Chlorhexidine (diacetate)_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.188499
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.165651
NAMPT nicotinamide phosphoribosyltransferase 0.163525
TRIO trio Rho guanine nucleotide exchange factor 0.124996
MYH9 myosin, heavy chain 9, non-muscle 0.113241
NDRG1 N-myc downstream regulated 1 0.110194
FNDC3B fibronectin type III domain containing 3B 0.10995
ELL2 elongation factor, RNA polymerase II, 2 0.106152
FN1 fibronectin 1 0.0987689
DST dystonin 0.0904936
CD44 CD44 molecule (Indian blood group) 0.0872376
ARRDC3 arrestin domain containing 3 0.0750145
CADM1 cell adhesion molecule 1 0.0747093
SOD2 superoxide dismutase 2, mitochondrial 0.0727553
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0722768
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0688476
UGCG UDP-glucose ceramide glucosyltransferase 0.0658404
CALR calreticulin 0.0644976
COL6A3 collagen, type VI, alpha 3 0.0638124
ZNF292 zinc finger protein 292 0.0624666
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0617567
TENT5A terminal nucleotidyltransferase 5A 0.0617095
ZMIZ1 zinc finger, MIZ-type containing 1 0.0613515
SMAD3 SMAD family member 3 0.0612613
PPARD peroxisome proliferator-activated receptor delta 0.0611183
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0594582
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0563472
BASP1 brain abundant, membrane attached signal protein 1 0.0559145
PRELID2 PRELI domain containing 2 0.0543189
STC1 stanniocalcin 1 0.0512467
RPS12 ribosomal protein S12 0.0508216
NAV2 neuron navigator 2 0.0497778
STAT1 signal transducer and activator of transcription 1, 91kDa 0.048134
UBA6 ubiquitin-like modifier activating enzyme 6 0.0479072
EXT1 exostosin glycosyltransferase 1 0.0475771
FLNB filamin B, beta 0.0475248
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0473638
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0472952
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0471874
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0458042
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0451856
GLIS3 GLIS family zinc finger 3 0.0446444
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0441615
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0423878
FMNL2 formin-like 2 0.0418498
B2M beta-2-microglobulin 0.0413023
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.0400526
PDE10A phosphodiesterase 10A 0.0399085
YEATS2 YEATS domain containing 2 0.0397013
CDK19 cyclin-dependent kinase 19 0.037964
HLA-B major histocompatibility complex, class I, B 0.0377086
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0376666
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.037554
OGA O-GlcNAcase 0.0373753
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0370679
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0370465
DUSP5 dual specificity phosphatase 5 0.0370396
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0363737
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0362128
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0358794
HLA-A major histocompatibility complex, class I, A 0.0349449
ATXN1 ataxin 1 0.0346111
EFNA5 ephrin-A5 0.034238
INHBA inhibin, beta A 0.0339966
ADM adrenomedullin 0.0337912
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0334385
MCL1 myeloid cell leukemia 1 0.033312
RAD51B RAD51 paralog B 0.0326509
MACF1 microtubule-actin crosslinking factor 1 0.0314847
TGFBI transforming growth factor, beta-induced, 68kDa 0.0314609
ESYT2 extended synaptotagmin-like protein 2 0.030457
ANLN anillin, actin binding protein 0.0303127
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0301536
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0298976
DENND5A DENN/MADD domain containing 5A 0.0298138
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0296142
CEP250 centrosomal protein 250kDa 0.0295945
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0291312
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0289389
BCLAF1 BCL2-associated transcription factor 1 0.0285041
DOCK5 dedicator of cytokinesis 5 0.0284733
RASA2 RAS p21 protein activator 2 0.028186
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0280377
RUNX1 runt-related transcription factor 1 0.0279896
AFDN afadin, adherens junction formation factor 0.0276744
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.027575
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0267007
TPM3 tropomyosin 3 0.0266712
KDM2A lysine (K)-specific demethylase 2A 0.0266353
ABTB3 ankyrin repeat and BTB domain containing 3 0.0265204
KLF6 Kruppel-like factor 6 0.0264532
VCAN versican 0.026426
SPAG9 sperm associated antigen 9 0.0262406
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0257485
STC2 stanniocalcin 2 0.0256837
TNIP1 TNFAIP3 interacting protein 1 0.025483
TSC22D2 TSC22 domain family, member 2 0.0253141
