Chlorhexidine (diacetate)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0926372
AREG amphiregulin 0.0808444
MYO5B myosin VB 0.0723374
RPS3 ribosomal protein S3 0.0696495
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0694331
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0670238
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0654435
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0636813
RPS12 ribosomal protein S12 0.0632955
HSPA8 heat shock 70kDa protein 8 0.0554237
FMNL2 formin-like 2 0.0515747
RPS2 ribosomal protein S2 0.0509115
LAMB3 laminin, beta 3 0.0486732
OSBPL10 oxysterol binding protein-like 10 0.0483047
FRAS1 Fraser extracellular matrix complex subunit 1 0.0465068
RPL26 ribosomal protein L26 0.0461528
EMP1 epithelial membrane protein 1 0.044673
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0445937
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0433953
RPL3 ribosomal protein L3 0.042485
SNX9 sorting nexin 9 0.0424083
SET SET nuclear proto-oncogene 0.0417756
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0417189
UBE3C ubiquitin protein ligase E3C 0.040152
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0400881
TSC22D2 TSC22 domain family, member 2 0.0393594
EPHA2 EPH receptor A2 0.0391844
NDRG1 N-myc downstream regulated 1 0.0390235
HMGA1 high mobility group AT-hook 1 0.0389536
CD9 CD9 molecule 0.0372136
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.036072
KLC1 kinesin light chain 1 0.0359196
NCKAP1 NCK-associated protein 1 0.0348222
NBAS neuroblastoma amplified sequence 0.0341464
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0336181
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0333164
EXOC4 exocyst complex component 4 0.0329658
RPS27A ribosomal protein S27a 0.0328355
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 0.0327142
MPRIP myosin phosphatase Rho interacting protein 0.032436
ITPRID2 ITPR interacting domain containing 2 0.0322538
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0322146
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0317174
HMGA2 high mobility group AT-hook 2 0.0311246
ESYT2 extended synaptotagmin-like protein 2 0.0297963
RUNX2 runt-related transcription factor 2 0.0297374
RPS17 ribosomal protein S17 0.0292917
DOCK5 dedicator of cytokinesis 5 0.0292625
FAR1 fatty acyl CoA reductase 1 0.0292265
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0291901
YTHDC1 YTH domain containing 1 0.0291034
ZCCHC7 zinc finger, CCHC domain containing 7 0.0288202
EIF3B eukaryotic translation initiation factor 3, subunit B 0.0285075
RPL23 ribosomal protein L23 0.0282305
SFPQ splicing factor proline/glutamine-rich 0.0275658
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0272285
SBF2 SET binding factor 2 0.0270432
KMT2C lysine (K)-specific methyltransferase 2C 0.0268133
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0263791
SCFD1 sec1 family domain containing 1 0.0262518
RPL35A ribosomal protein L35a 0.0261213
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0260316
GOLGA4 golgin A4 0.0258918
PTPRF protein tyrosine phosphatase, receptor type, F 0.0254733
CMIP c-Maf inducing protein 0.0253945
UBE3A ubiquitin protein ligase E3A 0.0253074
KDM6A lysine (K)-specific demethylase 6A 0.0250649
SIK3 SIK family kinase 3 0.0250482
PTPRG protein tyrosine phosphatase, receptor type, G 0.0246181
PARD3 par-3 family cell polarity regulator 0.0245478
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0245196
NUP58 nucleoporin 58 0.0241636
CCNY cyclin Y 0.024063
RPS19 ribosomal protein S19 0.0237455
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0237003
LMO7 LIM domain 7 0.0233858
CLDND1 claudin domain containing 1 0.0232406
ABHD3 abhydrolase domain containing 3 0.0231681
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0231661
NEMF nuclear export mediator factor 0.0230708
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0230324
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 0.0229342
PNN pinin, desmosome associated protein 0.0229184
BMP4 bone morphogenetic protein 4 0.0225004
ITGB4 integrin, beta 4 0.022462
COBL cordon-bleu WH2 repeat protein 0.0220703
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 0.021917
CHD7 chromodomain helicase DNA binding protein 7 0.0217615
MAT2A methionine adenosyltransferase II, alpha 0.0217096
RPL13A ribosomal protein L13a 0.0216684
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.021595
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0214751
DGLUCY D-glutamate cyclase 0.0214035
EP300 E1A binding protein p300 0.0213051
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0211117
MED13 mediator complex subunit 13 0.0210866
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0210271
RCOR1 REST corepressor 1 0.0210139
DSPP dentin sialophosphoprotein 0.0208792
PIBF1 progesterone immunomodulatory binding factor 1 0.0205622

