Chlorhexidine (diacetate)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.131687
TXNRD1 thioredoxin reductase 1 0.116316
PDGFC platelet derived growth factor C 0.105385
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.100033
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.071151
EEF2 eukaryotic translation elongation factor 2 0.0699389
PDE4D phosphodiesterase 4D, cAMP-specific 0.0682316
PYGB phosphorylase, glycogen; brain 0.0677934
RPS12 ribosomal protein S12 0.0596551
VCL vinculin 0.0576186
NCEH1 neutral cholesterol ester hydrolase 1 0.0493619
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0489699
SAMD4A sterile alpha motif domain containing 4A 0.0474199
RPL3 ribosomal protein L3 0.0451115
ADAM10 ADAM metallopeptidase domain 10 0.0451039
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.044011
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0439509
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0433382
LDHA lactate dehydrogenase A 0.0429246
RPL26 ribosomal protein L26 0.04204
ZNF608 zinc finger protein 608 0.0419753
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0417842
TMEM65 transmembrane protein 65 0.0409518
SMYD3 SET and MYND domain containing 3 0.0408833
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0403179
LPP LIM domain containing preferred translocation partner in lipoma 0.0399471
RPL23 ribosomal protein L23 0.0388387
HDAC9 histone deacetylase 9 0.0387774
SRRM2 serine/arginine repetitive matrix 2 0.0380327
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0378984
SET SET nuclear proto-oncogene 0.0375915
RPS3 ribosomal protein S3 0.0372557
ENO1 enolase 1, (alpha) 0.0362838
LOXL3 lysyl oxidase-like 3 0.0360113
TBC1D5 TBC1 domain family, member 5 0.0349574
N4BP2L2 NEDD4 binding protein 2-like 2 0.0346645
MACF1 microtubule-actin crosslinking factor 1 0.0341481
MYO5C myosin VC 0.0340099
ZNF292 zinc finger protein 292 0.0339304
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0334746
SENP6 SUMO1/sentrin specific peptidase 6 0.0328644
ZBTB20 zinc finger and BTB domain containing 20 0.0325154
COG5 component of oligomeric golgi complex 5 0.032338
GLI2 GLI family zinc finger 2 0.0318073
RPL35A ribosomal protein L35a 0.0316336
APP amyloid beta (A4) precursor protein 0.0311841
RPL37A ribosomal protein L37a 0.0309892
SOX6 SRY (sex determining region Y)-box 6 0.0308512
CSDE1 cold shock domain containing E1, RNA-binding 0.0307681
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0306902
KIF5B kinesin family member 5B 0.0301538
PRELID2 PRELI domain containing 2 0.0296197
GOLGA4 golgin A4 0.0292648
EXT1 exostosin glycosyltransferase 1 0.0291446
RPS2 ribosomal protein S2 0.0291249
TM4SF1 transmembrane 4 L six family member 1 0.0291023
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0290814
TGFBR3 transforming growth factor, beta receptor III 0.0290226
ANKRD12 ankyrin repeat domain 12 0.0282869
HSPA8 heat shock 70kDa protein 8 0.0279424
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0278778
GSK3B glycogen synthase kinase 3 beta 0.0275742
OSMR oncostatin M receptor 0.0274304
AKAP9 A kinase (PRKA) anchor protein 9 0.027229
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.027122
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0266224
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0264831
ANXA1 annexin A1 0.0262184
KLC1 kinesin light chain 1 0.0260835
TRERF1 transcriptional regulating factor 1 0.0258092
PRRC2C proline-rich coiled-coil 2C 0.0257911
RTN4 reticulon 4 0.0257535
TNRC6B trinucleotide repeat containing 6B 0.0256352
PIWIL1 piwi-like RNA-mediated gene silencing 1 0.0251444
EZR ezrin 0.0250597
RBM39 RNA binding motif protein 39 0.024903
YBX3 Y box binding protein 3 0.0247306
WARS1 tryptophanyl-tRNA synthetase 1 0.0246856
SFPQ splicing factor proline/glutamine-rich 0.0246713
BPTF bromodomain PHD finger transcription factor 0.0246034
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0245383
FHAD1 forkhead-associated (FHA) phosphopeptide binding domain 1 0.0242912
KLF3 Kruppel-like factor 3 (basic) 0.0242477
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0241593
EIF4B eukaryotic translation initiation factor 4B 0.0240129
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0238999
SMAD6 SMAD family member 6 0.0238365
RIGI RNA sensor RIG-I 0.0234825
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.0233975
CENPF centromere protein F, 350/400kDa 0.0232095
DPYD dihydropyrimidine dehydrogenase 0.0231037
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0230377
GSE1 Gse1 coiled-coil protein 0.0229853
CHD9 chromodomain helicase DNA binding protein 9 0.0229354
EEF1G eukaryotic translation elongation factor 1 gamma 0.0229147
XPOT exportin, tRNA 0.0227562
AMOTL2 angiomotin like 2 0.0227325
NFE2L1 nuclear factor, erythroid 2-like 1 0.0227168
VGLL4 vestigial-like family member 4 0.0224053
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0223029

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.282993
PTMA prothymosin, alpha -0.166856