CD59 CD59 molecule, complement regulatory protein 0.0251572
NPEPPS aminopeptidase puromycin sensitive 0.0251376
LDHA lactate dehydrogenase A 0.0250165

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.165545
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.14402
FTH1 ferritin, heavy polypeptide 1 -0.117576
VIM vimentin -0.116891
VCL vinculin -0.0960087
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0900907
IGFBP3 insulin-like growth factor binding protein 3 -0.0889561
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0753051
AHNAK AHNAK nucleoprotein -0.0731186
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0633102
MT1E metallothionein 1E -0.0617065
FTL ferritin, light polypeptide -0.0589393
RPS6 ribosomal protein S6 -0.0575851
IER3 immediate early response 3 -0.054899
MT1X metallothionein 1X -0.051538
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0499541
AKAP12 A kinase (PRKA) anchor protein 12 -0.047713
SLC38A2 solute carrier family 38, member 2 -0.0460562
FRMD4A FERM domain containing 4A -0.0454808
EIF1 eukaryotic translation initiation factor 1 -0.0444453
TMSB4X thymosin beta 4, X-linked -0.0419519
DIAPH2 diaphanous-related formin 2 -0.0416175
PALLD palladin, cytoskeletal associated protein -0.0412889
GOLGB1 golgin B1 -0.0381518
TKT transketolase -0.0377033
MAP1B microtubule-associated protein 1B -0.0362087
GNAS GNAS complex locus -0.0360733
INTS6 integrator complex subunit 6 -0.0354943
PTPRK protein tyrosine phosphatase, receptor type, K -0.0352488
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0350937
ACTG1 actin gamma 1 -0.0350434
RPLP1 ribosomal protein, large, P1 -0.0342606
GPC6 glypican 6 -0.0324237
LOC112694756 uncharaterized LOC112694756 -0.0323959
RRBP1 ribosome binding protein 1 -0.0307433
IFI16 interferon, gamma-inducible protein 16 -0.0280457
MAP4 microtubule-associated protein 4 -0.0278934
QKI QKI, KH domain containing, RNA binding -0.0275781
DEK DEK proto-oncogene -0.0273957
TUBB tubulin, beta class I -0.0270231
ZBTB20 zinc finger and BTB domain containing 20 -0.0268594
RPS24 ribosomal protein S24 -0.0267906
IARS1 isoleucyl-tRNA synthetase 1 -0.0265729
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0265556
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0256002
TBL1X transducin (beta)-like 1X-linked -0.0256
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0254504
NABP1 nucleic acid binding protein 1 -0.0254319
GARS1 glycyl-tRNA synthetase 1 -0.0243382
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0242339
MORF4L2 mortality factor 4 like 2 -0.0242
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0234321
KYNU kynureninase -0.023207
PKM pyruvate kinase, muscle -0.0231523
SQSTM1 sequestosome 1 -0.0231149
SLC38A1 solute carrier family 38, member 1 -0.0230053
CANX calnexin -0.0229566
RPL28 ribosomal protein L28 -0.0226795
VDAC1 voltage-dependent anion channel 1 -0.0226384
CAVIN1 caveolae associated protein 1 -0.0222353
XPOT exportin, tRNA -0.0218941
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0218877
MT1G metallothionein 1G -0.021619
CENPF centromere protein F, 350/400kDa -0.0215482
PHF3 PHD finger protein 3 -0.021406
HDLBP high density lipoprotein binding protein -0.0209943
RPL14 ribosomal protein L14 -0.0209042
SMAD2 SMAD family member 2 -0.0207152
ZC3H11A zinc finger CCCH-type containing 11A -0.0206609
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase -0.0204954
SENP6 SUMO1/sentrin specific peptidase 6 -0.0202777
XAF1 XIAP associated factor 1 -0.0202176
NIPBL Nipped-B homolog (Drosophila) -0.0200656
ATF4 activating transcription factor 4 -0.0198593
GOLGA3 golgin A3 -0.0196711
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0196623
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0196336
CLIP1 CAP-GLY domain containing linker protein 1 -0.019558
KLHL24 kelch-like family member 24 -0.0195334
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.019465
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0193664
RTN3 reticulon 3 -0.0192916
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0192678
TOP2A topoisomerase (DNA) II alpha 170kDa -0.019128
SLC30A1 solute carrier family 30 (zinc transporter), member 1 -0.0190823
BICC1 BicC family RNA binding protein 1 -0.0188675
ZNF609 zinc finger protein 609 -0.0187484
RPS4X ribosomal protein S4, X-linked -0.0187143
INSIG1 insulin induced gene 1 -0.018703
CTSD cathepsin D -0.0183462
RPL19 ribosomal protein L19 -0.0183067
UBC ubiquitin C -0.0180616
RHOBTB3 Rho-related BTB domain containing 3 -0.0180281
TXNRD1 thioredoxin reductase 1 -0.0176339
BTG1 B-cell translocation gene 1, anti-proliferative -0.0175475
BRD2 bromodomain containing 2 -0.0174577
DDIT3 DNA-damage-inducible transcript 3 -0.0174548
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0174504
AAK1 AP2 associated kinase 1 -0.0174198
SH3PXD2B SH3 and PX domains 2B -0.0173975