Chlorhexidine (diacetate)_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.276624
MYH9 myosin, heavy chain 9, non-muscle 0.112445
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0928261
NDRG1 N-myc downstream regulated 1 0.0918806
TGFBI transforming growth factor, beta-induced, 68kDa 0.0851004
CALR calreticulin 0.0810304
ANLN anillin, actin binding protein 0.0792017
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0765045
CD44 CD44 molecule (Indian blood group) 0.0756027
TMSB10 thymosin beta 10 0.0745479
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0709184
MACF1 microtubule-actin crosslinking factor 1 0.0672477
ARRDC3 arrestin domain containing 3 0.0641607
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0615612
EFNA5 ephrin-A5 0.060116
THBS1 thrombospondin 1 0.0592333
ZBTB20 zinc finger and BTB domain containing 20 0.0561946
BACE2 beta-site APP-cleaving enzyme 2 0.0559
FAM13A family with sequence similarity 13, member A 0.0553617
COL5A1 collagen, type V, alpha 1 0.0524767
PHC2 polyhomeotic homolog 2 (Drosophila) 0.050679
LIMS1 LIM and senescent cell antigen-like domains 1 0.0489725
SMAD3 SMAD family member 3 0.0486295
ANKRD36 ankyrin repeat domain 36 0.0474633
SETBP1 SET binding protein 1 0.0463947
PRELID2 PRELI domain containing 2 0.0462599
AVL9 AVL9 homolog (S. cerevisiase) 0.0455331
ANXA2 annexin A2 0.0441291
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0439953
LPP LIM domain containing preferred translocation partner in lipoma 0.0439805
MAML2 mastermind-like 2 (Drosophila) 0.0428679
RUNX1 runt-related transcription factor 1 0.0422148
NAMPT nicotinamide phosphoribosyltransferase 0.0420975
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0410193
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0406935
PDE4D phosphodiesterase 4D, cAMP-specific 0.0401115
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0398781
DPYD dihydropyrimidine dehydrogenase 0.0395459
ENO1 enolase 1, (alpha) 0.0394143
SMYD3 SET and MYND domain containing 3 0.0391203
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0384614
CSNK1A1 casein kinase 1, alpha 1 0.0384143
FBXL7 F-box and leucine-rich repeat protein 7 0.0379365
ERRFI1 ERBB receptor feedback inhibitor 1 0.0378724
TSC22D1 TSC22 domain family, member 1 0.0372382
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.037226
BMERB1 bMERB domain containing 1 0.0371429
NIBAN2 niban apoptosis regulator 2 0.0370378
LDHA lactate dehydrogenase A 0.0369741
MT1X metallothionein 1X 0.0367385
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0365728
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0360401
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0359547
FLNA filamin A, alpha 0.035804
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0354546
FAM20C family with sequence similarity 20, member C 0.0353725
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0351364
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0346331
CD59 CD59 molecule, complement regulatory protein 0.0343307
NEK7 NIMA-related kinase 7 0.0342008
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0338671
NACA nascent polypeptide-associated complex alpha subunit 0.0334243
MKI67 marker of proliferation Ki-67 0.0334132
ASPH aspartate beta-hydroxylase 0.0333067
DIAPH3 diaphanous-related formin 3 0.0323107
SERINC1 serine incorporator 1 0.0322481
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0321337
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0321235
CENPF centromere protein F, 350/400kDa 0.0320853
NAV1 neuron navigator 1 0.0320587
CTSA cathepsin A 0.0319715
CMIP c-Maf inducing protein 0.0317489
RASA3 RAS p21 protein activator 3 0.0316797
ACTN4 actinin, alpha 4 0.0311869
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0302339
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0301798
RPL35A ribosomal protein L35a 0.0300779
PRKN parkin RBR E3 ubiquitin protein ligase 0.0300417
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0299466
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0298447
MYLK myosin light chain kinase 0.029139
ABI2 abl-interactor 2 0.0289899
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0289288
BCAS3 breast carcinoma amplified sequence 3 0.0287198
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0286235
ANKRD11 ankyrin repeat domain 11 0.0281476
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0281011
RPL5 ribosomal protein L5 0.0278621
STK17A serine/threonine kinase 17a 0.0278348
VIM vimentin 0.0277314
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0275635
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0273917
MMP2 matrix metallopeptidase 2 0.0271022
ACTN1 actinin, alpha 1 0.0269828
PDIA6 protein disulfide isomerase family A, member 6 0.0269604
GOLGA4 golgin A4 0.0267969
SRPK2 SRSF protein kinase 2 0.0266317
EXT1 exostosin glycosyltransferase 1 0.0265269
KIDINS220 kinase D-interacting substrate, 220kDa 0.0265121
