Chlorhexidine (diacetate)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LAMB3 laminin, beta 3 0.125057
ZEB1 zinc finger E-box binding homeobox 1 0.120645
RPS12 ribosomal protein S12 0.0889222
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0763121
CAPRIN2 caprin family member 2 0.0712826
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0712423
RPL23 ribosomal protein L23 0.0669931
STAT1 signal transducer and activator of transcription 1, 91kDa 0.061339
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0602532
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0601943
ZFAND3 zinc finger, AN1-type domain 3 0.059229
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0556114
MYH9 myosin, heavy chain 9, non-muscle 0.0532228
HSPA8 heat shock 70kDa protein 8 0.0523953
ENO1 enolase 1, (alpha) 0.0515582
NCKAP1 NCK-associated protein 1 0.0512304
FMNL2 formin-like 2 0.0512004
C2CD2 C2 calcium-dependent domain containing 2 0.0509432
PGK1 phosphoglycerate kinase 1 0.0508751
RPL3 ribosomal protein L3 0.0490799
ATP13A3 ATPase type 13A3 0.0489551
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0486571
PUM2 pumilio RNA-binding family member 2 0.0479201
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0478343
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0466027
SFPQ splicing factor proline/glutamine-rich 0.0454629
TXNRD1 thioredoxin reductase 1 0.0453738
ACTN1 actinin, alpha 1 0.0448211
NAV2 neuron navigator 2 0.0424208
CDK17 cyclin-dependent kinase 17 0.0423477
RPL11 ribosomal protein L11 0.042163
RPL26 ribosomal protein L26 0.0417028
MKI67 marker of proliferation Ki-67 0.0414436
CORO1C coronin, actin binding protein, 1C 0.0413516
NIPBL Nipped-B homolog (Drosophila) 0.040666
UBE3A ubiquitin protein ligase E3A 0.0400972
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0400232
APP amyloid beta (A4) precursor protein 0.039974
STK4 serine/threonine kinase 4 0.0399559
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0399156
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0396685
UPP1 uridine phosphorylase 1 0.0393223
CCNY cyclin Y 0.0392917
ARHGAP22 Rho GTPase activating protein 22 0.0387903
RPL35A ribosomal protein L35a 0.0382181
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0372774
PRRC2C proline-rich coiled-coil 2C 0.0365444
CAMTA1 calmodulin binding transcription activator 1 0.0360535
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0360106
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0359355
SPRED1 sprouty-related, EVH1 domain containing 1 0.0358828
XRN2 5'-3' exoribonuclease 2 0.0356991
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0355022
KMT2C lysine (K)-specific methyltransferase 2C 0.0352768
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0351161
KDM3A lysine (K)-specific demethylase 3A 0.0348583
OGA O-GlcNAcase 0.0347122
KLC1 kinesin light chain 1 0.0346842
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0345803
RPS3 ribosomal protein S3 0.0345307
RBM33 RNA binding motif protein 33 0.0344908
USP9X ubiquitin specific peptidase 9, X-linked 0.034035
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0338476
DSCAM Down syndrome cell adhesion molecule 0.0331765
RBM26 RNA binding motif protein 26 0.033101
CCND2 cyclin D2 0.032773
TMSB10 thymosin beta 10 0.0326995
KDM5C lysine (K)-specific demethylase 5C 0.0326597
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0326048
YTHDC1 YTH domain containing 1 0.0325267
STX3 syntaxin 3 0.0324897
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0324499
NSUN2 NOP2/Sun RNA methyltransferase family, member 2 0.0323738
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0322548
TRIO trio Rho guanine nucleotide exchange factor 0.0322131
PLAUR plasminogen activator, urokinase receptor 0.0322021
GSE1 Gse1 coiled-coil protein 0.0321169
RASA2 RAS p21 protein activator 2 0.0319193
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0316701
NUP58 nucleoporin 58 0.0316583
EFR3A EFR3 homolog A (S. cerevisiae) 0.0311425
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0306448
YEATS2 YEATS domain containing 2 0.0306165
CALR calreticulin 0.0305347
FLNB filamin B, beta 0.0304125
NAMPT nicotinamide phosphoribosyltransferase 0.0302485
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0301077
TOMM34 translocase of outer mitochondrial membrane 34 0.0300597
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0299987
ANKRD11 ankyrin repeat domain 11 0.0299545
BIRC2 baculoviral IAP repeat containing 2 0.0299073
SBF2 SET binding factor 2 0.0298599
ELL2 elongation factor, RNA polymerase II, 2 0.029858
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.0293611
TEX10 testis expressed 10 0.0292827
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0292515
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0289094
EHBP1L1 EH domain binding protein 1-like 1 0.0286689
SHANK1 SH3 and multiple ankyrin repeat domains 1 0.0286684
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0286062

