Chlorhexidine (diacetate)_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SMYD3 SET and MYND domain containing 3 0.0922781
NAMPT nicotinamide phosphoribosyltransferase 0.0739862
SOD2 superoxide dismutase 2, mitochondrial 0.0739453
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0671658
PDE8A phosphodiesterase 8A 0.0660029
FNDC3A fibronectin type III domain containing 3A 0.0640313
NCEH1 neutral cholesterol ester hydrolase 1 0.0620794
YBX3 Y box binding protein 3 0.0600459
OASL 2'-5'-oligoadenylate synthetase-like 0.0597518
CSNK1A1 casein kinase 1, alpha 1 0.0594406
DST dystonin 0.0581494
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0567185
RPS12 ribosomal protein S12 0.0552774
ARL15 ADP-ribosylation factor-like 15 0.0545998
KMT2E lysine (K)-specific methyltransferase 2E 0.0545374
ZFAND6 zinc finger, AN1-type domain 6 0.0512518
SBNO1 strawberry notch homolog 1 (Drosophila) 0.050918
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0491664
TXNRD1 thioredoxin reductase 1 0.0488571
STK24 serine/threonine kinase 24 0.0481248
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0473978
UGCG UDP-glucose ceramide glucosyltransferase 0.04682
SVIL supervillin 0.0460861
MYH9 myosin, heavy chain 9, non-muscle 0.0456713
YAP1 Yes-associated protein 1 0.0454375
RAB7A RAB7A, member RAS oncogene family 0.0449327
LDHA lactate dehydrogenase A 0.0443411
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0442511
PLCB4 phospholipase C, beta 4 0.043668
EXT1 exostosin glycosyltransferase 1 0.0427775
NBAS neuroblastoma amplified sequence 0.0421561
SRRM2 serine/arginine repetitive matrix 2 0.0420549
PRRC2C proline-rich coiled-coil 2C 0.0411733
TRIO trio Rho guanine nucleotide exchange factor 0.0410407
IFIH1 interferon induced with helicase C domain 1 0.0409986
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0407906
CEP295 centrosomal protein 295kDa 0.0407121
KIF5B kinesin family member 5B 0.0406844
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0401602
RIGI RNA sensor RIG-I 0.0398263
CD44 CD44 molecule (Indian blood group) 0.0391589
JMJD1C jumonji domain containing 1C 0.0389797
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0382559
ELL2 elongation factor, RNA polymerase II, 2 0.0378564
RDX radixin 0.0376251
OGA O-GlcNAcase 0.0375319
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0372996
FLNB filamin B, beta 0.0372592
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0365428
RPL11 ribosomal protein L11 0.0363937
DERA deoxyribose-phosphate aldolase (putative) 0.0361775
NDRG1 N-myc downstream regulated 1 0.0361725
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0361113
B2M beta-2-microglobulin 0.0357772
TRA2A transformer 2 alpha homolog (Drosophila) 0.0357133
FMNL2 formin-like 2 0.0356563
TENT2 terminal nucleotidyltransferase 2 0.0356145
BTBD9 BTB (POZ) domain containing 9 0.0354733
PGK1 phosphoglycerate kinase 1 0.0353584
AFF4 AF4/FMR2 family, member 4 0.0351694
HLA-A major histocompatibility complex, class I, A 0.034303
MAN2A1 mannosidase, alpha, class 2A, member 1 0.0342303
FKBP15 FK506 binding protein 15, 133kDa 0.0341199
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0340822
ESYT2 extended synaptotagmin-like protein 2 0.0335839
DGKD diacylglycerol kinase, delta 130kDa 0.0335007
SLMAP sarcolemma associated protein 0.0334456
UBAP2L ubiquitin associated protein 2-like 0.0333988
ZMYM2 zinc finger, MYM-type 2 0.033361
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.032855
RPL35A ribosomal protein L35a 0.0327633
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0325852
RBM39 RNA binding motif protein 39 0.0325436
NCKAP1 NCK-associated protein 1 0.0324037
MACF1 microtubule-actin crosslinking factor 1 0.0323849
RICTOR RPTOR independent companion of MTOR, complex 2 0.0323556
SET SET nuclear proto-oncogene 0.0323352
EXOC4 exocyst complex component 4 0.0319811
UBR1 ubiquitin protein ligase E3 component n-recognin 1 0.0318259
MAP2K5 mitogen-activated protein kinase kinase 5 0.0318157
CBFB core-binding factor, beta subunit 0.0316396
ZC3H13 zinc finger CCCH-type containing 13 0.031626
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0315904
CUL3 cullin 3 0.0312703
ACIN1 apoptotic chromatin condensation inducer 1 0.0311829
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.0308333
MIS18BP1 MIS18 binding protein 1 0.0307826
ANKHD1 ankyrin repeat and KH domain containing 1 0.0307021
IGF1R insulin-like growth factor 1 receptor 0.03034
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0303048
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.029811
MBD5 methyl-CpG binding domain protein 5 0.0295498
SCAPER S-phase cyclin A-associated protein in the ER 0.0294313
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0294105
RSAD2 radical S-adenosyl methionine domain containing 2 0.0293683
NEMF nuclear export mediator factor 0.0291164
NBEA neurobeachin 0.0290539
NFE2L2 nuclear factor, erythroid 2-like 2 0.0288836
RPL9 ribosomal protein L9 0.028878
TPM3 tropomyosin 3 0.0288435

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.294652
