Chlorhexidine (diacetate)_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DST dystonin 0.156918
ZNF292 zinc finger protein 292 0.137735
TSC22D2 TSC22 domain family, member 2 0.135564
CADM2 cell adhesion molecule 2 0.13088
THBS1 thrombospondin 1 0.129767
COL11A1 collagen, type XI, alpha 1 0.127007
ZFAND3 zinc finger, AN1-type domain 3 0.120742
COL5A2 collagen, type V, alpha 2 0.113284
NCKAP1 NCK-associated protein 1 0.0884326
PDGFC platelet derived growth factor C 0.0872564
ANKRD33B ankyrin repeat domain 33B 0.0868616
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0793938
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.073823
WDR43 WD repeat domain 43 0.0725449
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0722824
COL3A1 collagen, type III, alpha 1 0.0710086
PEG10 paternally expressed 10 0.0702606
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0673968
ITGAV integrin, alpha V 0.0631685
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0624341
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0607763
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0590327
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0582871
CALR calreticulin 0.0557594
HDAC9 histone deacetylase 9 0.0556763
USP3 ubiquitin specific peptidase 3 0.053421
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0506554
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.050334
RPL5 ribosomal protein L5 0.0499391
ENAH enabled homolog (Drosophila) 0.0496154
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0494937
IGF1R insulin-like growth factor 1 receptor 0.0487353
FUBP1 far upstream element (FUSE) binding protein 1 0.0468588
RHEB Ras homolog enriched in brain 0.0460925
PDE4D phosphodiesterase 4D, cAMP-specific 0.0456407
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0437148
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0436421
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0435961
PUM2 pumilio RNA-binding family member 2 0.0421608
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0414928
RYBP RING1 and YY1 binding protein 0.0414007
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0411369
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0409424
ADAM9 ADAM metallopeptidase domain 9 0.0408999
MEMO1 mediator of cell motility 1 0.040764
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.040496
SET SET nuclear proto-oncogene 0.0404147
PUM1 pumilio RNA-binding family member 1 0.0403835
BCLAF1 BCL2-associated transcription factor 1 0.0387485
MYH9 myosin, heavy chain 9, non-muscle 0.0386114
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 0.0378592
PRRC2C proline-rich coiled-coil 2C 0.0377169
PDS5B PDS5 cohesin associated factor B 0.0376611
OSBPL8 oxysterol binding protein-like 8 0.0372012
KMT2C lysine (K)-specific methyltransferase 2C 0.0371768
KMT2E lysine (K)-specific methyltransferase 2E 0.0370922
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.036997
CDC73 cell division cycle 73 0.0364115
CCDC88A coiled-coil domain containing 88A 0.0360875
PDIA6 protein disulfide isomerase family A, member 6 0.035925
NAMPT nicotinamide phosphoribosyltransferase 0.0355185
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0350289
MCTP1 multiple C2 domains, transmembrane 1 0.0350262
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0350144
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0346569
RPS12 ribosomal protein S12 0.0345274
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0344203
CCN2 cellular communication network factor 2 0.034048
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.033999
RBM33 RNA binding motif protein 33 0.0338744
CFL2 cofilin 2 (muscle) 0.0333218
ANKRD12 ankyrin repeat domain 12 0.0332266
MYO10 myosin X 0.0331959
APP amyloid beta (A4) precursor protein 0.0330983
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.032812
SLC38A2 solute carrier family 38, member 2 0.0327356
RAD23B RAD23 homolog B (S. cerevisiae) 0.0324909
AGO3 argonaute RISC catalytic component 3 0.0323794
UPP1 uridine phosphorylase 1 0.0320689
QKI QKI, KH domain containing, RNA binding 0.0320426
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0319167
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0319123
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0315625
TPM3 tropomyosin 3 0.0312445
ZNF207 zinc finger protein 207 0.0307328
MTF2 metal response element binding transcription factor 2 0.0306917
ZEB2 zinc finger E-box binding homeobox 2 0.030592
RPL23 ribosomal protein L23 0.0305266
CCNL1 cyclin L1 0.0305188
NAP1L1 nucleosome assembly protein 1-like 1 0.0304742
SYT1 synaptotagmin I 0.0304242
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E 0.0300774
PNN pinin, desmosome associated protein 0.0298943
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0297219
GPBP1 GC-rich promoter binding protein 1 0.0296395
ANKRD11 ankyrin repeat domain 11 0.0292258
XPR1 xenotropic and polytropic retrovirus receptor 1 0.0291636
CSDE1 cold shock domain containing E1, RNA-binding 0.029121
