Chlorhexidine (diacetate)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NKD1 naked cuticle homolog 1 (Drosophila) 0.167922
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0918037
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0843421
DST dystonin 0.0757005
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0754248
RPS12 ribosomal protein S12 0.0728511
MYH9 myosin, heavy chain 9, non-muscle 0.0567275
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0566669
SPATA13 spermatogenesis associated 13 0.0540194
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0486598
ATXN1 ataxin 1 0.0473129
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0456056
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0447951
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0443139
ANLN anillin, actin binding protein 0.0427491
SET SET nuclear proto-oncogene 0.0418867
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0412269
AOPEP aminopeptidase O (putative) 0.0410914
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0394478
SNX9 sorting nexin 9 0.0391498
RPS3 ribosomal protein S3 0.0373094
MACF1 microtubule-actin crosslinking factor 1 0.0368262
ZNF292 zinc finger protein 292 0.0367805
RUNX1 runt-related transcription factor 1 0.0351956
ITGA6 integrin, alpha 6 0.0347828
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0341673
ETNK1 ethanolamine kinase 1 0.033548
LPP LIM domain containing preferred translocation partner in lipoma 0.0332047
ITGB4 integrin, beta 4 0.0331175
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0328876
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0328859
RPL26 ribosomal protein L26 0.0324879
AFDN afadin, adherens junction formation factor 0.0316065
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.031231
KIZ kizuna centrosomal protein 0.0311501
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0310484
MKI67 marker of proliferation Ki-67 0.0310372
CEMIP2 cell migration inducing hyaluronidase 2 0.031019
ENO1 enolase 1, (alpha) 0.0309411
EEF2 eukaryotic translation elongation factor 2 0.0309204
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.030443
MACC1 metastasis associated in colon cancer 1 0.0304271
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0304127
RPL3 ribosomal protein L3 0.0301529
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0301396
CD46 CD46 molecule, complement regulatory protein 0.0299333
RPL37A ribosomal protein L37a 0.0290666
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0284282
RPL23 ribosomal protein L23 0.0284121
PROX1 prospero homeobox 1 0.0275951
ANKRD36 ankyrin repeat domain 36 0.0273715
PCCA propionyl CoA carboxylase, alpha polypeptide 0.026968
ANKRD28 ankyrin repeat domain 28 0.0268436
TPM3 tropomyosin 3 0.0265947
YEATS2 YEATS domain containing 2 0.0265625
ESYT2 extended synaptotagmin-like protein 2 0.0263063
NDRG1 N-myc downstream regulated 1 0.026281
ABHD2 abhydrolase domain containing 2 0.0260509
LDHA lactate dehydrogenase A 0.0259069
ZBTB20 zinc finger and BTB domain containing 20 0.0257944
KLF6 Kruppel-like factor 6 0.025615
KDM7A lysine (K)-specific demethylase 7A 0.0253862
RAD51B RAD51 paralog B 0.0246522
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0245439
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0245157
RPS2 ribosomal protein S2 0.0242563
DSPP dentin sialophosphoprotein 0.0240563
NAV2 neuron navigator 2 0.0239504
RPS7 ribosomal protein S7 0.0239345
TXNIP thioredoxin interacting protein 0.023682
AVL9 AVL9 homolog (S. cerevisiase) 0.0236779
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0234831
BACE2 beta-site APP-cleaving enzyme 2 0.0233045
TNS4 tensin 4 0.0232908
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0232873
SRSF5 serine/arginine-rich splicing factor 5 0.0231478
ANXA3 annexin A3 0.0231447
MAML2 mastermind-like 2 (Drosophila) 0.0229837
HDAC4 histone deacetylase 4 0.0226913
RPS17 ribosomal protein S17 0.0226016
CTNND1 catenin (cadherin-associated protein), delta 1 0.022539
SAMD4A sterile alpha motif domain containing 4A 0.0223986
ARGLU1 arginine and glutamate rich 1 0.0223845
CMIP c-Maf inducing protein 0.0223049
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0222373
HSPA8 heat shock 70kDa protein 8 0.0221671
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0218564
AKAP9 A kinase (PRKA) anchor protein 9 0.0217378
NCEH1 neutral cholesterol ester hydrolase 1 0.0215896
RBM26 RNA binding motif protein 26 0.021553
ITPRID2 ITPR interacting domain containing 2 0.021547
DOCK5 dedicator of cytokinesis 5 0.0212734
ASPH aspartate beta-hydroxylase 0.0212617
MINK1 misshapen-like kinase 1 0.0211943
YAP1 Yes-associated protein 1 0.0210914
AKAP13 A kinase (PRKA) anchor protein 13 0.0210877
UBA6 ubiquitin-like modifier activating enzyme 6 0.0210139
ANO6 anoctamin 6 0.0209155
KMT2C lysine (K)-specific methyltransferase 2C 0.020899
