Chlorhexidine (diacetate)_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A 0.341424
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0598044
SMOC1 SPARC related modular calcium binding 1 0.0471676
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0434899
CAMTA1 calmodulin binding transcription activator 1 0.0424132
ZNF292 zinc finger protein 292 0.039882
FAT1 FAT atypical cadherin 1 0.0397865
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0397652
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0396297
AOPEP aminopeptidase O (putative) 0.0393584
PDE4B phosphodiesterase 4B, cAMP-specific 0.038518
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0360789
RPH3AL rabphilin 3A-like (without C2 domains) 0.0341283
TENT5A terminal nucleotidyltransferase 5A 0.0328796
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0313364
CKAP5 cytoskeleton associated protein 5 0.0307913
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0306949
DPYSL3 dihydropyrimidinase-like 3 0.0301274
NCKAP1 NCK-associated protein 1 0.0292926
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0287538
CADM1 cell adhesion molecule 1 0.0286692
RIT2 Ras-like without CAAX 2 0.0286246
RPS12 ribosomal protein S12 0.02707
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0268976
TRIO trio Rho guanine nucleotide exchange factor 0.0267761
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0260847
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0259412
ARB2A ARB2 cotranscriptional regulator A 0.0258326
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0247744
CDH12 cadherin 12, type 2 (N-cadherin 2) 0.0243217
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0241942
SASH1 SAM and SH3 domain containing 1 0.0239018
FOXN3 forkhead box N3 0.023826
XPO1 exportin 1 0.0237142
IRS2 insulin receptor substrate 2 0.0233089
MIS18BP1 MIS18 binding protein 1 0.0230149
ANKRD28 ankyrin repeat domain 28 0.0229547
MATR3 matrin 3 0.0228887
NCAM1 neural cell adhesion molecule 1 0.02278
CENPF centromere protein F, 350/400kDa 0.0227321
IGF1R insulin-like growth factor 1 receptor 0.0227008
SET SET nuclear proto-oncogene 0.0225821
VGF VGF nerve growth factor inducible 0.0224795
NAMPT nicotinamide phosphoribosyltransferase 0.0223029
SFPQ splicing factor proline/glutamine-rich 0.022193
SINHCAF SIN3-HDAC complex associated factor 0.0221394
MTMR7 myotubularin related protein 7 0.0218657
MKI67 marker of proliferation Ki-67 0.0218314
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0217472
TMEM255B transmembrane protein 255B 0.0214958
PARD3 par-3 family cell polarity regulator 0.021447
GRAMD4 GRAM domain containing 4 0.0213078
PTBP2 polypyrimidine tract binding protein 2 0.0212254
RTN4 reticulon 4 0.0211617
WWOX WW domain containing oxidoreductase 0.0209954
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0206763
KDM3A lysine (K)-specific demethylase 3A 0.0206655
ANKRD11 ankyrin repeat domain 11 0.0205198
MARCHF6 membrane associated ring-CH-type finger 6 0.0203859
IFI6 interferon, alpha-inducible protein 6 0.02035
ZEB1 zinc finger E-box binding homeobox 1 0.0202364
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0201473
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0200871
CNBD1 cyclic nucleotide binding domain containing 1 0.0198536
ANKRD10 ankyrin repeat domain 10 0.019722
SSBP2 single-stranded DNA binding protein 2 0.0196344
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0195316
ANLN anillin, actin binding protein 0.0194989
NAP1L1 nucleosome assembly protein 1-like 1 0.0194092
PRRC2C proline-rich coiled-coil 2C 0.0192388
GSE1 Gse1 coiled-coil protein 0.019174
RPS7 ribosomal protein S7 0.0191691
SLCO3A1 solute carrier organic anion transporter family, member 3A1 0.0191016
RPL26 ribosomal protein L26 0.0190174
TMEM178B transmembrane protein 178B 0.0188039
FANCL Fanconi anemia, complementation group L 0.0185266
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0183789
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0183721
UBAP2L ubiquitin associated protein 2-like 0.0181326
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0181159
NUP58 nucleoporin 58 0.0180894
IQGAP3 IQ motif containing GTPase activating protein 3 0.018014
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0178821
KANTR KDM5C adjacent non-coding transcript 0.0178388
MT2A metallothionein 2A 0.0176282
RFLNA refilin A 0.0176251
STK24 serine/threonine kinase 24 0.0175331
NCOR1 nuclear receptor corepressor 1 0.0175231
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0173793
CHD7 chromodomain helicase DNA binding protein 7 0.0173611
AFDN afadin, adherens junction formation factor 0.0173009
SPAG5 sperm associated antigen 5 0.017159
PUM2 pumilio RNA-binding family member 2 0.0169455
ECT2 epithelial cell transforming 2 0.0169028
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0168446
TUBGCP3 tubulin, gamma complex associated protein 3 0.0167132
PRKD1 protein kinase D1 0.0166192
