Chlorhexidine (diacetate)_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LAMB3 laminin, beta 3 0.286283
MUC4 mucin 4, cell surface associated 0.263856
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.123983
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0920884
CTNND1 catenin (cadherin-associated protein), delta 1 0.0847108
MACF1 microtubule-actin crosslinking factor 1 0.0838808
SMAD3 SMAD family member 3 0.0736577
IL1RAP interleukin 1 receptor accessory protein 0.0723811
DSCAM Down syndrome cell adhesion molecule 0.0720812
TRIO trio Rho guanine nucleotide exchange factor 0.0698754
AFDN afadin, adherens junction formation factor 0.0665452
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0637223
RPS3 ribosomal protein S3 0.0613088
RUNX1 runt-related transcription factor 1 0.060155
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0569472
KRT17 keratin 17, type I 0.0550415
EPS8 epidermal growth factor receptor pathway substrate 8 0.0519125
FRMD5 FERM domain containing 5 0.0510653
NRIP1 nuclear receptor interacting protein 1 0.0508891
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0506119
OSBPL3 oxysterol binding protein-like 3 0.0503186
PLAUR plasminogen activator, urokinase receptor 0.0501458
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0488996
MBNL2 muscleblind-like splicing regulator 2 0.0488957
KLF6 Kruppel-like factor 6 0.0487017
CD59 CD59 molecule, complement regulatory protein 0.0481815
BCAR3 breast cancer anti-estrogen resistance 3 0.0467395
EGFR epidermal growth factor receptor 0.0454579
CALR calreticulin 0.044033
PLAT plasminogen activator, tissue 0.0439546
RASA2 RAS p21 protein activator 2 0.0434867
MACC1 metastasis associated in colon cancer 1 0.0429512
EZR ezrin 0.042675
RPL23 ribosomal protein L23 0.0426222
ARRDC3 arrestin domain containing 3 0.0421515
LPP LIM domain containing preferred translocation partner in lipoma 0.0414545
WWC1 WW and C2 domain containing 1 0.041376
MYH9 myosin, heavy chain 9, non-muscle 0.0397796
SVIL supervillin 0.03953
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0391355
MYO5B myosin VB 0.0389549
FAM107B family with sequence similarity 107, member B 0.0380826
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 0.0380748
MTAP methylthioadenosine phosphorylase 0.0380098
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0376385
OGA O-GlcNAcase 0.0373493
RPL26 ribosomal protein L26 0.0372916
MYOF myoferlin 0.0372911
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0365795
SLTM SAFB-like, transcription modulator 0.0364311
BCL2L1 BCL2-like 1 0.0363394
ANLN anillin, actin binding protein 0.0355675
MKI67 marker of proliferation Ki-67 0.0353439
RPS12 ribosomal protein S12 0.0352101
CLTC clathrin, heavy chain (Hc) 0.0351863
THBS1 thrombospondin 1 0.0349183
DLG1 discs, large homolog 1 (Drosophila) 0.0345323
ARHGAP29 Rho GTPase activating protein 29 0.0344443
ANKRD10 ankyrin repeat domain 10 0.03419
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0340359
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0340212
KDM3A lysine (K)-specific demethylase 3A 0.0338313
DLC1 DLC1 Rho GTPase activating protein 0.0335162
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0334674
NPEPPS aminopeptidase puromycin sensitive 0.0332117
BACE2 beta-site APP-cleaving enzyme 2 0.0332075
SMC4 structural maintenance of chromosomes 4 0.0330562
HLA-B major histocompatibility complex, class I, B 0.0328999
SRSF5 serine/arginine-rich splicing factor 5 0.0324161
NAV2 neuron navigator 2 0.032066
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0319547
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0319523
ANKRD28 ankyrin repeat domain 28 0.0315055
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0314183
NECTIN2 nectin cell adhesion molecule 2 0.0311706
CELF1 CUGBP, Elav-like family member 1 0.0309168
INHBA inhibin, beta A 0.0308864
ERBIN erbb2 interacting protein 0.0306578
PPARD peroxisome proliferator-activated receptor delta 0.0301705
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0296115
TM4SF1 transmembrane 4 L six family member 1 0.0296091
APP amyloid beta (A4) precursor protein 0.0294212
ITGB4 integrin, beta 4 0.0288468
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0287209
LATS2 large tumor suppressor kinase 2 0.0285937
ATP13A3 ATPase type 13A3 0.0284731
ZFAND3 zinc finger, AN1-type domain 3 0.0284676
STK24 serine/threonine kinase 24 0.0284046
TACSTD2 tumor-associated calcium signal transducer 2 0.0281218
DOCK1 dedicator of cytokinesis 1 0.0280944
TMCC1 transmembrane and coiled-coil domain family 1 0.0278709
NCKAP1 NCK-associated protein 1 0.0277749
NCEH1 neutral cholesterol ester hydrolase 1 0.0273675
TGM2 transglutaminase 2 0.0273168
ACTN4 actinin, alpha 4 0.0272636
USP6NL USP6 N-terminal like 0.0270773
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0269002
ANXA11 annexin A11 0.0265991
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0264219
