Chlorhexidine (diacetate)_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS12 ribosomal protein S12 0.0865281
RPL35A ribosomal protein L35a 0.062147
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0580416
GOLGA4 golgin A4 0.0517955
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0510671
MACC1 metastasis associated in colon cancer 1 0.0497918
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0477687
TXNRD1 thioredoxin reductase 1 0.0442209
MATR3 matrin 3 0.0440927
MKI67 marker of proliferation Ki-67 0.0428501
FTL ferritin, light polypeptide 0.0421638
KMT2E lysine (K)-specific methyltransferase 2E 0.0401621
SET SET nuclear proto-oncogene 0.0401338
TMEM41B transmembrane protein 41B 0.0376607
CCNL1 cyclin L1 0.036885
RPS3 ribosomal protein S3 0.0367637
RPS2 ribosomal protein S2 0.0365067
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0359563
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0335245
ANXA11 annexin A11 0.0331689
RPL37A ribosomal protein L37a 0.0311553
SRRM2 serine/arginine repetitive matrix 2 0.0310263
SNX9 sorting nexin 9 0.0303398
RPS19 ribosomal protein S19 0.0300445
LOC102724023 ES1 protein homolog, mitochondrial 0.0291527
KMT2C lysine (K)-specific methyltransferase 2C 0.0289532
GCLC glutamate-cysteine ligase, catalytic subunit 0.0287752
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0285432
NAMPT nicotinamide phosphoribosyltransferase 0.0282016
FOSL1 FOS-like antigen 1 0.0279308
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0263485
PNN pinin, desmosome associated protein 0.0263221
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 0.0259013
CD46 CD46 molecule, complement regulatory protein 0.0258752
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0253614
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0249181
FTH1 ferritin, heavy polypeptide 1 0.0248746
MKRN1 makorin ring finger protein 1 0.0246281
LMTK2 lemur tyrosine kinase 2 0.0242363
TMF1 TATA element modulatory factor 1 0.0237583
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0229137
SFTPA2 surfactant protein A2 0.0224289
TPM3 tropomyosin 3 0.0223396
RPL18 ribosomal protein L18 0.0221695
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0221563
ZNF148 zinc finger protein 148 0.0220406
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0217441
RPS17 ribosomal protein S17 0.0216904
RAB6A RAB6A, member RAS oncogene family 0.0215243
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0214597
SLK STE20-like kinase 0.0212025
NDRG1 N-myc downstream regulated 1 0.0210323
UBXN1 UBX domain protein 1 0.0209884
RPS27 ribosomal protein S27 0.020971
RPL36 ribosomal protein L36 0.0207626
RPL3 ribosomal protein L3 0.0206448
CENPF centromere protein F, 350/400kDa 0.0205863
MLEC malectin 0.0205056
HSPA8 heat shock 70kDa protein 8 0.0204844
RAD23B RAD23 homolog B (S. cerevisiae) 0.0203763
RPL11 ribosomal protein L11 0.0199229
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.019728
RPLP1 ribosomal protein, large, P1 0.0197089
KIF5B kinesin family member 5B 0.0196902
KDM7A lysine (K)-specific demethylase 7A 0.0191724
RPL37 ribosomal protein L37 0.0189246
TMED2 transmembrane emp24 domain trafficking protein 2 0.0189191
ESYT2 extended synaptotagmin-like protein 2 0.0188291
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0187531
KTN1 kinectin 1 (kinesin receptor) 0.018749
RPL30 ribosomal protein L30 0.0184324
MYH9 myosin, heavy chain 9, non-muscle 0.0183564
MT2A metallothionein 2A 0.0181748
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0180399
RFLNA refilin A 0.0179636
HMGA1 high mobility group AT-hook 1 0.0178551
RND3 Rho family GTPase 3 0.0177465
RPS7 ribosomal protein S7 0.0176661
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0176032
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0170146
ARRDC3 arrestin domain containing 3 0.0169965
FAM3C family with sequence similarity 3, member C 0.0169426
KPNB1 karyopherin (importin) beta 1 0.0169062
LAMB3 laminin, beta 3 0.0167759
USP3 ubiquitin specific peptidase 3 0.016734
CYP2S1 cytochrome P450, family 2, subfamily S, polypeptide 1 0.0166914
DST dystonin 0.0165667
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae) 0.0165286
AVL9 AVL9 homolog (S. cerevisiase) 0.016454
DPY19L1 dpy-19-like 1 (C. elegans) 0.0163485
PELI1 pellino E3 ubiquitin protein ligase 1 0.0162921
PLAUR plasminogen activator, urokinase receptor 0.0161819
CLDN3 claudin 3 0.0160811
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0159042
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0157721
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0157292
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0155667
AKAP13 A kinase (PRKA) anchor protein 13 0.0154332
RPS26 ribosomal protein S26 0.0153735
ANXA1 annexin A1 0.0152062

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.277467
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.192829