PDS5B PDS5 cohesin associated factor B 0.0162484
RPL23 ribosomal protein L23 0.0161006
CDK17 cyclin-dependent kinase 17 0.0160977

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.123083
MCL1 myeloid cell leukemia 1 -0.109027
IGFBP5 insulin-like growth factor binding protein 5 -0.0971052
EGR1 early growth response 1 -0.0926404
STC1 stanniocalcin 1 -0.0898699
NRG1 neuregulin 1 -0.0848802
GPC6 glypican 6 -0.0769945
ACTG1 actin gamma 1 -0.0763332
MAP1B microtubule-associated protein 1B -0.0755385
PTMA prothymosin, alpha -0.0737837
CPE carboxypeptidase E -0.069576
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0659288
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0634945
TSHZ2 teashirt zinc finger homeobox 2 -0.059043
INHBA inhibin, beta A -0.0571311
SNTG1 syntrophin, gamma 1 -0.0561612
ESRRG estrogen-related receptor gamma -0.0554075
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0553559
MCTP1 multiple C2 domains, transmembrane 1 -0.0509801
FOS FBJ murine osteosarcoma viral oncogene homolog -0.050669
SCG2 secretogranin II -0.0504135
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -0.0487264
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 -0.0481688
PTCHD4 patched domain containing 4 -0.0479377
NDRG1 N-myc downstream regulated 1 -0.0450737
KIF26B kinesin family member 26B -0.0449686
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0442282
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0439762
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0421935
TOP1 topoisomerase (DNA) I -0.0420903
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0412109
ENO1 enolase 1, (alpha) -0.0410008
NAV2 neuron navigator 2 -0.0404171
ZBTB20 zinc finger and BTB domain containing 20 -0.0401137
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0398333
CANX calnexin -0.0371184
HOMER1 homer scaffolding protein 1 -0.0370144
PDIA3 protein disulfide isomerase family A, member 3 -0.0369135
GPC5 glypican 5 -0.036843
TMSB4X thymosin beta 4, X-linked -0.0365085
CALCA calcitonin-related polypeptide alpha -0.0361172
TPM4 tropomyosin 4 -0.0353949
EPHA6 EPH receptor A6 -0.0345277
SETX senataxin -0.0342486
PKM pyruvate kinase, muscle -0.0339756
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0333496
CHGA chromogranin A -0.0332545
JUN jun proto-oncogene -0.03322
CHGB chromogranin B -0.0331985
NANOS1 nanos homolog 1 (Drosophila) -0.0326361
BCL2 B-cell CLL/lymphoma 2 -0.0325618
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit -0.0324847
ST18 suppression of tumorigenicity 18, zinc finger -0.0323527
TENM1 teneurin transmembrane protein 1 -0.0318028
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0314332
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0310438
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0309871
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.030729
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0306399
HM13 histocompatibility (minor) 13 -0.0302699
NELL1 NEL-like 1 (chicken) -0.0302664
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0302136
NBEA neurobeachin -0.0297323
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0293902
POTEF POTE ankyrin domain family, member F -0.028742
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0284256
ASIC2 acid sensing (proton gated) ion channel 2 -0.0278224
INTS6 integrator complex subunit 6 -0.0277712
GOLGB1 golgin B1 -0.0273514
RORA RAR-related orphan receptor A -0.0271084
ARFGEF3 ARFGEF family member 3 -0.0269681
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.02651
SLC38A2 solute carrier family 38, member 2 -0.0262642
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.0262044
FNDC3A fibronectin type III domain containing 3A -0.025999
MAP7 microtubule-associated protein 7 -0.0254683
SMYD3 SET and MYND domain containing 3 -0.0245605
LMAN1 lectin, mannose-binding, 1 -0.0238482
FN1 fibronectin 1 -0.0234889
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0230949
COPA coatomer protein complex, subunit alpha -0.0230919
GNAS GNAS complex locus -0.0230674
IARS1 isoleucyl-tRNA synthetase 1 -0.0228967
ATF6 activating transcription factor 6 -0.0220692
UBB ubiquitin B -0.0219241
KCNMB3 potassium channel subfamily M regulatory beta subunit 3 -0.021836
SRP54 signal recognition particle 54kDa -0.0216506
DOCK5 dedicator of cytokinesis 5 -0.0214613
RAB1A RAB1A, member RAS oncogene family -0.0214328
RIMS2 regulating synaptic membrane exocytosis 2 -0.0214263
ZNF638 zinc finger protein 638 -0.0213032
RHOBTB3 Rho-related BTB domain containing 3 -0.0212434
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0210739
FAM13A family with sequence similarity 13, member A -0.0210686
DENND4A DENN/MADD domain containing 4A -0.0210248
ONECUT2 one cut homeobox 2 -0.0208949
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0206816
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0206631
VMP1 vacuole membrane protein 1 -0.0206444
CDK13 cyclin-dependent kinase 13 -0.0203695