Chlorhexidine (diacetate)_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.143353
FNDC3B fibronectin type III domain containing 3B 0.0834276
NDRG1 N-myc downstream regulated 1 0.0828475
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0825505
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0798839
TMEM156 transmembrane protein 156 0.0723566
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0678176
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.067433
MCTP2 multiple C2 domains, transmembrane 2 0.0616111
PELO pelota homolog (Drosophila) 0.057971
EFNA5 ephrin-A5 0.0557142
MYH9 myosin, heavy chain 9, non-muscle 0.0531068
CAB39 calcium binding protein 39 0.0517169
SMOX spermine oxidase 0.051578
CD109 CD109 molecule 0.0506092
SMAD3 SMAD family member 3 0.0485004
NRP1 neuropilin 1 0.0474455
PRRC2C proline-rich coiled-coil 2C 0.0466833
ITGA1 integrin, alpha 1 0.0457375
ETV6 ets variant 6 0.0448572
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0439693
ELL2 elongation factor, RNA polymerase II, 2 0.0433196
STC2 stanniocalcin 2 0.0428909
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0420714
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.040173
FAM13A family with sequence similarity 13, member A 0.0400375
HIPK2 homeodomain interacting protein kinase 2 0.0393495
TPM3 tropomyosin 3 0.0391533
PTK2 protein tyrosine kinase 2 0.0388279
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0376124
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.037463
RUNX2 runt-related transcription factor 2 0.0374389
ITGB5 integrin, beta 5 0.0368014
AFDN afadin, adherens junction formation factor 0.0365764
OGA O-GlcNAcase 0.0349152
DOCK5 dedicator of cytokinesis 5 0.0346867
NRIP1 nuclear receptor interacting protein 1 0.0340916
UBA6 ubiquitin-like modifier activating enzyme 6 0.0334652
AHR aryl hydrocarbon receptor 0.0327173
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0322971
SPRED1 sprouty-related, EVH1 domain containing 1 0.0322805
ARRDC3 arrestin domain containing 3 0.0307532
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0305943
ASPH aspartate beta-hydroxylase 0.0301627
SLTM SAFB-like, transcription modulator 0.0300887
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0299671
TRIO trio Rho guanine nucleotide exchange factor 0.0299238
RPS12 ribosomal protein S12 0.0296821
FAT1 FAT atypical cadherin 1 0.0296623
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0294628
MAP3K9 mitogen-activated protein kinase kinase kinase 9 0.0293371
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0292253
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0285111
RTN4 reticulon 4 0.0283396
CDCP1 CUB domain containing protein 1 0.028285
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0280556
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0280122
SEC23A Sec23 homolog A (S. cerevisiae) 0.0271048
PHC2 polyhomeotic homolog 2 (Drosophila) 0.027102
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0268781
AOPEP aminopeptidase O (putative) 0.0268372
VEGFA vascular endothelial growth factor A 0.0267214
NPC1 Niemann-Pick disease, type C1 0.026704
VEGFC vascular endothelial growth factor C 0.0265736
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0264311
PRELID2 PRELI domain containing 2 0.0259238
ZNF292 zinc finger protein 292 0.0258269
DNMBP dynamin binding protein 0.0253706
ETNK1 ethanolamine kinase 1 0.0252949
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.0252068
OSMR oncostatin M receptor 0.0250654
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0248637
DUSP6 dual specificity phosphatase 6 0.0245407
DST dystonin 0.0244213
CFB complement factor B 0.0242839
KLHL5 kelch-like family member 5 0.0242019
UGCG UDP-glucose ceramide glucosyltransferase 0.0241395
ANXA5 annexin A5 0.023977
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0238457
WWTR1 WW domain containing transcription regulator 1 0.0238108
NUP58 nucleoporin 58 0.0236486
TXNRD1 thioredoxin reductase 1 0.0236395
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0233698
NAV2 neuron navigator 2 0.0230263
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0227295
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0225084
SYNJ2 synaptojanin 2 0.0222651
MGST1 microsomal glutathione S-transferase 1 0.0222196
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0220878
TENT2 terminal nucleotidyltransferase 2 0.0219596
MAML2 mastermind-like 2 (Drosophila) 0.0218705
FBXL5 F-box and leucine-rich repeat protein 5 0.0218226
ANKRD11 ankyrin repeat domain 11 0.0217781
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0215982
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0215762
PRPF8 pre-mRNA processing factor 8 0.0213678
PTBP2 polypyrimidine tract binding protein 2 0.0213449
RB1CC1 RB1-inducible coiled-coil 1 0.0212506
SNX9 sorting nexin 9 0.0211719