ETV6 ets variant 6 0.0263232

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.341767
INTS6 integrator complex subunit 6 -0.0924209
POTEF POTE ankyrin domain family, member F -0.0836634
FTH1 ferritin, heavy polypeptide 1 -0.0797926
RPS6 ribosomal protein S6 -0.0796002
TXNIP thioredoxin interacting protein -0.0754252
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0740371
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0653416
KRT19 keratin 19, type I -0.0603456
SQSTM1 sequestosome 1 -0.0552859
PTMA prothymosin, alpha -0.0544528
PKM pyruvate kinase, muscle -0.0532288
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0522224
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0518858
FTL ferritin, light polypeptide -0.049816
TMSB4X thymosin beta 4, X-linked -0.0450695
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0424355
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0422715
LY6E lymphocyte antigen 6 complex, locus E -0.0408722
EGR1 early growth response 1 -0.0387511
FN1 fibronectin 1 -0.035701
TPM4 tropomyosin 4 -0.0356914
S100A6 S100 calcium binding protein A6 -0.0356533
CANX calnexin -0.0349728
MT2A metallothionein 2A -0.0349716
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0344523
TPI1 triosephosphate isomerase 1 -0.0343053
BTG1 B-cell translocation gene 1, anti-proliferative -0.0332395
S100A10 S100 calcium binding protein A10 -0.0332344
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0329424
SP100 SP100 nuclear antigen -0.0328603
VEGFA vascular endothelial growth factor A -0.0320786
CD44 CD44 molecule (Indian blood group) -0.0317183
LOC102724023 ES1 protein homolog, mitochondrial -0.0311945
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0307655
VIM vimentin -0.0303416
B2M beta-2-microglobulin -0.0302446
CCND1 cyclin D1 -0.0292132
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0290303
SKIL SKI-like proto-oncogene -0.02894
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0286656
DEK DEK proto-oncogene -0.0286261
FOSL1 FOS-like antigen 1 -0.0280912
TAPBP TAP binding protein (tapasin) -0.0277776
LOC112694756 uncharaterized LOC112694756 -0.0276857
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0273761
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0271094
HMGA1 high mobility group AT-hook 1 -0.026947
COPB1 coatomer protein complex, subunit beta 1 -0.0262808
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0261319
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0260821
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0260079
ACTG1 actin gamma 1 -0.0252031
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0244345
ITGA6 integrin, alpha 6 -0.02439
GNAS GNAS complex locus -0.024117
ATF7IP activating transcription factor 7 interacting protein -0.0240491
JARID2 jumonji, AT rich interactive domain 2 -0.0238988
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0238215
LRRC23 leucine rich repeat containing 23 -0.0233677
LYST lysosomal trafficking regulator -0.0230725
RPL28 ribosomal protein L28 -0.0227942
RCOR1 REST corepressor 1 -0.0227399
CCNL1 cyclin L1 -0.0225659
RPS5 ribosomal protein S5 -0.0224063
RIGI RNA sensor RIG-I -0.0223006
ASPH aspartate beta-hydroxylase -0.0221922
ATN1 atrophin 1 -0.0221334
PERP PERP, TP53 apoptosis effector -0.0220772
WARS1 tryptophanyl-tRNA synthetase 1 -0.0218295
HOMER1 homer scaffolding protein 1 -0.0217727
IFI27 interferon, alpha-inducible protein 27 -0.0217346
PDE4D phosphodiesterase 4D, cAMP-specific -0.0215987
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0215968
MIDEAS mitotic deacetylase associated SANT domain protein -0.02143
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0210862
PDIA3 protein disulfide isomerase family A, member 3 -0.0209915
SULF2 sulfatase 2 -0.0203033
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0202993
NSD1 nuclear receptor binding SET domain protein 1 -0.0201541
EPB41L5 erythrocyte membrane protein band 4.1 like 5 -0.0199511
RRBP1 ribosome binding protein 1 -0.0198202
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0197953
ATP5F1B ATP synthase F1 subunit beta -0.0197831
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0197462
G0S2 G0/G1 switch 2 -0.0197009
VDAC1 voltage-dependent anion channel 1 -0.0196911
RPL21 ribosomal protein L21 -0.0196568
DSTN destrin (actin depolymerizing factor) -0.0194836
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0193037
FHIT fragile histidine triad -0.0192875
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.019263
RPLP1 ribosomal protein, large, P1 -0.0192619
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0192301
KRT7 keratin 7, type II -0.0191776
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0190521
MX2 MX dynamin-like GTPase 2 -0.0189656
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.018884
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.0188499
TMEM123 transmembrane protein 123 -0.0188099