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0208619

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.211961
INTS6 integrator complex subunit 6 -0.128595
PTMA prothymosin, alpha -0.115242
VCL vinculin -0.110124
ACTG1 actin gamma 1 -0.106886
RPS6 ribosomal protein S6 -0.0886626
RPS24 ribosomal protein S24 -0.0757235
CCND1 cyclin D1 -0.0754507
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0613879
TPT1 tumor protein, translationally-controlled 1 -0.0568865
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0504691
IARS1 isoleucyl-tRNA synthetase 1 -0.0490509
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0489068
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0472856
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0471059
TMSB10 thymosin beta 10 -0.046953
AHNAK AHNAK nucleoprotein -0.0455569
PKM pyruvate kinase, muscle -0.0443516
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0442972
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0412994
GNAS GNAS complex locus -0.0395204
RPS23 ribosomal protein S23 -0.0379792
RPS5 ribosomal protein S5 -0.0364623
GMDS GDP-mannose 4,6-dehydratase -0.0349044
SLC38A2 solute carrier family 38, member 2 -0.0346705
CANX calnexin -0.0334847
POTEF POTE ankyrin domain family, member F -0.0334818
RTN3 reticulon 3 -0.0333828
S100A10 S100 calcium binding protein A10 -0.0332933
FUS FUS RNA binding protein -0.0327693
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0326692
HMGB1 high mobility group box 1 -0.0322988
KRT8 keratin 8, type II -0.0322367
KRT18 keratin 18, type I -0.0321773
H1-0 H1.0 linker histone -0.032132
CDK6 cyclin-dependent kinase 6 -0.0316088
STAU1 staufen double-stranded RNA binding protein 1 -0.0312536
UBB ubiquitin B -0.03092
RPLP0 ribosomal protein, large, P0 -0.0309188
RPL28 ribosomal protein L28 -0.0308881
DEK DEK proto-oncogene -0.0305997
AKAP12 A kinase (PRKA) anchor protein 12 -0.0305859
PERP PERP, TP53 apoptosis effector -0.0304048
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0303419
TUBA1B tubulin, alpha 1b -0.0303007
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0300978
MORF4L2 mortality factor 4 like 2 -0.0300316
RPS21 ribosomal protein S21 -0.0295784
RPL14 ribosomal protein L14 -0.0295316
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.029512
EIF1 eukaryotic translation initiation factor 1 -0.0294418
RPS11 ribosomal protein S11 -0.0290635
ATP5F1B ATP synthase F1 subunit beta -0.0290411
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0289864
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0286121
UBAP2 ubiquitin associated protein 2 -0.0285585
ABLIM1 actin binding LIM protein 1 -0.0283014
THOC2 THO complex 2 -0.0282765
LRPPRC leucine-rich pentatricopeptide repeat containing -0.028123
TMSB4X thymosin beta 4, X-linked -0.0280115
GARS1 glycyl-tRNA synthetase 1 -0.027909
TUBB tubulin, beta class I -0.0277406
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0276225
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0274536
RPL27A ribosomal protein L27a -0.0274355
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0272151
HDLBP high density lipoprotein binding protein -0.0270049
TRA2A transformer 2 alpha homolog (Drosophila) -0.0268207
RPLP1 ribosomal protein, large, P1 -0.0266697
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0266028
IER3 immediate early response 3 -0.0265033
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0264395
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 -0.026432
BZW1 basic leucine zipper and W2 domains 1 -0.0262075
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.026065
RBM39 RNA binding motif protein 39 -0.0260154
RPS16 ribosomal protein S16 -0.0259948
NPR2 natriuretic peptide receptor 2 -0.0259904
RPL32 ribosomal protein L32 -0.025849
TOP1 topoisomerase (DNA) I -0.0257709
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0257671
MT1E metallothionein 1E -0.025228
ANXA2 annexin A2 -0.0249703
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.024841
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0248357
PDLIM5 PDZ and LIM domain 5 -0.0247072
MED13 mediator complex subunit 13 -0.0246343
TPM4 tropomyosin 4 -0.0245338
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0243624
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.02385
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0236316
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0235484
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0234351
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0233689
SLC30A1 solute carrier family 30 (zinc transporter), member 1 -0.0231925
WASF2 WAS protein family, member 2 -0.0230059
TPI1 triosephosphate isomerase 1 -0.0229542
RPS25 ribosomal protein S25 -0.0229297
EIF5B eukaryotic translation initiation factor 5B -0.0228981
LOC102724023 ES1 protein homolog, mitochondrial -0.0228163