decreased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.160339
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.145417
HDAC9 histone deacetylase 9 -0.121931
ZNF438 zinc finger protein 438 -0.107643
RPS6 ribosomal protein S6 -0.104168
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0894253
POTEF POTE ankyrin domain family, member F -0.0866594
ACTG1 actin gamma 1 -0.0804838
IARS1 isoleucyl-tRNA synthetase 1 -0.0722413
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0719532
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0694251
NAV3 neuron navigator 3 -0.0668287
NABP1 nucleic acid binding protein 1 -0.0661874
PBX3 pre-B-cell leukemia homeobox 3 -0.0623563
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0608708
JMJD1C jumonji domain containing 1C -0.0595993
RPL8 ribosomal protein L8 -0.0564582
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0562014
MTDH metadherin -0.0534372
FRMD6 FERM domain containing 6 -0.0527573
SLC38A2 solute carrier family 38, member 2 -0.0488427
ZBTB20 zinc finger and BTB domain containing 20 -0.0475194
ALCAM activated leukocyte cell adhesion molecule -0.0459693
PDIA3 protein disulfide isomerase family A, member 3 -0.0446886
EXT1 exostosin glycosyltransferase 1 -0.0416524
RPL28 ribosomal protein L28 -0.0397732
PCNX4 pecanex 4 -0.0393813
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0390462
RPLP0 ribosomal protein, large, P0 -0.0388354
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0387841
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0385052
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0375682
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0367496
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.036683
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0365561
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0358543
RPLP2 ribosomal protein, large, P2 -0.03576
LDHB lactate dehydrogenase B -0.0352096
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0351132
PKM pyruvate kinase, muscle -0.0347717
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0341394
TPM4 tropomyosin 4 -0.03386
CALU calumenin -0.0330035
DLC1 DLC1 Rho GTPase activating protein -0.03256
RPS16 ribosomal protein S16 -0.0321659
RPS24 ribosomal protein S24 -0.0320543
RPS25 ribosomal protein S25 -0.0315847
RPS29 ribosomal protein S29 -0.0314585
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0309
FAF1 Fas (TNFRSF6) associated factor 1 -0.0306779
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.030562
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.030557
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0302021
BNC2 basonuclin 2 -0.0296342
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0294206
DEK DEK proto-oncogene -0.0285738
TRAM1 translocation associated membrane protein 1 -0.0285033
ATP5F1B ATP synthase F1 subunit beta -0.0280998
RPL21 ribosomal protein L21 -0.0280429
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0276509
RPS11 ribosomal protein S11 -0.0275769
RPS23 ribosomal protein S23 -0.0273113
RAB3IP RAB3A interacting protein -0.027212
RPL14 ribosomal protein L14 -0.0265602
RRBP1 ribosome binding protein 1 -0.0265427
RPS5 ribosomal protein S5 -0.0264278
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0264218
RPLP1 ribosomal protein, large, P1 -0.0264084
CREB5 cAMP responsive element binding protein 5 -0.026277
BLZF1 basic leucine zipper nuclear factor 1 -0.0262706
LOC112694756 uncharaterized LOC112694756 -0.0256065
RPL27A ribosomal protein L27a -0.025292
AKAP9 A kinase (PRKA) anchor protein 9 -0.0249149
EIF1 eukaryotic translation initiation factor 1 -0.0247766
MCTP1 multiple C2 domains, transmembrane 1 -0.0247749
ZBTB38 zinc finger and BTB domain containing 38 -0.0247571
SP100 SP100 nuclear antigen -0.0247385
RPS20 ribosomal protein S20 -0.0244206
PHF3 PHD finger protein 3 -0.0242295
FRMD4A FERM domain containing 4A -0.0241402
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -0.0240373
TUBA1B tubulin, alpha 1b -0.0237601
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0235713
GNAS GNAS complex locus -0.023453
WNT2B wingless-type MMTV integration site family, member 2B -0.0233749
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0231093
RPS15 ribosomal protein S15 -0.0230928
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0230451
RAP1B RAP1B, member of RAS oncogene family -0.0227719
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0227546
PKP4 plakophilin 4 -0.0226273
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.022603
ATM ATM serine/threonine kinase -0.0223137
EGR1 early growth response 1 -0.0222583
CCT8 chaperonin containing TCP1, subunit 8 (theta) -0.0221201
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0215905
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0212403
CANX calnexin -0.0210505
RPL7A ribosomal protein L7a -0.0206461
SEC31A SEC31 homolog A (S. cerevisiae) -0.0203499