Chlorhexidine (diacetate)_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VCL vinculin 0.130599
DST dystonin 0.115698
MYH9 myosin, heavy chain 9, non-muscle 0.104318
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0997595
RPS12 ribosomal protein S12 0.095376
CD44 CD44 molecule (Indian blood group) 0.0917231
ASPH aspartate beta-hydroxylase 0.0898229
ERRFI1 ERBB receptor feedback inhibitor 1 0.085482
WWTR1 WW domain containing transcription regulator 1 0.0759711
JMJD1C jumonji domain containing 1C 0.0721626
SFTPA2 surfactant protein A2 0.0672069
SDK1 sidekick cell adhesion molecule 1 0.0656587
RPL35A ribosomal protein L35a 0.0654636
MCL1 myeloid cell leukemia 1 0.0653858
ANKRD11 ankyrin repeat domain 11 0.0632649
RPS3 ribosomal protein S3 0.0627846
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.062414
MKI67 marker of proliferation Ki-67 0.0617287
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0616575
FNDC3B fibronectin type III domain containing 3B 0.0601577
ACTN4 actinin, alpha 4 0.060013
SMAD3 SMAD family member 3 0.0572793
MACF1 microtubule-actin crosslinking factor 1 0.0552427
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0550307
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.053955
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0531882
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0528698
RPL37A ribosomal protein L37a 0.0525755
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0521441
ENO1 enolase 1, (alpha) 0.051163
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0507296
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0487826
SMYD3 SET and MYND domain containing 3 0.0482454
CSNK1A1 casein kinase 1, alpha 1 0.0469436
TM4SF1 transmembrane 4 L six family member 1 0.0467457
TXNRD1 thioredoxin reductase 1 0.0465729
EGR1 early growth response 1 0.0463525
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0455925
MT2A metallothionein 2A 0.0433927
SLC38A2 solute carrier family 38, member 2 0.0425223
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0425142
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0416934
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0408476
KTN1 kinectin 1 (kinesin receptor) 0.0400955
SET SET nuclear proto-oncogene 0.0396595
SAMD4B sterile alpha motif domain containing 4B 0.0395217
VMP1 vacuole membrane protein 1 0.0394523
LPP LIM domain containing preferred translocation partner in lipoma 0.0392624
EFNA5 ephrin-A5 0.0391826
RPL26 ribosomal protein L26 0.038763
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0386776
TPM3 tropomyosin 3 0.0382333
PRELID2 PRELI domain containing 2 0.0380476
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0376708
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.0374128
SEPTIN9 septin 9 0.0373082
SPTBN1 spectrin, beta, non-erythrocytic 1 0.03729
RPS17 ribosomal protein S17 0.0369256
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.036636
SRRM2 serine/arginine repetitive matrix 2 0.0359298
DGKD diacylglycerol kinase, delta 130kDa 0.035535
CENPF centromere protein F, 350/400kDa 0.0354195
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0351845
SFPQ splicing factor proline/glutamine-rich 0.0346547
NAP1L1 nucleosome assembly protein 1-like 1 0.0344712
RTN4 reticulon 4 0.0343774
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0342655
MCTP1 multiple C2 domains, transmembrane 1 0.0342201
ATXN1 ataxin 1 0.0339239
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 0.0338314
ANGPTL4 angiopoietin-like 4 0.0337847
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.0337815
SPRED2 sprouty-related, EVH1 domain containing 2 0.0336776
AHNAK2 AHNAK nucleoprotein 2 0.0334044
BIRC2 baculoviral IAP repeat containing 2 0.0331881
RPL23 ribosomal protein L23 0.0324324
THSD4 thrombospondin, type I, domain containing 4 0.0320257
ITGB5 integrin, beta 5 0.031868
DNMBP dynamin binding protein 0.0317282
PDE10A phosphodiesterase 10A 0.0314402
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0312816
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0310553
LDHA lactate dehydrogenase A 0.0310055
DSCAM Down syndrome cell adhesion molecule 0.0308494
SATB2 SATB homeobox 2 0.0301836
NCEH1 neutral cholesterol ester hydrolase 1 0.0300097
CARD18 caspase recruitment domain family, member 18 0.0296882
RPS27A ribosomal protein S27a 0.0295268
AFDN afadin, adherens junction formation factor 0.029431
EXT1 exostosin glycosyltransferase 1 0.0293317
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0293054
ARRDC3 arrestin domain containing 3 0.0292912
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0291996
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0287233
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0283733
NFE2L1 nuclear factor, erythroid 2-like 1 0.0281647
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.0280091
RAD51B RAD51 paralog B 0.0279258