SYNJ2 synaptojanin 2 0.0264775

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.151435
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.125837
CXCL8 chemokine (C-X-C motif) ligand 8 -0.123981
FN1 fibronectin 1 -0.0935232
IL6 interleukin 6 -0.0811412
PKM pyruvate kinase, muscle -0.0755067
MT2A metallothionein 2A -0.0668
FTH1 ferritin, heavy polypeptide 1 -0.0650071
AKAP12 A kinase (PRKA) anchor protein 12 -0.0593657
PDIA3 protein disulfide isomerase family A, member 3 -0.0589625
LOX lysyl oxidase -0.056948
RPS6 ribosomal protein S6 -0.0536974
F3 coagulation factor III (thromboplastin, tissue factor) -0.0528289
CLIC4 chloride intracellular channel 4 -0.0525202
ESYT2 extended synaptotagmin-like protein 2 -0.0508821
CDH13 cadherin 13 -0.0507932
SLC38A2 solute carrier family 38, member 2 -0.0504112
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.047344
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0471085
SAMD4A sterile alpha motif domain containing 4A -0.0442096
POTEF POTE ankyrin domain family, member F -0.0441742
ACTG1 actin gamma 1 -0.04395
SEPTIN2 septin 2 -0.0439081
HLA-C major histocompatibility complex, class I, C -0.0418457
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0415889
IARS1 isoleucyl-tRNA synthetase 1 -0.0392632
BRWD1 bromodomain and WD repeat domain containing 1 -0.0391908
B2M beta-2-microglobulin -0.0384018
PRRC2C proline-rich coiled-coil 2C -0.0382337
ADAM9 ADAM metallopeptidase domain 9 -0.03769
FTL ferritin, light polypeptide -0.0375865
SEC31A SEC31 homolog A (S. cerevisiae) -0.0374879
KTN1 kinectin 1 (kinesin receptor) -0.0373766
CALD1 caldesmon 1 -0.0368527
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0368124
TNS3 tensin 3 -0.0365175
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0365117
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0362802
COL6A1 collagen, type VI, alpha 1 -0.0361433
USP34 ubiquitin specific peptidase 34 -0.0357838
SPAG9 sperm associated antigen 9 -0.0357576
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0352326
JAK1 Janus kinase 1 -0.0352069
AKAP9 A kinase (PRKA) anchor protein 9 -0.0349216
GARS1 glycyl-tRNA synthetase 1 -0.034604
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0344907
EPAS1 endothelial PAS domain protein 1 -0.0344431
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0343955
DDIT4 DNA-damage-inducible transcript 4 -0.0342311
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0340724
PDLIM5 PDZ and LIM domain 5 -0.034014
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0338515
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0337884
CADM1 cell adhesion molecule 1 -0.0335873
RTN4 reticulon 4 -0.0334967
CYLD cylindromatosis (turban tumor syndrome) -0.032957
RHOBTB3 Rho-related BTB domain containing 3 -0.0329463
PARD3 par-3 family cell polarity regulator -0.0328926
ADAM10 ADAM metallopeptidase domain 10 -0.0328281
EGR1 early growth response 1 -0.0326025
UBC ubiquitin C -0.0325592
PTK2 protein tyrosine kinase 2 -0.0325493
ERBIN erbb2 interacting protein -0.031575
AHNAK AHNAK nucleoprotein -0.031156
RPL28 ribosomal protein L28 -0.030506
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0304545
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0304047
SOD2 superoxide dismutase 2, mitochondrial -0.0303963
STC1 stanniocalcin 1 -0.0302563
TMEM263 transmembrane protein 263 -0.0299513
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0298196
IL6ST interleukin 6 signal transducer -0.0291945
VCL vinculin -0.0290416
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0288726
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0287319
KCMF1 potassium channel modulatory factor 1 -0.0286771
NABP1 nucleic acid binding protein 1 -0.0285457
NBEAL1 neurobeachin-like 1 -0.0285432
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.028484
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0283361
CUL3 cullin 3 -0.0280094
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0279872
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0279299
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.0277185
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0276561
RSF1 remodeling and spacing factor 1 -0.0274428
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) -0.0274029
ACIN1 apoptotic chromatin condensation inducer 1 -0.0273724
FNDC3A fibronectin type III domain containing 3A -0.0269519
IRF1 interferon regulatory factor 1 -0.0269278
MYADM myeloid-associated differentiation marker -0.0267539
SEC24A SEC24 family member A -0.0265184
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0264065
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0263714
RDX radixin -0.0263635
WDR45B WD repeat domain 45B -0.0260421
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0260344
CDK6 cyclin-dependent kinase 6 -0.0260131
CD109 CD109 molecule -0.0259898
EIF5B eukaryotic translation initiation factor 5B -0.0255932