SRRM2 serine/arginine repetitive matrix 2 0.0290347
COLEC11 collectin sub-family member 11 0.0286313

decreased expression

Symbol Name Standardized Value
CDH10 cadherin 10, type 2 (T2-cadherin) -0.157594
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.151324
VIM vimentin -0.108689
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0865197
PCDH9 protocadherin 9 -0.0802933
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0776265
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0694375
RPS6 ribosomal protein S6 -0.0646409
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0630356
PARD3B par-3 family cell polarity regulator beta -0.0608802
ACTG1 actin gamma 1 -0.0575712
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0548791
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0542576
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0541572
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0520084
PRELID2 PRELI domain containing 2 -0.0497417
PHIP pleckstrin homology domain interacting protein -0.0468088
RPLP1 ribosomal protein, large, P1 -0.0438086
GOLGA4 golgin A4 -0.0437735
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.043296
TAS2R14 taste receptor, type 2, member 14 -0.0423319
GNAS GNAS complex locus -0.0409315
TENM3 teneurin transmembrane protein 3 -0.0403959
CENPF centromere protein F, 350/400kDa -0.0400294
MAP4 microtubule-associated protein 4 -0.0399906
MRPS6 mitochondrial ribosomal protein S6 -0.039298
CAVIN1 caveolae associated protein 1 -0.0377082
MT2A metallothionein 2A -0.0356478
THOC2 THO complex 2 -0.0355342
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0348035
RPLP0 ribosomal protein, large, P0 -0.0344508
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.0340978
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0339567
MT1E metallothionein 1E -0.0338903
ADGRL2 adhesion G protein-coupled receptor L2 -0.0337694
TPT1 tumor protein, translationally-controlled 1 -0.0337666
RPS8 ribosomal protein S8 -0.0337557
WSB1 WD repeat and SOCS box containing 1 -0.0337369
SREBF2 sterol regulatory element binding transcription factor 2 -0.0335515
CDH19 cadherin 19, type 2 -0.0331774
XPO1 exportin 1 -0.0324834
ZCCHC7 zinc finger, CCHC domain containing 7 -0.032251
NFIA nuclear factor I/A -0.0322496
AHNAK AHNAK nucleoprotein -0.032089
INTS6 integrator complex subunit 6 -0.0316109
ESYT2 extended synaptotagmin-like protein 2 -0.0315719
FTL ferritin, light polypeptide -0.0313208
DOCK7 dedicator of cytokinesis 7 -0.031114
MT1X metallothionein 1X -0.0304046
LRRC4C leucine rich repeat containing 4C -0.0301872
ATXN2 ataxin 2 -0.0294874
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0291739
TUT4 terminal uridylyl transferase 4 -0.0290037
WNK1 WNK lysine deficient protein kinase 1 -0.0287772
ZNF638 zinc finger protein 638 -0.0286398
RSF1 remodeling and spacing factor 1 -0.0284813
RAD51B RAD51 paralog B -0.0283347
TMSB4X thymosin beta 4, X-linked -0.0282903
TUBA1B tubulin, alpha 1b -0.0280087
HDLBP high density lipoprotein binding protein -0.0278109
RPS24 ribosomal protein S24 -0.0278086
HSPB1 heat shock 27kDa protein 1 -0.0277555
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.027497
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.027301
MDK midkine (neurite growth-promoting factor 2) -0.0267373
WASF2 WAS protein family, member 2 -0.0266612
OXSR1 oxidative stress responsive 1 -0.0265662
MED13L mediator complex subunit 13-like -0.0265233
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0263164
ZMYM4 zinc finger, MYM-type 4 -0.0263062
EMP1 epithelial membrane protein 1 -0.0260742
NEBL nebulette -0.0260557
SRP54 signal recognition particle 54kDa -0.0255685
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0252711
HMGB1 high mobility group box 1 -0.0252202
SLC44A5 solute carrier family 44, member 5 -0.0251943
TTC3 tetratricopeptide repeat domain 3 -0.0250034
CDIN1 CDAN1 interacting nuclease 1 -0.0249982
PDIA3 protein disulfide isomerase family A, member 3 -0.024973
NPR2 natriuretic peptide receptor 2 -0.024971
IARS1 isoleucyl-tRNA synthetase 1 -0.0248318
SNX6 sorting nexin 6 -0.0248232
RCOR1 REST corepressor 1 -0.0243298
S100A10 S100 calcium binding protein A10 -0.0240976
RPL28 ribosomal protein L28 -0.024078
DLG1 discs, large homolog 1 (Drosophila) -0.0240159
NALF1 NALCN channel auxiliary factor 1 -0.0237016
UBB ubiquitin B -0.0236745
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0235855
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0235333
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0234159
RASAL2 RAS protein activator like 2 -0.0231301
TBL1X transducin (beta)-like 1X-linked -0.023122
RIGI RNA sensor RIG-I -0.0230796
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0229637
SKIL SKI-like proto-oncogene -0.022909
COPA coatomer protein complex, subunit alpha -0.0227942
ZMYM2 zinc finger, MYM-type 2 -0.0227385
BPTF bromodomain PHD finger transcription factor -0.0227237
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0226844