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0278623
SLC35F3 solute carrier family 35, member F3 0.0277226

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.271166
VIM vimentin -0.210803
RPS16 ribosomal protein S16 -0.186667
FBL fibrillarin -0.10022
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0599596
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0590653
AHNAK AHNAK nucleoprotein -0.0560773
S100A6 S100 calcium binding protein A6 -0.054698
ACTG1 actin gamma 1 -0.0488525
PTMA prothymosin, alpha -0.0452904
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0416619
AKAP12 A kinase (PRKA) anchor protein 12 -0.0392498
LOC112694756 uncharaterized LOC112694756 -0.0355221
CTSD cathepsin D -0.0343324
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0330079
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.032543
WASF2 WAS protein family, member 2 -0.0310972
HSPG2 heparan sulfate proteoglycan 2 -0.0305067
RPLP0 ribosomal protein, large, P0 -0.029422
WDR45B WD repeat domain 45B -0.0284426
PDGFB platelet-derived growth factor beta polypeptide -0.0258661
RPS5 ribosomal protein S5 -0.0245639
TMEM123 transmembrane protein 123 -0.023521
FTH1 ferritin, heavy polypeptide 1 -0.0213897
RPL28 ribosomal protein L28 -0.0202116
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0197692
RPL27A ribosomal protein L27a -0.0195449
HDLBP high density lipoprotein binding protein -0.0193137
TMSB10 thymosin beta 10 -0.0193087
USP3 ubiquitin specific peptidase 3 -0.019157
UBC ubiquitin C -0.0190646
GNAS GNAS complex locus -0.0189415
TUBB tubulin, beta class I -0.0181581
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.0180254
POTEF POTE ankyrin domain family, member F -0.0179644
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0175192
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.017327
ASTN2 astrotactin 2 -0.0172571
RLF rearranged L-myc fusion -0.0171868
H1-0 H1.0 linker histone -0.0171386
CANX calnexin -0.0170739
ACBD3 acyl-CoA binding domain containing 3 -0.0169901
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0167634
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0164064
NPR2 natriuretic peptide receptor 2 -0.0163468
KMT2A lysine (K)-specific methyltransferase 2A -0.0162776
TAPBP TAP binding protein (tapasin) -0.0156879
CCND1 cyclin D1 -0.0156296
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0153203
PKM pyruvate kinase, muscle -0.0151097
SEC24A SEC24 family member A -0.0150532
S100A10 S100 calcium binding protein A10 -0.0147075
ZFP36 ZFP36 ring finger protein -0.0146707
COPB1 coatomer protein complex, subunit beta 1 -0.0145428
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0143513
LARS1 leucyl-tRNA synthetase 1 -0.0139708
FBXO17 F-box protein 17 -0.0138912
ATP5F1B ATP synthase F1 subunit beta -0.0137472
RBM3 RNA binding motif (RNP1, RRM) protein 3 -0.0135923
MYADM myeloid-associated differentiation marker -0.0134561
RPL8 ribosomal protein L8 -0.0133542
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0132053
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0132038
SRP54 signal recognition particle 54kDa -0.0131755
VDAC1 voltage-dependent anion channel 1 -0.0131142
RTN3 reticulon 3 -0.0128778
CCNI cyclin I -0.012837
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0128313
LMAN1 lectin, mannose-binding, 1 -0.0127257
INSIG1 insulin induced gene 1 -0.012543
RPL39 ribosomal protein L39 -0.0124396
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0123043
PPARG peroxisome proliferator-activated receptor gamma -0.0122481
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0121362
TMEM263 transmembrane protein 263 -0.0118428
ECH1 enoyl CoA hydratase 1, peroxisomal -0.0117352
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0116679
CKB creatine kinase, brain -0.0115904
SUCO SUN domain containing ossification factor -0.0115174
OXSR1 oxidative stress responsive 1 -0.0114551
SQLE squalene epoxidase -0.0113094
NOLC1 nucleolar and coiled-body phosphoprotein 1 -0.0111381
KDM5B lysine (K)-specific demethylase 5B -0.0110909
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0110072
ARF1 ADP-ribosylation factor 1 -0.0107496
HSPB1 heat shock 27kDa protein 1 -0.0107052
TUBA1B tubulin, alpha 1b -0.0106655
KNOP1 lysine-rich nucleolar protein 1 -0.0106037
IARS1 isoleucyl-tRNA synthetase 1 -0.0105071
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0104577
PDIA3 protein disulfide isomerase family A, member 3 -0.010369
DEK DEK proto-oncogene -0.0103602
FBXO27 F-box protein 27 -0.0100245
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0100211
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -0.00988657
NPEPPS aminopeptidase puromycin sensitive -0.00979235
KLHL24 kelch-like family member 24 -0.00955783
BTG1 B-cell translocation gene 1, anti-proliferative -0.009542
TPD52 tumor protein D52 -0.00948078
ESYT2 extended synaptotagmin-like protein 2 -0.00943176