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.1742
PTMA prothymosin, alpha -0.162733
IER3 immediate early response 3 -0.146138
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.145853
VCL vinculin -0.088952
RPS24 ribosomal protein S24 -0.0871647
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0865311
RPS6 ribosomal protein S6 -0.0823832
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0694668
FHL2 four and a half LIM domains 2 -0.0678773
TOP1 topoisomerase (DNA) I -0.0597914
EIF1 eukaryotic translation initiation factor 1 -0.0567718
FERMT1 fermitin family member 1 -0.0565861
CENPF centromere protein F, 350/400kDa -0.0550116
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0530203
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0506756
CANX calnexin -0.0483838
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0475837
IARS1 isoleucyl-tRNA synthetase 1 -0.0475549
PDE4D phosphodiesterase 4D, cAMP-specific -0.047484
GDF15 growth differentiation factor 15 -0.0473791
FLOT1 flotillin 1 -0.0461284
S100A10 S100 calcium binding protein A10 -0.0458027
RAD21 RAD21 homolog (S. pombe) -0.0454743
TUBB tubulin, beta class I -0.0450376
ATXN1 ataxin 1 -0.0444338
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0442316
KITLG KIT ligand -0.0429566
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0424536
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0423282
CBX3 chromobox homolog 3 -0.0408419
GARS1 glycyl-tRNA synthetase 1 -0.0407388
DEK DEK proto-oncogene -0.0407047
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0396333
NT5DC3 5'-nucleotidase domain containing 3 -0.0386151
CD36 CD36 molecule (thrombospondin receptor) -0.0377166
RBM25 RNA binding motif protein 25 -0.0374833
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0373986
RPLP1 ribosomal protein, large, P1 -0.0369532
RRBP1 ribosome binding protein 1 -0.0356466
TXNIP thioredoxin interacting protein -0.0352966
KIAA0040 KIAA0040 -0.034814
HILPDA hypoxia inducible lipid droplet-associated -0.0347956
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0343523
RPLP0 ribosomal protein, large, P0 -0.0342976
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0336788
SLC38A2 solute carrier family 38, member 2 -0.0336311
FNDC3B fibronectin type III domain containing 3B -0.033393
TRA2A transformer 2 alpha homolog (Drosophila) -0.0331835
YAP1 Yes-associated protein 1 -0.0329299
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0329133
RPL4 ribosomal protein L4 -0.0322427
CCSER1 coiled-coil serine-rich protein 1 -0.0313737
HMGB2 high mobility group box 2 -0.0313354
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) -0.0308639
SDC4 syndecan 4 -0.0301075
RSRC2 arginine/serine-rich coiled-coil 2 -0.0294862
MT2A metallothionein 2A -0.0290831
ATP5F1B ATP synthase F1 subunit beta -0.0290675
NAMPT nicotinamide phosphoribosyltransferase -0.0290126
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0289072
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.028852
MTAP methylthioadenosine phosphorylase -0.0287611
RNF43 ring finger protein 43 -0.0283756
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0283234
GPHN gephyrin -0.0282952
LCORL ligand dependent nuclear receptor corepressor-like -0.0281064
AHNAK AHNAK nucleoprotein -0.0277581
PKM pyruvate kinase, muscle -0.0274721
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0274679
SCLT1 sodium channel and clathrin linker 1 -0.0270235
ALCAM activated leukocyte cell adhesion molecule -0.0267903
RPS4X ribosomal protein S4, X-linked -0.0266315
HDLBP high density lipoprotein binding protein -0.0263512
EGFR epidermal growth factor receptor -0.0261743
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0258282
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0258127
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0256674
RPL28 ribosomal protein L28 -0.0253382
TPM4 tropomyosin 4 -0.0252113
RPL14 ribosomal protein L14 -0.0248071
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0242642
ECT2 epithelial cell transforming 2 -0.0242014
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0240892
SOX4 SRY (sex determining region Y)-box 4 -0.0239959
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 -0.0239823
TTC3 tetratricopeptide repeat domain 3 -0.0239733
IPO7 importin 7 -0.0236712
ATL2 atlastin GTPase 2 -0.0236358
RAB10 RAB10, member RAS oncogene family -0.0236097
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0235073
SLC38A1 solute carrier family 38, member 1 -0.0234894
GNAT3 guanine nucleotide binding protein, alpha transducing 3 -0.0234047
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0233846
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0232119
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0229638
FUS FUS RNA binding protein -0.022851
R3HDM1 R3H domain containing 1 -0.022446
H1-4 H1.4 linker histone, cluster member -0.0223935
TPI1 triosephosphate isomerase 1 -0.0223226