ADAR adenosine deaminase, RNA-specific 0.0210246

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.276839
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.241863
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.177447
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.142154
PTMA prothymosin, alpha -0.120688
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.117362
SQSTM1 sequestosome 1 -0.11339
FN1 fibronectin 1 -0.10079
CANX calnexin -0.0880206
INTS6 integrator complex subunit 6 -0.0845954
NRG1 neuregulin 1 -0.0748579
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0658058
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0613598
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0581962
VCL vinculin -0.0576801
AEBP2 AE binding protein 2 -0.0494631
SYT1 synaptotagmin I -0.0493383
GNAS GNAS complex locus -0.0489692
TMSB4X thymosin beta 4, X-linked -0.0487794
TPT1 tumor protein, translationally-controlled 1 -0.047532
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0466219
FTL ferritin, light polypeptide -0.0447045
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -0.0443563
IER3 immediate early response 3 -0.0420194
RPS24 ribosomal protein S24 -0.0405738
BZW1 basic leucine zipper and W2 domains 1 -0.037171
UGDH UDP-glucose 6-dehydrogenase -0.0366553
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0360635
NCOA7 nuclear receptor coactivator 7 -0.0358416
HDLBP high density lipoprotein binding protein -0.0358366
SLC38A2 solute carrier family 38, member 2 -0.0347363
TMEM263 transmembrane protein 263 -0.034594
H1-0 H1.0 linker histone -0.034266
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0337172
ACTG1 actin gamma 1 -0.0333545
LRRC23 leucine rich repeat containing 23 -0.032029
RPS6 ribosomal protein S6 -0.0319701
LOC102724023 ES1 protein homolog, mitochondrial -0.0316147
S100A6 S100 calcium binding protein A6 -0.0314989
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0305169
RPS5 ribosomal protein S5 -0.0304351
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0297748
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0294751
S100A10 S100 calcium binding protein A10 -0.0287121
TGFB1 transforming growth factor, beta 1 -0.027985
RRBP1 ribosome binding protein 1 -0.0278706
PALLD palladin, cytoskeletal associated protein -0.0274943
ARF1 ADP-ribosylation factor 1 -0.0272939
FBXO11 F-box protein 11 -0.027242
MTDH metadherin -0.0271993
TMSB10 thymosin beta 10 -0.0267812
RTN3 reticulon 3 -0.0266522
ADIPOR2 adiponectin receptor 2 -0.0264949
ERO1B endoplasmic reticulum oxidoreductase 1 beta -0.0263989
VIM vimentin -0.0263115
RAB1A RAB1A, member RAS oncogene family -0.0261915
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0259739
STAU1 staufen double-stranded RNA binding protein 1 -0.0258586
BICD1 bicaudal D homolog 1 (Drosophila) -0.0252425
ATF6 activating transcription factor 6 -0.0249701
PLIN2 perilipin 2 -0.0246217
TTC3 tetratricopeptide repeat domain 3 -0.02404
RPL28 ribosomal protein L28 -0.0239656
FUS FUS RNA binding protein -0.0238509
INSIG1 insulin induced gene 1 -0.023844
GOLGB1 golgin B1 -0.0230266
KDM3A lysine (K)-specific demethylase 3A -0.0228859
CCDC138 coiled-coil domain containing 138 -0.0225025
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0223222
SPDYA speedy/RINGO cell cycle regulator family member A -0.0223075
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0222187
SP100 SP100 nuclear antigen -0.022155
FTH1 ferritin, heavy polypeptide 1 -0.0221368
RPS20 ribosomal protein S20 -0.0220264
RPS19 ribosomal protein S19 -0.0219268
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0218138
KRT81 keratin 81, type II -0.0217745
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0216974
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0216656
RPL31 ribosomal protein L31 -0.0216124
EIF1 eukaryotic translation initiation factor 1 -0.0215002
SEC31A SEC31 homolog A (S. cerevisiae) -0.021462
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0214424
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0214031
ABLIM1 actin binding LIM protein 1 -0.0213024
RAB7A RAB7A, member RAS oncogene family -0.0212481
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0210782
RAB31 RAB31, member RAS oncogene family -0.0207831
TTC19 tetratricopeptide repeat domain 19 -0.0207516
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0207391
POU2F2 POU class 2 homeobox 2 -0.020732
MBD5 methyl-CpG binding domain protein 5 -0.0207056
RPS25 ribosomal protein S25 -0.0206329
MORF4L2 mortality factor 4 like 2 -0.0206269
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.0206001
CLIC4 chloride intracellular channel 4 -0.020561
WSB1 WD repeat and SOCS box containing 1 -0.0204858
GLG1 golgi glycoprotein 1 -0.0204526
LY6E lymphocyte antigen 6 complex, locus E -0.0204108
RHEB Ras homolog enriched in brain -0.0203108