PDE4B phosphodiesterase 4B, cAMP-specific -0.107886
DLG1 discs, large homolog 1 (Drosophila) -0.0886096
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0859189
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.066741
SSBP2 single-stranded DNA binding protein 2 -0.0655815
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0613348
TPT1 tumor protein, translationally-controlled 1 -0.0569459
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0569075
ACTG1 actin gamma 1 -0.0512794
AHNAK AHNAK nucleoprotein -0.0493243
CCND1 cyclin D1 -0.0488342
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0454286
DIAPH3 diaphanous-related formin 3 -0.0453182
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0411425
POTEF POTE ankyrin domain family, member F -0.039381
PKM pyruvate kinase, muscle -0.039365
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0388746
ECT2 epithelial cell transforming 2 -0.0364944
BMP2K BMP2 inducible kinase -0.0355604
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0342618
RPS23 ribosomal protein S23 -0.033557
RFC3 replication factor C (activator 1) 3, 38kDa -0.0334879
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0330343
IARS1 isoleucyl-tRNA synthetase 1 -0.0329737
TMEM135 transmembrane protein 135 -0.032675
HSPB1 heat shock 27kDa protein 1 -0.0323539
S100A4 S100 calcium binding protein A4 -0.0320621
FNDC3B fibronectin type III domain containing 3B -0.0313877
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0307547
CAMTA1 calmodulin binding transcription activator 1 -0.0297767
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0297613
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0292403
WDR45B WD repeat domain 45B -0.0289355
RPS25 ribosomal protein S25 -0.0286549
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0278297
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.027527
UNC13A unc-13 homolog A (C. elegans) -0.0260661
FAM162A family with sequence similarity 162, member A -0.0252172
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0245169
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0235742
DEK DEK proto-oncogene -0.0234858
RPS6 ribosomal protein S6 -0.0234698
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0226816
CUX1 cut-like homeobox 1 -0.0225486
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0224135
RPS16 ribosomal protein S16 -0.0223975
TUBA1B tubulin, alpha 1b -0.0222649
BMP10 bone morphogenetic protein 10 -0.0220439
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0220034
LARS1 leucyl-tRNA synthetase 1 -0.021292
ZNF638 zinc finger protein 638 -0.0211837
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0211381
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0205313
INSIG2 insulin induced gene 2 -0.020105
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0199656
VDAC1 voltage-dependent anion channel 1 -0.019894
P4HB prolyl 4-hydroxylase, beta polypeptide -0.019767
CCNI cyclin I -0.0197626
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.019745
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0194807
USP34 ubiquitin specific peptidase 34 -0.0192668
NSD2 nuclear receptor binding SET domain protein 2 -0.0192623
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0192047
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0189392
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0189034
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0188115
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0188025
RPS24 ribosomal protein S24 -0.0185617
RPL28 ribosomal protein L28 -0.0185361
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0185178
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0181225
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 -0.0177944
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 -0.0177138
HMGB1 high mobility group box 1 -0.0176505
ATAD2 ATPase family, AAA domain containing 2 -0.0176149
THOC2 THO complex 2 -0.017582
TXNIP thioredoxin interacting protein -0.0174765
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0173526
RPLP0 ribosomal protein, large, P0 -0.0173223
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0172717
TUBB tubulin, beta class I -0.017159
RPL19 ribosomal protein L19 -0.0171074
RPL32 ribosomal protein L32 -0.0170991
IGF2 insulin-like growth factor 2 -0.0169249
RBM3 RNA binding motif (RNP1, RRM) protein 3 -0.0167519
RPS5 ribosomal protein S5 -0.0167218
RAB18 RAB18, member RAS oncogene family -0.0166113
SCAF11 SR-related CTD-associated factor 11 -0.0164424
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0163717
ZCCHC8 zinc finger, CCHC domain containing 8 -0.0162254
TPI1 triosephosphate isomerase 1 -0.0161525
MBNL1 muscleblind-like splicing regulator 1 -0.0161289
UBE2K ubiquitin-conjugating enzyme E2K -0.0161103
FUS FUS RNA binding protein -0.016094
GATAD2A GATA zinc finger domain containing 2A -0.0157311
RPL27A ribosomal protein L27a -0.015697
PDE7B phosphodiesterase 7B -0.0156819
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0156647