INTS6 integrator complex subunit 6 -0.0976018
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0949357
HMGA2 high mobility group AT-hook 2 -0.0850004
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0760191
PTMA prothymosin, alpha -0.0720757
UBC ubiquitin C -0.0693954
AHNAK AHNAK nucleoprotein -0.0690538
CALU calumenin -0.0669446
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0659302
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0544829
PKM pyruvate kinase, muscle -0.0494695
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0473342
SPDYA speedy/RINGO cell cycle regulator family member A -0.045518
GNAS GNAS complex locus -0.0410258
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0376867
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0374573
CCDC138 coiled-coil domain containing 138 -0.0370928
TPT1 tumor protein, translationally-controlled 1 -0.0359453
SEC31A SEC31 homolog A (S. cerevisiae) -0.0357991
FNDC3B fibronectin type III domain containing 3B -0.0341892
VMP1 vacuole membrane protein 1 -0.0341376
CDCP1 CUB domain containing protein 1 -0.0317343
DNER delta/notch-like EGF repeat containing -0.0316228
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0314505
TUBA1B tubulin, alpha 1b -0.0313505
ARB2A ARB2 cotranscriptional regulator A -0.0311308
ZC3H12C zinc finger CCCH-type containing 12C -0.0310306
PCED1B PC-esterase domain containing 1B -0.0308321
RACK1 receptor for activated C kinase 1 -0.0308001
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0306164
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0304758
ZMYND8 zinc finger, MYND-type containing 8 -0.0301843
ERCC6L2 excision repair cross-complementation group 6-like 2 -0.0298203
SEC24D SEC24 family member D -0.029413
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0292436
RPS27A ribosomal protein S27a -0.0291543
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0289928
TOP1 topoisomerase (DNA) I -0.0288395
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0287783
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0286242
USP53 ubiquitin specific peptidase 53 -0.0284959
POTEF POTE ankyrin domain family, member F -0.0284721
ZC3H12B zinc finger CCCH-type containing 12B -0.0282171
COL5A1 collagen, type V, alpha 1 -0.027911
PRR16 proline rich 16 -0.0279093
PRH1 proline-rich protein HaeIII subfamily 1 -0.0278672
RPL28 ribosomal protein L28 -0.0276817
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0275747
ATM ATM serine/threonine kinase -0.0275468
MON2 MON2 homolog (S. cerevisiae) -0.0272283
UBR4 ubiquitin protein ligase E3 component n-recognin 4 -0.0271173
RAI14 retinoic acid induced 14 -0.0271066
ITGAV integrin, alpha V -0.0269126
PDCD6IP programmed cell death 6 interacting protein -0.0267832
RPL27A ribosomal protein L27a -0.0265798
RYBP RING1 and YY1 binding protein -0.0263609
EVI5 ecotropic viral integration site 5 -0.0260045
FOXO3 forkhead box O3 -0.0259806
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0258221
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0256734
ATG10 autophagy related 10 -0.0256111
HM13 histocompatibility (minor) 13 -0.0255118
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0255003
CSDE1 cold shock domain containing E1, RNA-binding -0.0254612
NABP1 nucleic acid binding protein 1 -0.0254393
CANX calnexin -0.0254176
TULP4 tubby like protein 4 -0.0252392
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0251719
NLK nemo-like kinase -0.0250442
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0250181
TMSB10 thymosin beta 10 -0.0249265
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -0.0249221
RNGTT RNA guanylyltransferase and 5'-phosphatase -0.0248061
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0247851
PRKCA protein kinase C, alpha -0.0246072
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -0.0245709
PDIA4 protein disulfide isomerase family A, member 4 -0.0244718
PDGFA platelet-derived growth factor alpha polypeptide -0.0243681
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0242478
TUBB4B tubulin, beta 4B class IVb -0.0242205
XRN2 5'-3' exoribonuclease 2 -0.0240781
TOP6BL TOP6B like initiator of meiotic double strand breaks -0.0240761
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0240479
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0239789
MTMR3 myotubularin related protein 3 -0.0237305
ANKRD28 ankyrin repeat domain 28 -0.0236747
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -0.0235796
FRMD6 FERM domain containing 6 -0.0234732
ATG7 autophagy related 7 -0.0233276
WDR59 WD repeat domain 59 -0.0233004
CAPN2 calpain 2, (m/II) large subunit -0.0232705
LMAN1 lectin, mannose-binding, 1 -0.0232696
TTC19 tetratricopeptide repeat domain 19 -0.023216
JUN jun proto-oncogene -0.0231025
FXR1 fragile X mental retardation, autosomal homolog 1 -0.022825
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0227879
GCC2 GRIP and coiled-coil domain containing 2 -0.0227714
RRBP1 ribosome binding protein 1 -0.0227137
ARL13B ADP-ribosylation factor-like 13B -0.0227133