosomal protein L34 -0.0169735
TBCA tubulin folding cofactor A -0.0166411
PAPPA2 pappalysin 2 -0.0163998
STEAP1B STEAP family member 1B -0.0163674
RPS5 ribosomal protein S5 -0.0162376
SQSTM1 sequestosome 1 -0.0161375
QPCT glutaminyl-peptide cyclotransferase -0.0160336
FOXK1 forkhead box K1 -0.0159708
STC1 stanniocalcin 1 -0.0157793
EGR1 early growth response 1 -0.0157611
TMEM263 transmembrane protein 263 -0.0157458
ATF4 activating transcription factor 4 -0.015267
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0152349
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.0151299
MYOF myoferlin -0.0148163