UBC ubiquitin C -0.151383
AHNAK AHNAK nucleoprotein -0.138119
KRT8 keratin 8, type II -0.110116
TMSB10 thymosin beta 10 -0.109453
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.102386
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0888059
MAML2 mastermind-like 2 (Drosophila) -0.088422
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.076547
IFRD1 interferon-related developmental regulator 1 -0.075303
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0746497
GNAS GNAS complex locus -0.0709932
CCND1 cyclin D1 -0.069064
STAU1 staufen double-stranded RNA binding protein 1 -0.0671908
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0660223
GMDS GDP-mannose 4,6-dehydratase -0.0654655
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.062712
PERP PERP, TP53 apoptosis effector -0.0615181
ACTG1 actin gamma 1 -0.060137
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0598649
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0596502
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0591254
ANXA2 annexin A2 -0.0590196
IER3 immediate early response 3 -0.0585827
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0582445
VCL vinculin -0.0582278
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0555812
CANX calnexin -0.0539589
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0533014
DLG1 discs, large homolog 1 (Drosophila) -0.0532897
INTS6 integrator complex subunit 6 -0.0527558
RPS27A ribosomal protein S27a -0.0517248
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0506643
RPS24 ribosomal protein S24 -0.0498877
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0497862
ZMYND8 zinc finger, MYND-type containing 8 -0.0492939
HDLBP high density lipoprotein binding protein -0.0481808
KDM3A lysine (K)-specific demethylase 3A -0.0477598
PKM pyruvate kinase, muscle -0.0470791
ZBTB20 zinc finger and BTB domain containing 20 -0.0470181
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.045852
TPT1 tumor protein, translationally-controlled 1 -0.0457609
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0444081
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0439617
SPDYA speedy/RINGO cell cycle regulator family member A -0.0419935
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0415649
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0413619
NFIA nuclear factor I/A -0.0409981
IARS1 isoleucyl-tRNA synthetase 1 -0.0403812
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0403673
H1-0 H1.0 linker histone -0.040181
LARS1 leucyl-tRNA synthetase 1 -0.0386261
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0381611
TMEM123 transmembrane protein 123 -0.0379294
ZNF217 zinc finger protein 217 -0.0377933
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0376974
SDC4 syndecan 4 -0.0375253
ARHGAP26 Rho GTPase activating protein 26 -0.0374024
EHBP1 EH domain binding protein 1 -0.0370829
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0369445
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0369079
S100A10 S100 calcium binding protein A10 -0.0366862
CTBP2 C-terminal binding protein 2 -0.0366685
PTPRK protein tyrosine phosphatase, receptor type, K -0.0366099
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 -0.036234
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0357876
RCOR1 REST corepressor 1 -0.0357096
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0355723
CD2AP CD2-associated protein -0.0355093
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0351886
RPL28 ribosomal protein L28 -0.0349966
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0349785
SP100 SP100 nuclear antigen -0.0347499
PCSK5 proprotein convertase subtilisin/kexin type 5 -0.0347481
SLC38A2 solute carrier family 38, member 2 -0.0347168
ZNFX1 zinc finger, NFX1-type containing 1 -0.0344413
NEBL nebulette -0.0344011
CDK13 cyclin-dependent kinase 13 -0.0343671
UBAP2 ubiquitin associated protein 2 -0.0339698
CUX1 cut-like homeobox 1 -0.0339043
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0337629
RPS11 ribosomal protein S11 -0.033604
S100A6 S100 calcium binding protein A6 -0.0332843
EIF4A1 eukaryotic translation initiation factor 4A1 -0.033232
RHEB Ras homolog enriched in brain -0.0329997
RPL14 ribosomal protein L14 -0.0326868
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0325139
FAM107B family with sequence similarity 107, member B -0.0324128
FUS FUS RNA binding protein -0.0320148
PCLO piccolo presynaptic cytomatrix protein -0.0320031
SDK1 sidekick cell adhesion molecule 1 -0.0315836
FNDC3B fibronectin type III domain containing 3B -0.0310927
OSBPL8 oxysterol binding protein-like 8 -0.0310143
SMAD3 SMAD family member 3 -0.0308358
EXOC4 exocyst complex component 4 -0.0307898
POTEF POTE ankyrin domain family, member F -0.0307633
SERINC5 serine incorporator 5 -0.0305831
RNF213 ring finger protein 213 -0.0303646
PDIA4 protein disulfide isomerase family A, member 4 -0.0303461